메뉴 건너뛰기




Volumn 3, Issue 5, 2008, Pages

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4posCD25high T cells for immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3;

EID: 48249098901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002233     Document Type: Article
Times cited : (79)

References (37)
  • 1
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T Cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL (2002) CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med 196: 401-406.
    • (2002) J Exp Med , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 2
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, et al. (2003) CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9: 1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3    Drago, K.4    Fathman, C.G.5
  • 3
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S (2002) Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196: 389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 4
    • 2542496868 scopus 로고    scopus 로고
    • Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes
    • Joffre O, Gorsse N, Romagnoli P, Hudrisier D, van Meerwijk JP (2004) Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood 103: 4216-4221.
    • (2004) Blood , vol.103 , pp. 4216-4221
    • Joffre, O.1    Gorsse, N.2    Romagnoli, P.3    Hudrisier, D.4    van Meerwijk, J.P.5
  • 5
    • 0242557055 scopus 로고    scopus 로고
    • Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response
    • Jones SC, Murphy Gr, Korngold R (2003) Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transplant 9: 243-256.
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 243-256
    • Jones, S.C.1    Murphy, G.2    Korngold, R.3
  • 6
    • 0346690399 scopus 로고    scopus 로고
    • Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • Trenado A, Charlotte F, Fisson S, Yagello M, Klatzmann D, et al. (2003) Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 112: 1688-1696.
    • (2003) J Clin Invest , vol.112 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3    Yagello, M.4    Klatzmann, D.5
  • 7
    • 32644461186 scopus 로고    scopus 로고
    • Effective expansion of alloantigen-specific Foxp3+CD25+CD4-+ regulatory T cells by dendritic cells during the mixed leukocyte reaction
    • Yamazaki S, Patel M, Harper A, Bonito A, Fukuyama H, et al. (2006) Effective expansion of alloantigen-specific Foxp3+CD25+CD4-+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci U S A 103: 2758-2763.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2758-2763
    • Yamazaki, S.1    Patel, M.2    Harper, A.3    Bonito, A.4    Fukuyama, H.5
  • 8
    • 14844365222 scopus 로고    scopus 로고
    • The generation of CD25+CD4-+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen
    • Bushell A, Jones E, Gallimore A, Wood K (2005) The generation of CD25+CD4-+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen. J Immunol 174: 3290-3297.
    • (2005) J Immunol , vol.174 , pp. 3290-3297
    • Bushell, A.1    Jones, E.2    Gallimore, A.3    Wood, K.4
  • 10
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreaactive immune responses and central nervous system inflammation during active experimental autommune encephalomyelitis
    • Kohm AP, Carpentier PA, Anger HA, Miller SD (2002) Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreaactive immune responses and central nervous system inflammation during active experimental autommune encephalomyelitis. J Immunol 169: 4712-1716.
    • (2002) J Immunol , vol.169 , pp. 4712-1716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 11
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • Mottet C, Uhlig HH, Powrie F (2003) Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 170: 3939-3943.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 12
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G et al (2001) In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199: 1455-1465.
    • (2001) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5
  • 13
    • 23844455192 scopus 로고    scopus 로고
    • Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice
    • Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, et al. (2005) Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol 175: 3053-3059.
    • (2005) J Immunol , vol.175 , pp. 3053-3059
    • Masteller, E.L.1    Warner, M.R.2    Tang, Q.3    Tarbell, K.V.4    McDevitt, H.5
  • 14
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM (2004) CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.J Exp Med 199: 1467-1177.
    • (2004) J Exp Med , vol.199 , pp. 1467-1177
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 15
    • 4644262666 scopus 로고    scopus 로고
    • Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings
    • Jin LP, Li DJ, Zhang JP, Wang MY, Zhu XY, et al. (2004) Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings. J Immunol 173: 3612-3619.
    • (2004) J Immunol , vol.173 , pp. 3612-3619
    • Jin, L.P.1    Li, D.J.2    Zhang, J.P.3    Wang, M.Y.4    Zhu, X.Y.5
  • 16
    • 18144396195 scopus 로고    scopus 로고
    • In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
    • Earle KE, Tang Q, Zhou X, Liu W, Zhu S, et al. (2005) In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation Clin Immunol 115: 3-9.
    • (2005) Clin Immunol , vol.115 , pp. 3-9
    • Earle, K.E.1    Tang, Q.2    Zhou, X.3    Liu, W.4    Zhu, S.5
  • 17
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
    • Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M (2004) Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 104: 895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 18
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, et al. (2001) In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104: 453-461.
    • (2001) Blood , vol.104 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3    Levine, B.L.4    June, C.H.5
  • 20
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG (2001) Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193: 1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 21
    • 33746037632 scopus 로고    scopus 로고
    • Highly efficient expansion of human CD4+CD25+ regulatory T cells for cellular immunotherapy in patients with graft-versus-host disease
    • Karakhanova S, Munder M, Schneider M, Bonyhadi M, Ho AD, et al. (2006) Highly efficient expansion of human CD4+CD25+ regulatory T cells for cellular immunotherapy in patients with graft-versus-host disease. J Immunother 29: 336-349.
    • (2006) J Immunother , vol.29 , pp. 336-349
    • Karakhanova, S.1    Munder, M.2    Schneider, M.3    Bonyhadi, M.4    Ho, A.D.5
  • 22
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self anjgcris and alloantigens in humans
    • Roncarolo MG, Battaglia M (2007) Regulatory T-cell immunotherapy for tolerance to self anjgcris and alloantigens in humans. Nat Rev Immunol 7: 585-598.
    • (2007) Nat Rev Immunol , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 24
    • 0742284032 scopus 로고    scopus 로고
    • CD4+CD25+CD62+T-regulatory cell subset has optimal suppressive and proliferative potential
    • Fu S, Yopp AC, Mao X, Chen D, Zhang N, et al. (2004) CD4+CD25+CD62+T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 4: 65-78.
    • (2004) Am J Transplant , vol.4 , pp. 65-78
    • Fu, S.1    Yopp, A.C.2    Mao, X.3    Chen, D.4    Zhang, N.5
  • 25
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive funcuon of human CD4+ T reg cells
    • Liu, W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive funcuon of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5
  • 26
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203: 1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3    Zaunders, J.4    Sasson, S.5
  • 27
    • 20444374502 scopus 로고    scopus 로고
    • CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells
    • Koenen HJ, Fasse E, Joosten I (2005) CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells. J Immunol 174: 7573-7583.
    • (2005) J Immunol , vol.174 , pp. 7573-7583
    • Koenen, H.J.1    Fasse, E.2    Joosten, I.3
  • 29
    • 34247633481 scopus 로고    scopus 로고
    • Allogeneic stimulation of naturally occurring CDI(+)CD25(+) T cells induces strong regulatory capacity with increased donor-reactivity
    • Coenen D, Koenen HJ, Emmer PM, van RE, Hilbrands LB, et al. (2007) Allogeneic stimulation of naturally occurring CDI(+)CD25(+) T cells induces strong regulatory capacity with increased donor-reactivity. Transpl Immunol 17: 237-242.
    • (2007) Transpl Immunol , vol.17 , pp. 237-242
    • Coenen, D.1    Koenen, H.J.2    Emmer, P.M.3    van, R.E.4    Hilbrands, L.B.5
  • 30
    • 4344653864 scopus 로고    scopus 로고
    • Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
    • Nishimura E, Sakihama T, Setoguchi R, Tanaka K, Sakaguchi S (2001) Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol 16: 1189-1201.
    • (2001) Int Immunol , vol.16 , pp. 1189-1201
    • Nishimura, E.1    Sakihama, T.2    Setoguchi, R.3    Tanaka, K.4    Sakaguchi, S.5
  • 34
    • 35348816122 scopus 로고    scopus 로고
    • Allogeneir: Hematopoietic stem cell transplant using mismatched/haploidentical donors
    • Koh LP, Rizzieri DA, Chao NJ (2007) Allogeneir: hematopoietic stem cell transplant using mismatched/haploidentical donors. Biol Blood Marrow Transplant 13: 1249-1267.
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 1249-1267
    • Koh, L.P.1    Rizzieri, D.A.2    Chao, N.J.3
  • 35
  • 36
    • 0141678976 scopus 로고    scopus 로고
    • Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo
    • Jiang S, Camara N, Lombardi G, Lechler RI (2003) Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 102: 2180-2186.
    • (2003) Blood , vol.102 , pp. 2180-2186
    • Jiang, S.1    Camara, N.2    Lombardi, G.3    Lechler, R.I.4
  • 37
    • 0346366991 scopus 로고    scopus 로고
    • IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression
    • Koenen HJ, Fasse E, Joosten I (2003) IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J Immunol 171: 6431-6441.
    • (2003) J Immunol , vol.171 , pp. 6431-6441
    • Koenen, H.J.1    Fasse, E.2    Joosten, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.