-
1
-
-
79957871035
-
Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death
-
Abeti R, Abramov AY, Duchen MR. Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain 134: 1658-1672, 2011.
-
(2011)
Brain
, vol.134
, pp. 1658-1672
-
-
Abeti, R.1
Abramov, A.Y.2
Duchen, M.R.3
-
2
-
-
1642499152
-
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
Abramov AY, Canevari L, Duchen MR. Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24: 565-575, 2004.
-
(2004)
J Neurosci
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
3
-
-
10044244916
-
Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture
-
Abramov AY, Canevari L, Duchen MR. Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim Biophys Acta 1742: 81-87, 2004.
-
(2004)
Biochim Biophys Acta
, vol.1742
, pp. 81-87
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
4
-
-
0038452658
-
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
-
Abramov AY, Canevari L, Duchen MR. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci 23: 5088-5095, 2003.
-
(2003)
J Neurosci
, vol.23
, pp. 5088-5095
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
5
-
-
76749154427
-
Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons
-
Abramov AY, Duchen MR. Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. Biochim Biophys Acta 1800: 297-304, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1800
, pp. 297-304
-
-
Abramov, A.Y.1
Duchen, M.R.2
-
6
-
-
80155167229
-
Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria
-
Alikhani N, Guo L, Yan S, Du H, Pinho CM, Chen JX, Glaser E, Yan SS. Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria. J Alzheimers Dis 27: 75-87, 2011.
-
(2011)
J Alzheimers Dis
, vol.27
, pp. 75-87
-
-
Alikhani, N.1
Guo, L.2
Yan, S.3
Du, H.4
Pinho, C.M.5
Chen, J.X.6
Glaser, E.7
Yan, S.S.8
-
7
-
-
0037437192
-
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
-
Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161: 41-54, 2003.
-
(2003)
J Cell Biol
, vol.161
, pp. 41-54
-
-
Anandatheerthavarada, H.K.1
Biswas, G.2
Robin, M.A.3
Avadhani, N.G.4
-
8
-
-
33750323814
-
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: Relevance to Alzheimer's disease and other oxidative stressrelated neurodegenerative disorders
-
Ansari MA, Joshi G, Huang Q, Opii WO, Abdul HM, Sultana R, Butterfield DA. In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stressrelated neurodegenerative disorders. Free Radic Biol Med 41: 1694-1703, 2006.
-
(2006)
Free Radic Biol Med
, vol.41
, pp. 1694-1703
-
-
Ansari, M.A.1
Joshi, G.2
Huang, Q.3
Opii, W.O.4
Abdul, H.M.5
Sultana, R.6
Butterfield, D.A.7
-
9
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77: 817-827, 1994.
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
10
-
-
0036592758
-
The role of the metabolic lesion in Alzheimer's disease
-
Blass JP, Gibson GE, Hoyer S. The role of the metabolic lesion in Alzheimer's disease. J Alzheimers Dis 4: 225-232, 2002.
-
(2002)
J Alzheimers Dis
, vol.4
, pp. 225-232
-
-
Blass, J.P.1
Gibson, G.E.2
Hoyer, S.3
-
11
-
-
0032517186
-
Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease
-
Bobinski M, de Leon MJ, Tarnawski M, Wegiel J, Reisberg B, Miller DC, Wisniewski HM. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain Res 805: 267-269, 1998.
-
(1998)
Brain Res
, vol.805
, pp. 267-269
-
-
Bobinski, M.1
de Leon, M.J.2
Tarnawski, M.3
Wegiel, J.4
Reisberg, B.5
Miller, D.C.6
Wisniewski, H.M.7
-
12
-
-
67349200006
-
Protective actions of epoxyeicosatrienoic acid: Dual targeting of cardiovascular PI3K and KATP channels
-
Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM. Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol 46: 978-988, 2009.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 978-988
-
-
Bodiga, S.1
Zhang, R.2
Jacobs, D.E.3
Larsen, B.T.4
Tampo, A.5
Manthati, V.L.6
Kwok, W.M.7
Zeldin, D.C.8
Falck, J.R.9
Gutterman, D.D.10
Jacobs, E.R.11
Medhora, M.M.12
-
13
-
-
0036905921
-
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review
-
Butterfield DA. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res 36: 1307-1313, 2002.
-
(2002)
Free Radic Res
, vol.36
, pp. 1307-1313
-
-
Butterfield, D.A.1
-
14
-
-
0032810909
-
Beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria
-
Canevari L, Clark JB, Bates TE. beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457: 131-134, 1999.
-
(1999)
FEBS Lett
, vol.457
, pp. 131-134
-
-
Canevari, L.1
Clark, J.B.2
Bates, T.E.3
-
15
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80: 91-100, 2002.
-
(2002)
J Neurochem
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
16
-
-
0036403832
-
Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons
-
Casley CS, Land JM, Sharpe MA, Clark JB, Duchen MR, Canevari L. Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis 10: 258-267, 2002.
-
(2002)
Neurobiol Dis
, vol.10
, pp. 258-267
-
-
Casley, C.S.1
Land, J.M.2
Sharpe, M.A.3
Clark, J.B.4
Duchen, M.R.5
Canevari, L.6
-
17
-
-
33746238205
-
Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
-
de la Monte SM, Wands JR. Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis 9: 167-181, 2006.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 167-181
-
-
de la Monte, S.M.1
Wands, J.R.2
-
18
-
-
81955164821
-
Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
-
Devi L, Ohno M. Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis 45: 417-424, 2012.
-
(2012)
Neurobiol Dis
, vol.45
, pp. 417-424
-
-
Devi, L.1
Ohno, M.2
-
19
-
-
33748283747
-
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
-
Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 26: 9057-9068, 2006.
-
(2006)
J Neurosci
, vol.26
, pp. 9057-9068
-
-
Devi, L.1
Prabhu, B.M.2
Galati, D.F.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
20
-
-
53549129483
-
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
-
Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14: 1097-1105, 2008.
-
(2008)
Nat Med
, vol.14
, pp. 1097-1105
-
-
Du, H.1
Guo, L.2
Fang, F.3
Chen, D.4
Sosunov, A.A.5
McKhann, G.M.6
Yan, Y.7
Wang, C.8
Zhang, H.9
Molkentin, J.D.10
Gunn-Moore, F.J.11
Vonsattel, J.P.12
Arancio, O.13
Chen, J.X.14
Yan, S.D.15
-
21
-
-
40449090190
-
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice
-
Eckert A, Hauptmann S, Scherping I, Rhein V, Muller-Spahn F, Gotz J, Muller WE. Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis 5: 157-159, 2008.
-
(2008)
Neurodegener Dis
, vol.5
, pp. 157-159
-
-
Eckert, A.1
Hauptmann, S.2
Scherping, I.3
Rhein, V.4
Muller-Spahn, F.5
Gotz, J.6
Muller, W.E.7
-
22
-
-
81455157378
-
Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity
-
Eckert A, Schmitt K, Gotz J. Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity. Alzheimers Res Ther 3: 15, 2011.
-
(2011)
Alzheimers Res Ther
, vol.3
, pp. 15
-
-
Eckert, A.1
Schmitt, K.2
Gotz, J.3
-
23
-
-
84856049851
-
Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: Mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid
-
El-Sikhry HE, Miller GG, Madiyalakan MR, Seubert JM. Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid. Invest New Drugs 29: 1328-1336, 2011.
-
(2011)
Invest New Drugs
, vol.29
, pp. 1328-1336
-
-
El-Sikhry, H.E.1
Miller, G.G.2
Madiyalakan, M.R.3
Seubert, J.M.4
-
24
-
-
33749391917
-
Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP
-
Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M, Glaser E. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP. J Biol Chem 281: 29096-29104, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 29096-29104
-
-
Falkevall, A.1
Alikhani, N.2
Bhushan, S.3
Pavlov, P.F.4
Busch, K.5
Johnson, K.A.6
Eneqvist, T.7
Tjernberg, L.8
Ankarcrona, M.9
Glaser, E.10
-
25
-
-
33847419892
-
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts
-
Gross GJ, Hsu A, Falck JR, Nithipatikom K. Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. J Mol Cell Cardiol 42: 687-691, 2007.
-
(2007)
J Mol Cell Cardiol
, vol.42
, pp. 687-691
-
-
Gross, G.J.1
Hsu, A.2
Falck, J.R.3
Nithipatikom, K.4
-
27
-
-
33744974998
-
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
-
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE. Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease. Exp Gerontol 41: 668-673, 2006.
-
(2006)
Exp Gerontol
, vol.41
, pp. 668-673
-
-
Hauptmann, S.1
Keil, U.2
Scherping, I.3
Bonert, A.4
Eckert, A.5
Muller, W.E.6
-
28
-
-
69249211284
-
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
-
Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Muller WE. Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30: 1574-1586, 2009.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1574-1586
-
-
Hauptmann, S.1
Scherping, I.2
Drose, S.3
Brandt, U.4
Schulz, K.L.5
Jendrach, M.6
Leuner, K.7
Eckert, A.8
Muller, W.E.9
-
29
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA. Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21: 3017-3023, 2001.
-
(2001)
J Neurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
30
-
-
0033653771
-
Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
-
Hoyer S. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Exp Gerontol 35: 1363-1372, 2000.
-
(2000)
Exp Gerontol
, vol.35
, pp. 1363-1372
-
-
Hoyer, S.1
-
31
-
-
67349123094
-
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells
-
Katragadda D, Batchu SN, Cho WJ, Chaudhary KR, Falck JR, Seubert JM. Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells. J Mol Cell Cardiol 46: 867-875, 2009.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 867-875
-
-
Katragadda, D.1
Batchu, S.N.2
Cho, W.J.3
Chaudhary, K.R.4
Falck, J.R.5
Seubert, J.M.6
-
32
-
-
25444446126
-
Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency
-
Koopman WJ, Visch HJ, Verkaart S, van den Heuvel LW, Smeitink JA, Willems PH. Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency. Am J Physiol Cell Physiol 289: C881-C890, 2005.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
-
-
Koopman, W.J.1
Visch, H.J.2
Verkaart, S.3
van den Heuvel, L.W.4
Smeitink, J.A.5
Willems, P.H.6
-
33
-
-
84860198618
-
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
-
Leuner K, Schutt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Drose S, Wittig I, Willem M, Haass C, Reichert AS, Mueller WE. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 16: 1421-1433, 2012.
-
(2012)
Antioxid Redox Signal
, vol.16
, pp. 1421-1433
-
-
Leuner, K.1
Schutt, T.2
Kurz, C.3
Eckert, S.H.4
Schiller, C.5
Occhipinti, A.6
Mai, S.7
Jendrach, M.8
Eckert, G.P.9
Kruse, S.E.10
Palmiter, R.D.11
Brandt, U.12
Drose, S.13
Wittig, I.14
Willem, M.15
Haass, C.16
Reichert, A.S.17
Mueller, W.E.18
-
34
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155: 853-862, 1999.
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
35
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452, 2004.
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.F.14
Walker, D.G.15
Kuppusamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.20
Wu, H.21
more..
-
36
-
-
33646152108
-
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
-
Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15: 1437-1449, 2006.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
Park, B.S.4
Quinn, J.5
Reddy, P.H.6
-
37
-
-
79958721260
-
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
-
Manczak M, Calkins MJ, Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet 20: 2495-2509, 2011.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 2495-2509
-
-
Manczak, M.1
Calkins, M.J.2
Reddy, P.H.3
-
38
-
-
77956207531
-
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons
-
Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH. Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis 20, Suppl 2: S609-S631, 2010.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Manczak, M.1
Mao, P.2
Calkins, M.J.3
Cornea, A.4
Reddy, A.P.5
Murphy, M.P.6
Szeto, H.H.7
Park, B.8
Reddy, P.H.9
-
39
-
-
2342628596
-
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
-
Manczak M, Park BS, Jung Y, Reddy PH. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5: 147-162, 2004.
-
(2004)
Neuromolecular Med
, vol.5
, pp. 147-162
-
-
Manczak, M.1
Park, B.S.2
Jung, Y.3
Reddy, P.H.4
-
40
-
-
0032902974
-
Oxidative alterations in Alzheimer's disease
-
Markesbery WR, Carney JM. Oxidative alterations in Alzheimer's disease. Brain Pathol 9: 133-146, 1999.
-
(1999)
Brain Pathol
, vol.9
, pp. 133-146
-
-
Markesbery, W.R.1
Carney, J.M.2
-
41
-
-
80155148269
-
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
-
McManus MJ, Murphy MP, Franklin JL. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci 31: 15703-15715, 2011.
-
(2011)
J Neurosci
, vol.31
, pp. 15703-15715
-
-
McManus, M.J.1
Murphy, M.P.2
Franklin, J.L.3
-
42
-
-
0037192392
-
Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria
-
Morais Cardoso S, Swerdlow RH, Oliveira CR. Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res 931: 117-125, 2002.
-
(2002)
Brain Res
, vol.931
, pp. 117-125
-
-
Morais Cardoso, S.1
Swerdlow, R.H.2
Oliveira, C.R.3
-
43
-
-
33746829910
-
Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury
-
Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ. Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol 291: H537-H542, 2006.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
-
-
Nithipatikom, K.1
Moore, J.M.2
Isbell, M.A.3
Falck, J.R.4
Gross, G.J.5
-
44
-
-
0036838975
-
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors
-
Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC. Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol 283: H2029-H2037, 2002.
-
(2002)
Am J Physiol Heart Circ Physiol
, vol.283
-
-
Peng, X.1
Carhuapoma, J.R.2
Bhardwaj, A.3
Alkayed, N.J.4
Falck, J.R.5
Harder, D.R.6
Traystman, R.J.7
Koehler, R.C.8
-
45
-
-
73949142307
-
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
-
Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Drose S, Brandt U, Savaskan E, Czech C, Gotz J, Eckert A. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci USA 106: 20057-20062, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20057-20062
-
-
Rhein, V.1
Song, X.2
Wiesner, A.3
Ittner, L.M.4
Baysang, G.5
Meier, F.6
Ozmen, L.7
Bluethmann, H.8
Drose, S.9
Brandt, U.10
Savaskan, E.11
Czech, C.12
Gotz, J.13
Eckert, A.14
-
46
-
-
80053098381
-
Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain
-
Sarkar P, Narayanan J, Harder DR. Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain. Neuroscience 194: 241-249, 2011.
-
(2011)
Neuroscience
, vol.194
, pp. 241-249
-
-
Sarkar, P.1
Narayanan, J.2
Harder, D.R.3
-
47
-
-
0001181116
-
Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
-
Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43: 545-584, 2003.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 545-584
-
-
Selkoe, D.J.1
Schenk, D.2
-
48
-
-
70350365853
-
NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures
-
Serrano F, Chang A, Hernandez C, Pautler RG, Sweatt JD, Klann E. NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures. Mol Brain 2: 31, 2009.
-
(2009)
Mol Brain
, vol.2
, pp. 31
-
-
Serrano, F.1
Chang, A.2
Hernandez, C.3
Pautler, R.G.4
Sweatt, J.D.5
Klann, E.6
-
49
-
-
33747422507
-
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
-
Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res 99: 442-450, 2006.
-
(2006)
Circ Res
, vol.99
, pp. 442-450
-
-
Seubert, J.M.1
Sinal, C.J.2
Graves, J.3
DeGraff, L.M.4
Bradbury, J.A.5
Lee, C.R.6
Goralski, K.7
Carey, M.A.8
Luria, A.9
Newman, J.W.10
Hammock, B.D.11
Falck, J.R.12
Roberts, H.13
Rockman, H.A.14
Murphy, E.15
Zeldin, D.C.16
-
50
-
-
84857706184
-
Age-induced alterations in hippocampal function and metabolism
-
Shetty PK, Galeffi F, Turner DA. Age-induced alterations in hippocampal function and metabolism. Aging Dis 2: 196-218, 2011.
-
(2011)
Aging Dis
, vol.2
, pp. 196-218
-
-
Shetty, P.K.1
Galeffi, F.2
Turner, D.A.3
-
51
-
-
84865450193
-
The protective effect of astrocyte-derived 14, 15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture
-
Terashvili M, Sarkar P, Nostrand MV, Falck JR, Harder DR. The protective effect of astrocyte-derived 14, 15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. Neuroscience 223: 68-76, 2012.
-
(2012)
Neuroscience
, vol.223
, pp. 68-76
-
-
Terashvili, M.1
Sarkar, P.2
Nostrand, M.V.3
Falck, J.R.4
Harder, D.R.5
-
52
-
-
77954617065
-
High glucose disrupts mitochondrial morphology in retinal endothelial cells: Implications for diabetic retinopathy
-
Trudeau K, Molina AJ, Guo W, Roy S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol 177: 447-455, 2010.
-
(2010)
Am J Pathol
, vol.177
, pp. 447-455
-
-
Trudeau, K.1
Molina, A.J.2
Guo, W.3
Roy, S.4
-
53
-
-
48749085779
-
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
-
Wang X, Su B, Fujioka H, Zhu X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 173: 470-482, 2008.
-
(2008)
Am J Pathol
, vol.173
, pp. 470-482
-
-
Wang, X.1
Su, B.2
Fujioka, H.3
Zhu, X.4
-
54
-
-
58049218922
-
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
-
Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 105: 19318-19323, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
Su, B.2
Siedlak, S.L.3
Moreira, P.I.4
Fujioka, H.5
Wang, Y.6
Casadesus, G.7
Zhu, X.8
-
55
-
-
79959802475
-
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease
-
Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One 6: e21788, 2011.
-
(2011)
PLoS One
, vol.6
-
-
Yao, J.1
Chen, S.2
Mao, Z.3
Cadenas, E.4
Brinton, R.D.5
-
56
-
-
79951548587
-
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease
-
Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS. Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci 31: 2313-2320, 2011.
-
(2011)
J Neurosci
, vol.31
, pp. 2313-2320
-
-
Yao, J.1
Du, H.2
Yan, S.3
Fang, F.4
Wang, C.5
Lue, L.F.6
Guo, L.7
Chen, D.8
Stern, D.M.9
Gunn Moore, F.J.10
Xi Chen, J.11
Arancio, O.12
Yan, S.S.13
-
57
-
-
70149093436
-
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
-
Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106: 14670-14675, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14670-14675
-
-
Yao, J.1
Irwin, R.W.2
Zhao, L.3
Nilsen, J.4
Hamilton, R.T.5
Brinton, R.D.6
-
59
-
-
47649121828
-
Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia
-
Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ. Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. Stroke 39: 2073-2078, 2008.
-
(2008)
Stroke
, vol.39
, pp. 2073-2078
-
-
Zhang, W.1
Otsuka, T.2
Sugo, N.3
Ardeshiri, A.4
Alhadid, Y.K.5
Iliff, J.J.6
DeBarber, A.E.7
Koop, D.R.8
Alkayed, N.J.9
|