Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells

Cellular Signalling

Volumn 18, Issue 11, 2006, Pages 1876-1886

  Shin, Soon Young ^a   Choi, Byeong Hyeok ^a   Ko, Jesang ^b   Kim, Se Hyun ^c   Kim, Yong Sik ^c   Lee, Young Han ^a  

^a Hanyang University   (South Korea)

^b Korea University   (South Korea)

^c Seoul National University Hospital   (South Korea)

Author keywords

Akt; Calmodulin antagonist; Cell cycle; Clozapine; Cyclin D1; U 87MG glioblastoma

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CALMODULIN; CALMODULIN INHIBITOR; CLOZAPINE; CYCLIN D1; EPIDERMAL GROWTH FACTOR; NEUROLEPTIC AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEASOME; PROTEIN KINASE B;

ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANTIPSYCHOTIC AGENTS; CALCIUM; CALMODULIN; CELL LINE, TUMOR; CLOZAPINE; CYTOSKELETAL PROTEINS; GENE DELETION; GLIOBLASTOMA; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 33749253862     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2006.02.004     Document Type: Article

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