메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

Interleukin 6 and rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; INTERLEUKIN 6;

EID: 84893733932     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/698313     Document Type: Review
Times cited : (163)

References (100)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • 2-s2.0-84855172814
    • McInnes I. B., Schett G., The pathogenesis of rheumatoid arthritis. The New England Journal of Medicine 2011 365 23 2205 2219 2-s2.0-84855172814
    • (2011) The New England Journal of Medicine , vol.365 , Issue.23 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 77950307115 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: Recommendations of an international task force
    • 10.1136/ard.2009.123919
    • Smolen J. S., Aletaha D., Bijlsma J. W., Treating rheumatoid arthritis to target: recommendations of an international task force. Annals of the Rheumatic Diseases 2010 69 4 631 637 10.1136/ard.2009.123919
    • (2010) Annals of the Rheumatic Diseases , vol.69 , Issue.4 , pp. 631-637
    • Smolen, J.S.1    Aletaha, D.2    Bijlsma, J.W.3
  • 3
    • 78049445876 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of rheumatoid arthritis
    • 2-s2.0-78049445876 10.1586/eci.10.70
    • Tanaka T., Ogata A., Narazaki M., Tocilizumab for the treatment of rheumatoid arthritis. Expert Review of Clinical Immunology 2010 6 6 843 854 2-s2.0-78049445876 10.1586/eci.10.70
    • (2010) Expert Review of Clinical Immunology , vol.6 , Issue.6 , pp. 843-854
    • Tanaka, T.1    Ogata, A.2    Narazaki, M.3
  • 4
    • 84862908496 scopus 로고    scopus 로고
    • Therapeutic targeting of the interleukin-6 receptor
    • 2-s2.0-84555200149 10.1146/annurev-pharmtox-010611-134715
    • Tanaka T., Narazaki M., Kishimoto T., Therapeutic targeting of the interleukin-6 receptor. Annual Review of Pharmacology and Toxicology 2012 52 199 219 2-s2.0-84555200149 10.1146/annurev-pharmtox-010611-134715
    • (2012) Annual Review of Pharmacology and Toxicology , vol.52 , pp. 199-219
    • Tanaka, T.1    Narazaki, M.2    Kishimoto, T.3
  • 5
    • 84893737647 scopus 로고    scopus 로고
    • Targeting of interleukin-6 for the treatment of rheumatoid arthritis: A review and update
    • Tanaka T., Ogata A., Kishimoto T., Targeting of interleukin-6 for the treatment of rheumatoid arthritis: a review and update. Rheumatology: Current Research 2013 3 2, article S4:002
    • (2013) Rheumatology: Current Research , vol.3 , Issue.2
    • Tanaka, T.1    Ogata, A.2    Kishimoto, T.3
  • 6
    • 0020081571 scopus 로고
    • Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors
    • Yoshizaki K., Nakagawa T., Kaieda T., Muraguchi A., Yamamura Y., Kishimoto T., Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors. The Journal of Immunology 1982 128 3 1296 1301 2-s2.0-0020081571 (Pubitemid 12188454)
    • (1982) Journal of Immunology , vol.128 , Issue.3 , pp. 1296-1301
    • Yoshizaki, K.1    Nakagawa, T.2    Kaieda, T.3
  • 7
    • 0022315832 scopus 로고
    • Factors affecting B-cell growth and differentiation
    • 2-s2.0-0022315832
    • Kishimoto T., Factors affecting B-cell growth and differentiation. Annual Review of Immunology 1985 3 133 157 2-s2.0-0022315832
    • (1985) Annual Review of Immunology , vol.3 , pp. 133-157
    • Kishimoto, T.1
  • 8
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T., Yasukawa K., Harada H., Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986 324 6092 73 76 2-s2.0-0022499547 (Pubitemid 16008419)
    • (1986) Nature , vol.324 , Issue.6092 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 10
    • 0023432812 scopus 로고
    • Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
    • 2-s2.0-0023432812
    • Gauldie J., Richards C., Harnish D., Lansdorp P., Baumann H., Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proceedings of the National Academy of Sciences of the United States of America 1987 84 20 7251 7255 2-s2.0-0023432812
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.20 , pp. 7251-7255
    • Gauldie, J.1    Richards, C.2    Harnish, D.3    Lansdorp, P.4    Baumann, H.5
  • 11
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich P. C., Castell J. V., Andus T., Interleukin-6 and the acute phase response. Biochemical Journal 1990 265 3 621 636 2-s2.0-0025190892 (Pubitemid 20053863)
    • (1990) Biochemical Journal , vol.265 , Issue.3 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 12
    • 0025226107 scopus 로고
    • Biological and clinical aspects of interleukin 6
    • 2-s2.0-0025226107
    • Hirano T., Akira S., Taga T., Kishimoto T., Biological and clinical aspects of interleukin 6. Immunology Today 1990 11 12 443 449 2-s2.0-0025226107
    • (1990) Immunology Today , vol.11 , Issue.12 , pp. 443-449
    • Hirano, T.1    Akira, S.2    Taga, T.3    Kishimoto, T.4
  • 13
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • Akira S., Taga T., Kishimoto T., Interleukin-6 in biology and medicine. Advances in Immunology 1993 54 1 78 2-s2.0-0027421831 (Pubitemid 23289250)
    • (1993) Advances in Immunology , vol.54 , pp. 1-78
    • Akira, S.1    Taga, T.2    Kishimoto, T.3
  • 14
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine - 40 Years in immunology
    • DOI 10.1146/annurev.immunol.23.021704.115806
    • Kishimoto T., Interleukin-6: from basic science to medicine-40 years in immunology. Annual Review of Immunology 2005 23 1 21 2-s2.0-17644368573 10.1146/annurev.immunol.23.021704.115806 (Pubitemid 40563163)
    • (2005) Annual Review of Immunology , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 16
    • 0026485304 scopus 로고
    • Interleukin-6 and its receptor: A paradigm for cytokines
    • 2-s2.0-0026485304
    • Kishimoto T., Akira S., Taga T., Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992 258 5082 593 597 2-s2.0-0026485304
    • (1992) Science , vol.258 , Issue.5082 , pp. 593-597
    • Kishimoto, T.1    Akira, S.2    Taga, T.3
  • 17
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • DOI 10.1016/0092-8674(89)90438-8
    • Taga T., Hibi M., Hirata Y., Yamasaki K., Yasukawa K., Matsuda T., Hirano T., Kishimoto T., Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989 58 3 573 581 2-s2.0-0024393839 (Pubitemid 19203542)
    • (1989) Cell , vol.58 , Issue.3 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3    Yamasaki, K.4    Yasukawa, K.5    Matsuda, T.6    Hirano, T.7    Kishimoto, T.8
  • 18
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T., Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990 63 6 1149 1157 2-s2.0-0025630163 10.1016/0092-8674(90)90411-7 (Pubitemid 120035064)
    • (1990) Cell , vol.63 , Issue.6 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 21
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the proinflammatory activities of IL-6
    • Rose-John S., IL-6 trans-signaling via the soluble IL-6 receptor: importance for the proinflammatory activities of IL-6. International Journal of Biological Sciences 2012 8 9 1237 1247
    • (2012) International Journal of Biological Sciences , vol.8 , Issue.9 , pp. 1237-1247
    • Rose-John, S.1
  • 22
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • 2-s2.0-0028303977
    • Akira S., Nishio Y., Inoue M., Wang X.-J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T., Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994 77 1 63 71 2-s2.0-0028303977
    • (1994) Cell , vol.77 , Issue.1 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.-J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 23
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • 2-s2.0-0028931604
    • Stahl N., Farruggella T. J., Boulton T. G., Zhong Z., Darnell J. E. Jr., Yancopoulos G. D., Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 1995 267 5202 1349 1353 2-s2.0-0028931604
    • (1995) Science , vol.267 , Issue.5202 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell Jr., J.E.5    Yancopoulos, G.D.6
  • 24
    • 0029887373 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130: I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
    • 2-s2.0-0029887373
    • Gerhartz C., Heesel B., Sasse J., Hemmann U., Landgraf C., Schneider-Mergener J., Horn F., Heinrich P. C., Graeve L., Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130: I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. The Journal of Biological Chemistry 1996 271 22 12991 12998 2-s2.0-0029887373
    • (1996) The Journal of Biological Chemistry , vol.271 , Issue.22 , pp. 12991-12998
    • Gerhartz, C.1    Heesel, B.2    Sasse, J.3    Hemmann, U.4    Landgraf, C.5    Schneider-Mergener, J.6    Horn, F.7    Heinrich, P.C.8    Graeve, L.9
  • 25
    • 0030907589 scopus 로고    scopus 로고
    • Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6
    • DOI 10.1074/jbc.272.24.15135
    • Kuropatwinski K. K., de Imus C., Gearing D., Baumann H., Mosley B., Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6. The Journal of Biological Chemistry 1997 272 24 15135 15144 2-s2.0-0030907589 10.1074/jbc.272.24.15135 (Pubitemid 27255528)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.24 , pp. 15135-15144
    • Kuropatwinski, K.K.1    De Imus, C.2    Gearing, D.3    Baumann, H.4    Mosley, B.5
  • 26
    • 0033559707 scopus 로고    scopus 로고
    • Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells
    • Tomida M., Heike T., Yokota T., Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells. Blood 1999 93 6 1934 1941 2-s2.0-0033559707 (Pubitemid 29128495)
    • (1999) Blood , vol.93 , Issue.6 , pp. 1934-1941
    • Tomida, M.1    Heike, T.2    Yokota, T.3
  • 27
    • 32044466838 scopus 로고    scopus 로고
    • Exploiting the PI3K/AKT pathway for cancer drug discovery
    • 2-s2.0-32044466838 10.1038/nrd1902
    • Hennessy B. T., Smith D. L., Ram P. T., Lu Y., Mills G. B., Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews Drug Discovery 2005 4 12 988 1004 2-s2.0-32044466838 10.1038/nrd1902
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.12 , pp. 988-1004
    • Hennessy, B.T.1    Smith, D.L.2    Ram, P.T.3    Lu, Y.4    Mills, G.B.5
  • 28
    • 77952668738 scopus 로고    scopus 로고
    • Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: Involvement of EGF receptor/PI3K/Akt signaling pathway
    • 2-s2.0-77952668738 10.1016/j.ejphar.2010.03.030
    • Chien C.-M., Lin K.-L., Su J.-C., Chuang P.-W., Tseng C.-H., Chen Y.-L., Chang L.-S., Lin S.-R., Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. The European Journal of Pharmacology 2010 636 1-3 52 58 2-s2.0-77952668738 10.1016/j.ejphar.2010.03.030
    • (2010) The European Journal of Pharmacology , vol.636 , Issue.1-3 , pp. 52-58
    • Chien, C.-M.1    Lin, K.-L.2    Su, J.-C.3    Chuang, P.-W.4    Tseng, C.-H.5    Chen, Y.-L.6    Chang, L.-S.7    Lin, S.-R.8
  • 31
    • 61949463911 scopus 로고    scopus 로고
    • IL-17 and Th17 cells
    • 2-s2.0-61949463911 10.1146/annurev.immunol.021908.132710
    • Korn T., Bettelli E., Oukka M., Kuchroo V. K., IL-17 and Th17 cells. Annual Review of Immunology 2009 27 485 517 2-s2.0-61949463911 10.1146/annurev.immunol.021908.132710
    • (2009) Annual Review of Immunology , vol.27 , pp. 485-517
    • Korn, T.1    Bettelli, E.2    Oukka, M.3    Kuchroo, V.K.4
  • 32
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • 2-s2.0-77954096689 10.1002/eji.201040391
    • Kimura A., Kishimoto T., IL-6: regulator of Treg/Th17 balance. European Journal of Immunology 2010 40 7 1830 1835 2-s2.0-77954096689 10.1002/eji.201040391
    • (2010) European Journal of Immunology , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 33
  • 36
    • 73649103466 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: Effect on the expression of chemokine and adhesion molecule
    • 2-s2.0-73649103466 10.1007/s00296-009-0953-0
    • Suzuki M., Hashizume M., Yoshida H., Mihara M., Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule. Rheumatology International 2010 30 3 309 315 2-s2.0-73649103466 10.1007/s00296-009-0953-0
    • (2010) Rheumatology International , vol.30 , Issue.3 , pp. 309-315
    • Suzuki, M.1    Hashizume, M.2    Yoshida, H.3    Mihara, M.4
  • 37
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S., Sato K., Kim K. J., Takahashi N., Udagawa N., Nakamura I., Yamaguchi A., Kishimoto T., Suda T., Kashiwazaki S., Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. Journal of Bone and Mineral Research 1996 11 1 88 95 2-s2.0-13344250490 (Pubitemid 26026748)
    • (1996) Journal of Bone and Mineral Research , vol.11 , Issue.1 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6    Yamaguchi, A.7    Kishimoto, T.8    Suda, T.9    Kashiwazaki, S.10
  • 38
    • 0037105542 scopus 로고    scopus 로고
    • IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-κB ligand, osteoprotegerin, and receptor activator of NF-κB in mouse calvariae
    • Palmqvist P., Persson E., Conaway H. H., Lerner U. H., IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF- B ligand, osteoprotegerin, and receptor activator of NF- B in mouse calvariae. The Journal of Immunology 2002 169 6 3353 3362 2-s2.0-0037105542 (Pubitemid 35013185)
    • (2002) Journal of Immunology , vol.169 , Issue.6 , pp. 3353-3362
    • Palmqvist, P.1    Persson, E.2    Conaway, H.H.3    Lerner, U.H.4
  • 39
    • 77954085343 scopus 로고    scopus 로고
    • IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor i expression
    • 2-s2.0-77954085343 10.1016/j.cyto.2010.03.017
    • Suzuki M., Hashizume M., Yoshida H., Shiina M., Mihara M., IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Cytokine 2010 51 2 178 183 2-s2.0-77954085343 10.1016/j.cyto.2010.03.017
    • (2010) Cytokine , vol.51 , Issue.2 , pp. 178-183
    • Suzuki, M.1    Hashizume, M.2    Yoshida, H.3    Shiina, M.4    Mihara, M.5
  • 40
    • 0038798085 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
    • DOI 10.1002/art.11143
    • Nakahara H., Song J., Sugimoto M., Hagihara K., Kishimoto T., Yoshizaki K., Nishimoto N., Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis & Rheumatism 2003 48 6 1521 1529 2-s2.0-0038798085 10.1002/art.11143 (Pubitemid 36682359)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.6 , pp. 1521-1529
    • Nakahara, H.1    Song, J.2    Sugimoto, M.3    Hagihara, K.4    Kishimoto, T.5    Yoshizaki, K.6    Nishimoto, N.7
  • 41
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • DOI 10.1172/JCI200420945
    • Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B. K., Ganz T., IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of Clinical Investigation 2004 113 9 1271 1276 2-s2.0-2342510407 10.1172/JCI200420945 (Pubitemid 39069926)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.9 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 44
    • 0026047994 scopus 로고
    • Relationships between local inflammation, interleukin-6 concentration and the acute phase protein response in arthritis patients
    • 2-s2.0-0026047994
    • Holt I., Cooper R. G., Hopkins S. J., Relationships between local inflammation, interleukin-6 concentration and the acute phase protein response in arthritis patients. European Journal of Clinical Investigation 1991 21 5 479 484 2-s2.0-0026047994
    • (1991) European Journal of Clinical Investigation , vol.21 , Issue.5 , pp. 479-484
    • Holt, I.1    Cooper, R.G.2    Hopkins, S.J.3
  • 45
    • 0026537579 scopus 로고
    • Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
    • 2-s2.0-0026537579
    • Dasgupta B., Corkill M., Kirkham B., Gibson T., Panayi G., Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. The Journal of Rheumatology 1992 19 1 22 25 2-s2.0-0026537579
    • (1992) The Journal of Rheumatology , vol.19 , Issue.1 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3    Gibson, T.4    Panayi, G.5
  • 46
    • 0027518860 scopus 로고
    • Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
    • Madhok R., Crilly A., Watson J., Capell H. A., Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Annals of the Rheumatic Diseases 1993 52 3 232 234 2-s2.0-0027518860 (Pubitemid 23094315)
    • (1993) Annals of the Rheumatic Diseases , vol.52 , Issue.3 , pp. 232-234
    • Madhok, R.1    Crilly, A.2    Watson, J.3    Capell, H.A.4
  • 47
    • 0344193128 scopus 로고    scopus 로고
    • Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease-modifying anti-rheumatic drugs
    • 2-s2.0-0344193128
    • Straub R. H., Müller-Ladner U., Lichtinger T., Schölmerich J., Menninger H., Lang B., Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease-modifying anti-rheumatic drugs. British Journal of Rheumatology 1997 36 12 1298 1303 2-s2.0-0344193128
    • (1997) British Journal of Rheumatology , vol.36 , Issue.12 , pp. 1298-1303
    • Straub, R.H.1    Müller-Ladner, U.2    Lichtinger, T.3    Schölmerich, J.4    Menninger, H.5    Lang, B.6
  • 48
    • 84897569032 scopus 로고    scopus 로고
    • Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study
    • 10.1007/s10165-013-0894-z
    • Nishimoto N., Amano K., Hirabayashi Y., Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study. Modern Rheumatology 2014 24 1 17 25 10.1007/s10165-013-0894-z
    • (2014) Modern Rheumatology , vol.24 , Issue.1 , pp. 17-25
    • Nishimoto, N.1    Amano, K.2    Hirabayashi, Y.3
  • 54
    • 31044449633 scopus 로고    scopus 로고
    • Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis
    • DOI 10.1002/art.21537
    • Wong P. K. K., Quinn J. M. W., Sims N. A., van Nieuwenhuijze A., Campbell I. K., Wicks I. P., Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis & Rheumatism 2006 54 1 158 168 2-s2.0-31044449633 10.1002/art.21537 (Pubitemid 43122198)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.1 , pp. 158-168
    • Wong, P.K.K.1    Quinn, J.M.W.2    Sims, N.A.3    Van Nieuwenhuijze, A.4    Campbell, I.K.5    Wicks, I.P.6
  • 58
    • 0027502201 scopus 로고
    • Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
    • Sato K., Tsuchiya M., Saldanha J., Koishihara Y., Ohsugi Y., Kishimoto T., Bendig M. M., Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Research 1993 53 4 851 856 2-s2.0-0027502201 (Pubitemid 23077873)
    • (1993) Cancer Research , vol.53 , Issue.4 , pp. 851-856
    • Sato, K.1    Tsuchiya, M.2    Saldanha, J.3    Koishihara, Y.4    Ohsugi, Y.5    Kishimoto, T.6    Bendig, M.M.7
  • 59
    • 0033959608 scopus 로고    scopus 로고
    • Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
    • Nishimoto N., Sasai M., Shima Y., Nakagawa M., Matsumoto T., Shirai T., Kishimoto T., Yoshizaki K., Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood 2000 95 1 56 61 2-s2.0-0033959608 (Pubitemid 30017224)
    • (2000) Blood , vol.95 , Issue.1 , pp. 56-61
    • Nishimoto, N.1    Sasai, M.2    Shima, Y.3    Nakagawa, M.4    Matsumoto, T.5    Shirai, T.6    Kishimoto, T.7    Yoshizaki, K.8
  • 61
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
    • DOI 10.1002/art.10623
    • Choy E. H. S., Isenberg D. A., Garrood T., Farrow S., Ioannou Y., Bird H., Cheung N., Williams B., Hazleman B., Price R., Yoshizaki K., Nishimoto N., Kishimoto T., Panayi G. S., Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis & Rheumatism 2002 46 12 3143 3150 2-s2.0-0036899812 10.1002/art.10623 (Pubitemid 35453522)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.12 , pp. 3143-3150
    • Choy, E.H.S.1    Isenberg, D.A.2    Garrood, T.3    Farrow, S.4    Ioannou, Y.5    Bird, H.6    Cheung, N.7    Williams, B.8    Hazleman, B.9    Price, R.10    Yoshizaki, K.11    Nishimoto, N.12    Kishimoto, T.13    Panayi, G.S.14
  • 62
    • 0038166958 scopus 로고    scopus 로고
    • Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study
    • Nishimoto N., Yoshizaki K., Maeda K., Kuritani T., Deguchi H., Sato B., Imai N., Suemura M., Kakehi T., Takagi N., Kishimoto T., Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. The Journal of Rheumatology 2003 30 7 1426 1435 2-s2.0-0038166958 (Pubitemid 36835435)
    • (2003) Journal of Rheumatology , vol.30 , Issue.7 , pp. 1426-1435
    • Nishimoto, N.1    Yoshizaki, K.2    Maeda, K.3    Kuritani, T.4    Deguchi, H.5    Sato, B.6    Imai, N.7    Suemura, M.8    Kakehi, T.9    Takagi, N.10    Kishimoto, T.11
  • 63
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • DOI 10.1002/art.22033
    • Maini R. N., Taylor P. C., Szechinski J., Pavelka K., Bröll J., Balint G., Emery P., Raemen F., Petersen J., Smolen J., Thomson D., Kishimoto T., Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis & Rheumatism 2006 54 9 2817 2829 2-s2.0-33749363027 10.1002/art.22033 (Pubitemid 44497760)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.9 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3    Pavelka, K.4    Broll, J.5    Balint, G.6    Emery, P.7    Raemen, F.8    Petersen, J.9    Smolen, J.10    Thomson, D.11    Kishimoto, T.12
  • 64
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • DOI 10.1016/S0140-6736(08)60453-5, PII S0140673608604535
    • Smolen J. S., Beaulieu A., Rubbert-Roth A., Ramos-Remus C., Rovensky J., Alecock E., Woodworth T., Alten R., Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. The Lancet 2008 371 9617 987 997 2-s2.0-40749114497 10.1016/S0140-6736(08)60453-5 (Pubitemid 351392039)
    • (2008) The Lancet , vol.371 , Issue.9617 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6    Woodworth, T.7    Alten, R.8
  • 65
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • 2-s2.0-54949150604 10.1002/art.23940
    • Genovese M. C., McKay J. D., Nasonov E. L., Mysler E. F., Da Silva N. A., Alecock E., Woodworth T., Gomez-Reino J. J., Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis & Rheumatism 2008 58 10 2968 2980 2-s2.0-54949150604 10.1002/art.23940
    • (2008) Arthritis & Rheumatism , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3    Mysler, E.F.4    Da Silva, N.A.5    Alecock, E.6    Woodworth, T.7    Gomez-Reino, J.J.8
  • 66
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • 2-s2.0-52149099504 10.1136/ard.2008.092932
    • Emery P., Keystone E., Tony H. P., Cantagrel A., Van Vollenhoven R., Sanchez A., Alecock E., Lee J., Kremer J., IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Annals of the Rheumatic Diseases 2008 67 11 1516 1523 2-s2.0-52149099504 10.1136/ard.2008.092932
    • (2008) Annals of the Rheumatic Diseases , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    Van Vollenhoven, R.5    Sanchez, A.6    Alecock, E.7    Lee, J.8    Kremer, J.9
  • 67
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
    • 2-s2.0-79953680176 10.1002/art.30158
    • Kremer J. M., Blanco R., Brzosko M., Burgos-Vargas R., Halland A.-M., Vernon E., Ambs P., Fleischmann R., Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis & Rheumatism 2011 63 3 609 621 2-s2.0-79953680176 10.1002/art.30158
    • (2011) Arthritis & Rheumatism , vol.63 , Issue.3 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3    Burgos-Vargas, R.4    Halland, A.-M.5    Vernon, E.6    Ambs, P.7    Fleischmann, R.8
  • 69
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • DOI 10.1136/ard.2006.068064
    • Nishimoto N., Hashimoto J., Miyasaka N., Yamamoto K., Kawai S., Takeuchi T., Murata N., Van Heijde D. D., Kishimoto T., Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Annals of the Rheumatic Diseases 2007 66 9 1162 1167 2-s2.0-34447300492 10.1136/ard.2006.068064 (Pubitemid 47309731)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.9 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6    Murata, N.7    Van Heijde, D.D.8    Kishimoto, T.9
  • 70
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • 2-s2.0-60149105639 10.1007/s10165-008-0125-1
    • Nishimoto N., Miyasaka N., Yamamoto K., Kawai S., Takeuchi T., Azuma J., Kishimoto T., Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Modern Rheumatology 2009 19 1 12 19 2-s2.0-60149105639 10.1007/s10165-008-0125-1
    • (2009) Modern Rheumatology , vol.19 , Issue.1 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6    Kishimoto, T.7
  • 71
    • 79960128977 scopus 로고    scopus 로고
    • Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: Results from a retrospective study (REACTION study)
    • 2-s2.0-79960128977 10.1007/s10165-010-0366-7
    • Yamanaka H., Tanaka Y., Inoue E., Hoshi D., Momohara S., Hanami K., Yunoue N., Saito K., Amano K., Kameda H., Takeuchi T., Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study). Modern Rheumatology 2011 21 2 122 133 2-s2.0-79960128977 10.1007/s10165-010-0366-7
    • (2011) Modern Rheumatology , vol.21 , Issue.2 , pp. 122-133
    • Yamanaka, H.1    Tanaka, Y.2    Inoue, E.3    Hoshi, D.4    Momohara, S.5    Hanami, K.6    Yunoue, N.7    Saito, K.8    Amano, K.9    Kameda, H.10    Takeuchi, T.11
  • 73
    • 84871093047 scopus 로고    scopus 로고
    • Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)
    • 2-s2.0-84860521298 10.1136/annrheumdis-2011-201282
    • Dougados M., Kissel K., Sheeran T., Tak P. P., Conaghan P. G., Mola E. M., Schett G., Amital H., Navarro-Sarabia F., Hou A., Bernasconi C., Huizinga T. W. J., Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY). Annals of the Rheumatic Diseases 2012 72 1 43 50 2-s2.0-84860521298 10.1136/annrheumdis-2011-201282
    • (2012) Annals of the Rheumatic Diseases , vol.72 , Issue.1 , pp. 43-50
    • Dougados, M.1    Kissel, K.2    Sheeran, T.3    Tak, P.P.4    Conaghan, P.G.5    Mola, E.M.6    Schett, G.7    Amital, H.8    Navarro-Sarabia, F.9    Hou, A.10    Bernasconi, C.11    Huizinga, T.W.J.12
  • 74
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • Gabay C., Emery P., van Vollenhoven R., Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. The Lancet 2013 381 9877 1541 1550
    • (2013) The Lancet , vol.381 , Issue.9877 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    Van Vollenhoven, R.3
  • 75
    • 84887426711 scopus 로고    scopus 로고
    • Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis
    • 10.1136/annrheumdis-2013-203485
    • Emery P., Sebba A., Huizinga T. W., Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis. Annals of the Rheumatic Diseases 2013 10.1136/annrheumdis-2013-203485
    • (2013) Annals of the Rheumatic Diseases
    • Emery, P.1    Sebba, A.2    Huizinga, T.W.3
  • 76
    • 78650907772 scopus 로고    scopus 로고
    • Tocilizumab for rheumatoid arthritis: A cochrane systematic review
    • 2-s2.0-78650907772 10.3899/jrheum.100717
    • Singh J. A., Saba B., Lopez-Olivo M. A., Tocilizumab for rheumatoid arthritis: a cochrane systematic review. The Journal of Rheumatology 2011 38 1 10 20 2-s2.0-78650907772 10.3899/jrheum.100717
    • (2011) The Journal of Rheumatology , vol.38 , Issue.1 , pp. 10-20
    • Singh, J.A.1    Saba, B.2    Lopez-Olivo, M.A.3
  • 77
    • 84896689880 scopus 로고    scopus 로고
    • A phase 3 study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis (MUSASHI)
    • 10.1002/acr.22110
    • Ogata A., Tanimura K., Sugimoto T., A phase 3 study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis (MUSASHI). Arthritis Care & Research 2013 10.1002/acr.22110
    • (2013) Arthritis Care & Research
    • Ogata, A.1    Tanimura, K.2    Sugimoto, T.3
  • 78
    • 84889667445 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)
    • 10.1136/annrheumdis-2013-203523
    • Burmester G. R., Rubbert-Roth A., Cantagrel A., A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study). Annals of the Rheumatic Diseases 2013 73 1 69 74 10.1136/annrheumdis-2013-203523
    • (2013) Annals of the Rheumatic Diseases , vol.73 , Issue.1 , pp. 69-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 80
    • 82755160877 scopus 로고    scopus 로고
    • Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: Interim analysis of 3881 patients
    • 2-s2.0-82755160877 10.1136/ard.2011.151092
    • Koike T., Harigai M., Inokuma S., Ishiguro N., Ryu J., Takeuchi T., Takei S., Tanaka Y., Ito K., Yamanaka H., Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: interim analysis of 3881 patients. Annals of the Rheumatic Diseases 2011 70 12 2148 2151 2-s2.0-82755160877 10.1136/ard.2011.151092
    • (2011) Annals of the Rheumatic Diseases , vol.70 , Issue.12 , pp. 2148-2151
    • Koike, T.1    Harigai, M.2    Inokuma, S.3    Ishiguro, N.4    Ryu, J.5    Takeuchi, T.6    Takei, S.7    Tanaka, Y.8    Ito, K.9    Yamanaka, H.10
  • 82
    • 84876259815 scopus 로고    scopus 로고
    • Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: A cumulative analysis of up to 4.6 years of exposure
    • Genovesse M. C., Rubbert-Roth A., Smolen J. S., Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: a cumulative analysis of up to 4.6 years of exposure. The Journal of Rheumatology 2013 40 6 768 780
    • (2013) The Journal of Rheumatology , vol.40 , Issue.6 , pp. 768-780
    • Genovesse, M.C.1    Rubbert-Roth, A.2    Smolen, J.S.3
  • 83
    • 80755182205 scopus 로고    scopus 로고
    • Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: A systematic literature review
    • 2-s2.0-80755182205 10.1007/s10067-011-1827-x
    • Gout T., Östör A. J. K., Nisar M. K., Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review. Clinical Rheumatology 2011 30 11 1471 1474 2-s2.0-80755182205 10.1007/s10067-011-1827-x
    • (2011) Clinical Rheumatology , vol.30 , Issue.11 , pp. 1471-1474
    • Gout, T.1    Östör, A.J.K.2    Nisar, M.K.3
  • 84
    • 77950335656 scopus 로고    scopus 로고
    • Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor
    • 2-s2.0-77950335656 10.1136/ard.2008.104844
    • Hashizume M., Yoshida H., Koike N., Suzuki M., Mihara M., Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor. Annals of the Rheumatic Diseases 2010 69 4 741 746 2-s2.0-77950335656 10.1136/ard.2008.104844
    • (2010) Annals of the Rheumatic Diseases , vol.69 , Issue.4 , pp. 741-746
    • Hashizume, M.1    Yoshida, H.2    Koike, N.3    Suzuki, M.4    Mihara, M.5
  • 85
    • 84874406256 scopus 로고    scopus 로고
    • Sarilumab for the treatment of moderate to severe rheumatoid arthritis: Results of a phase 2, randomized, double-blind, placebo-controlled, international study
    • supplement 3
    • Huizinga T. W., Kivitz A. J., Rell-Bakalarska M., Sarilumab for the treatment of moderate to severe rheumatoid arthritis: results of a phase 2, randomized, double-blind, placebo-controlled, international study. Annals of the Rheumatic Diseases 2012 71 supplement 3 60
    • (2012) Annals of the Rheumatic Diseases , vol.71 , pp. 60
    • Huizinga, T.W.1    Kivitz, A.J.2    Rell-Bakalarska, M.3
  • 86
    • 84874433423 scopus 로고    scopus 로고
    • Results from a 2-part, proof of concept, dose ranging, randomized, double-blind, placebo-controlled, phase 2 study of sirukumab, a human anti-interleukin-6 monoclonal antibody, in patients with active rheumatoid arthritis despite methotrexate therapy
    • supplement 3
    • Hsu B., Sheng S., Smolen J. S., Weinblatt M. E., Results from a 2-part, proof of concept, dose ranging, randomized, double-blind, placebo-controlled, phase 2 study of sirukumab, a human anti-interleukin-6 monoclonal antibody, in patients with active rheumatoid arthritis despite methotrexate therapy. Annals of the Rheumatic Diseases 2012 71 supplement 3 188
    • (2012) Annals of the Rheumatic Diseases , vol.71 , pp. 188
    • Hsu, B.1    Sheng, S.2    Smolen, J.S.3    Weinblatt, M.E.4
  • 87
    • 84866405043 scopus 로고    scopus 로고
    • Osteoprotegerin expression in bone marrow by treatment with tocilizumab in rheumatoid arthritis
    • 2-s2.0-79960556769 10.1007/s00296-011-2021-9
    • Kanbe K., Nakamura A., Inoue Y., Hobo K., Osteoprotegerin expression in bone marrow by treatment with tocilizumab in rheumatoid arthritis. Rheumatology International 2012 32 9 2669 2674 2-s2.0-79960556769 10.1007/s00296-011-2021-9
    • (2012) Rheumatology International , vol.32 , Issue.9 , pp. 2669-2674
    • Kanbe, K.1    Nakamura, A.2    Inoue, Y.3    Hobo, K.4
  • 89
    • 84894903557 scopus 로고    scopus 로고
    • Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study
    • 10.1016/j.semarthrit.2013.07.008
    • Bay-Jensen A. C., Platt A., Byrjalsen I., Vergnoud P., Christiansen C., Karsdal M. A., Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study. Seminars in Arthritis and Rheumatism 2013 10.1016/j.semarthrit.2013.07.008
    • (2013) Seminars in Arthritis and Rheumatism
    • Bay-Jensen, A.C.1    Platt, A.2    Byrjalsen, I.3    Vergnoud, P.4    Christiansen, C.5    Karsdal, M.A.6
  • 90
    • 84880084417 scopus 로고    scopus 로고
    • Can IL-6 blockade rectify imbalance between Tregs and Th17 cells?
    • Tanaka T., Can IL-6 blockade rectify imbalance between Tregs and Th17 cells? Immunotherapy 2013 5 7 695 697
    • (2013) Immunotherapy , vol.5 , Issue.7 , pp. 695-697
    • Tanaka, T.1
  • 91
    • 84864481289 scopus 로고    scopus 로고
    • Brief report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis
    • Samson M., Audia S., Janikashvili N., Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis & Rheumatism 2012 64 8 2499 2503
    • (2012) Arthritis & Rheumatism , vol.64 , Issue.8 , pp. 2499-2503
    • Samson, M.1    Audia, S.2    Janikashvili, N.3
  • 92
    • 84873286047 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients
    • Pesce B., Soto L., Sabugo F., Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients. Clinical & Experimental Immunology 2013 171 3 237 242
    • (2013) Clinical & Experimental Immunology , vol.171 , Issue.3 , pp. 237-242
    • Pesce, B.1    Soto, L.2    Sabugo, F.3
  • 93
    • 84874957237 scopus 로고    scopus 로고
    • Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
    • Carbone G., Wilson A., Diehl S. A., Bunn J., Cooper S. M., Ricon M., Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis. International Journal of Biological Sciences 2013 9 3 279 288
    • (2013) International Journal of Biological Sciences , vol.9 , Issue.3 , pp. 279-288
    • Carbone, G.1    Wilson, A.2    Diehl, S.A.3    Bunn, J.4    Cooper, S.M.5    Ricon, M.6
  • 94
    • 84869888919 scopus 로고    scopus 로고
    • A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis
    • 10.1186/ar4100
    • Liu R., Wu Q., Su D., A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Research & Therapy 2012 23 14, article R255 10.1186/ar4100
    • (2012) Arthritis Research & Therapy , vol.23 , Issue.14
    • Liu, R.1    Wu, Q.2    Su, D.3
  • 95
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis
    • Fishman D., Faulds G., Jeffey R., Mohamed-Ali V., Yudkin J. S., Humphries S., Woo P., The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis. The Journal of Clinical Investigation 1998 102 7 1369 1376 2-s2.0-0032189103 (Pubitemid 28467565)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffey, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 96
    • 84865145810 scopus 로고    scopus 로고
    • Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: A meta-analysis
    • 2-s2.0-84857714041 10.1007/s00011-012-0455-5
    • Lee Y. H., Bae S.-C., Choi S. J., Ji J. D., Song G. G., Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis. Inflammation Research 2012 61 7 665 671 2-s2.0-84857714041 10.1007/s00011-012- 0455-5
    • (2012) Inflammation Research , vol.61 , Issue.7 , pp. 665-671
    • Lee, Y.H.1    Bae, S.-C.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 97
    • 84893751178 scopus 로고    scopus 로고
    • Interleukin-6, pathogenesis and treatment of autoimmune inflammatory diseases
    • Tanaka T., Narazaki M., Masuda K., Kishimoto T., Interleukin-6, pathogenesis and treatment of autoimmune inflammatory diseases. Inflammation and Regeneration 2013 33 1 54 65
    • (2013) Inflammation and Regeneration , vol.33 , Issue.1 , pp. 54-65
    • Tanaka, T.1    Narazaki, M.2    Masuda, K.3    Kishimoto, T.4
  • 99


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.