Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Saha, Piu ^a   Bhattacharjee, Surajit ^b,c   Sarkar, Avijit ^a   Manna, Alak ^a   Majumder, Subrata ^b   Chatterjee, Mitali ^a  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b BOSE INSTITUTE   (India)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEISHMANIAL AGENT; BERBERINE CHLORIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; BERBERINE; MITOGEN ACTIVATED PROTEIN KINASE;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASSAY; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG SAFETY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GRIESS ASSAY; HOST PARASITE INTERACTION; IC 50; IMMUNOMODULATION; LEISHMANIA DONOVANI; LEISHMANIASIS; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; PARASITOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIPROTOZOAL AGENTS; BERBERINE; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERLEUKIN-10; INTERLEUKIN-12; LEISHMANIA DONOVANI; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER;

EID: 79953674515     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018467     Document Type: Article

References (40)

1. Naderer T, McConville MJ, (2008) The Leishmania-macrophage interaction: a metabolic perspective. Cell Microbiol 10: 301-308.
2. Roberts MT, (2006) Current understandings on the immunology of leishmaniasis and recent developments in prevention and treatment. Br Med Bull 75-76: 115-130 Review.
3. Kane MM, Mosser DM, (2001) The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol 166: 1141-1147.
4. Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B, (2004) Reciprocal CD40 signals though p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med 10: 540-544.
5. Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, et al. (1999) Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 163: 6403-6412.
6. Chatterjee A, Pakrashi SC, (1994) Plant Species. In: Chatterjee A, Pakrashi SC, editors. The treatise on INDn medicinal plants, Publications & Information Directorate, New Delhi. Vol. 1 pp. 129-130.
7. Kang BY, Chung SW, Cho D, (2002) Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. Biochem Pharmacol 63: 1901-1910.
8. Ghosh AK, Rakshit MM, Ghosh DK, (1983) Effect of berberine chloride on Leishmania donovani. INDn J Med Res 78: 407-416.
9. Ghosh AK, Bhattacharyya FK, Ghosh DK, (1985) Leishmania donovani: amastigote inhibition and mode of action of berberine. Exp Parasitol 60: 404-413.
10. Saha P, Sen R, Hariharan C, Kumar D, Das P, et al. (2009) Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes. Free Radic Res 43: 1101-1110.
11. da Luz RI, Vermeersch M, Dujardin JC, Cos P, Maes L, (2009) In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells. Antimicrob Agents Chemother 53: 5197-5203.
12. Ganguly S, Bandyopadhyay S, Sarkar A, (2006) Development of a semi-automated colorimetric assay for screening anti-leishmanial agents. J Microbiol Methods 66: 79-86.
13. Chatton JY, Broillet MC, (2002) Detection of nitric oxide production by fluorescent indicators. Methods Enzymol 359: 134-148.
14. Sarkar A, Saha P, Mandal G, Mukhopadhyay D, Roy S, et al. (2011) Monitoring of intracellular NO in Leishmaniasis; its applicability in patients with Visceral Leishmaniasis. Cytometry A 79: 35-45.
15. Tiscornia A, Cairoli E, Marquez M, Denicola A, Pritsch O, et al. (2009) Use of diaminofluoresceins to detect and measure nitric oxide in low level generating human immune cells. J Immunol Methods 342: 49-57.
16. Hibbs JB, Jr Taintor RR, Vavrin Z, (1988) Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157: 87-94.
17. Sarkar D, Saha P, Gamre S, Bhattacharjee S, Hariharan C, et al. (2008) Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-kappaB pathway. Int Immunopharmacol 8: 1264-1271.
18. Ganguly S, Mula S, Chattopadhyay S, Chatterjee M, (2007) An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide. J Pharm Pharmacol 59: 711-718.
19. Bhattacharyya S, Ghosh S, Jhonson PL, Bhattacharya SK, (2001) Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infect Immun 69: 1499-1507.
20. Ukil A, Biswas A, Das T, Das PK, (2005) 18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B. J Immunol 175: 1161-1169.
21. Bhattacharjee S, Gupta G, Bhattacharya P, Mukherjee A, Mujumdar SB, et al. (2009) Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. J Antimicrob Chemother 63: 317-324.
22. Trinchieri G, (1998) Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 16: 365-396.
23. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM, (1995) Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol 15: 5258-5267.
24. Ma X, Neurath M, Gri G, Trinchieri G, (1997) Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem 272: 10389-10395.
25. Yang Z, Mosser DM, Zhang X, (2007) Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. J Immunol 178: 1077-1085.
26. Tripathi P, Singh V, Naik S, (2007) Immune response to Leishmania: paradox rather than paradigm. FEMS Immunol Med Microbiol 51: 229-242.
27. Murray HW, Lu CM, Mauze S, Freeman S, Moreira AL, et al. (2002) Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect Immun 70: 6284-6293.
28. Buchmüller-Rouiller Y, Mauël J, (1987) Impairment of the oxidative metabolism of mouse peritoneal macrophages by intracellular Leishmania spp. Infect Immun 55: 587-593.
29. Gantt KR, Goldman TL, McCormick ML, Miller MA, Jeronimo SM, et al. (2001) Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi. J Immunol 167: 893-901.
30. Sen R, Ganguly S, Saha P, Chatterjee M, (2010) Efficacy of Artemisinin in experimental visceral leishmaniasis. Int J Antimicrob Agents 36: 43-49.
31. Kropf P, Freudenberg MA, Modolell M, Price HP, Herath S, et al. (2004) Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun 72: 1920-1928.
32. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A, (2009) The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets 8: 40-52 Review.
33. Kim TS, Kang BY, Cho D, (2003) Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinoline alkaloid, deviates CD4+ T cells from Th2 to Th1 response. Immunology 109: 407-414.
34. Ghazanfari T, Hassan ZM, Ebtekar M, Ahmadiani A, Naderi G, et al. (2000) Garlic induces a shift in cytokine pattern in Leishmania major-infected BALB/c mice. Scand J Immunol 52: 491-495.
35. Kaye PM, Curry AJ, Blackwell JM, (1991) Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J Immunol 146: 2763-2770.
36. Sacks D, Noben-Trauth N, (2002) The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2: 845-858 Review.
37. Seger R, Krebs EG, (1995) The MAPK signaling cascade. FASEB J 9: 726-735 Review.
38. Yang J, Lin Y, Guo Z, Cheng J, Huang J, et al. (2001) The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2: 620-624.
39. May MJ, Ghosh S, (1998) Signal transduction through NF-kappa B. Immunol Today 19: 80-88 Review.
40. Bhardwaj S, Srivastava N, Sudan R, Saha B, (2010) Leishmania interferes with host cell signaling to devise a survival strategy. J Biomed Biotechnol 2010: Article ID 109189.