-
1
-
-
0029788211
-
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
-
Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-396.
-
(1996)
J Exp Med
, vol.184
, pp. 387-396
-
-
Asano, M.1
Toda, M.2
Sakaguchi, N.3
Sakaguchi, S.4
-
2
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
3
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
4
-
-
0037385314
-
An essential role for Scurfin in CD4+CD25+ T regulatory cells
-
Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003;4:337-342.
-
(2003)
Nat Immunol
, vol.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
5
-
-
0035806244
-
Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
-
Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001;193:1303-1310.
-
(2001)
J Exp Med
, vol.193
, pp. 1303-1310
-
-
Dieckmann, D.1
Plottner, H.2
Berchtold, S.3
Berger, T.4
Schuler, G.5
-
6
-
-
0035806290
-
Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
-
Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001;193:1285-1294.
-
(2001)
J Exp Med
, vol.193
, pp. 1285-1294
-
-
Jonuleit, H.1
Schmitt, E.2
Stassen, M.3
Tuettenberg, A.4
Knop, J.5
Enk, A.H.6
-
7
-
-
0035806323
-
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
-
Levings MK, Sangregorio R, Roncarolo MG. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-1302.
-
(2001)
J Exp Med
, vol.193
, pp. 1295-1302
-
-
Levings, M.K.1
Sangregorio, R.2
Roncarolo, M.G.3
-
8
-
-
3242801352
-
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
-
Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 2004;104:895-903.
-
(2004)
Blood
, vol.104
, pp. 895-903
-
-
Hoffmann, P.1
Eder, R.2
Kunz-Schughart, L.A.3
Andreesen, R.4
Edinger, M.5
-
9
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-1711.
-
(2006)
J Exp Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
-
10
-
-
33745813929
-
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
-
Seddiki N, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-1700.
-
(2006)
J Exp Med
, vol.203
, pp. 1693-1700
-
-
Seddiki, N.1
-
11
-
-
66949171924
-
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
-
Miyara M, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911.
-
(2009)
Immunity
, vol.30
, pp. 899-911
-
-
Miyara, M.1
-
12
-
-
47249119632
-
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
-
Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol 2008;180:7327-7337.
-
(2008)
J Immunol
, vol.180
, pp. 7327-7337
-
-
Chen, M.L.1
Yan, B.S.2
Bando, Y.3
Kuchroo, V.K.4
Weiner, H.L.5
-
13
-
-
65549168545
-
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures
-
Tran DQ, Andersson J, Hardwick D, Bebris L, Illei GG, Shevach EM. Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures. Blood 2009;113:5125-5133.
-
(2009)
Blood
, vol.113
, pp. 5125-5133
-
-
Tran, D.Q.1
Andersson, J.2
Hardwick, D.3
Bebris, L.4
Illei, G.G.5
Shevach, E.M.6
-
14
-
-
59649091305
-
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells
-
Kleinewietfeld M, et al. CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Blood 2009;113:827-836.
-
(2009)
Blood
, vol.113
, pp. 827-836
-
-
Kleinewietfeld, M.1
-
15
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
Grohmann U, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002;3:1097-1101.
-
(2002)
Nat Immunol
, vol.3
, pp. 1097-1101
-
-
Grohmann, U.1
-
16
-
-
0037136266
-
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites
-
Terness P, et al. Inhibition of allogeneic T cell proliferation by indoleamine 2, 3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002;196:447-457.
-
(2002)
J Exp Med
, vol.196
, pp. 447-457
-
-
Terness, P.1
-
17
-
-
0042591467
-
Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
-
Mellor AL, et al. Cutting edge: induced indoleamine 2, 3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 2003;171:1652-1655.
-
(2003)
J Immunol
, vol.171
, pp. 1652-1655
-
-
Mellor, A.L.1
-
18
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011;332:600-603.
-
(2011)
Science
, vol.332
, pp. 600-603
-
-
Qureshi, O.S.1
-
19
-
-
60149085254
-
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
-
Yu A, Zhu L, Altman NH, Malek TR. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 2009;30:204-217.
-
(2009)
Immunity
, vol.30
, pp. 204-217
-
-
Yu, A.1
Zhu, L.2
Altman, N.H.3
Malek, T.R.4
-
20
-
-
0028821858
-
Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene
-
Kramer S, Schimpl A, Hunig T. Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J Exp Med 1995;182:1769-1776.
-
(1995)
J Exp Med
, vol.182
, pp. 1769-1776
-
-
Kramer, S.1
Schimpl, A.2
Hunig, T.3
-
21
-
-
27544446622
-
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
D'Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005;6:1152-1159.
-
(2005)
Nat Immunol
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
23
-
-
27544483288
-
Fueling regulation: IL-2 keeps CD4+ Treg cells fit
-
Maloy KJ, Powrie F. Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat Immunol 2005;6:1071-1072.
-
(2005)
Nat Immunol
, vol.6
, pp. 1071-1072
-
-
Maloy, K.J.1
Powrie, F.2
-
24
-
-
36248976097
-
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
-
Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007;8:1353-1362.
-
(2007)
Nat Immunol
, vol.8
, pp. 1353-1362
-
-
Pandiyan, P.1
Zheng, L.2
Ishihara, S.3
Reed, J.4
Lenardo, M.J.5
-
25
-
-
41549159660
-
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
-
Rubtsov YP, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008;28:546-558.
-
(2008)
Immunity
, vol.28
, pp. 546-558
-
-
Rubtsov, Y.P.1
-
26
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison LW, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007;450:566-569.
-
(2007)
Nature
, vol.450
, pp. 566-569
-
-
Collison, L.W.1
-
27
-
-
15444363794
-
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
-
Fahlen L, et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005;201:737-746.
-
(2005)
J Exp Med
, vol.201
, pp. 737-746
-
-
Fahlen, L.1
-
28
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
-
Shull MM, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992;359:693-699.
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
-
29
-
-
0036786468
-
Reconstitution of lethally irradiated adult mice with dominant negative TGF-beta type II receptor-transduced bone marrow leads to myeloid expansion and inflammatory disease
-
Shah AH, Tabayoyong WB, Kimm SY, Kim SJ, Van Parijs L, Lee C. Reconstitution of lethally irradiated adult mice with dominant negative TGF-beta type II receptor-transduced bone marrow leads to myeloid expansion and inflammatory disease. J Immunol 2002;169:3485-3491.
-
(2002)
J Immunol
, vol.169
, pp. 3485-3491
-
-
Shah, A.H.1
Tabayoyong, W.B.2
Kimm, S.Y.3
Kim, S.J.4
Van Parijs, L.5
Lee, C.6
-
30
-
-
0037099613
-
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
-
Piccirillo CA, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002;196:237-246.
-
(2002)
J Exp Med
, vol.196
, pp. 237-246
-
-
Piccirillo, C.A.1
-
31
-
-
0035801335
-
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
-
Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-644.
-
(2001)
J Exp Med
, vol.194
, pp. 629-644
-
-
Nakamura, K.1
Kitani, A.2
Strober, W.3
-
32
-
-
70049118519
-
Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
-
Collison LW, Pillai MR, Chaturvedi V, Vignali DA. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 2009;182:6121-6128.
-
(2009)
J Immunol
, vol.182
, pp. 6121-6128
-
-
Collison, L.W.1
Pillai, M.R.2
Chaturvedi, V.3
Vignali, D.A.4
-
33
-
-
0036467522
-
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
-
Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002;168:1080-1086.
-
(2002)
J Immunol
, vol.168
, pp. 1080-1086
-
-
Kingsley, C.I.1
Karim, M.2
Bushell, A.R.3
Wood, K.J.4
-
35
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009;10:595-602.
-
(2009)
Nat Immunol
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
36
-
-
84866483591
-
The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology
-
Hall AO, et al. The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 2012;37:511-523.
-
(2012)
Immunity
, vol.37
, pp. 511-523
-
-
Hall, A.O.1
-
37
-
-
84866499256
-
T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor beta2
-
Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ. T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor beta2. Immunity 2012;37:501-510.
-
(2012)
Immunity
, vol.37
, pp. 501-510
-
-
Koch, M.A.1
Thomas, K.R.2
Perdue, N.R.3
Smigiel, K.S.4
Srivastava, S.5
Campbell, D.J.6
-
38
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
Zheng Y, et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009;458:351-356.
-
(2009)
Nature
, vol.458
, pp. 351-356
-
-
Zheng, Y.1
-
39
-
-
78650124721
-
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice
-
Sharma MD, et al. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity 2010;33:942-954.
-
(2010)
Immunity
, vol.33
, pp. 942-954
-
-
Sharma, M.D.1
-
40
-
-
69549120242
-
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
-
Pan F, et al. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science 2009;325:1142-1146.
-
(2009)
Science
, vol.325
, pp. 1142-1146
-
-
Pan, F.1
-
41
-
-
84878169329
-
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos
-
Sharma MD, et al. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity 2013;38:998-1012.
-
(2013)
Immunity
, vol.38
, pp. 998-1012
-
-
Sharma, M.D.1
-
42
-
-
79952769679
-
CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model
-
Pandiyan P, et al. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 2011;34:422-434.
-
(2011)
Immunity
, vol.34
, pp. 422-434
-
-
Pandiyan, P.1
-
43
-
-
0028882526
-
Survival of mouse pancreatic islografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
-
Parker DC, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci USA 1995;92:9560-9564.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9560-9564
-
-
Parker, D.C.1
-
44
-
-
0030474264
-
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
-
Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 1996;93:13967-13972.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13967-13972
-
-
Hancock, W.W.1
Sayegh, M.H.2
Zheng, X.G.3
Peach, R.4
Linsley, P.S.5
Turka, L.A.6
-
45
-
-
34248385683
-
CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation
-
Pearl JP, Xu H, Leopardi F, Preston E, Kirk AD. CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation. Transplantation 2007;83:1219-1225.
-
(2007)
Transplantation
, vol.83
, pp. 1219-1225
-
-
Pearl, J.P.1
Xu, H.2
Leopardi, F.3
Preston, E.4
Kirk, A.D.5
-
46
-
-
17644410067
-
IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates
-
Preston EH, et al. IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. Am J Transplant 2005;5:1032-1041.
-
(2005)
Am J Transplant
, vol.5
, pp. 1032-1041
-
-
Preston, E.H.1
-
47
-
-
0004880266
-
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
-
Zheng XX, et al. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol 1999;162:4983-4990.
-
(1999)
J Immunol
, vol.162
, pp. 4983-4990
-
-
Zheng, X.X.1
-
48
-
-
0032103285
-
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4
-
Markees TG, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest 1998;101:2446-2455.
-
(1998)
J Clin Invest
, vol.101
, pp. 2446-2455
-
-
Markees, T.G.1
-
49
-
-
0035806276
-
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
-
Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001;193:1311-1318.
-
(2001)
J Exp Med
, vol.193
, pp. 1311-1318
-
-
Taylor, P.A.1
Noelle, R.J.2
Blazar, B.R.3
-
50
-
-
84855503657
-
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade
-
Ferrer IR, Wagener ME, Song M, Kirk AD, Larsen CP, Ford ML. Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. Proc Natl Acad Sci USA 2011;108:20701-20706.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 20701-20706
-
-
Ferrer, I.R.1
Wagener, M.E.2
Song, M.3
Kirk, A.D.4
Larsen, C.P.5
Ford, M.L.6
-
51
-
-
84881419279
-
Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo
-
Liu D, Ferrer IR, Konomos M, Ford ML. Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo. J Immunol 2013;191:1957-1964.
-
(2013)
J Immunol
, vol.191
, pp. 1957-1964
-
-
Liu, D.1
Ferrer, I.R.2
Konomos, M.3
Ford, M.L.4
-
52
-
-
0028362675
-
Nondepleting anti-CD4 antibodies in transplantation. Evidence that modulation is far less effective than prolonged CD4 blockade
-
Darby CR, Bushell A, Morris PJ, Wood KJ. Nondepleting anti-CD4 antibodies in transplantation. Evidence that modulation is far less effective than prolonged CD4 blockade. Transplantation 1994;57:1419-1426.
-
(1994)
Transplantation
, vol.57
, pp. 1419-1426
-
-
Darby, C.R.1
Bushell, A.2
Morris, P.J.3
Wood, K.J.4
-
53
-
-
0027956754
-
Induction of operational tolerance by random blood transfusion combined with anti-CD4 antibody therapy. A protocol with significant clinical potential
-
Bushell A, Morris PJ, Wood KJ. Induction of operational tolerance by random blood transfusion combined with anti-CD4 antibody therapy. A protocol with significant clinical potential. Transplantation 1994;58:133-139.
-
(1994)
Transplantation
, vol.58
, pp. 133-139
-
-
Bushell, A.1
Morris, P.J.2
Wood, K.J.3
-
54
-
-
49649108520
-
Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection
-
Oliveira V, et al. Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection. Eur J Immunol 2008;38:1677-1688.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1677-1688
-
-
Oliveira, V.1
-
55
-
-
84890364201
-
Generation of highly effective and stable murine alloreactive Treg cells by combined anti-CD4 mAb, TGF-beta, and RA treatment
-
doi:10.1002/eji.201243292.
-
Schliesser U, et al. Generation of highly effective and stable murine alloreactive Treg cells by combined anti-CD4 mAb, TGF-beta, and RA treatment. Eur J Immunol 2013. doi:10.1002/eji.201243292.
-
(2013)
Eur J Immunol
-
-
Schliesser, U.1
-
56
-
-
0024561069
-
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen
-
Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989;169:493-502.
-
(1989)
J Exp Med
, vol.169
, pp. 493-502
-
-
Sharabi, Y.1
Sachs, D.H.2
-
57
-
-
0028860210
-
Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys
-
Kawai T, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995;59:256-262.
-
(1995)
Transplantation
, vol.59
, pp. 256-262
-
-
Kawai, T.1
-
58
-
-
38549088096
-
HLA-mismatched renal transplantation without maintenance immunosuppression
-
Kawai T, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008;358:353-361.
-
(2008)
N Engl J Med
, vol.358
, pp. 353-361
-
-
Kawai, T.1
-
59
-
-
38549134052
-
Tolerance and chimerism after renal and hematopoietic-cell transplantation
-
Scandling JD, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008;358:362-368.
-
(2008)
N Engl J Med
, vol.358
, pp. 362-368
-
-
Scandling, J.D.1
-
60
-
-
79958863773
-
Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation
-
Andreola G, et al. Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation. Am J Transplant 2011;11:1236-1247.
-
(2011)
Am J Transplant
, vol.11
, pp. 1236-1247
-
-
Andreola, G.1
-
61
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005;105:4743-4748.
-
(2005)
Blood
, vol.105
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
62
-
-
33845379986
-
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
-
Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006;177:8338-8347.
-
(2006)
J Immunol
, vol.177
, pp. 8338-8347
-
-
Battaglia, M.1
Stabilini, A.2
Migliavacca, B.3
Horejs-Hoeck, J.4
Kaupper, T.5
Roncarolo, M.G.6
-
63
-
-
12144249838
-
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
-
Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005;54:92-99.
-
(2005)
Diabetes
, vol.54
, pp. 92-99
-
-
Lindley, S.1
Dayan, C.M.2
Bishop, A.3
Roep, B.O.4
Peakman, M.5
Tree, T.I.6
-
64
-
-
84864463754
-
Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
-
Hester J, Schiopu A, Nadig SN, Wood KJ. Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2012;12:2008-2016.
-
(2012)
Am J Transplant
, vol.12
, pp. 2008-2016
-
-
Hester, J.1
Schiopu, A.2
Nadig, S.N.3
Wood, K.J.4
-
65
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-1886.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
66
-
-
2442425262
-
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
-
Cobbold SP, et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol 2004;172:6003-6010.
-
(2004)
J Immunol
, vol.172
, pp. 6003-6010
-
-
Cobbold, S.P.1
-
67
-
-
55249099643
-
Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells
-
Feng G, et al. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol 2008;38:2512-2527.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2512-2527
-
-
Feng, G.1
-
68
-
-
52449099834
-
Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy
-
Feng G, Wood KJ, Bushell A. Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy. Transplantation 2008;86:578-589.
-
(2008)
Transplantation
, vol.86
, pp. 578-589
-
-
Feng, G.1
Wood, K.J.2
Bushell, A.3
-
69
-
-
0018152224
-
Induction and separation of antigen-dependent T helper and T suppressor cells in man
-
Shore A, Dosch H, Gelfand EW. Induction and separation of antigen-dependent T helper and T suppressor cells in man. Nature 1978;274:586-587.
-
(1978)
Nature
, vol.274
, pp. 586-587
-
-
Shore, A.1
Dosch, H.2
Gelfand, E.W.3
-
70
-
-
0020003546
-
Suppressor cells induced in the human autologous mixed lymphocyte reaction
-
Goeken NE, Thompson JS. Suppressor cells induced in the human autologous mixed lymphocyte reaction. Hum Immunol 1982;4:37-45.
-
(1982)
Hum Immunol
, vol.4
, pp. 37-45
-
-
Goeken, N.E.1
Thompson, J.S.2
-
71
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007;445:771-775.
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
-
72
-
-
79956272192
-
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection
-
Feng G, et al. Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med 2011;3:83ra40.
-
(2011)
Sci Transl Med
, vol.3
-
-
Feng, G.1
-
73
-
-
33846980131
-
Epigenetic control of the foxp3 locus in regulatory T cells
-
Floess S, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 2007;5:e38.
-
(2007)
PLoS Biol
, vol.5
-
-
Floess, S.1
-
74
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010;463:808-812.
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
Josefowicz, S.2
Chaudhry, A.3
Peng, X.P.4
Forbush, K.5
Rudensky, A.Y.6
-
75
-
-
59849085588
-
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
-
Lal G, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009;182:259-273.
-
(2009)
J Immunol
, vol.182
, pp. 259-273
-
-
Lal, G.1
-
76
-
-
0028027043
-
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells
-
Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994;24:2383-2392.
-
(1994)
Eur J Immunol
, vol.24
, pp. 2383-2392
-
-
Scully, R.1
Qin, S.2
Cobbold, S.3
Waldmann, H.4
-
77
-
-
33244455884
-
Isolation of CD4+CD25+ regulatory T cells for clinical trials
-
Hoffmann P, et al. Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biol Blood Marrow Transplant 2006;12:267-274.
-
(2006)
Biol Blood Marrow Transplant
, vol.12
, pp. 267-274
-
-
Hoffmann, P.1
-
78
-
-
48249098901
-
Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy
-
Peters JH, Hilbrands LB, Koenen HJ, Joosten I. Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy. PLoS ONE 2008;3:e2233.
-
(2008)
PLoS ONE
, vol.3
-
-
Peters, J.H.1
Hilbrands, L.B.2
Koenen, H.J.3
Joosten, I.4
-
79
-
-
77954539326
-
In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
-
Nadig SN, et al. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010;16:809-813.
-
(2010)
Nat Med
, vol.16
, pp. 809-813
-
-
Nadig, S.N.1
-
80
-
-
84865483192
-
Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children
-
Marek-Trzonkowska N, et al. Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children. Diabetes Care 2012;35:1817-1820.
-
(2012)
Diabetes Care
, vol.35
, pp. 1817-1820
-
-
Marek-Trzonkowska, N.1
-
81
-
-
53149092106
-
CD28 costimulation is essential for human T regulatory expansion and function
-
Golovina TN, et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008;181:2855-2868.
-
(2008)
J Immunol
, vol.181
, pp. 2855-2868
-
-
Golovina, T.N.1
-
82
-
-
33845915103
-
Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
-
Strauss L, Whiteside TL, Knights A, Bergmann C, Knuth A, Zippelius A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J Immunol 2007;178:320-329.
-
(2007)
J Immunol
, vol.178
, pp. 320-329
-
-
Strauss, L.1
Whiteside, T.L.2
Knights, A.3
Bergmann, C.4
Knuth, A.5
Zippelius, A.6
-
83
-
-
79956288367
-
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
-
Sagoo P, Ali N, Garg G, Nestle FO, Lechler RI, Lombardi G. Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med 2011;3:83ra42.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sagoo, P.1
Ali, N.2
Garg, G.3
Nestle, F.O.4
Lechler, R.I.5
Lombardi, G.6
-
84
-
-
78650835204
-
Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
-
Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, Wood K. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010;90:1321-1327.
-
(2010)
Transplantation
, vol.90
, pp. 1321-1327
-
-
Issa, F.1
Hester, J.2
Goto, R.3
Nadig, S.N.4
Goodacre, T.E.5
Wood, K.6
-
85
-
-
84871731716
-
Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model
-
Issa F, Hester J, Milward K, Wood KJ. Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model. PLoS ONE 2012;7:e53331.
-
(2012)
PLoS ONE
, vol.7
-
-
Issa, F.1
Hester, J.2
Milward, K.3
Wood, K.J.4
-
86
-
-
34250156673
-
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
-
Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007;7:1722-1732.
-
(2007)
Am J Transplant
, vol.7
, pp. 1722-1732
-
-
Gao, W.1
Lu, Y.2
El Essawy, B.3
Oukka, M.4
Kuchroo, V.K.5
Strom, T.B.6
-
87
-
-
33745633856
-
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
-
Zeiser R, et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006;108:390-399.
-
(2006)
Blood
, vol.108
, pp. 390-399
-
-
Zeiser, R.1
-
88
-
-
79954787760
-
Th17 cells in alemtuzumab-treated patients: the effect of long-term maintenance immunosuppressive therapy
-
Hester J, Mills N, Shankar S, Carvalho-Gaspar M, Friend P, Wood KJ. Th17 cells in alemtuzumab-treated patients: the effect of long-term maintenance immunosuppressive therapy. Transplantation 2011;91:744-750.
-
(2011)
Transplantation
, vol.91
, pp. 744-750
-
-
Hester, J.1
Mills, N.2
Shankar, S.3
Carvalho-Gaspar, M.4
Friend, P.5
Wood, K.J.6
-
89
-
-
33947249410
-
Regulatory T cells and T cell depletion: role of immunosuppressive drugs
-
Noris M, et al. Regulatory T cells and T cell depletion: role of immunosuppressive drugs. J Am Soc Nephrol 2007;18:1007-1018.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1007-1018
-
-
Noris, M.1
-
90
-
-
33747889822
-
Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients
-
Segundo DS, et al. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients. Transplantation 2006;82:550-557.
-
(2006)
Transplantation
, vol.82
, pp. 550-557
-
-
Segundo, D.S.1
-
91
-
-
33847397525
-
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
-
Crellin NK, Garcia RV, Levings MK. Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood 2007;109:2014-2022.
-
(2007)
Blood
, vol.109
, pp. 2014-2022
-
-
Crellin, N.K.1
Garcia, R.V.2
Levings, M.K.3
-
93
-
-
0033561405
-
A randomized, double-blinded comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients
-
Brennan DC, et al. A randomized, double-blinded comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients. Transplantation 1999;67:1011-1018.
-
(1999)
Transplantation
, vol.67
, pp. 1011-1018
-
-
Brennan, D.C.1
-
94
-
-
40449101381
-
CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H
-
Bloom DD, et al. CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant 2008;8:793-802.
-
(2008)
Am J Transplant
, vol.8
, pp. 793-802
-
-
Bloom, D.D.1
-
96
-
-
27944455288
-
Sequential development of interleukin 2 dependent effector and regulatory T cells in response to endogenous systemic antigen
-
Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. Sequential development of interleukin 2 dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 2005;202:1375-1386.
-
(2005)
J Exp Med
, vol.202
, pp. 1375-1386
-
-
Knoechel, B.1
Lohr, J.2
Kahn, E.3
Bluestone, J.A.4
Abbas, A.K.5
-
97
-
-
33646057433
-
CD4(+) regulatory T cells are spared from deletion by antilymphocyte serum, a polyclonal anti-T cell antibody
-
Minamimura K, Gao WD, Maki T. CD4(+) regulatory T cells are spared from deletion by antilymphocyte serum, a polyclonal anti-T cell antibody. J Immunol 2006;176:4125-4132.
-
(2006)
J Immunol
, vol.176
, pp. 4125-4132
-
-
Minamimura, K.1
Gao, W.D.2
Maki, T.3
-
98
-
-
33749259809
-
A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells
-
Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol 2006;17:2844-2853.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2844-2853
-
-
Lopez, M.1
Clarkson, M.R.2
Albin, M.3
Sayegh, M.H.4
Najafian, N.5
-
99
-
-
0031586439
-
Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group
-
Nashan B, Moore R, Amlot P, Schmidt AG, Abeywickrama K, Soulillou JP. Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group. Lancet 1997;350:1193-1198.
-
(1997)
Lancet
, vol.350
, pp. 1193-1198
-
-
Nashan, B.1
Moore, R.2
Amlot, P.3
Schmidt, A.G.4
Abeywickrama, K.5
Soulillou, J.P.6
-
100
-
-
0033608073
-
Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody. United States Simulect Renal Study Group
-
Kahan BD, Rajagopalan PR, Hall M. Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody. United States Simulect Renal Study Group. Transplantation 1999;67:276-284.
-
(1999)
Transplantation
, vol.67
, pp. 276-284
-
-
Kahan, B.D.1
Rajagopalan, P.R.2
Hall, M.3
-
101
-
-
51849108540
-
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
-
Bluestone JA, et al. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant 2008;8:2086-2096.
-
(2008)
Am J Transplant
, vol.8
, pp. 2086-2096
-
-
Bluestone, J.A.1
-
102
-
-
20044386299
-
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
-
Larsen CP, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005;5:443-453.
-
(2005)
Am J Transplant
, vol.5
, pp. 443-453
-
-
Larsen, C.P.1
-
103
-
-
0030058433
-
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
-
Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 1996;184:19-29.
-
(1996)
J Exp Med
, vol.184
, pp. 19-29
-
-
Groux, H.1
Bigler, M.2
de Vries, J.E.3
Roncarolo, M.G.4
-
104
-
-
0030704726
-
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux H, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742.
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
-
105
-
-
0028158319
-
High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
-
Bacchetta R, et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994;179:493-502.
-
(1994)
J Exp Med
, vol.179
, pp. 493-502
-
-
Bacchetta, R.1
-
106
-
-
0035164360
-
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development
-
Kumanogoh A, et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J Immunol 2001;166:353-360.
-
(2001)
J Immunol
, vol.166
, pp. 353-360
-
-
Kumanogoh, A.1
-
107
-
-
0036687184
-
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
-
Bacchetta R, Sartirana C, Levings MK, Bordignon C, Narula S, Roncarolo MG. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol 2002;32:2237-2245.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2237-2245
-
-
Bacchetta, R.1
Sartirana, C.2
Levings, M.K.3
Bordignon, C.4
Narula, S.5
Roncarolo, M.G.6
-
108
-
-
0037450740
-
Prevention of arthritis by interleukin 10-producing B cells
-
Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003;197:489-501.
-
(2003)
J Exp Med
, vol.197
, pp. 489-501
-
-
Mauri, C.1
Gray, D.2
Mushtaq, N.3
Londei, M.4
-
109
-
-
0036197923
-
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
-
Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002;16:219-230.
-
(2002)
Immunity
, vol.16
, pp. 219-230
-
-
Mizoguchi, A.1
Mizoguchi, E.2
Takedatsu, H.3
Blumberg, R.S.4
Bhan, A.K.5
-
110
-
-
84859385739
-
Immune regulatory function of B cells
-
Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol 2012;30:221-241.
-
(2012)
Annu Rev Immunol
, vol.30
, pp. 221-241
-
-
Mauri, C.1
Bosma, A.2
-
111
-
-
78751469622
-
Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
-
Iwata Y, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117:530-541.
-
(2011)
Blood
, vol.117
, pp. 530-541
-
-
Iwata, Y.1
-
112
-
-
54949141219
-
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
-
Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008;118:3420-3430.
-
(2008)
J Clin Invest
, vol.118
, pp. 3420-3430
-
-
Matsushita, T.1
Yanaba, K.2
Bouaziz, J.D.3
Fujimoto, M.4
Tedder, T.F.5
-
113
-
-
43049156086
-
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
-
Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008;28:639-650.
-
(2008)
Immunity
, vol.28
, pp. 639-650
-
-
Yanaba, K.1
Bouaziz, J.D.2
Haas, K.M.3
Poe, J.C.4
Fujimoto, M.5
Tedder, T.F.6
-
114
-
-
77953178765
-
Identification of a B cell signature associated with renal transplant tolerance in humans
-
Newell KA, et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010;120:1836-1847.
-
(2010)
J Clin Invest
, vol.120
, pp. 1836-1847
-
-
Newell, K.A.1
-
115
-
-
77953209236
-
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
-
Sagoo P, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010;120:1848-1861.
-
(2010)
J Clin Invest
, vol.120
, pp. 1848-1861
-
-
Sagoo, P.1
-
116
-
-
79951992393
-
Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile
-
Le Texier L, et al. Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile. Am J Transplant 2011;11:429-438.
-
(2011)
Am J Transplant
, vol.11
, pp. 429-438
-
-
Le Texier, L.1
-
117
-
-
80052382391
-
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
-
Ding Q, et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest 2011;121:3645-3656.
-
(2011)
J Clin Invest
, vol.121
, pp. 3645-3656
-
-
Ding, Q.1
-
118
-
-
35948935946
-
B lymphocyte-directed immunotherapy promotes long-term islograft survival in nonhuman primates
-
Liu C, et al. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. Nat Med 2007;13:1295-1298.
-
(2007)
Nat Med
, vol.13
, pp. 1295-1298
-
-
Liu, C.1
-
119
-
-
79955549389
-
Phenotypic evaluation of B-cell subsets after rituximab for treatment of acute renal allograft rejection in pediatric recipients
-
Zarkhin V, Lovelace PA, Li L, Hsieh SC, Sarwal MM. Phenotypic evaluation of B-cell subsets after rituximab for treatment of acute renal allograft rejection in pediatric recipients. Transplantation 2011;91:1010-1018.
-
(2011)
Transplantation
, vol.91
, pp. 1010-1018
-
-
Zarkhin, V.1
Lovelace, P.A.2
Li, L.3
Hsieh, S.C.4
Sarwal, M.M.5
-
120
-
-
84863200586
-
B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naive B cells
-
Heidt S, Hester J, Shankar S, Friend PJ, Wood KJ. B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naive B cells. Am J Transplant 2012;12:1784-1792.
-
(2012)
Am J Transplant
, vol.12
, pp. 1784-1792
-
-
Heidt, S.1
Hester, J.2
Shankar, S.3
Friend, P.J.4
Wood, K.J.5
-
121
-
-
33749358615
-
Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation
-
Rowe V, et al. Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation. Blood 2006;108:2485-2492.
-
(2006)
Blood
, vol.108
, pp. 2485-2492
-
-
Rowe, V.1
-
122
-
-
84879154724
-
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
-
Le Huu D, et al. Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. Blood 2013;121:3274-3283.
-
(2013)
Blood
, vol.121
, pp. 3274-3283
-
-
Le Huu, D.1
-
123
-
-
76949083647
-
Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance
-
Mollov JL, et al. Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance. Am J Transplant 2010;10:518-526.
-
(2010)
Am J Transplant
, vol.10
, pp. 518-526
-
-
Mollov, J.L.1
-
124
-
-
0742318926
-
Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L
-
Takeuchi Y, Ito H, Kurtz J, Wekerle T, Ho L, Sykes M. Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant 2004;4:31-40.
-
(2004)
Am J Transplant
, vol.4
, pp. 31-40
-
-
Takeuchi, Y.1
Ito, H.2
Kurtz, J.3
Wekerle, T.4
Ho, L.5
Sykes, M.6
-
125
-
-
56149117346
-
Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells
-
Fehr T, et al. Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol 2008;181:4371-4380.
-
(2008)
J Immunol
, vol.181
, pp. 4371-4380
-
-
Fehr, T.1
-
126
-
-
47949126592
-
Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II
-
Fehr T, Haspot F, Mollov J, Chittenden M, Hogan T, Sykes M. Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II. J Immunol 2008;181:165-173.
-
(2008)
J Immunol
, vol.181
, pp. 165-173
-
-
Fehr, T.1
Haspot, F.2
Mollov, J.3
Chittenden, M.4
Hogan, T.5
Sykes, M.6
-
127
-
-
80355131976
-
Protective and pathogenic functions of macrophage subsets
-
Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723-737.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 723-737
-
-
Murray, P.J.1
Wynn, T.A.2
-
128
-
-
80052180187
-
Regulatory macrophages: setting the threshold for therapy
-
Fleming BD, Mosser DM. Regulatory macrophages: setting the threshold for therapy. Eur J Immunol 2011;41:2498-2502.
-
(2011)
Eur J Immunol
, vol.41
, pp. 2498-2502
-
-
Fleming, B.D.1
Mosser, D.M.2
-
129
-
-
84873406485
-
IFN-gamma-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients
-
Riquelme P, et al. IFN-gamma-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Mol Ther 2013;21:409-422.
-
(2013)
Mol Ther
, vol.21
, pp. 409-422
-
-
Riquelme, P.1
-
130
-
-
84880918509
-
Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs
-
Riquelme P, Geissler EK, Hutchinson JA. Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs. Transplant Res 2012;1:17.
-
(2012)
Transplant Res
, vol.1
, pp. 17
-
-
Riquelme, P.1
Geissler, E.K.2
Hutchinson, J.A.3
-
131
-
-
80052650727
-
Cutting edge: immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients
-
Hutchinson JA, et al. Cutting edge: immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol 2011;187:2072-2078.
-
(2011)
J Immunol
, vol.187
, pp. 2072-2078
-
-
Hutchinson, J.A.1
-
132
-
-
53549101269
-
A cell-based approach to the minimization of immunosuppression in renal transplantation
-
Hutchinson JA, et al. A cell-based approach to the minimization of immunosuppression in renal transplantation. Transpl Int 2008;21:742-754.
-
(2008)
Transpl Int
, vol.21
, pp. 742-754
-
-
Hutchinson, J.A.1
-
133
-
-
63349100101
-
Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible
-
Hutchinson JA, et al. Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible. Clin Transplant 2009;23:140-145.
-
(2009)
Clin Transplant
, vol.23
, pp. 140-145
-
-
Hutchinson, J.A.1
-
134
-
-
53549133080
-
Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation
-
Hutchinson JA, et al. Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl Int 2008;21:728-741.
-
(2008)
Transpl Int
, vol.21
, pp. 728-741
-
-
Hutchinson, J.A.1
-
135
-
-
34547152610
-
Tolerogenic dendritic cells and the quest for transplant tolerance
-
Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007;7:610-621.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 610-621
-
-
Morelli, A.E.1
Thomson, A.W.2
-
136
-
-
0033939942
-
Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo
-
Lutz MB, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 2000;30:1813-1822.
-
(2000)
Eur J Immunol
, vol.30
, pp. 1813-1822
-
-
Lutz, M.B.1
-
137
-
-
10744221193
-
Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells
-
Roelen DL, et al. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 2003;76:1608-1615.
-
(2003)
Transplantation
, vol.76
, pp. 1608-1615
-
-
Roelen, D.L.1
-
138
-
-
84876786196
-
Tolerogenic donor-derived dendritic cells risk sensitization in vivo owing to processing and presentation by recipient APCs
-
Smyth LA, et al. Tolerogenic donor-derived dendritic cells risk sensitization in vivo owing to processing and presentation by recipient APCs. J Immunol 2013;190:4848-4860.
-
(2013)
J Immunol
, vol.190
, pp. 4848-4860
-
-
Smyth, L.A.1
-
139
-
-
34249805413
-
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
-
Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007;178:7018-7031.
-
(2007)
J Immunol
, vol.178
, pp. 7018-7031
-
-
Turnquist, H.R.1
Raimondi, G.2
Zahorchak, A.F.3
Fischer, R.T.4
Wang, Z.5
Thomson, A.W.6
-
140
-
-
13144253118
-
Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors
-
Peche H, Trinite B, Martinet B, Cuturi MC. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005;5:255-267.
-
(2005)
Am J Transplant
, vol.5
, pp. 255-267
-
-
Peche, H.1
Trinite, B.2
Martinet, B.3
Cuturi, M.C.4
-
141
-
-
17844398032
-
Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression
-
Beriou G, Peche H, Guillonneau C, Merieau E, Cuturi MC. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 2005;79:969-972.
-
(2005)
Transplantation
, vol.79
, pp. 969-972
-
-
Beriou, G.1
Peche, H.2
Guillonneau, C.3
Merieau, E.4
Cuturi, M.C.5
-
142
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-174.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
143
-
-
77956920766
-
Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
-
Lechner MG, Liebertz DJ, Epstein AL. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol 2010;185:2273-2284.
-
(2010)
J Immunol
, vol.185
, pp. 2273-2284
-
-
Lechner, M.G.1
Liebertz, D.J.2
Epstein, A.L.3
-
144
-
-
81555228400
-
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
-
Obermajer N, Muthuswamy R, Lesnock J, Edwards RP, Kalinski P. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood 2011;118:5498-5505.
-
(2011)
Blood
, vol.118
, pp. 5498-5505
-
-
Obermajer, N.1
Muthuswamy, R.2
Lesnock, J.3
Edwards, R.P.4
Kalinski, P.5
-
145
-
-
77954977151
-
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
-
Garcia MR, et al. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest 2010;120:2486-2496.
-
(2010)
J Clin Invest
, vol.120
, pp. 2486-2496
-
-
Garcia, M.R.1
-
146
-
-
50949120674
-
Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion
-
Dugast AS, et al. Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion. J Immunol 2008;180:7898-7906.
-
(2008)
J Immunol
, vol.180
, pp. 7898-7906
-
-
Dugast, A.S.1
-
147
-
-
84856453086
-
Myeloid-derived suppressor cells protect islet transplants by B7-H1 mediated enhancement of T regulatory cells
-
Chou HS, et al. Myeloid-derived suppressor cells protect islet transplants by B7-H1 mediated enhancement of T regulatory cells. Transplantation 2012;93:272-282.
-
(2012)
Transplantation
, vol.93
, pp. 272-282
-
-
Chou, H.S.1
-
148
-
-
70249122695
-
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
-
Trzonkowski P, et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin Immunol 2009;133:22-26.
-
(2009)
Clin Immunol
, vol.133
, pp. 22-26
-
-
Trzonkowski, P.1
-
149
-
-
78751696183
-
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
-
Brunstein CG, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011;117:1061-1070.
-
(2011)
Blood
, vol.117
, pp. 1061-1070
-
-
Brunstein, C.G.1
-
150
-
-
79953809817
-
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
-
Di Ianni M, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011;117:3921-3928.
-
(2011)
Blood
, vol.117
, pp. 3921-3928
-
-
Di Ianni, M.1
-
151
-
-
80053597291
-
Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
-
Edinger M, Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr Opin Immunol 2011;23:679-684.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 679-684
-
-
Edinger, M.1
Hoffmann, P.2
-
152
-
-
78649982672
-
Interleukin-10 anergized donor T cell infusion improves immune reconstitution without severe graft-versus-host-disease after haploidentical hematopoietic stem cell transplantation
-
Bacchetta R, et al. Interleukin-10 anergized donor T cell infusion improves immune reconstitution without severe graft-versus-host-disease after haploidentical hematopoietic stem cell transplantation. Blood 2009;114:24.
-
(2009)
Blood
, vol.114
, pp. 24
-
-
Bacchetta, R.1
|