Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes

Folia Histochemica et Cytobiologica

Volumn 50, Issue 1, 2012, Pages 137-143

  Chen, Qingzhi ^a,b   Zhang, Bing ^a   Yi, Tingting ^a   Xia, Chun ^a  

^a XIAMEN UNIVERSITY   (China)

^b The Third Hospital of Xiamen   (China)

Author keywords

Akt; Chondrocytes; Correlation; Human OA cartilage; PKC

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE C ALPHA;

ADULT; AGED; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL STRUCTURE; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; FEMUR CONDYLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE ARTHROPLASTY; KNEE OSTEOARTHRITIS; MICROSCOPY; OPTICAL DENSITY; PROTEIN EXPRESSION; PROTEIN INTERACTION; WESTERN BLOTTING;

EID: 84860277806     PISSN: 02398508     EISSN: 18975631     Source Type: Journal    
DOI: 10.5603/FHC.2012.0020     Document Type: Article

References (26)

1. Kuhn K, D'Lima DD, Hashimoto S et al. Cell death in cartilage. Osteoarthritis Cartilage. 2004;12:1-16.
2. Kim HA, Blanco FJ. Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets. 2007;8:333-345.
3. Kim HA, Suh D-I, Song Y-W. Relationship between chondrocyte apoptosis and matrix depletion in human articular carilage. J Rheumatol. 2001;28:2038-2045.
4. Kim SJ, Kim HG, Oh CD et al. p38 kinase-dependent and-independent inhibition of protein kinase C zeta and-alpha regulates nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes. J Biol Chem. 2002;277:30375--30381.
5. Brazil DP, Hemmings BA. Ten years of protein kinase B signaling:a hard Akt to follow. Trends Biochem Sci. 2001;26:657-664.
6. Franke TF, Hornik CP, Segev L et al. PI3K/Akt and apoptosis: size matters. Oncogene. 2003;8;22:8983-8998.
7. Chen WS, Xu PZ, Gottlob K et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Gens Dev. 2001;15:2203-2208.
8. Kawamura N, Kugimiya F, Oshima Y et al. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLos ONE. 2007;2:e1058.
9. Kim SJ, Hwang SG, Kim IC et al. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. J Biol Chem. 2003;278:42448-42456.
10. Mankin HJ, Dorfman H, Lippiello L et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971;53:523-537.
11. Oh CD, Chun JS. Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem. 2003;19;278:36563-36571.
12. Słuczanowska-Gła{ogonek}bowska S, Laszczyńska M, Wylot M et al. Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia. Folia Histochem Cytobiol. 2010;48:447-454.
13. Wang WZ, Liu HO, Wu YH et al. Estrogen receptor a (ERa) mediates 17b-estradiol (E2)-activated expression of HBO1. J Exp Clin Cancer Res. 2010;29:140-146.
14. Zhang B, Xia C.12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis. Cell Mol Biol Lett. 2010:15:377-394.
15. Negoescu A, Guillermet C, Lorimier P et al. Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomed Pharmacother. 1998;52:252-258.
16. Sharif M, Whitehouse A, Sharman P et al. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum. 2004;50:507-515.
17. D'Lima D, Hermida J, Hashimoto S et al. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum. 2006;54:1814-1821.
18. Roach HI, Aigner T, Kouri JB. Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis. 2004;9:265-277.
19. Maiuri MC, Zalckvar E, Kimchi A et al. Self-eating and self--killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8:741-752.
20. Keisuke Kita, Tohru Kimura, Norimasa Nakamura et al. PI3K/ /Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation. Genes to Cells. 2008;13:839-850.
21. García S, Liz M, Gómez-Reino JJ et al. Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. Arthritis Research & Therapy. 2010;12:R33.
22. Cravero JD, Carlson CS, Im HJ et al. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009;60:492-500.
23. Boileau C, Martel-Pelletier J, Brunet J et al. PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect. Ann Rheum Dis. 2006;65:573-580.
24. Yeh CC, Chang HI, Chiang JK et al. Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: role of protein kinase Calpha. Arthritis Rheum. 2009;60:2350-2361.
25. Doornbos RP, Theelen M, Van Der Hoeven PC et al. Protein kinase Czeta is a negative regulator of protein kinase B activity. J Biol Chem. 1999;274:8589-8596.
26. Li W, Zhang J, Flechner L et al. Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene. 1999:6564-6572.