The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

Nature Immunology

Volumn 12, Issue 12, 2011, Pages 1167-1175

  Iwasaki, Hidenori ^a,b   Takeuchi, Osamu ^a,c   Teraguchi, Shunsuke ^a   Matsushita, Kazufumi ^a,e   Uehata, Takuya ^a,d   Kuniyoshi, Kanako ^a,c   Satoh, Takashi ^a   Saitoh, Tatsuya ^a,c   Matsushita, Mutsuyoshi ^b   Standley, Daron M ^a   Akira, Shizuo ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN TOBACCO INC   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; REGNASE 1; RIBONUCLEASE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME MODIFICATION; ENZYME STABILITY; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; RNA STRUCTURE; SIGNAL TRANSDUCTION; UBIQUITINATION; ZINC FINGER MOTIF;

AMINO ACID MOTIFS; ANIMALS; CELL LINE, TUMOR; CYTOKINES; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-6; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-1; RIBONUCLEASES; RNA STABILITY; RNA, MESSENGER; TOLL-LIKE RECEPTORS;

EID: 81255154489     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2137     Document Type: Article

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