Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting β cells

Biochemistry

Volumn 44, Issue 34, 2005, Pages 11342-11352

  Yang, Jichun ^a   Gao, Zhiyong ^a   Robert, Claudia E ^a   Burkhardt, Brant R ^a   Gaweska, Helena ^a   Wagner, Amary ^a   Wu, Jianmei ^a   Greene, Scott R ^a   Young, Robert A ^a   Wolf, Bryan A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; CHEMICAL BONDS; FUNCTIONS; IMMUNOLOGY; RNA;

CELL DEATH; HELICAL BUNDLES; MUTANTS; SECONDARY STRUCTURES;

INSULIN;

CYSTEINE; CYTOKINE; INSULIN; MESSENGER RNA; MUTANT PROTEIN; PANCREATIC DERIVED FACTOR; PHENYLALANINE; PROTEIN FAM3B; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; DISULFIDE BOND; IMMUNOBLOTTING; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; CELL DEATH; CELL SURVIVAL; CYTOKINES; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; PLASMIDS; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFECTION;

EID: 23944511121     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0503908     Document Type: Article

References (42)

1. Mordes, J. P., Bortell, R., Blankenhorn, E. P., Rossini, A. A., and Greiner, D. L. (2004) Rat models of type 1 diabetes: genetics, environment, and autoimmunity, ILAR J. 45, 278-291.
2. Bach, J.-F. (1994) Insulin-dependent diabetes mellitus as an autoimmune disease, Endocr. Rev. 15, 516-542.
3. Atkinson, M. A., and Eisenbarth, G. S. (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment, Lancet 358, 221-229.
4. Mauricio, D., and Mandrup-Poulsen, T. (1998) Apoptosis and the pathogenesis of IDDM: a question of life and death, Diabetes 47, 1537-1543.
5. Nerup, J., Mandrup-Poulsen, T., Helqvist, S., Andersen, H. U., Pociot, F., Reimers, J. I., Cuartero, B. G., Karlsen, A. E., Bjerre, U., and Lorenzen, T. (1994) On the pathogenesis of IDDM. Diabetologia 37 (Suppl. 2), S82-S89.
6. Rabinovitch, A., and Suarez-Pinzon, W. L. (1998) Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol. 55, 1139-1149.
7. Major, C. D., and Wolf, B. A. (2001) Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction, Diabetes 50, 2721-2728.
8. Kutlu, B., Darville, M. I., Cardozo, A. K., and Eizirik, D. L. (2003) Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells, Diabetes 52, 348-355.
9. Chang, I., Cho, N., Kim, S., Kim, J. Y., Kim, E., Woo, J. E., Nam, J. H., Kim, S. J., and Lee, M. S. (2004) Role of Calcium in Pancreatic Islet Cell Death by IFN-{gamma}/TNF-{alpha}, J. Immunol. 172, 7008-7014.
10. Lacy, P. E. (1994) The intraislet macrophage and type I diabetes, Mt. Sinai J. Med. 61, 170-174.
11. Peterson, D. A., Lucidi-Phillipi, C. A., Murphy, D. P., Ray, J., and Gage, F. H. (1996) Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death, J. Neurosci. 16, 886-898.
12. Bergman, B., and Haskins, K. (1997) Autoreactive T-cell clones from the nonobese diabetic mouse, Proc. Soc. Exp. Biol. Med. 214, 41-48.
13. Toyoda, H., and Formby, B. (1998) Contribution of T cells to the development of autoimmune diabetes in the NOD mouse model. BioEssays 20, 750-757.
14. Arnush, M., Scarim, A. L., Heitmeier, M. R., Kelly, C. B., and Corbett, J. A. (1998) Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes, J. Immunol. 160, 2684-2691.
15. Borst, S. E. (2004) The role of TNF-alpha in insulin resistance, Endocrine 23, 177-182.
16. Silha, J. V., Krsek, M., Skrha, J., Sucharda, P., Nyomba, B. L. G., and Murphy, L. J. (2004) Plasma resistin, leptin and adiponectin levels in non-diabetic and diabetic obese subjects, Diabetic Med. 21, 497-499.
17. Stejskal, D., Lacnak, B., Hamplova, A., Proskova, J., Horalik, D., Adamovska, S., and Jurakova, R. (2003) Resistin - determination in persons with diabetes mellitus of Type 2 or in individuals with acute inflammatory disease, Diabetologia 46, A384.
18. McTernan, P. G., Fisher, F. M., Valsamakis, G., Chetty, R., Harte, A., McTernan, C. L., Clark, P. M. S., Smith, S. A., Barnett, A. H., and Kumar, S. (2003) Resistin and type 2 diabetes: Regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes, J. Clin. Endocrinol. Metab. 88, 6098-6106.
19. Scheen, A. J. (2003) Current management strategies for coexisting diabetes mellitus and obesity, Drugs 63, 1165-1184.
20. Mandrup-Poulsen, T. (2003) Beta cell death and protection, Ann. N.Y. Acad. Sci. 1005, 32-42.
21. Eizirik, D. L., and Darville, M. I. (2001) Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes, Diabetes 50 (Suppl. 1), S64-S69.
22. Sarvetnick, N., Liggitt, D., Pitts, S. L., Hansen, S. E., and Stewart, T. A. (1988) Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma, Cell 52, 773-782.
23. Stewart, A. G., Tomlinson, P. R., and Wilson, J. (1993) Airway wall remodelling in asthma: A novel target for the development of anti-asthma drugs, Trends Pharmacol. Sci. 14, 275-279.
24. Picarella, D. E., Kratz, A., Li, C., Ruddle, N. H., and Flavell, R. A. (1993) Transgenic tumor necrosis factor (TNF)-α production in pancreatic islets leads to insulitis, not diabetes: Distinct patterns of inflammation in TNF-α and TNF-β transgenic mice, J. Immunol. 150, 4136-4150.
25. Aurora, R., and Rose, G. D. (1998) Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons, Proc. Natl. Acad. Sci. U.S.A. 95, 2818-2823.
26. Zhu, Y., Xu, G., Patel, A., McLaughlin, M. M., Silverman, C., Knecht, K., Sweitzer, S., Li, X., McDonnell, P., Mirabile, R., Zimmerman, D., Boyce, R., Tierney, L. A., Hu, E., Livi, G. P., Wolf, B., Abdel-Meguid, S. S., Rose, G. D., Aurora, R., Hensley, P., Briggs, M., and Young, P. R. (2002) Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80, 144-150.
27. Cao, X., Gao, Z., Robert, C. E., Greene, S., Xu, G., Xu, W., Bell, E., Campbell, D., Zhu, Y., Young, R., Trucco, M., Markmann, J. F., Naji, A., and Wolf, B. A. (2003) Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting beta-Cells, Diabetes 52, 2296-2303.
28. Cao, X., Yang, J., Burkhardt, B., Gao, Z., Wong, R. K., Greene, S., Wu, J., and Wolf, B. A. (2005) Effects of over-expression of Pancreatic-Derived Factor (FAM3B) in isolated mouse islets and insulin-secreting Beta-TC3 cells. Am. J. Physiol. (in press).
29. Fitzhugh, D. J., Naik, S., Caughman, S. W., and Hwang, S. T. (2000) Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro, J. Immunol. 165, 6677-6681.
30. Yang, J., Wong, R. K., Wang, X., Moibi, J., Hessner, M. J., Greene, S., Wu, J., Sukumvanich, S., Wolf, B. A., and Gao, Z. (2004) Leucine Culture Reveals That ATP Synthase Functions as a Fuel Sensor in Pancreatic {beta}-Cells, J. Biol. Chem. 279, 53915-53923.
31. Bell, E., Cao, X., Moibi, J. A., Greene, S. R., Young, R., Trucco, M., Gao, Z., Matschinsky, F. M., Deng, S., Markman, J. F., Naji, A., and Wolf, B. A. (2003) Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets, Diabetes 52, 2731-2739.
32. Snouwaert, J. N., Leebeek, F. W., and Fowlkes, D. M. (1991) Role of disulfide bonds in biologic activity of human interleukin-6, J. Biol. Chem. 266, 23097-23102.
33. Breton, J., La, F. A., Bertolero, F., Orsini, G., Valsasina, B., Ziliotto, R., De, F., V, Polverino de, L. P., and Fontana, A. (1995) Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond, Eur. J. Biochem. 227, 573-581.
34. Bencsath, M., Blaskovits, A., and Borvendeg, J. (2003) Biomolecular cytokine therapy, Pathol. Oncol. Res. 9, 24-29.
35. Fernandez-Real, J. M. and Ricart, W. (1999) Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness, Diabetologia 42, 1367-1374.
36. Kotenko, S. V., and Langer, J. A. (2004) Full house: 12 receptors for 27 cytokines, Int. Immunopharmacol. 4, 593-608.
37. Kwan, T. S., Padrines, M., Theoleyre, S., Heymann, D., and Fortun, Y. (2004) IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology, Cytokine Growth Factor Rev. 15, 49-60.
38. Levine, S. J. (2004) Mechanisms of soluble cytokine receptor generation, J. Immunol. 173, 5343-5348.
39. Walter, M. R. (2002) Crystal structures of alpha-helical cytokine-receptor complexes: we've only scratched the surface, BioTechniques Suppl., 46-47.
40. Xu, W., Gao, Z., Wu, J., and Wolf, B. A. (2005) Interferon-γ- induced Regulation of the Pancreatic Derived Cytokine FAM3B in Islets and Insulin-secreting βTC3 Cells, Mol. Cell. Endocrinol. (in press).
41. Burkhardt, B. R., Yang, M. C., Robert, C. E., Yang, J., Greene, S. R., McFadden, K., Gao, Z. Y., and Wolf, B. A. (2005) Islet cell-line specific and glucose-responsive expression of the PANDER promoter, Biochim. Biophys. Acta (in press).
42. Yang, J., Young, R. A., Robert, C., Burkhardt, B., Wu, J., Gao, Z., and Wolf, B. A. (2005) Mechanisms of glucose-induced secretion of PANDER in pancreatic beta cells, Diabetes 54 (Suppl. 1), A646.