Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: Effect on the expression of chemokine and adhesion molecule

Rheumatology International

Volumn 30, Issue 3, 2010, Pages 309-315

  Suzuki, Miho ^a   Hashizume, Misato ^a   Yoshida, Hiroto ^a   Mihara, Masahiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Adhesion molecules; Chemokines; IL 6; IL 6 receptor; Tocilizumab

Indexed keywords

CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ANTIBODY; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR ANTIBODY; TOCILIZUMAB; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL STRAIN U937; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN UMBILICAL VESSEL ENDOTHELIAL CELL; MONOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVITIS;

ANTIBODIES, MONOCLONAL; ARTHRITIS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINES; ENDOTHELIAL CELLS; FIBROBLASTS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; INTERLEUKIN-8; SYNOVIAL MEMBRANE;

EID: 73649103466     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-009-0953-0     Document Type: Article

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