-
1
-
-
42649134105
-
Interleukin-21: Basic biology and implications for cancer and autoimmunity
-
10.1146/annurev.immunol.26.021607.090316, 17953510
-
Spolski R, Leonard WJ. Interleukin-21: Basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008, 26:57-79. 10.1146/annurev.immunol.26.021607.090316, 17953510.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 57-79
-
-
Spolski, R.1
Leonard, W.J.2
-
2
-
-
0034633734
-
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
-
10.1073/pnas.200360997, 17218, 11016959
-
Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 2000, 97:11439-11444. 10.1073/pnas.200360997, 17218, 11016959.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11439-11444
-
-
Ozaki, K.1
Kikly, K.2
Michalovich, D.3
Young, P.R.4
Leonard, W.J.5
-
3
-
-
0035400054
-
Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
-
Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K. Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001, 167:1-5.
-
(2001)
J Immunol
, vol.167
, pp. 1-5
-
-
Asao, H.1
Okuyama, C.2
Kumaki, S.3
Ishii, N.4
Tsuchiya, S.5
Foster, D.6
Sugamura, K.7
-
4
-
-
0035752146
-
Cytokines and immunodeficiency diseases
-
10.1038/35105066, 11905829
-
Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol 2001, 1:200-208. 10.1038/35105066, 11905829.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 200-208
-
-
Leonard, W.J.1
-
5
-
-
0036784616
-
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
-
Strengeil M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002, 169:3600-3605.
-
(2002)
J Immunol
, vol.169
, pp. 3600-3605
-
-
Strengeil, M.1
Sareneva, T.2
Foster, D.3
Julkunen, I.4
Matikainen, S.5
-
6
-
-
84861798801
-
Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis
-
10.1002/art.34327, 22147555
-
Terrier B, Geri G, Chaara W, Allenbach Y, Rosenzwajg M, Costedoat-Chalumeau N, Fouret P, Musset L, Benveniste O, Six A, Klatzmann D, Saadoun D, Cacoub P. Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis. Arthritis Rheum 2012, 64:2001-2011. 10.1002/art.34327, 22147555.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2001-2011
-
-
Terrier, B.1
Geri, G.2
Chaara, W.3
Allenbach, Y.4
Rosenzwajg, M.5
Costedoat-Chalumeau, N.6
Fouret, P.7
Musset, L.8
Benveniste, O.9
Six, A.10
Klatzmann, D.11
Saadoun, D.12
Cacoub, P.13
-
7
-
-
44549084734
-
Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses
-
10.1016/j.it.2008.02.008, 18440864
-
Monteleone G, Pallone F, MacDonald TT. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol 2008, 29:290-294. 10.1016/j.it.2008.02.008, 18440864.
-
(2008)
Trends Immunol
, vol.29
, pp. 290-294
-
-
Monteleone, G.1
Pallone, F.2
MacDonald, T.T.3
-
8
-
-
45449104408
-
The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
-
Spolski R, Leonard WJ. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Op Immunol 2008, 20:295-301.
-
(2008)
Curr Op Immunol
, vol.20
, pp. 295-301
-
-
Spolski, R.1
Leonard, W.J.2
-
9
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
10.1084/jem.20091738, 2822609, 20142429
-
Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ, Verma NK, Smyth MJ, Rigby RJ, Vinuesa CG. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010, 207:353-363. 10.1084/jem.20091738, 2822609, 20142429.
-
(2010)
J Exp Med
, vol.207
, pp. 353-363
-
-
Linterman, M.A.1
Beaton, L.2
Yu, D.3
Ramiscal, R.R.4
Srivastava, M.5
Hogan, J.J.6
Verma, N.K.7
Smyth, M.J.8
Rigby, R.J.9
Vinuesa, C.G.10
-
10
-
-
41549131849
-
T follicular helper (T(FH)) cells in normal and dysregulated immune responses
-
King C, Tangye SG, Mackay CR. T follicular helper (T(FH)) cells in normal and dysregulated immune responses. Ann Rev Immunol 2008, 26:741-766.
-
(2008)
Ann Rev Immunol
, vol.26
, pp. 741-766
-
-
King, C.1
Tangye, S.G.2
Mackay, C.R.3
-
11
-
-
29144519767
-
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
-
Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R, Leonard WJ, Lipsky PE. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005, 175:7867-7879.
-
(2005)
J Immunol
, vol.175
, pp. 7867-7879
-
-
Ettinger, R.1
Sims, G.P.2
Fairhurst, A.M.3
Robbins, R.4
da Silva, Y.S.5
Spolski, R.6
Leonard, W.J.7
Lipsky, P.E.8
-
12
-
-
33749531054
-
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
-
Good KL, Bryant VL, Tangye SG. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006, 177:5236-5247.
-
(2006)
J Immunol
, vol.177
, pp. 5236-5247
-
-
Good, K.L.1
Bryant, V.L.2
Tangye, S.G.3
-
13
-
-
11144355735
-
Cutting edge: IL-21 is a switch factor for the production of IgG(1) and IgG(3) by human B cells
-
Pene J, Gauchat JF, Lecart S, Drouet E, Guglielmi P, Boulay V, Delwail A, Foster D, Lecron JC, Yssel H. Cutting edge: IL-21 is a switch factor for the production of IgG(1) and IgG(3) by human B cells. J Immunol 2004, 172:5154-5157.
-
(2004)
J Immunol
, vol.172
, pp. 5154-5157
-
-
Pene, J.1
Gauchat, J.F.2
Lecart, S.3
Drouet, E.4
Guglielmi, P.5
Boulay, V.6
Delwail, A.7
Foster, D.8
Lecron, J.C.9
Yssel, H.10
-
14
-
-
46749151286
-
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
-
10.1016/j.immuni.2008.05.009, 2556461, 18599325
-
Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29:138-149. 10.1016/j.immuni.2008.05.009, 2556461, 18599325.
-
(2008)
Immunity
, vol.29
, pp. 138-149
-
-
Nurieva, R.I.1
Chung, Y.2
Hwang, D.3
Yang, X.O.4
Kang, H.S.5
Ma, L.6
Wang, Y.H.7
Watowich, S.S.8
Jetten, A.M.9
Tian, Q.10
Dong, C.11
-
15
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
10.1016/j.immuni.2008.06.001, 18602282
-
Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008, 29:127-137. 10.1016/j.immuni.2008.06.001, 18602282.
-
(2008)
Immunity
, vol.29
, pp. 127-137
-
-
Vogelzang, A.1
McGuire, H.M.2
Yu, D.3
Sprent, J.4
Mackay, C.R.5
King, C.6
-
16
-
-
38049101408
-
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5(+) T follicular helper cells
-
Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, Malefyt RD, Tangye SG. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5(+) T follicular helper cells. J Immunol 2007, 179:8180-8190.
-
(2007)
J Immunol
, vol.179
, pp. 8180-8190
-
-
Bryant, V.L.1
Ma, C.S.2
Avery, D.T.3
Li, Y.4
Good, K.L.5
Corcoran, L.M.6
Malefyt, R.D.7
Tangye, S.G.8
-
17
-
-
79251521021
-
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
-
10.1016/j.immuni.2010.12.012, 3046815, 21215658
-
Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G, Foucat E, Dullaers M, Oh S, Sabzghabaei N, Lavecchio EM, Punaro M, Pascual V, Banchereau J, Ueno H. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011, 34:108-121. 10.1016/j.immuni.2010.12.012, 3046815, 21215658.
-
(2011)
Immunity
, vol.34
, pp. 108-121
-
-
Morita, R.1
Schmitt, N.2
Bentebibel, S.E.3
Ranganathan, R.4
Bourdery, L.5
Zurawski, G.6
Foucat, E.7
Dullaers, M.8
Oh, S.9
Sabzghabaei, N.10
Lavecchio, E.M.11
Punaro, M.12
Pascual, V.13
Banchereau, J.14
Ueno, H.15
-
18
-
-
78049354525
-
B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses
-
10.4049/jimmunol.0903839, 20660710
-
Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H. B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses. J Immunol 2010, 185:2730-2736. 10.4049/jimmunol.0903839, 20660710.
-
(2010)
J Immunol
, vol.185
, pp. 2730-2736
-
-
Kashiwakuma, D.1
Suto, A.2
Hiramatsu, Y.3
Ikeda, K.4
Takatori, H.5
Suzuki, K.6
Kagami, S.7
Hirose, K.8
Watanabe, N.9
Iwamoto, I.10
Nakajima, H.11
-
19
-
-
79251547700
-
IL-21 Receptor is critical for the development of memory B cell responses
-
10.4049/jimmunol.0903207, 21169545
-
Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H. IL-21 Receptor is critical for the development of memory B cell responses. J Immunol 2011, 186:667-674. 10.4049/jimmunol.0903207, 21169545.
-
(2011)
J Immunol
, vol.186
, pp. 667-674
-
-
Rankin, A.L.1
MacLeod, H.2
Keegan, S.3
Andreyeva, T.4
Lowe, L.5
Bloom, L.6
Collins, M.7
Nickerson-Nutter, C.8
Young, D.9
Guay, H.10
-
20
-
-
77149142640
-
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
-
10.1084/jem.20091777, 2822601, 20142430
-
Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, Nutt SL, Tarlinton DM. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010, 207:365-378. 10.1084/jem.20091777, 2822601, 20142430.
-
(2010)
J Exp Med
, vol.207
, pp. 365-378
-
-
Zotos, D.1
Coquet, J.M.2
Zhang, Y.3
Light, A.4
D'Costa, K.5
Kallies, A.6
Corcoran, L.M.7
Godfrey, D.I.8
Toellner, K.M.9
Smyth, M.J.10
Nutt, S.L.11
Tarlinton, D.M.12
-
21
-
-
79957568265
-
Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis
-
10.1186/1471-2474-12-120, 3123613, 21624120
-
Salaffi F, Carotti M, Ciapetti A, Gasparini S, Filippucci E, Grassi W. Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis. BMC Musculoskelet Disord 2011, 12:120. 10.1186/1471-2474-12-120, 3123613, 21624120.
-
(2011)
BMC Musculoskelet Disord
, vol.12
, pp. 120
-
-
Salaffi, F.1
Carotti, M.2
Ciapetti, A.3
Gasparini, S.4
Filippucci, E.5
Grassi, W.6
-
22
-
-
0141839077
-
Rheumatoid factor is the strongest predictor of radiological progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients
-
10.1093/rheumatology/keg257, 12730503
-
Vittecoq O, Pouplin S, Krzanowska K, Jouen-Beades F, Menard JF, Gayet A, Daragon A, Tron F, Le Loet X. Rheumatoid factor is the strongest predictor of radiological progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients. Rheumatology 2003, 42:939-946. 10.1093/rheumatology/keg257, 12730503.
-
(2003)
Rheumatology
, vol.42
, pp. 939-946
-
-
Vittecoq, O.1
Pouplin, S.2
Krzanowska, K.3
Jouen-Beades, F.4
Menard, J.F.5
Gayet, A.6
Daragon, A.7
Tron, F.8
Le Loet, X.9
-
23
-
-
77955000386
-
Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis
-
10.1136/ard.2009.122739, 3122886, 20439294
-
Miriovsky BJ, Michaud K, Thiele GM, O'Dell JR, Cannon GW, Kerr G, Richards JS, Johnson D, Caplan L, Reimold A, Hooker R, Mikuls TR. Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis. Ann Rheum Dis 2010, 69:1292-1297. 10.1136/ard.2009.122739, 3122886, 20439294.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1292-1297
-
-
Miriovsky, B.J.1
Michaud, K.2
Thiele, G.M.3
O'Dell, J.R.4
Cannon, G.W.5
Kerr, G.6
Richards, J.S.7
Johnson, D.8
Caplan, L.9
Reimold, A.10
Hooker, R.11
Mikuls, T.R.12
-
24
-
-
34147219949
-
Prediction models for rheumatoid arthritis during diagnostic investigation: evaluation of combinations of rheumatoid factor, anti-citrullinated protein/peptide antibodies and the human leucocyte antigen-shared epitope
-
10.1136/ard.2006.053470, 1856010, 16840502
-
Vander Cruyssen B, Hoffman IEA, Peene I, Union A, Mielants H, Meheus L, De Keyser F. Prediction models for rheumatoid arthritis during diagnostic investigation: evaluation of combinations of rheumatoid factor, anti-citrullinated protein/peptide antibodies and the human leucocyte antigen-shared epitope. Ann Rheum Dis 2007, 66:364-369. 10.1136/ard.2006.053470, 1856010, 16840502.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 364-369
-
-
Vander Cruyssen, B.1
Hoffman, I.E.A.2
Peene, I.3
Union, A.4
Mielants, H.5
Meheus, L.6
De Keyser, F.7
-
25
-
-
58249097071
-
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
-
10.1002/art.24135, 2874319, 19116921
-
Ding B, Padyukov L, Lundstrom E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L. Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum 2009, 60:30-38. 10.1002/art.24135, 2874319, 19116921.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 30-38
-
-
Ding, B.1
Padyukov, L.2
Lundstrom, E.3
Seielstad, M.4
Plenge, R.M.5
Oksenberg, J.R.6
Gregersen, P.K.7
Alfredsson, L.8
Klareskog, L.9
-
26
-
-
33645511657
-
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
-
10.1172/JCI25422, 1421345, 16585962
-
Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006, 116:961-973. 10.1172/JCI25422, 1421345, 16585962.
-
(2006)
J Clin Invest
, vol.116
, pp. 961-973
-
-
Kuhn, K.A.1
Kulik, L.2
Tomooka, B.3
Braschler, K.J.4
Arend, W.P.5
Robinson, W.H.6
Holers, V.M.7
-
27
-
-
33344472728
-
Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB
-
10.1084/jem.20051951, 2118221, 16476768
-
Petkova SB, Konstantinov KN, Sproule TJ, Lyons BL, Al Awwami M, Roopenian DC. Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB. J Exp Med 2006, 203:275-280. 10.1084/jem.20051951, 2118221, 16476768.
-
(2006)
J Exp Med
, vol.203
, pp. 275-280
-
-
Petkova, S.B.1
Konstantinov, K.N.2
Sproule, T.J.3
Lyons, B.L.4
Al Awwami, M.5
Roopenian, D.C.6
-
28
-
-
2342491493
-
Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
-
10.1002/art.20218, 15146416
-
Jungel A, Distler JHW, Kurowska-Stolarska M, Seemayer CA, Seibl R, Forster A, Michel BA, Gay RE, Emmrich F, Gay S, Distler O. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004, 50:1468-1476. 10.1002/art.20218, 15146416.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1468-1476
-
-
Jungel, A.1
Distler, J.H.W.2
Kurowska-Stolarska, M.3
Seemayer, C.A.4
Seibl, R.5
Forster, A.6
Michel, B.A.7
Gay, R.E.8
Emmrich, F.9
Gay, S.10
Distler, O.11
-
29
-
-
65249180981
-
A positive feedback loop of IL-21 signaling provoked by homeostatic CD4(+)CD25(-) T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice
-
10.4049/jimmunol.0804350, 19342640
-
Jang E, Cho SH, Park H, Paik DJ, Kim JM, Youn J. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4(+)CD25(-) T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 2009, 182:4649-4656. 10.4049/jimmunol.0804350, 19342640.
-
(2009)
J Immunol
, vol.182
, pp. 4649-4656
-
-
Jang, E.1
Cho, S.H.2
Park, H.3
Paik, D.J.4
Kim, J.M.5
Youn, J.6
-
30
-
-
0028815803
-
Modified disease-activity scores that include 28-joint counts-development and validation in a prospective longitudinal-study of patients with rheumatoid-arthritis
-
10.1002/art.1780380107, 7818570
-
Prevoo MLL, Vanthof MA, Kuper HH, Vanleeuwen MA, Vandeputte LBA, Vanriel P. Modified disease-activity scores that include 28-joint counts-development and validation in a prospective longitudinal-study of patients with rheumatoid-arthritis. Arthritis Rheum 1995, 38:44-48. 10.1002/art.1780380107, 7818570.
-
(1995)
Arthritis Rheum
, vol.38
, pp. 44-48
-
-
Prevoo, M.L.L.1
Vanthof, M.A.2
Kuper, H.H.3
Vanleeuwen, M.A.4
Vandeputte, L.B.A.5
Vanriel, P.6
-
31
-
-
61949131896
-
Follicular helper T cells: lineage and location
-
10.1016/j.immuni.2009.03.003, 2731675, 19303387
-
Fazilleau N, Mark L, McHeyzer-Williams LJ, McHeyzer-Williams MG. Follicular helper T cells: lineage and location. Immunity 2009, 30:324-335. 10.1016/j.immuni.2009.03.003, 2731675, 19303387.
-
(2009)
Immunity
, vol.30
, pp. 324-335
-
-
Fazilleau, N.1
Mark, L.2
McHeyzer-Williams, L.J.3
McHeyzer-Williams, M.G.4
-
32
-
-
2942709751
-
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or bim-dependent apoptosis
-
Jin HL, Carrio R, Yu AX, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or bim-dependent apoptosis. J Immunol 2004, 173:657-665.
-
(2004)
J Immunol
, vol.173
, pp. 657-665
-
-
Jin, H.L.1
Carrio, R.2
Yu, A.X.3
Malek, T.R.4
-
33
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of blimp-1 and bcl-61
-
Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse HC, Lipsky PE, Leonard WJ. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of blimp-1 and bcl-61. J Immunol 2004, 173:5361-5371.
-
(2004)
J Immunol
, vol.173
, pp. 5361-5371
-
-
Ozaki, K.1
Spolski, R.2
Ettinger, R.3
Kim, H.P.4
Wang, G.5
Qi, C.F.6
Hwu, P.7
Shaffer, D.J.8
Akilesh, S.9
Roopenian, D.C.10
Morse, H.C.11
Lipsky, P.E.12
Leonard, W.J.13
-
34
-
-
33749552196
-
Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
-
10.1111/j.1365-3083.2006.01795.x, 17032244
-
Li J, Shen W, Kong K, Liu Z. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006, 64:515-522. 10.1111/j.1365-3083.2006.01795.x, 17032244.
-
(2006)
Scand J Immunol
, vol.64
, pp. 515-522
-
-
Li, J.1
Shen, W.2
Kong, K.3
Liu, Z.4
-
35
-
-
77957879962
-
Increased Interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
-
10.3899/jrheum.100259, 20682664
-
Rasmussen TK, Andersen T, Hvid M, Hetland ML, Horslev-Petersen K, Stengaard-Pedersen K, Holm CK, Deleuran B. Increased Interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 2010, 37:2014-2020. 10.3899/jrheum.100259, 20682664.
-
(2010)
J Rheumatol
, vol.37
, pp. 2014-2020
-
-
Rasmussen, T.K.1
Andersen, T.2
Hvid, M.3
Hetland, M.L.4
Horslev-Petersen, K.5
Stengaard-Pedersen, K.6
Holm, C.K.7
Deleuran, B.8
-
36
-
-
38049110981
-
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4(+) T cell-B cell collaboration
-
Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4(+) T cell-B cell collaboration. J Immunol 2007, 179:5886-5896.
-
(2007)
J Immunol
, vol.179
, pp. 5886-5896
-
-
Kuchen, S.1
Robbins, R.2
Sims, G.P.3
Sheng, C.4
Phillips, T.M.5
Lipsky, P.E.6
Ettinger, R.7
-
37
-
-
0037446642
-
IL-21 induces the apoptosis of resting and activated primary B cells
-
Mehta DS, Wurster AL, Whitters MJ, Young DA, Collins M, Grusby MJ. IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol 2003, 170:4111-4118.
-
(2003)
J Immunol
, vol.170
, pp. 4111-4118
-
-
Mehta, D.S.1
Wurster, A.L.2
Whitters, M.J.3
Young, D.A.4
Collins, M.5
Grusby, M.J.6
-
38
-
-
76149139419
-
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
-
10.1084/jem.20091706, 2812540, 20048285
-
Avery DT, Deenick EK, Ma CS, Suryani S, Simpson N, Chew GY, Chan TD, Palendira U, Bustamante J, Boisson-Dupuis S, Choo S, Bleasel KE, Peake J, King C, French MA, Engelhard D, Al-Hajjar S, Al-Muhsen S, Magdorf K, Roesler J, Arkwright PD, Hissaria P, Riminton DS, Wong M, Brink R, Fulcher DA, Casanova JL, Cook MC, Tangye SG. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 2010, 207:155-171. 10.1084/jem.20091706, 2812540, 20048285.
-
(2010)
J Exp Med
, vol.207
, pp. 155-171
-
-
Avery, D.T.1
Deenick, E.K.2
Ma, C.S.3
Suryani, S.4
Simpson, N.5
Chew, G.Y.6
Chan, T.D.7
Palendira, U.8
Bustamante, J.9
Boisson-Dupuis, S.10
Choo, S.11
Bleasel, K.E.12
Peake, J.13
King, C.14
French, M.A.15
Engelhard, D.16
Al-Hajjar, S.17
Al-Muhsen, S.18
Magdorf, K.19
Roesler, J.20
Arkwright, P.D.21
Hissaria, P.22
Riminton, D.S.23
Wong, M.24
Brink, R.25
Fulcher, D.A.26
Casanova, J.L.27
Cook, M.C.28
Tangye, S.G.29
more..
-
39
-
-
41949097030
-
The biology of interleukin-2
-
Matek TR. The biology of interleukin-2. Ann Rev Immunol 2008, 26:453-479.
-
(2008)
Ann Rev Immunol
, vol.26
, pp. 453-479
-
-
Matek, T.R.1
-
40
-
-
0026328818
-
Generation and analysis of interleukin-4 deficient mice
-
10.1126/science.1948049, 1948049
-
Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991, 254:707-710. 10.1126/science.1948049, 1948049.
-
(1991)
Science
, vol.254
, pp. 707-710
-
-
Kuhn, R.1
Rajewsky, K.2
Muller, W.3
-
41
-
-
0022499547
-
Complementary-DNA for a novel human interleukin (BSF-2) that induces lymphocytes-B to produce immunoglobulin
-
10.1038/324073a0, 3491322
-
Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary-DNA for a novel human interleukin (BSF-2) that induces lymphocytes-B to produce immunoglobulin. Nature 1986, 324:73-76. 10.1038/324073a0, 3491322.
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
Taga, T.4
Watanabe, Y.5
Matsuda, T.6
Kashiwamura, S.7
Nakajima, K.8
Koyama, K.9
Iwamatsu, A.10
Tsunasawa, S.11
Sakiyama, F.12
Matsui, H.13
Takahara, Y.14
Taniguchi, T.15
Kishimoto, T.16
-
42
-
-
0028929565
-
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
-
10.1084/jem.181.4.1519, 2191954, 7699333
-
Vonfreedenjeffry U, Vieira P, Lucian LA, McNeil T, Burdach SEG, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995, 181:1519-1526. 10.1084/jem.181.4.1519, 2191954, 7699333.
-
(1995)
J Exp Med
, vol.181
, pp. 1519-1526
-
-
Vonfreedenjeffry, U.1
Vieira, P.2
Lucian, L.A.3
McNeil, T.4
Burdach, S.E.G.5
Murray, R.6
-
43
-
-
63449090874
-
Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
-
10.1016/j.jaci.2009.02.030, 19348912
-
Akdis CA, Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009, 123:735-746. 10.1016/j.jaci.2009.02.030, 19348912.
-
(2009)
J Allergy Clin Immunol
, vol.123
, pp. 735-746
-
-
Akdis, C.A.1
Akdis, M.2
-
44
-
-
34247257447
-
Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
-
10.1002/art.22452, 17393408
-
Young DA, Hegen M, Ma HLM, Whitters MJ, Albert LM, Lowe L, Senices M, Wu PW, Sibley B, Leathurby Y, Brown TP, Nickerson-Nutter C, Keith JC, Collins M. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007, 56:1152-1163. 10.1002/art.22452, 17393408.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1152-1163
-
-
Young, D.A.1
Hegen, M.2
Ma, H.L.M.3
Whitters, M.J.4
Albert, L.M.5
Lowe, L.6
Senices, M.7
Wu, P.W.8
Sibley, B.9
Leathurby, Y.10
Brown, T.P.11
Nickerson-Nutter, C.12
Keith, J.C.13
Collins, M.14
-
45
-
-
60849107595
-
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
-
10.1073/pnas.0807309106, 2635818, 19164519
-
Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse HC, Leonard WJ, Roopenian DC. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009, 106:1518-1523. 10.1073/pnas.0807309106, 2635818, 19164519.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1518-1523
-
-
Bubier, J.A.1
Sproule, T.J.2
Foreman, O.3
Spolski, R.4
Shaffer, D.J.5
Morse, H.C.6
Leonard, W.J.7
Roopenian, D.C.8
-
46
-
-
33947215987
-
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
-
Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007, 178:3822-3830.
-
(2007)
J Immunol
, vol.178
, pp. 3822-3830
-
-
Herber, D.1
Brown, T.P.2
Liang, S.3
Young, D.A.4
Collins, M.5
Dunussi-Joannopoulos, K.6
-
47
-
-
35748930247
-
Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus
-
Bubier JA, Bennett SM, Sproule TJ, Lyons BL, Olland S, Young DA, Roopenian DC. Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Autoimmunity, Pt B: Novel Applications of Basic Research 2007, 1110:590-601.
-
(2007)
Autoimmunity, Pt B: Novel Applications of Basic Research
, vol.1110
, pp. 590-601
-
-
Bubier, J.A.1
Bennett, S.M.2
Sproule, T.J.3
Lyons, B.L.4
Olland, S.5
Young, D.A.6
Roopenian, D.C.7
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