Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 23, 2013, Pages 9409-9414

  Masuda, Kazuya ^a   Ripley, Barry ^a   Nishimura, Riko ^a   Mino, Takashi ^b   Takeuchi, Osamu ^b   Shioi, Go ^c   Kiyonari, Hiroshi ^c   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

Immune regulation; Rna protein complex

Indexed keywords

AT RICH INTERACTIVE DOMAIN CONTAINING PROTEIN 5A; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; RNA BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH17 CELL;

IMMUNE REGULATION; RNA-PROTEIN COMPLEX;

3' UNTRANSLATED REGIONS; ANIMALS; CELL CULTURE TECHNIQUES; DNA-BINDING PROTEINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; RNA STABILITY; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84878696872     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307419110     Document Type: Article

References (29)

1. Kishimoto T (2005) Interleukin-6: From basic science to medicine - 40 years in immunology. Annu Rev Immunol 23:1-21.
2. Legrand-Poels S, Schoonbroodt S, Piette J (2000) Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochem J 349(Pt 3):765-773.
3. Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22(2):83-89.
4. Tanaka T, Kishimoto T (2012) Immunotherapeutic implication of IL-6 blockade. Immunotherapy 4(1):87-105.
5. Mima T, Nishimoto N (2009) Clinical value of blocking IL-6 receptor. Curr Opin Rheumatol 21(3):224-230.
6. Libermann TA, Baltimore D (1990) Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10(5):2327-2334.
7. Matsusaka T, et al. (1993) Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90(21):10193-10197.
8. Iwasaki H, et al. (2011) The IκB kinase complex regulates the stability of cytokineencoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol 12(12):1167-1175.
9. Matsushita K, et al. (2009) Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458(7242):1185-1190.
10. Gingerich TJ, Feige JJ, LaMarre J (2004) AU-rich elements and the control of gene expression through regulated mRNA stability. Anim Health Res Rev 5(1):49-63.
11. Patil C, Zhu X, Rossa C, Jr., Kim YJ, Kirkwood KL (2004) p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Invest 33(2):213-233.
12. Schoenberg DR, Maquat LE (2012) Regulation of cytoplasmic mRNA decay. Nat Rev Genet 13(4):246-259.
13. Masuda K, et al. (2011) Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol 23(10):637-645.
14. Sarkar S, Kantara C, Singh P (2012) Clathrin mediates endocytosis of progastrin and activates MAPKs: Role of cell surface annexin A2. Am J Physiol Gastrointest Liver Physiol 302(7):G712-G722.
15. Zhao W, Liu M, Kirkwood KL (2008) p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements. J Biol Chem 283(4):1778-1785.
16. Patsialou A, Wilsker D, Moran E (2005) DNA-binding properties of ARID family proteins. Nucleic Acids Res 33(1):66-80.
17. Amano K, et al. (2011) Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription. Mol Biol Cell 22(8):1300-1311.
18. Weigert C, et al. (2007) Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: Role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms. Am J Physiol Cell Physiol 293(3):C1139-C1147.
19. Okuda Y, et al. (1998) IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int Immunol 10(5):703-708.
20. Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y (1998) IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 161(12):6480-6486.
21. Serada S, et al. (2008) IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 105(26):9041-9046.
22. Paschoud S, et al. (2006) Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1. Mol Cell Biol 26(22):8228-8241.
23. Zhao W, Liu M, D'Silva NJ, Kirkwood KL (2011) Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region. J Interferon Cytokine Res 31(8):629-637.
24. Anderson P (2008) Post-transcriptional control of cytokine production. Nat Immunol 9(4):353-359.
25. Uehata T, Akira S (March 13, 2013) mRNA degradation by the endoribonuclease Regnase- 1 /ZC3H12a/MCPIP-1. Biochim Biophys Acta, 10.1016/j.bbagrm.2013.03.001.
26. Peng SS, Chen CY, Xu N, Shyu AB (1998) RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 17(12):3461-3470.
27. Yiakouvaki A, et al. (2012) Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest 122(1):48-61.
28. Mahtani KR, et al. (2001) Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 21(19):6461-6469.
29. Kimura A, et al. (2009) Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med 206(9):2027-2035.