Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism

Journal of Endocrinology

Volumn 216, Issue 3, 2013, Pages 353-362

  Ma, Chan Juan ^a,b,c   Nie, Ai Fang ^a,b   Zhang, Zhi Jian ^a,b   Du, Zhi Guo Zhang ^a,b   Li, Xiao Ying ^a,b   Ning, Guang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Chinese Academy of Sciences   (China)

^c SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

Author keywords

Genipin; Glucose uptake; Insulin signaling; Myotubes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; EGTAZIC ACID; GENIPIN; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 3; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL FRACTIONATION; CELL LEVEL; CELL MEMBRANE; CELL SURFACE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CYTOPLASM; DOSE RESPONSE; GENE TRANSLOCATION; GLUCOSE TRANSPORT; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; IRIDOIDS; MICE; MUSCLE FIBERS, SKELETAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84875063009     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0473     Document Type: Article

References (34)

1. Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I & Garvey WT, 1998 Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. Journal of Clinical Investigation 102 1345-1351. (doi:10.1172/JCI4115)
2. Bezaire V, Seifert EL & Harper ME, 2007 Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB Journal 21 312-324. (doi:10.1096/fj.06-6966rev)
3. Chang WL, Wang HY, Shi LS, Lai JH & Lin HC, 2005 Immunosuppressive iridoids from the fruits of Gardenia jasminoides. Journal of Natural Products 68 1683-1685. (doi:10.1021/np0580816)
4. Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB & Shulman GI, 2001 In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. Journal of Biological Chemistry 276 20240-20244. (doi:10.1074/jbc.M102540200)
5. Costford SR, Chaudhry SN, Salkhordeh M & Harper ME, 2006 Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. American Journal of Physiology. Endocrinology and Metabolism 290 E1304-E1312. (doi:10.1152/ajpendo.00401.2005)
6. Danbuo Y 1984 Zabing Guagyao, 2nd edn, pp 414. Beijing, P R China: People's Health Publishers.
7. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otin M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ et al. 2003 A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO Journal 22 4103-4110. (doi:10.1093/emboj/cdg412)
8. Higaki Y, Mikami T, Fujii N, Hirshman MF, Koyama K, Seino T, Tanaka K & Goodyear LJ, 2008 Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway. American Journal of Physiology. Endocrinology and Metabolism 294 E889-E897. (doi:10.1152/ajpendo.00150.2007)
9. Jensen TE, Rose AJ, Hellsten Y, Wojtaszewski JF & Richter EA, 2007 Caffeineinduced Ca(2C) release increases AMPK-dependent glucose uptake in rodent soleus muscle. American Journal of Physiology. Endocrinology and Metabolism 293 E286-E292. (doi:10.1152/ajpendo.00693.2006)
10. Jeon WK, Hong HY & Kim BC, 2011 Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the antiinflammatory capacity in RAW264.7 macrophages. Archives of Biochemistry and Biophysics 512 119-125. (doi:10.1016/j.abb.2011.05.016)
11. Jessen N; & Goodyear LJ, 2005 Contraction signaling to glucose transport in skeletal muscle. Journal of Applied Physiology 99 330-337. (doi:10.1152/ japplphysiol.00175.2005)
12. 2-terminal kinase-dependent activation of mitochondrial pathway. Biochemical Pharmacology 70 1398-1407. (doi:10.1016/j.bcp.2005.07.025)
13. Kim ES, Jeong CS & Moon A, 2012 Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis. Oncology Reports 27 567-572. (doi:10.3892/2011.1508) Koo HJ, Lee S, Shin KH, Kim BC, Lim CJ & Park EH 2004a Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Medica 70 467-469. (doi:10.1055/s-2004-818978)
14. Koo HJ, Song YS, Kim HJ, Lee YH, Hong SM, Kim SJ, Kim BC, Jin C, Lim CJ & Park EH, 2004b Antiinflammatory effects of genipin, an active principle of gardenia. European Journal of Pharmacology 495 201-208. (doi:10.1016/j.ejphar.2004.05.031)
15. Koo HJ, Lim KH, Jung HJ & Park EH, 2006 Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. Journal of Ethnopharmacology 103 496-500. (doi:10.1016/j.jep.2005.08.011)
16. Krook A, Wallberg-Henriksson H & Zierath JR 2004 Sending the signal: molecular mechanisms regulating glucose uptake. Medicine and Science in Sports and Exercise 36 1212-1217. (doi:10.1249/01.MSS.0000132387. 25853.3B)
17. Kuang W, Tan J, Duan Y, Duan J, Wang W, Jin F, Jin Z, Yuan X & Liu Y, 2009 Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb. Biochemical and Biophysical Research Communications 378 259-263. (doi:10.1016/ j.bbrc.2008.11.041)
18. Kuo WH, Wang CJ, Young SC, Sun YC, Chen YJ & Chou FP, 2004 Differential induction of the expression of GST subunits by geniposide in rat hepatocytes. Pharmacology 70 15-22. (doi:10.1159/000074238)
19. Kuo WH, Chou FP, Young SC, Chang YC & Wang CJ, 2005 Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Toxicology and Applied Pharmacology 208 155-162. (doi:10.1016/j.taap.2005.02.013)
20. Lanner JT, Katz A, Tavi P, Sandstrom ME, Zhang SJ, Wretman C, James S, Fauconnier J, Lannergren J, Bruton JD et al. 2006 The role of Ca2C influx for insulin-mediated glucose uptake in skeletal muscle. Diabetes 55 2077-2083. (doi:10.2337/db05-1613).
21. Lee P, Lee J, Choi SY, Lee SE, Lee S & Son D, 2006 Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture. Biological & Pharmaceutical Bulletin 29 174-176. (doi:10.1248/bpb.29.174)
22. Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM et al. 2009 Reactive oxygen species enhance insulin sensitivity. Cell Metabolism 10 260-272. (doi:10.1016/j.cmet. 2009.08.009)
23. Mahadev K, Wu X, Zilbering A, Zhu L, Lawrence JT & Goldstein BJ, 2001 Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. Journal of Biological Chemistry 276 48662-48669. (doi:10.1074/jbc.M105061200)
24. Mitani Y, Dubyak GR & Ismail-Beigi F, 1996 Induction of GLUT-1 mRNA in response to inhibition of oxidative phosphorylation: role of increased [Ca2C]i. American Journal of Physiology 270 C235-C242.
25. Nam KN, Choi YS, Jung HJ, Park GH, Park JM, Moon SK, Cho KH, Kang C, Kang I, Oh MS et al. 2010 Genipin inhibits the inflammatory response of rat brain microglial cells. International Immunopharmacology 10 493-499. (doi:10.1016/j.intimp.2010.01.011)
26. Shisheva A, Buxton J & Czech MP, 1994 Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulindependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. Journal of Biological Chemistry 269 23865-23868.
27. Suzuki Y, Kondo K, Ikeda Y & Umemura K, 2001 Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Medica 67 807-810. (doi:10.1055/s-2001-18842)
28. Tortorella LL & Pilch PF, 2002 C2C12 myocytes lack an insulin-responsive vesicular compartment despite dexamethasone-induced GLUT4 expression. American Journal of Physiology. Endocrinology and Metabolism 283 E514-E524.
29. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R et al. 2000 Energy metabolism in uncoupling protein 3 gene knockout mice. Journal of Biological Chemistry 275 16258-16266. (doi:10.1074/jbc.M910179199)
30. Wang X 1991 Zhongyi Neike Bianzheng Xue, 1st edn, pp 238-241. Beijing, P R China: People's Health Publishers.
31. Wang GF, Wu SY, Rao JJ, Lu L, Xu W, Pang JX, Liu ZQ, Wu SG & Zhang JJ, 2009 Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells. Acta Pharmacologica Sinica 30 589-596. (doi:10.1038/aps.2009.31)
32. Yamazaki M, Sakura N, Chiba K & Mohri T, 2001 Prevention of the neurotoxicity of the amyloid b protein by genipin. Biological & Pharmaceutical Bulletin 24 1454-1455. (doi:10.1248/bpb.24.1454)
33. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr & Lowell BB, 2006 Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced b cell dysfunction in isolated pancreatic islets. Cell Metabolism 3 417-427. (doi:10.1016/ j.cmet.2006.04.010)
34. Zhou H, Zhao J & Zhang X, 2009 Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics 486 88-93. (doi:10.1016/ j.abb.2009.02.017)