Sustained release of PTH(1-34) from PLGA microspheres suppresses osteoarthritis progression in rats

Acta Biomaterialia

Volumn 8, Issue 6, 2012, Pages 2254-2262

  Eswaramoorthy, Rajalakshmanan ^a,b   Chang, Chia Chi ^a   Wu, Shun Cheng ^a   Wang, Gwo Jaw ^a,c   Chang, Je Ken ^a,d   Ho, Mei Ling ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b University of California   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Kaohsiung Municipal Ta Tung Hospital   (Taiwan)

Author keywords

Controlled release; Osteoarthritis (OA); Parathyroid hormone 1 34; Poly (lactic co glycolic acid) (PLGA) microsphere

Indexed keywords

ENCAPSULATION; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; RATS; SCANNING ELECTRON MICROSCOPY; SPHERES;

ARTICULAR CHONDROCYTES; CONTROLLED RELEASE; OSTEOARTHRITIS; PARATHYROID HORMONE 1-34; PARATHYROID HORMONES; POLY LACTIC-CO-GLYCOLIC ACID; POLY(LACTIC-CO-GLYCOLIC ACID); POLY(LACTICCO-GLYCOLIC ACID) MICROSPHERE; SUSTAINED RELEASE; TERMINAL DIFFERENTIATION;

MICROSPHERES;

COLLAGEN TYPE 10; COLLAGEN TYPE 2; CYCLIC AMP; GLYCOSAMINOGLYCAN; MICROSPHERE; PAPAIN; PARATHYROID HORMONE[1-34]; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISEASE COURSE; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KNEE OSTEOARTHRITIS; MALE; NONHUMAN; OSTEOARTHRITIS; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING;

RATTUS;

EID: 84860528632     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.03.015     Document Type: Article

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