Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis

Biochemical and Biophysical Research Communications

Volumn 423, Issue 3, 2012, Pages 606-612

  Zheng, Xinpeng ^a   Xia, Chun ^a   Chen, Zhongyi ^a,b   Huang, Jiagu ^a,c   Gao, Fengguang ^a   Li, Guideng ^d   Zhang, Bing ^a  

^a XIAMEN UNIVERSITY   (China)

^b Second Hospital of Xiamen   (China)

^c Ningde Municipal Hospital   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell apoptosis; IL 1 stimulated chondrocytes; Nicotine; PI3K Akt pathway

Indexed keywords

COLLAGENASE 3; INTERLEUKIN 1BETA; NICOTINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P70S6KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL ISOLATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; MALE; NEWBORN; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CHONDROCYTES; CHROMONES; ENZYME INHIBITORS; INTERLEUKIN-1BETA; MALE; MORPHOLINES; NICOTINE; OSTEOARTHRITIS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

RATTUS;

EID: 84863310849     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.045     Document Type: Article

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