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Volumn 110, Issue 3, 2010, Pages 573-580

Biology and pathology of rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

Author keywords

Cell signaling; Chondrocytes; Kinases

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN KINASE B; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN;

EID: 77952705182     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22604     Document Type: Review
Times cited : (125)

References (73)
  • 1
    • 73349091526 scopus 로고    scopus 로고
    • Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    • Appleton CT, Usmani SE, Mort JS, Beier F. 2010. Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation. Lab Invest 90:20-30.
    • (2010) Lab Invest , vol.90 , pp. 20-30
    • Appleton, C.T.1    Usmani, S.E.2    Mort, J.S.3    Beier, F.4
  • 2
    • 0141483387 scopus 로고    scopus 로고
    • Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
    • DOI 10.1101/gad.277003
    • Aszodi A, Hunziker EB, Brakebusch C, Fassler R. 2003. Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev 17:2465-2479. (Pubitemid 37214793)
    • (2003) Genes and Development , vol.17 , Issue.19 , pp. 2465-2479
    • Aszodi, A.1    Hunziker, E.B.2    Brakebusch, C.3    Fassler, R.4
  • 3
    • 34447504847 scopus 로고    scopus 로고
    • Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7
    • DOI 10.1002/art.22637
    • Bobacz K, Sunk IG, Hofstaetter JG, Amoyo L, Toma CD, Akira S, Weichhart T, Saemann M, Smolen JS. 2007. Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum 56:1880-1893. (Pubitemid 47110387)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.6 , pp. 1880-1893
    • Bobacz, K.1    Sunk, I.G.2    Hofstaetter, J.G.3    Amoyo, L.4    Toma, C.D.5    Akira, S.6    Weichhart, T.7    Saemann, M.8    Smolen, J.S.9
  • 4
    • 46849098011 scopus 로고    scopus 로고
    • Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling
    • Bobick BE, Kulyk WM. 2008. Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth Defects Res Part C 84:131-154.
    • (2008) Birth Defects Res Part C , vol.84 , pp. 131-154
    • Bobick, B.E.1    Kulyk, W.M.2
  • 5
    • 34547451736 scopus 로고    scopus 로고
    • Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes
    • DOI 10.1002/art.22664
    • Boehm AK, Seth M, Mayr KG, Fortier LA. 2007. Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes. Arthritis Rheum 56:2335-2343. (Pubitemid 47173581)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.7 , pp. 2335-2343
    • Boehm, A.K.1    Seth, M.2    Mayr, K.G.3    Fortier, L.A.4
  • 6
    • 40849126775 scopus 로고    scopus 로고
    • mTOR signaling contributes to chondrocyte differentiation
    • Chanika P, Ke-Ying W, Valerie A, Qian C, Philip AG. 2008. mTOR signaling contributes to chondrocyte differentiation. Dev Dyn 237:702-712.
    • (2008) Dev Dyn , vol.237 , pp. 702-712
    • Chanika, P.1    Ke-Ying, W.2    Valerie, A.3    Qian, C.4    Philip, A.G.5
  • 7
    • 0035008314 scopus 로고    scopus 로고
    • Activation of stress-activated protein kinase in osteoarthritic cartilage: Evidence for nitric oxide dependence
    • DOI 10.1053/joca.2000.0388
    • Clancy R, Rediske J, Koehne C, Stoyanovsky D, Amin A, Attur M, Iyama K, Abramson SB. 2001. Activation of stress-activated protein kinase in osteoarthritic cartilage: Evidence for nitric oxide dependence. Osteoarthritis Cartilage 9:294-299. (Pubitemid 32454772)
    • (2001) Osteoarthritis and Cartilage , vol.9 , Issue.4 , pp. 294-299
    • Clancy, R.1    Rediske, J.2    Koehne, C.3    Stoyanovsky, D.4    Amin, A.5    Attur, M.6    Iyama, K.7    Abramson, S.B.8
  • 8
    • 59649084411 scopus 로고    scopus 로고
    • Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis
    • Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. 2009. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum 60:492-500.
    • (2009) Arthritis Rheum , vol.60 , pp. 492-500
    • Cravero, J.D.1    Carlson, C.S.2    Im, H.J.3    Yammani, R.R.4    Long, D.5    Loeser, R.F.6
  • 10
    • 34548816723 scopus 로고    scopus 로고
    • Activation of interleukin-1 signaling cascades in normal and osteoarthritis articular cartilage
    • DOI 10.2353/ajpath.2007.061083
    • Fan Z, Soder S, Oehler S, Fundel K, Aigner T. 2007. Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol 171:938-946. (Pubitemid 47440992)
    • (2007) American Journal of Pathology , vol.171 , Issue.3 , pp. 938-946
    • Fan, Z.1    Soder, S.2    Oehler, S.3    Fundel, K.4    Aigner, T.5
  • 11
    • 34548081463 scopus 로고    scopus 로고
    • Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth
    • DOI 10.1359/jbmr.070420
    • Ford-Hutchinson AF, Ali Z, Lines SE, Hallgrimsson B, Boyd SK, Jirik FR. 2007. Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth. J Bone Miner Res 22:1245-1259. (Pubitemid 351339707)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.8 , pp. 1245-1259
    • Ford-Hutchinson, A.F.1    Ali, Z.2    Lines, S.E.3    Hallgrimsson, B.4    Boyd, S.K.5    Jirik, F.R.6
  • 12
    • 0036746088 scopus 로고    scopus 로고
    • Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes
    • Forsyth CB, Pulai J, Loeser RF. 2002. Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum 46:2368-2376.
    • (2002) Arthritis Rheum , vol.46 , pp. 2368-2376
    • Forsyth, C.B.1    Pulai, J.2    Loeser, R.F.3
  • 13
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    • DOI 10.1083/jcb.200401138
    • Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T. 2004. Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166:85-95. (Pubitemid 38931919)
    • (2004) Journal of Cell Biology , vol.166 , Issue.1 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5    Koida, M.6    Ogita, K.7    Komori, T.8
  • 15
    • 77952698410 scopus 로고    scopus 로고
    • SirT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway
    • in press. in press
    • Gagarina V, Gabay O, Dvir-Ginzberg M, Lee EJ, Brady JK, Quon MJ, Hall DJ. in press. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway. Arthritis Rheum. in press.
    • Arthritis Rheum
    • Gagarina, V.1    Gabay, O.2    Dvir-Ginzberg, M.3    Lee, E.J.4    Brady, J.K.5    Quon, M.J.6    Hall, D.J.7
  • 16
    • 0038323946 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates chondrocyte shape and proliferation
    • DOI 10.1038/sj.embor.embor801
    • Grashoff C, Aszodi A, Sakai T, Hunziker EB, Fassler R. 2003. Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep 4:432-438. (Pubitemid 36622011)
    • (2003) EMBO Reports , vol.4 , Issue.4 , pp. 432-438
    • Grashoff, C.1    Aszodi, A.2    Sakai, T.3    Hunziker, E.B.4    Fassler, R.5
  • 17
    • 76149085502 scopus 로고    scopus 로고
    • PTH stimulated growth and decreased Col-X deposition are phosphotidylinositol-3,4,5 triphosphate kinase and mitogen activating protein kinase dependent in avian sterna
    • Hoboken
    • Harrington EK, Coon DJ, Kern MF, Svoboda KK. 2010. PTH stimulated growth and decreased Col-X deposition are phosphotidylinositol-3,4,5 triphosphate kinase and mitogen activating protein kinase dependent in avian sterna. Anat Rec (Hoboken) 293:225-234.
    • (2010) Anat Rec , vol.293 , pp. 225-234
    • Harrington, E.K.1    Coon, D.J.2    Kern, M.F.3    Svoboda, K.K.4
  • 18
    • 51849111513 scopus 로고    scopus 로고
    • Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes
    • Haudenschild DR, Nguyen B, Chen J, D'Lima DD, Lotz MK. 2008. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum 58:2735-2742.
    • (2008) Arthritis Rheum , vol.58 , pp. 2735-2742
    • Haudenschild, D.R.1    Nguyen, B.2    Chen, J.3    D'Lima, D.D.4    Lotz, M.K.5
  • 20
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions from in vivo studies
    • Heasman SJ, Ridley AJ. 2008. Mammalian Rho GTPases: New insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9:690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 21
    • 65749093920 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation
    • Hsieh SC, Chen NT, Lo SH. 2009. Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog 48:545-552.
    • (2009) Mol Carcinog , vol.48 , pp. 545-552
    • Hsieh, S.C.1    Chen, N.T.2    Lo, S.H.3
  • 22
    • 34249688522 scopus 로고    scopus 로고
    • Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes
    • DOI 10.1074/jbc.M609040200
    • Im H-J, Muddasani P, Natarajan V, Schmid TM, Block JA, Davis F, van Wijnen AJ, Loeser RF. 2007. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem 282:11110-11121. (Pubitemid 47100793)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 11110-11121
    • Im, H.-J.1    Muddasani, P.2    Natarajan, V.3    Schmid, T.M.4    Block, J.A.5    Davis, F.6    Van Wijnen, A.J.7    Loeser, R.F.8
  • 23
    • 27644453166 scopus 로고    scopus 로고
    • Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    • DOI 10.1091/mbc.E05-01-0084
    • James CG, Appleton CT, Ulici V, Underhill TM, Beier F. 2005. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol Biol Cell 16:5316-5333. (Pubitemid 41566842)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.11 , pp. 5316-5333
    • James, C.G.1    Appleton, C.T.G.2    Ulici, V.3    Michael Underhill, T.4    Beier, F.5
  • 24
    • 33749548543 scopus 로고    scopus 로고
    • The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and a gene transcription
    • DOI 10.1186/1471-2199-7-30
    • James CG, Woods A, Underhill TM, Beier F. 2006. The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription. BMC Mol Biol 7:30. (Pubitemid 44529193)
    • (2006) BMC Molecular Biology , vol.7 , pp. 30
    • James, C.G.1    Woods, A.2    Underhill, T.M.3    Beier, F.4
  • 27
    • 48649110928 scopus 로고    scopus 로고
    • PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation
    • Keisuke K, Tohru K, Norimasa N, Hideki Y, Toru N. 2008. PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation. Genes Cells 13:839-850.
    • (2008) Genes Cells , vol.13 , pp. 839-850
    • Keisuke, K.1    Tohru, K.2    Norimasa, N.3    Hideki, Y.4    Toru, N.5
  • 28
    • 40149084152 scopus 로고    scopus 로고
    • Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes
    • Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M. 2008. Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Exp Cell Res 314:1301-1312.
    • (2008) Exp Cell Res , vol.314 , pp. 1301-1312
    • Kerr, B.A.1    Otani, T.2    Koyama, E.3    Freeman, T.A.4    Enomoto-Iwamoto, M.5
  • 29
    • 67651207668 scopus 로고    scopus 로고
    • The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization
    • Kumar D, Lassar AB. 2009. The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol 29:4262-4273.
    • (2009) Mol Cell Biol , vol.29 , pp. 4262-4273
    • Kumar, D.1    Lassar, A.B.2
  • 30
    • 0037474320 scopus 로고    scopus 로고
    • JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of Sox9 expression
    • DOI 10.1074/jbc.M110773200
    • Legendre F, Dudhia J, Pujol JP, Bogdanowicz P. 2003. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem 278:2903-2912. (Pubitemid 36801195)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 2903-2912
    • Legendre, F.1    Dudhia, J.2    Pujol, J.-P.3    Bogdanowicz, P.4
  • 31
    • 47249135425 scopus 로고    scopus 로고
    • Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent
    • Litherland GJ, Dixon C, Lakey RL, Robson T, Jones D, Young DA, Cawston TE, Rowan AD. 2008. Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent. J Biol Chem 283:14221-14229.
    • (2008) J Biol Chem , vol.283 , pp. 14221-14229
    • Litherland, G.J.1    Dixon, C.2    Lakey, R.L.3    Robson, T.4    Jones, D.5    Young, D.A.6    Cawston, T.E.7    Rowan, A.D.8
  • 32
    • 67650383738 scopus 로고    scopus 로고
    • Aging and osteoarthritis: The role of chondrocyte senescence and aging changes in the cartilage matrix
    • Loeser RF. 2009. Aging and osteoarthritis: The role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage 17:971-979.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 971-979
    • Loeser, R.F.1
  • 33
    • 0042090276 scopus 로고    scopus 로고
    • Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway
    • Loeser RF, Forsyth CB, Samarel AM, Im HJ. 2003. Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 278:24577-24585.
    • (2003) J Biol Chem , vol.278 , pp. 24577-24585
    • Loeser, R.F.1    Forsyth, C.B.2    Samarel, A.M.3    Im, H.J.4
  • 36
    • 34548245970 scopus 로고    scopus 로고
    • IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1beta
    • DOI 10.1016/j.ghir.2007.05.002, PII S109663740700069X
    • MacRae VE, Ahmed SF, Mushtaq T, Farquharson C. 2007. IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1[beta]. Growth Hormone IGF Res 17:435-439. (Pubitemid 47324309)
    • (2007) Growth Hormone and IGF Research , vol.17 , Issue.5 , pp. 435-439
    • MacRae, V.E.1    Ahmed, S.F.2    Mushtaq, T.3    Farquharson, C.4
  • 38
    • 0033851463 scopus 로고    scopus 로고
    • Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: Differential regulation of collagenase 1 and collagenase 3
    • Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. 2000. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: Differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 43:801-811.
    • (2000) Arthritis Rheum , vol.43 , pp. 801-811
    • Mengshol, J.A.1    Vincenti, M.P.2    Coon, C.I.3    Barchowsky, A.4    Brinckerhoff, C.E.5
  • 39
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • DOI 10.1101/gad.1179104
    • Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18:290-305. (Pubitemid 38199254)
    • (2004) Genes and Development , vol.18 , Issue.3 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    De Crombrugghe, B.6
  • 40
    • 55849133703 scopus 로고    scopus 로고
    • Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage
    • Namdari S, Wei L, Moore D, Chen Q. 2008. Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage. Arthritis Rheum 58:3520-3529.
    • (2008) Arthritis Rheum , vol.58 , pp. 3520-3529
    • Namdari, S.1    Wei, L.2    Moore, D.3    Chen, Q.4
  • 41
    • 58149260211 scopus 로고    scopus 로고
    • The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1alpha and insulin-like growth factor-I
    • Novakofski K, Boehm A, Fortier L. 2009. The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1alpha and insulin-like growth factor-I. J Orthop Res 27:58-64.
    • (2009) J Orthop Res , vol.27 , pp. 58-64
    • Novakofski, K.1    Boehm, A.2    Fortier, L.3
  • 42
    • 0141592429 scopus 로고    scopus 로고
    • Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1
    • Oh CD, Chun JS. 2003. Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem 278:36563-36571.
    • (2003) J Biol Chem , vol.278 , pp. 36563-36571
    • Oh, C.D.1    Chun, J.S.2
  • 43
    • 41749091574 scopus 로고    scopus 로고
    • Applications for ROCK kinase inhibition
    • Olson MF. 2008. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20:242-248.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 242-248
    • Olson, M.F.1
  • 45
    • 34250623251 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
    • DOI 10.1016/j.cellsig.2007.02.007, PII S0898656807000691
    • Qureshi HY, Ahmad R, Sylvester J, Zafarullah M. 2007. Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. Cell Signal 19:1643-1651. (Pubitemid 46935421)
    • (2007) Cellular Signalling , vol.19 , Issue.8 , pp. 1643-1651
    • Qureshi, H.Y.1    Ahmad, R.2    Sylvester, J.3    Zafarullah, M.4
  • 47
    • 0242607637 scopus 로고    scopus 로고
    • An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
    • DOI 10.1038/sj.embor.embor939
    • Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S. 2003. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep 4:964-968. (Pubitemid 37407464)
    • (2003) EMBO Reports , vol.4 , Issue.10 , pp. 964-968
    • Saba-El-Leil, M.K.1    Vella, F.D.J.2    Vernay, B.3    Voisin, L.4    Chen, L.5    Labrecque, N.6    Ang, S.-L.7    Meloche, S.8
  • 48
    • 63049094292 scopus 로고    scopus 로고
    • Bone growth during rapamycin therapy in young rats
    • Sanchez C, He Y-Z. 2009. Bone growth during rapamycin therapy in young rats. BMC Pediatrics 9:3.
    • (2009) BMC Pediatrics , vol.9 , pp. 3
    • Sanchez, C.1    He, Y.-Z.2
  • 49
    • 44449135139 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: Two case-control studies in East Asian populations and a meta-analysis
    • Shi D, Nakamura T, Nakajima M, Dai J, Qin J, Ni H, Xu Y, Yao C, Wei J, Liu B, Ikegawa S, Jiang Q. 2008. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: Two case-control studies in East Asian populations and a meta-analysis. Arthritis Res Ther 10:R54.
    • (2008) Arthritis Res Ther , vol.10
    • Shi, D.1    Nakamura, T.2    Nakajima, M.3    Dai, J.4    Qin, J.5    Ni, H.6    Xu, Y.7    Yao, C.8    Wei, J.9    Liu, B.10    Ikegawa, S.11    Jiang, Q.12
  • 50
    • 76549091830 scopus 로고    scopus 로고
    • MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation-Divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
    • Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M, Karsdal MA. 2010. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation-Divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage 18:279-288.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 279-288
    • Sondergaard, B.C.1    Schultz, N.2    Madsen, S.H.3    Bay-Jensen, A.C.4    Kassem, M.5    Karsdal, M.A.6
  • 51
    • 23644450412 scopus 로고    scopus 로고
    • IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
    • Starkman BG, Cravero JD, Delcarlo M, Loeser RF. 2005. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J 389:723-729.
    • (2005) Biochem J , vol.389 , pp. 723-729
    • Starkman, B.G.1    Cravero, J.D.2    Delcarlo, M.3    Loeser, R.F.4
  • 53
    • 46049093360 scopus 로고    scopus 로고
    • Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification
    • Teixeira CC, Agoston H, Beier F. 2008. Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification. Dev Biol 319:171-178.
    • (2008) Dev Biol , vol.319 , pp. 171-178
    • Teixeira, C.C.1    Agoston, H.2    Beier, F.3
  • 54
    • 0038148536 scopus 로고    scopus 로고
    • Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
    • Terpstra L, Prud'homme J,ArabianA, TakedaS, KarsentyG,DedharS, St-Arnaud R. 2003. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162:139-148.
    • (2003) J Cell Biol , vol.162 , pp. 139-148
    • Terpstra, L.1    Prud'homme, J.2    Arabian, A.3    Takeda, S.4    Karsenty, G.5    Dedhar, S.6    St-Arnaud, R.7
  • 55
    • 33845985323 scopus 로고    scopus 로고
    • Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization
    • Tew SR, Hardingham TE. 2006. Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. J Biol Chem 281:39471-39479.
    • (2006) J Biol Chem , vol.281 , pp. 39471-39479
    • Tew, S.R.1    Hardingham, T.E.2
  • 56
    • 42549158610 scopus 로고    scopus 로고
    • The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
    • DOI 10.1186/1471-213X-8-40
    • Ulici V, Hoenselaar KD, Gillespie JR, Beier F. 2008. The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation. BMC Dev Biol 8:40. (Pubitemid 351581162)
    • (2008) BMC Developmental Biology , vol.8 , pp. 40
    • Ulici, V.1    Hoenselaar, K.D.2    Gillespie, J.R.3    Beier, F.4
  • 58
    • 77749258183 scopus 로고    scopus 로고
    • Regulation of gene expression by PI3K in mouse growth plate chondrocytes
    • Ulici V, James CG, Hoenselaar KD, Beier F. 2010. Regulation of gene expression by PI3K in mouse growth plate chondrocytes. PLoS ONE 5:e8866.
    • (2010) PLoS ONE , vol.5
    • Ulici, V.1    James, C.G.2    Hoenselaar, K.D.3    Beier, F.4
  • 59
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega FM, Ridley AJ. 2008. Rho GTPases in cancer cell biology. FEBS Lett 582:2093-2101.
    • (2008) FEBS Lett , vol.582 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 60
    • 19044390915 scopus 로고    scopus 로고
    • Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
    • DOI 10.1359/JBMR.050113
    • Wang G, Beier F. 2005. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J Bone Miner Res 20:1022-1031. (Pubitemid 40712827)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.6 , pp. 1022-1031
    • Wang, G.1    Beier, F.2
  • 63
    • 34249899968 scopus 로고    scopus 로고
    • Genetic ablation of Rac1 in cartilage results in chondrodysplasia
    • DOI 10.1016/j.ydbio.2007.03.520, PII S001216060700245X
    • Wang G, Woods A, Agoston H, Ulici V, Glogauer M, Beier F. 2007. Genetic ablation of Rac1 in cartilage results in chondrodysplasia. Dev Biol 306:612-623. (Pubitemid 46873537)
    • (2007) Developmental Biology , vol.306 , Issue.2 , pp. 612-623
    • Wang, G.1    Woods, A.2    Agoston, H.3    Ulici, V.4    Glogauer, M.5    Beier, F.6
  • 64
    • 75049085759 scopus 로고    scopus 로고
    • The ILK/PINCH/parvin complex: The kinase is dead, long live the pseudokinase
    • Wickstrom SA, Lange A, Montanez E, Fassler R. 2010. The ILK/PINCH/parvin complex: The kinase is dead, long live the pseudokinase. EMBO J 29:281-291.
    • (2010) EMBO J , vol.29 , pp. 281-291
    • Wickstrom, S.A.1    Lange, A.2    Montanez, E.3    Fassler, R.4
  • 65
    • 33744956176 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner
    • DOI 10.1074/jbc.M509433200
    • Woods A, Beier F. 2006. RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner. J Biol Chem 281:13134-13140. (Pubitemid 43855224)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13134-13140
    • Woods, A.1    Beier, F.2
  • 66
    • 15744375543 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis
    • DOI 10.1074/jbc.M409158200
    • Woods A, Wang G, Beier F. 2005. RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. J Biol Chem 280:11626-11634. (Pubitemid 40418476)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.12 , pp. 11626-11634
    • Woods, A.1    Wang, G.2    Beier, F.3
  • 67
    • 34548489858 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation by the act in cytoskeleton and adhesive interactions
    • DOI 10.1002/jcp.21110
    • Woods A, Wang G, Beier F. 2007a. Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions. J Cell Physiol 213:1-8. (Pubitemid 47378786)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.1 , pp. 1-8
    • Woods, A.1    Wang, G.2    Beier, F.3
  • 68
    • 34548159747 scopus 로고    scopus 로고
    • Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis
    • DOI 10.1074/jbc.M700680200
    • Woods A, Wang G, Dupuis H, Shao Z, Beier F. 2007b. Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis. J Biol Chem 282:23500-23508. (Pubitemid 47311953)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.32 , pp. 23500-23508
    • Woods, A.1    Wang, G.2    Dupuis, H.3    Shao, Z.4    Beier, F.5
  • 69
    • 34547783916 scopus 로고    scopus 로고
    • Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis
    • DOI 10.1002/art.22761
    • Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, Olsen BR, Goldring MB, Li Y. 2007. Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum 56:2663-2673. (Pubitemid 47237284)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.8 , pp. 2663-2673
    • Xu, L.1    Peng, H.2    Glasson, S.3    Lee, P.L.4    Hu, K.5    Ijiri, K.6    Olsen, B.R.7    Goldring, M.B.8    Li, Y.9
  • 70
    • 58049197169 scopus 로고    scopus 로고
    • PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress
    • Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X. 2008. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development 135:3587-3597.
    • (2008) Development , vol.135 , pp. 3587-3597
    • Yang, G.1    Sun, Q.2    Teng, Y.3    Li, F.4    Weng, T.5    Yang, X.6
  • 71
    • 70450274965 scopus 로고    scopus 로고
    • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    • Yin W, Park JI, Loeser RF. 2009. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 284:31972-31981.
    • (2009) J Biol Chem , vol.284 , pp. 31972-31981
    • Yin, W.1    Park, J.I.2    Loeser, R.F.3
  • 72
    • 13444296903 scopus 로고    scopus 로고
    • Multiple functions of BMPs in chondrogenesis
    • Yoon BS, Lyons KM. 2004. Multiple functions of BMPs in chondrogenesis. J Cell Biochem 93:93-103.
    • (2004) J Cell Biochem , vol.93 , pp. 93-103
    • Yoon, B.S.1    Lyons, K.M.2


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