Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia

Acta Physiologica Hungarica

Volumn 99, Issue 3, 2012, Pages 311-323

  Zhang, Q ^a   Qian, Z ^a   Pan, L ^a   Li, H ^a   Zhu, H ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

anti apoptosis; berberine; cerebral ischemia; HIF 1; pro apoptosis

Indexed keywords

BERBERINE; CASPASE 3; CASPASE 9; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; BRAIN TISSUE; CELL SURVIVAL; CELL VIABILITY; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; STAINING; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; ANTIMUTAGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BERBERINE; CASPASE 3; CASPASE 9; CELL SURVIVAL; COBALT; DRUGS, CHINESE HERBAL; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-ISCHEMIA, BRAIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866528539     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/APhysiol.99.2012.3.8     Document Type: Article

References (33)

1. Ardyanto TD, Osaki M, Tokuyasu N, Nagahama Y, Ito H: CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: A possible role for the PI3K/Akt pathway. Int. J. Oncol. 29, 549-555 (2006
2. Barone FC: Ischemic stroke intervention requires mixed cellular protection of the penumbra. Curr. Opin. Investig. Drugs 10, 220-223 (2009
3. Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 79, 341-351 (1994 (Pubitemid 24324923)
4. Carrera E, Jones PS, Iglesias S, Guadagno JV, Warburton EA, Fryer TD, Aigbirhio FI, Baron JC: The vascular mean transit time: A surrogate for the penumbra flow threshold? J. Cereb. Blood Flow Metab. 31, 1027-1035 (2011
5. Chavez A, Miranda LF, Pichiule P, Chavez JC: Mitochondria and hypoxia-induced gene expression mediated by hypoxia-inducible factors. Ann. NY Acad. Sci. 1147, 312-320 (2008
6. Chen D, Li M, Luo J, Gu W: Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J. Biol. Chem. 278, 13595-13598 (2003 (Pubitemid 36799889)
7. Chen W, Jadhav V, Tang J, Zhang JH: HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxicischemic injury. Acta Neurochir. Suppl. 102, 395-399 (2008
8. Chen W, Ostrowski RP, Obenaus A, Zhang JH: Prodeath or prosurvival: Two facets of hypoxia inducible factor-1 in perinatal brain injury. Exp. Neurol. 216, 7-15 (2009
9. Gulfraz M, Mehmood S, Ahmad A, Fatima N, Praveen Z, Williamson EM: Comparison of the antidiabetic activity of Berberis lyceum root extract and berberine in alloxan-induced diabetic rats. Phytother. Res. 22, 1208-1212 (2008
10. Hayashi K, Minoda K, Nagaoka Y, Hayashi T, Uesato S: Antiviral activity of berberine and related compounds against human cytomegalovirus. Bioorg. Med. Chem. Lett. 17, 1562-1564 (2007
11. Huded V, Saraf R, Limaye U: Mechanical device the Penumbra system in the management of acute stroke: Report of five cases. Neurol. India 57, 310-312 (2009
12. Jung JY, Roh KH, Jeong YJ, Kim SH, Lee EJ, Kim MS, Oh WM, Oh HK, Kim WJ: Estradiol protects PC12 cells against CoCl2-induced apoptosis. Brain Res. Bull. 76, 579-585 (2008
13. Kaelin WG: The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865-873 (2008
14. Kaelin WG, Ratcliffe PJ: Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008 (Pubitemid 351681994)
15. Katiyar SK, Meeran SM, Katiyar N, Akhtar S: P53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol. Carcinog. 48, 24-37 (2009
16. Kim TS, Kang BY, Cho D, Kim SH: Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response. Immunology 109, 407-414 (2003 (Pubitemid 36783267)
17. Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB: BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22, 4734-4744 (2003
18. Kulkarni SK, Dhir A: Berberine: A plant alkaloid with therapeutic potential for central nervous system disorders. Phytother. Res. 24, 317-324 (2010
19. Kumar G, Goyal MK, Sahota PK, Jain R: Penumbra, the basis of neuroimaging in acute stroke treatment: Current evidence. J. Neurol. Sci. 288, 13-24 (2010
20. Leonardo CC, Hall AA, Collier LA, Green SM, Willing AE, Pennypacker KR: Administration of a sigma receptor agonist delays MCAO-induced neurodegeneration and white matter injury. Transl. Stroke Res. 1, 135-145 (2010
21. Lin S, Tsai SC, Lee CC, Wang BW, Liou JY, Shyu KG: Berberine inhibits HIF-1alpha expression via enhanced proteolysis. Mol. Pharmacol. 66, 612-619 (2004 (Pubitemid 39329260)
22. Schmid T, Zhou J, Brune B: HIF-1 and p53: Communication of transcription factors under hypoxia. J. Cell Mol. Med. 8, 423-431 (2004 (Pubitemid 44145475)
23. Taylor CT: Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem. J. 409, 19-26 (2008
24. Tokunaga E, Kimura Y, Oki E, Ueda N, Futatsugi M, Mashino K, Yamamoto M, Ikebe M, Kakeji Y, Baba H, Maehara Y: Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. Int. J. Cancer 118, 284-289 (2006 (Pubitemid 41779066)
25. Van Hoecke M, Prigent-Tessier AS, Garnier PE, Bertrand NM, Filomenko R, Bettaieb A, Marie C, Beley AG: Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia. Mol. Cell Neurosci. 34, 40-47 (2007 (Pubitemid 46026929)
26. Wang F, Zhao G, Cheng L, Zhou HY, Fu LY, Yao WX: Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res. 999, 91-97 (2004 (Pubitemid 38121454)
27. Wu JF, Liu TP: Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion. Yao Xue Xue Bao. 30, 98-102 (1995
28. Xu MG, Wang JM, Chen L, Wang Y, Yang Z, Tao J: Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity. J. Hum. Hypertens. 22, 389-393 (2008 (Pubitemid 351712384)
29. Yao H: Evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive rats. Stroke 41, e197 (2010
30. Ye M, Fu S, Pi R, He F: Neuropharmacological and pharmacokinetic properties of berberine: A review of recent research. J. Pharm. Pharmacol. 61, 831-837 (2009
31. Yoo KY, Hwang IK, Kim JD, Kang IJ, Park J, Yi JS, Kim JK et al.: Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion. Phytother. Res. 22, 1527-1532 (2008 (Pubitemid 352789624)
32. Yoo KY, Hwang IK, Lim BO, Kang TC, Kim DW, Kim SM, Lee HY et al.: Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia. Biol. Pharm. Bull. 29, 623-628 (2006
33. Zhou XQ, Zeng XN, Kong H, Sun XL: Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neurosci. Lett. 447, 31-36 (2008