Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 2, 2014, Pages 283-292

  Zhao, Honghai ^a   Zhang, Tongen ^a   Xia, Chun ^a   Shi, Lei ^a   Wang, Shaojie ^a   Zheng, Xinpeng ^a   Hu, Tianhui ^a   Zhang, Bing ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

Akt; Berberine; Cartilage degeneration; IL 1 stimulated chondrocytes; Rat OA model

Indexed keywords

RATTUS;

AGGRECAN; BERBERINE; CELL NUCLEUS ANTIGEN; COLLAGEN TYPE 2; INTERLEUKIN 1BETA; PROTECTIVE AGENT; PROTEIN KINASE B; S6 KINASE;

AKT; ANIMAL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IL-1Β-STIMULATED CHONDROCYTES; MALE; METABOLISM; NEWBORN; OSTEOARTHRITIS; PATHOLOGY; RAT; RAT OA MODEL; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AKT; BERBERINE; CARTILAGE DEGENERATION; IL-1Β-STIMULATED CHONDROCYTES; RAT OA MODEL;

AGGRECANS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, NUCLEAR; BERBERINE; CARTILAGE, ARTICULAR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; GENE EXPRESSION REGULATION; INTERLEUKIN-1BETA; MALE; OSTEOARTHRITIS; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 84893673065     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12186     Document Type: Article

References (38)

1. Vignon E, Arlot M, Meunier P, et al. Quantitative histological changes in osteoarthritic hip cartilage. Morphometric analysis of 29 osteoarthritic and 26 normal human femoral heads. Clin Orthop Relat Res. 1974; 103: 269-78.
2. Thomas CM, Fuller CJ, Whittles CE, et al. Chondrocyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation. Int J Rheum Dis. 2011; 14: 191-8.
3. Chen Q, Zhang B, Yi T, et al. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia Histochem Cytobiol. 2012; 50: 137-43.
4. Weimer A, Madry H, Venkatesan JK, et al. Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol Med. 2012; 18: 346-58.
5. Smith P, Shuler FD, Georgescu HI, et al. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum. 2000; 43: 1156-64.
6. Zheng X, Xia C, Chen Z, et al. Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochem Biophys Res Commun. 2012; 423: 606-12.
7. Zhou PH, Liu SQ, Peng H. The effect of hyaluronic acid on IL-1b induced chondrocyte apoptosis in a rat model of osteoarthritis. J Orthop Res. 2008; 26: 1643-8.
8. Goldring MB. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep. 2000; 2: 459-65.
9. López-Armada MJ, Caramés B, Lires-Deén M, et al. Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthritis Cartilage. 2006; 14: 600-69.
10. Yasuhara R, Miyamoto Y, Akaike T, et al. Interleukin-1b induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner. Biochem J. 2005; 389: 315-23.
11. Sanchez C, Deberg MA, Piccardi N, et al. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage. 2005; 13: 979-87.
12. Nishitani K, Ito H, Hiramitsu T, et al. PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J Cell Biochem. 2010; 109: 425-33.
13. Lee T, Heo H, Kim Kwon Y. Effect of berberine on cell survival in the developing rat brain damaged by MK-801. Exp Neurobiol. 2010; 19: 140-5.
14. Saha P, Bhattacharjee S, Sarkar A, et al. Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. PLoS ONE. 2011; 6: e18467.
15. Hu PF, Chen WP, Tang JL, et al. Protective effects of berberine in an experimental rat osteoarthritis model. Phytother Res. 2011; 25: 878-85.
16. Moon PD, Jeong HS, Chun CS, et al. Baekjeolyusin-tang and its active component berberine block the release of collagen and proteoglycan from IL-1beta-stimulated rabbit cartilage and down-regulate matrix metalloproteinases in rabbit chondrocytes. Phytother Res. 2011; 25: 844-50.
17. Beier F, Loeser RF. Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J Cell Biochem. 2010; 110: 573-80.
18. Cravero JD, Carlson CS, Im HJ, et al. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009; 60: 492-500.
19. Starkman BG, Cravero JD, Delcarlo M, et al. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J. 2005; 389: 723-9.
20. Huang JG, Xia C, Zheng XP, et al. 17beta-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway. Cell Mol Biol Lett. 2011; 16: 564-75.
21. Uenaka K, Imai S, Ando K, et al. Relation of low-intensity pulsed ultrasound to the cell density of scaffold-free cartilage in a high-density static semi-open culture system. J Orthop Sci. 2010; 15: 816-24.
22. Hayami T, Funaki H, Yaoeda K, et al. Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol. 2003; 30: 2207-17.
23. Yang S, Kim J, Ryu JH, et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med. 2010; 16: 687-93.
24. Schmitz N, Laverty S, Kraus VB, et al. Basic methods in histopathology of joint tissues. Osteoarthritis Cartilage. 2010; 18: S113-6.
25. Oh H, Chun CH, Chun JS. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum. 2012; 64: 2568-78.
26. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006; 38: 234-43.
27. Eswaramoorthy R, Chang CC, Wu SC, et al. Sustained release of PTH(1-34) from PLGA microspheres suppresses osteoarthritis progression in rats. Acta Biomater. 2012; 8: 2254-62.
28. Zhang W, Su X, Gao Y, et al. Berberine protects mesenchymal stem cells against hypoxia-induced apoptosis in vitro. Biol Pharm Bull. 2009; 32: 1335-42.
29. Zhang Q, Qian Z, Pan L, et al. Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia. Acta Physiol Hung. 2012; 99: 311-23.
30. Bouayad D, Pederzoli-Ribeil M, Mocek J, et al. Nuclear-to-cytoplasmic relocalization of the proliferating cell nuclear antigen (PCNA) during differentiation involves a chromosome region maintenance 1 (CRM1)-dependent export and is a prerequisite for PCNA antiapoptotic activity in mature neutrophils. J Biol Chem. 2012; 287: 33812-25.
31. Gallego-Sanchez A, Andres S, Conde F, et al. Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet. 2012; 8: e1002826.
32. Kuo HP, Chuang TC, Tsai SC, et al. Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via Akt pathway modulation. J Agric Food Chem. 2012; 60: 9649-58.
33. Wang N, Feng Y, Zhu M, et al. Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem. 2010; 111: 1426-36.
34. Keshwani MM, Gao X, Harris TK. Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase. J Biol Chem. 2009; 284: 22611-24.
35. Keshwani MM, von Daake S, Newton AC, et al. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011; 286: 23552-8.
36. Yin W, Park JI, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem. 2009; 284: 31972-81.
37. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004; 50: 1193-206.
38. Jay GD, Fleming BC, Watkins BA, et al. Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum. 2010; 62: 2382-91.