Baekjeolyusin-tang and its active component berberine block the release of collagen and proteoglycan from IL-1β-stimulated rabbit cartilage and down-regulate matrix metalloproteinases in rabbit chondrocytes

Phytotherapy Research

Volumn 25, Issue 6, 2011, Pages 844-850

  Moon, Phil Dong ^a   Jeong, Hyeon Seok ^a   Chun, Chang Sun ^a   Kim, Hyung Min ^a  

^a Kyung Hee University   (South Korea)

Author keywords

BaekJeolYuSin tang; berberine; collagen; glycosaminoglycan; matrix metalloproteinase 3; osteoarthritis

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; BAEKJEOLYUSINTANG; BERBERINE; COLLAGEN; COLLAGEN TYPE 2; COLLAGENASE 3; CYCLOOXYGENASE 2; DISINTEGRIN; GAG PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; PROTEOGLYCAN; STROMELYSIN; THROMBOSPONDIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL PROTECTION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; KOREAN MEDICINE; NONHUMAN; OSTEOARTHRITIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RABBIT;

ANIMALS; ATRACTYLODES; BERBERINE; CARTILAGE; CHONDROCYTES; COLLAGEN; DOWN-REGULATION; GENE EXPRESSION; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASES; MEDICINE, KOREAN TRADITIONAL; OSTEOARTHRITIS; PHELLODENDRON; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTEOGLYCANS; RABBITS; SOPHORA;

ORYCTOLAGUS CUNICULUS; ZIZIPHUS MAURITIANA;

EID: 79957793705     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3353     Document Type: Article

References (24)

1. Bonnet CS, Walsh DA,. 2005. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 44: 7-16. (Pubitemid 40136474)
2. Brandt KD, Mazzuca SA,. 2005. Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugs. Arthritis Rheum 52: 3349-3359. (Pubitemid 41612201)
3. Corvol MT, Dumontier MF, Rappaport R,. 1975. Culture of chondrocytes from the proliferative zone of epiphyseal growth plate cartilage from prepubertal rabbits. Biomedicine 23: 103-107.
4. Echtermeyer F, Bertrand J, Dreier R, et al. 2009. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med 15: 1072-1076.
5. Garnero P, Rousseau JC, Delmas PD,. 2000. Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases. Arthritis Rheum 43: 953-968. (Pubitemid 30368171)
6. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y,. 2008. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 67 (Suppl 3): iii75-iii82.
7. Harris ED Jr,. 2001. The bone and joint decade: a catalyst for progress. Arthritis Rheum 44: 1969-1970.
8. Jeong HW, Hsu KC, Lee JW, et al. 2009. Berberine suppresses proinflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab 296: E955-E964.
9. Kim YS, Kim SS, Cho JJ, et al. 2005. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. J Neurosci 25: 3701-3711.
10. Kobayashi M, Squires GR, Mousa A, et al. 2005. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum 52: 128-135. (Pubitemid 40129241)
11. Kullich W, Fagerer N, Schwann H,. 2007. Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee. Curr Med Res Opin 23: 1981-1986. (Pubitemid 47300397)
12. Kuo CL, Chi CW, Liu TY,. 2004. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 203: 127-137.
13. Lijnen HR,. 2002. Matrix metalloproteinases and cellular fibrinolytic activity. Biochemistry Mosc 67: 92-98.
14. Lin PM, Chen CT, Torzilli PA,. 2004. Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage. Osteoarthritis Cartilage 12: 485-496. (Pubitemid 38696949)
15. Loeser RF,. 2006. Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum 54: 1357-1360.
16. Macrory L, Vaughan-Thomas A, Clegg PD, Innes JF,. 2009. An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model. BMC Vet Res 5: 25.
17. Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD,. 2002. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 277: 22201-22208. (Pubitemid 34967185)
18. Mankin HJ,. 1982. The response for articular cartilage to mechanical injury. J Bone Joint Surg Am 64: 460-466. (Pubitemid 12153547)
19. O'Connell JP, Willenbrock F, Docherty AJ, Eaton D, Murphy G,. 1994. Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B. J Biol Chem 269: 14967-14973. (Pubitemid 24198336)
20. Pantsulaia I, Kalichman L, Kobyliansky E,. 2010. Association between radiographic hand osteoarthritis and RANKL, OPG and inflammatory markers. Osteoarthritis Cartilage doi: 10.1016/j.joca.2010.06.009
21. Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H, Takigawa M,. 1998. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem 123: 431-439. (Pubitemid 28143497)
22. Song RH, Tortorella MD, Malfait AM, et al. 2007. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 56: 575-585.
23. Stanton H, Rogerson FM, East CJ, et al. 2005. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434: 648-652. (Pubitemid 40488557)
24. Zeng W, Corcoran C, Collins-Racie LA, Lavallie ER, Morris EA, Flannery CR,. 2006. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Biochim Biophys Acta 1760: 517-524.