-
1
-
-
0024360388
-
The biology of interleukin-6
-
Kishimoto T. The biology of interleukin-6. Blood 74(1), 1-10 (1989).
-
(1989)
Blood
, vol.74
, Issue.1
, pp. 1-10
-
-
Kishimoto, T.1
-
2
-
-
17644368573
-
Interleukin-6: From basic science to medicine-40 years in immunology
-
Kishimoto T. Interleukin-6: from basic science to medicine-40 years in immunology. Annu. Rev. Immunol. 23, 1-21 (2005).
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
3
-
-
15444356801
-
Interleukin-6
-
Snapper CM (Ed.). John Wiley & Sons Ltd., Chichester, UK
-
Tanaka T, Katada Y, Suemura M, Kishimoto T. Interleukin-6. In: Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects. Snapper CM (Ed.). John Wiley & Sons Ltd., Chichester, UK, 251-272 (1996).
-
(1996)
Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects
, pp. 251-272
-
-
Tanaka, T.1
Katada, Y.2
Suemura, M.3
Kishimoto, T.4
-
4
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-defcient mice
-
Kopf M, Baumann H, Freer G et al. Impaired immune and acute-phase responses in interleukin-6-defcient mice. Nature 368, 339-342 (1994).
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
-
5
-
-
0027199126
-
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
-
Murakami M, Hibi M, Nakagawa N et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260, 1808-1810 (1993).
-
(1993)
Science
, vol.260
, pp. 1808-1810
-
-
Murakami, M.1
Hibi, M.2
Nakagawa, N.3
-
6
-
-
0028209870
-
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130
-
Narazaki M, Witthuhn BA, Yoshida K et al. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc. Natl Acad. Sci. USA 91(6), 2285-2289 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, Issue.6
, pp. 2285-2289
-
-
Narazaki, M.1
Witthuhn, B.A.2
Yoshida, K.3
-
7
-
-
0029084805
-
Interleukin-6 family of cytokines and gp130
-
Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood 86(4), 1243-1254 (1995).
-
(1995)
Blood
, vol.86
, Issue.4
, pp. 1243-1254
-
-
Kishimoto, T.1
Akira, S.2
Narazaki, M.3
Taga, T.4
-
8
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka T, Narazaki M, Hirata M et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
Narazaki, M.2
Hirata, M.3
-
9
-
-
0027293104
-
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
-
Narazaki M, Yasukawa K, Saito T et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82(4), 1120-1126 (1993).
-
(1993)
Blood
, vol.82
, Issue.4
, pp. 1120-1126
-
-
Narazaki, M.1
Yasukawa, K.2
Saito, T.3
-
10
-
-
0028117163
-
Cytokine signal transduction
-
Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 76(2), 253-262 (1994).
-
(1994)
Cell
, vol.76
, Issue.2
, pp. 253-262
-
-
Kishimoto, T.1
Taga, T.2
Akira, S.3
-
11
-
-
0343185888
-
Human B-cell differentiation factor defned by an anti-peptide antibody and its possible role in autoantibody production
-
Hirano T, Taga T, Yasukawa K et al. Human B-cell differentiation factor defned by an anti-peptide antibody and its possible role in autoantibody production. Proc. Natl Acad. Sci. USA 84(1), 228-231 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, Issue.1
, pp. 228-231
-
-
Hirano, T.1
Taga, T.2
Yasukawa, K.3
-
12
-
-
0024459013
-
Pathogenic signifcance of interleukin-6 (IL-6/BSF-2) in Castleman's disease
-
Yoshizaki K, Matsuda T, Nishimoto N et al. Pathogenic signifcance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74(4), 1360-1367 (1989).
-
(1989)
Blood
, vol.74
, Issue.4
, pp. 1360-1367
-
-
Yoshizaki, K.1
Matsuda, T.2
Nishimoto, N.3
-
13
-
-
0024269961
-
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
-
Hirano T, Matsuda T, Turner M et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18, 1797-1801 (1988).
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 1797-1801
-
-
Hirano, T.1
Matsuda, T.2
Turner, M.3
-
14
-
-
35648988128
-
New therapies for treatment of rheumatoid arthritis
-
Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 370, 1861-1874 (2007).
-
(2007)
Lancet
, vol.370
, pp. 1861-1874
-
-
Smolen, J.S.1
Aletaha, D.2
Koeller, M.3
Weisman, M.H.4
Emery, P.5
-
15
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
Ohshima S, Saeki Y, Mima T et al. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl Acad. Sci. USA 95(14), 8222-8226 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, Issue.14
, pp. 8222-8226
-
-
Ohshima, S.1
Saeki, Y.2
Mima, T.3
-
16
-
-
0036899812
-
Therapeutic beneft of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Choy EH, Isenberg DA, Garrood T et al. Therapeutic beneft of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 46, 143-150 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 143-150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
-
17
-
-
0038166958
-
Toxicity, pharmacokinetics, and dose-fnding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study
-
Nishimoto N, Yoshizaki K, Maeda K et al. Toxicity, pharmacokinetics, and dose-fnding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. J. Rheumatol. 30, 1426-1435 (2003).
-
(2003)
J. Rheumatol.
, vol.30
, pp. 1426-1435
-
-
Nishimoto, N.1
Yoshizaki, K.2
Maeda, K.3
-
18
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 50, 1761-1769 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
19
-
-
33749363027
-
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
Maini RN, Taylor PC, Szechinski J et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 54, 2817-2829 (2006).
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
-
20
-
-
70349402169
-
Long-term safety and effcacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and effcacy in a 5-year extension study
-
Nishimoto N, Miyasaka N, Yamamoto K et al. Long-term safety and effcacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and effcacy in a 5-year extension study. Ann. Rheum. Dis. 68, 1580-1584 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1580-1584
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
-
21
-
-
34447300492
-
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic beneft from an X-ray reader-blinded randomized controlled trial of tocilizumab
-
Nishimoto N, Hashimoto J, Miyasaka N et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic beneft from an X-ray reader-blinded randomized controlled trial of tocilizumab. Ann. Rheum. Dis. 66, 1162-1167 (2007).
-
(2007)
Ann. Rheum. Dis.
, vol.66
, pp. 1162-1167
-
-
Nishimoto, N.1
Hashimoto, J.2
Miyasaka, N.3
-
22
-
-
54949150604
-
Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The TCZ in combination with traditional disease-modifying antirheumatic drug therapy study
-
Genovese MC, McKay JD, Nasonov EL et al. Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the TCZ in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 58, 2968-2980 (2008).
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 2968-2980
-
-
Genovese, M.C.1
McKay, J.D.2
Nasonov, E.L.3
-
23
-
-
52149099504
-
IL-6 receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: Results from a 24-week multicentre randomized placebo controlled trial
-
Emery P, Keystone E, Tony HP et al. IL-6 receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre randomized placebo controlled trial. Ann. Rheum. Dis. 67(11), 1516-1523 (2008).
-
(2008)
Ann. Rheum. Dis.
, vol.67
, Issue.11
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
-
24
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomized trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomized trial. Lancet 371, 987-997 (2008).
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
25
-
-
74849102659
-
Rapid and sustained improvement in bone and cartilage turnover markers with anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate: Results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone
-
Garnero P, Thompson E, Woodworth T, Smolen JS. Rapid and sustained improvement in bone and cartilage turnover markers with anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone. Arthritis Rheum. 62, 33-43 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 33-43
-
-
Garnero, P.1
Thompson, E.2
Woodworth, T.3
Smolen, J.S.4
-
26
-
-
60149105639
-
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Signifcant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
-
Nishimoto N, Miyasaka N, Yamamoto K et al. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): signifcant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod. Rheumatol. 19, 12-19 (2009).
-
(2009)
Mod. Rheumatol.
, vol.19
, pp. 12-19
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
-
27
-
-
78049430011
-
LITHE: Tocilizumab inhibits radiographic progression and improves physical function in rheumatoid arthritis (RA) patients at 2 years with increasing clinical effcacy over time
-
Pennsylvania, PA, USA 17-21 October Abstract 637
-
Fleischmann R. LITHE: Tocilizumab inhibits radiographic progression and improves physical function in rheumatoid arthritis (RA) patients at 2 years with increasing clinical effcacy over time. Presented at: American College of Rheumatology Meeting Pennsylvania, PA, USA, 17-21 October 2009 (Abstract 637).
-
(2009)
Presented At: American College of Rheumatology Meeting
-
-
Fleischmann, R.1
-
28
-
-
73449118587
-
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study Ann
-
Jones G, Sebba A, Gu J et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study Ann. Rheum. Dis. 69, 88-96 (2010).
-
(2010)
Rheum. Dis.
, vol.69
, pp. 88-96
-
-
Jones, G.1
Sebba, A.2
Gu, J.3
-
29
-
-
77956646068
-
Safety and effcacy profles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: Meta-analysis of six initial trials and fve long-term extensions
-
Nishimoto N, Ito K, Takagi N. Safety and effcacy profles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and fve long-term extensions. Mod. Rheumatol. 20(3), 222-232 (2010)
-
(2010)
Mod. Rheumatol.
, vol.20
, Issue.3
, pp. 222-232
-
-
Nishimoto, N.1
Ito, K.2
Takagi, N.3
-
31
-
-
68549105886
-
Japanese College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis
-
Koike R, Harigai M, Atsumi T et al. Japanese College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis. Mod. Rheumatol. 19, 351-357 (2009).
-
(2009)
Mod. Rheumatol.
, vol.19
, pp. 351-357
-
-
Koike, R.1
Harigai, M.2
Atsumi, T.3
-
32
-
-
77953694972
-
Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: A systematic literature review informing the EULAR recommendations for the management of RA
-
Nam JL, Winthrop KL, van Vollenhoven RF et al. Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA. Ann. Rheum. Dis. 69(6), 976-986 (2010).
-
(2010)
Ann. Rheum. Dis.
, vol.69
, Issue.6
, pp. 976-986
-
-
Nam, J.L.1
Winthrop, K.L.2
Van Vollenhoven, R.F.3
-
33
-
-
77957668148
-
Recommendations of the German Rheumatology Society on the use of tocilizumab in rheumatoid arthritis
-
Gause A, Rubbert-Roth A, Michels H et al. [Recommendations of the German Rheumatology Society on the use of tocilizumab in rheumatoid arthritis]. Z. Rheumatol. 69(4), 365-372 (2010).
-
(2010)
Z Rheumatol.
, vol.69
, Issue.4
, pp. 365-372
-
-
Gause, A.1
Rubbert-Roth, A.2
Michels, H.3
-
34
-
-
77957598053
-
Portuguese guidelines for the use of biological agents in rheumatoid arthritis-March 2010 update
-
Fonseca JE, Canhao H, Reis P et al. Portuguese guidelines for the use of biological agents in rheumatoid arthritis-March 2010 update. Acta Rheumatol. Port. 35(1), 95-98 (2010).
-
(2010)
Acta Rheumatol. Port.
, vol.35
, Issue.1
, pp. 95-98
-
-
Fonseca, J.E.1
Canhao, H.2
Reis, P.3
-
35
-
-
73849131345
-
Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the 'age of remission'? Expert Opin
-
Moots RJ, Ostor AJK, Isaacs JD. Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the 'age of remission'? Expert Opin. Investig. Drugs 18(11), 1687-1699 (2009).
-
(2009)
Investig. Drugs
, vol.18
, Issue.11
, pp. 1687-1699
-
-
Moots, R.J.1
Ajk, O.2
Isaacs, J.D.3
-
36
-
-
67849128570
-
Anti-interleukin 6: A frst line in rheumatoid arthritis?
-
Marti L, Scheinberg M. Anti-interleukin 6: a frst line in rheumatoid arthritis? Clin. Rheumatol. 27, 877-879 (2009).
-
(2009)
Clin. Rheumatol.
, vol.27
, pp. 877-879
-
-
Marti, L.1
Scheinberg, M.2
-
37
-
-
64049108915
-
-
Scheinecker C, Smolen J, Yasothan U, Stoll J, Kirkpatrick P. Tocilizumab. Nat Rev. Drug Discov. 8, 273-274 (2009).
-
(2009)
Tocilizumab. Nat Rev. Drug Discov.
, vol.8
, pp. 273-274
-
-
Scheinecker, C.1
Smolen, J.2
Yasothan, U.3
Stoll, J.4
Kirkpatrick, P.5
-
38
-
-
54349087856
-
When patients with rheumatoid arthritis fail tumor necrosis factor inhibitors: What is the next step?
-
Smolen JS, Weinblatt ME. When patients with rheumatoid arthritis fail tumor necrosis factor inhibitors: what is the next step? Ann. Rheum. Dis. 67, 1497-1498 (2008).
-
(2008)
Ann. Rheum. Dis.
, vol.67
, pp. 1497-1498
-
-
Smolen, J.S.1
Weinblatt, M.E.2
-
39
-
-
57149091953
-
-
Van Ingen J, Boeree MJ, Dekhuizen PN, van Soolingen D. Mycobacterial diseases in patients with rheumatic disease. Nat Clin. Pract Rheumatol. 4(12), 649-656 (2008).
-
(2008)
Mycobacterial Diseases in Patients with Rheumatic Disease. Nat Clin. Pract Rheumatol.
, vol.4
, Issue.12
, pp. 649-656
-
-
Van Ingen, J.1
Boeree, M.J.2
Dekhuizen, P.N.3
Van Soolingen, D.4
-
40
-
-
77954761056
-
Minimal infuence of tocilizumab on IFN-γ synthesis by tuberculosis antigens
-
Ogata A, Mori M, Hashimoto S et al. Minimal infuence of tocilizumab on IFN-γ synthesis by tuberculosis antigens. Mod. Rheumatol. 20, 130-133 (2010).
-
(2010)
Mod. Rheumatol.
, vol.20
, pp. 130-133
-
-
Ogata, A.1
Mori, M.2
Hashimoto, S.3
-
41
-
-
43649104094
-
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis
-
Ohsugi Y, Kishimoto T. The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis. Expert Opin. Biol. Ther. 8(5), 669-681 (2008).
-
(2008)
Expert Opin. Biol. Ther.
, vol.8
, Issue.5
, pp. 669-681
-
-
Ohsugi, Y.1
Kishimoto, T.2
-
42
-
-
0345743620
-
IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinfammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system Biochem
-
Hagihara K, Nishikawa T, Isobe T, Song J, Sugamata Y, Yoshizaki K. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinfammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system Biochem. Biophys. Res. Commun. 314, 363-369 (2004).
-
(2004)
Biophys. Res. Commun.
, vol.314
, pp. 363-369
-
-
Hagihara, K.1
Nishikawa, T.2
Isobe, T.3
Song, J.4
Sugamata, Y.5
Yoshizaki, K.6
-
43
-
-
27644549634
-
Essential role of STAT3 in cytokine-driven NF-κB-mediated serum amyloid A gene expression
-
Hagihara K, Nishikawa T, Sugamata Y et al. Essential role of STAT3 in cytokine-driven NF-κB-mediated serum amyloid A gene expression. Genes Cells 10, 1051-1063 (2005).
-
(2005)
Genes Cells
, vol.10
, pp. 1051-1063
-
-
Hagihara, K.1
Nishikawa, T.2
Sugamata, Y.3
-
44
-
-
33749331603
-
Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis
-
Okuda Y, Takasugi K. Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum. 54(9), 2997-3000 (2006).
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.9
, pp. 2997-3000
-
-
Okuda, Y.1
Takasugi, K.2
-
45
-
-
67549125131
-
Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment
-
Nishida S, Hagihara K, Shima Y et al. Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment. Ann. Rheum. Dis. 68, 1235-1236 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, pp. 1235-1236
-
-
Nishida, S.1
Hagihara, K.2
Shima, Y.3
-
46
-
-
70350435731
-
Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis
-
Sato H, Sakai T, Sugaya T et al. Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis. Clin. Rheumatol. 28(9), 1113-1116 (2009).
-
(2009)
Clin. Rheumatol.
, vol.28
, Issue.9
, pp. 1113-1116
-
-
Sato, H.1
Sakai, T.2
Sugaya, T.3
-
47
-
-
79952110725
-
Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis
-
Inoue D, Arima H, Kawanami C et al. Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis. Clin. Rheumatol. 29(10), 1195-1197 (2010).
-
(2010)
Clin. Rheumatol.
, vol.29
, Issue.10
, pp. 1195-1197
-
-
Inoue, D.1
Arima, H.2
Kawanami, C.3
-
48
-
-
58149154996
-
Mechanisms and pathologic signifcances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
-
Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T Mechanisms and pathologic signifcances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 112(10), 3959-3964 (2008).
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 3959-3964
-
-
Nishimoto, N.1
Terao, K.2
Mima, T.3
Nakahara, H.4
Takagi, N.5
Kakehi, T.6
-
49
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohns disease
-
Ito H, Takazoe M, Fukuda Y et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohns disease. Gastroenterology 126(4), 989-996 (2004).
-
(2004)
Gastroenterology
, vol.126
, Issue.4
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
-
50
-
-
0036898472
-
Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease
-
Iwamoto M, Nara H, Hirata D, Minota S, Nishimoto N, Yoshizaki K. Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease. Arthritis Rheum. 46(12), 3388-3389 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
, Issue.12
, pp. 3388-3389
-
-
Iwamoto, M.1
Nara, H.2
Hirata, D.3
Minota, S.4
Nishimoto, N.5
Yoshizaki, K.6
-
51
-
-
60149096148
-
A case report of a patient with refractory adult-onset Stills disease who was successfully treated with tocilizumab over 6 years
-
Nakahara H, Mima T, Yoshio-Hoshino N, Matsushita M, Hashimoto J, Nishimoto N. A case report of a patient with refractory adult-onset Stills disease who was successfully treated with tocilizumab over 6 years. Mod. Rheumatol. 19(1), 69-72 (2009).
-
(2009)
Mod. Rheumatol.
, vol.19
, Issue.1
, pp. 69-72
-
-
Nakahara, H.1
Mima, T.2
Yoshio-Hoshino, N.3
Matsushita, M.4
Hashimoto, J.5
Nishimoto, N.6
-
52
-
-
61549119438
-
Glucocorticoid and cyclosporine refractory adult onset Stills disease successfully treated with tocilizumab
-
Matsumoto K, Nagashima T, Takatori S et al. Glucocorticoid and cyclosporine refractory adult onset Stills disease successfully treated with tocilizumab. Clin. Rheumatol. 24(4), 485-487 (2009).
-
(2009)
Clin. Rheumatol.
, vol.24
, Issue.4
, pp. 485-487
-
-
Matsumoto, K.1
Nagashima, T.2
Takatori, S.3
-
53
-
-
77949512903
-
Successful treatment with tocilizumab in a patient with refractory adult-onset Still's disease (AOSD)
-
Yoshimura M, Makiyama J, Koga T et al. Successful treatment with tocilizumab in a patient with refractory adult-onset Still's disease (AOSD). Clin. Exp. Rheumatol. 28(1), 141-142 (2010).
-
(2010)
Clin. Exp. Rheumatol.
, vol.28
, Issue.1
, pp. 141-142
-
-
Yoshimura, M.1
Makiyama, J.2
Koga, T.3
-
54
-
-
58349119558
-
Tocilizumab for multirefratory adult-onset Still's disease
-
De Bandt M, Saint-Marcoux B. Tocilizumab for multirefratory adult-onset Still's disease. Ann. Rheum. Dis. 68(1), 153-154 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, Issue.1
, pp. 153-154
-
-
De Bandt, M.1
Saint-Marcoux, B.2
-
55
-
-
42449088420
-
Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody
-
Nishimoto N, Nakahara H, Yoshio-Hoshino N, Mima T Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody Arthritis Rheum. 58(4), 1197-1200 (2008).
-
(2008)
Arthritis Rheum.
, vol.58
, Issue.4
, pp. 1197-1200
-
-
Nishimoto, N.1
Nakahara, H.2
Yoshio-Hoshino, N.3
Mima, T.4
-
56
-
-
75749113331
-
Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary effcacy, and impact on circulating plasma cells from an open-label Phase i dosage-escalation study
-
Illei GG, Shirota Y, Yarboro CH et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary effcacy, and impact on circulating plasma cells from an open-label Phase I dosage-escalation study. Arthritis Rheum. 62(2), 542-552 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, Issue.2
, pp. 542-552
-
-
Illei, G.G.1
Shirota, Y.2
Yarboro, C.H.3
-
57
-
-
61349092994
-
Sustained response to tocilizumab, anti-interleukin-6 receptor antibody in two patients with refractory relapsing polychondritis
-
Kawai M, Hagihara K, Hirano T et al. Sustained response to tocilizumab, anti-interleukin-6 receptor antibody in two patients with refractory relapsing polychondritis. Rheumatology 48, 318-319 (2009).
-
(2009)
Rheumatology
, vol.48
, pp. 318-319
-
-
Kawai, M.1
Hagihara, K.2
Hirano, T.3
-
58
-
-
73449141147
-
Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab
-
Tanaka T, Kuwahara Y, Shima Y et al. Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab. Arthritis Rheum. 61, 1762-1764 (2009).
-
(2009)
Arthritis Rheum.
, vol.61
, pp. 1762-1764
-
-
Tanaka, T.1
Kuwahara, Y.2
Shima, Y.3
-
59
-
-
78049418460
-
Mixed response to tocilizumab for ankylosing spondylitis
-
DOI: 10.1136/ard.2009.126706 Epub ahead of print
-
Henes JC, Horger M, Guenaydin I, Kanz L, Koetter I. Mixed response to tocilizumab for ankylosing spondylitis. Ann. Rheum. Dis. DOI: 10.1136/ard.2009.126706 (2010) (Epub ahead of print).
-
(2010)
Ann. Rheum. Dis.
-
-
Henes, J.C.1
Horger, M.2
Guenaydin, I.3
Kanz, L.4
Koetter, I.5
-
60
-
-
77951729315
-
Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody tocilizumab
-
Tanaka T, Hagihara K, Shima Y et al. Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody tocilizumab. Rheumatology 49, 824-826 (2010).
-
(2010)
Rheumatology
, vol.49
, pp. 824-826
-
-
Tanaka, T.1
Hagihara, K.2
Shima, Y.3
-
61
-
-
77951783966
-
Tocilizumab ameliorates clinical symptoms in polymyalgia rheumatica
-
Hagihara K, Kawase I, Tanaka T, Kishimoto T. Tocilizumab ameliorates clinical symptoms in polymyalgia rheumatica. J. Rheumatol. 37, 1075-1076 (2010).
-
(2010)
J. Rheumatol.
, vol.37
, pp. 1075-1076
-
-
Hagihara, K.1
Kawase, I.2
Tanaka, T.3
Kishimoto, T.4
-
62
-
-
78049421175
-
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
-
DOI: 10.1093/rheumatology/keq275 Epub ahead of print
-
Shima Y, Kuwahara Y, Murota H et al. The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology DOI: 10.1093/rheumatology/keq275 (2010) (Epub ahead of print).
-
(2010)
Rheumatology
-
-
Shima, Y.1
Kuwahara, Y.2
Murota, H.3
|