OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms

Journal of Neuro-Oncology

Volumn 104, Issue 2, 2011, Pages 423-438

  Otero, José Javier ^a   Rowitch, David ^a   Vandenberg, Scott ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

OLIG2; Pediatric astrocytoma; Pediatric ependymoma; Pediatric glioma; Pilocytic astrocytoma

Indexed keywords

KI 67 ANTIGEN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2;

ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; CANCER GRADING; CHILD; CONTROLLED STUDY; DIFFUSE TYPE ASTROCYTOMA; EPENDYMOMA; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PILOCYTIC ASTROCYTOMA; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TANYCYTE; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ASTROCYTOMA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINEAGE; CHILD; EPENDYMOMA; FEMALE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NERVE TISSUE PROTEINS; TISSUE ARRAY ANALYSIS;

EID: 80052622814     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0509-x     Document Type: Article

References (55)

1. IF Pollack SD Finkelstein J Woods J Burnham EJ Holmes RL Hamilton AJ Yates JM Boyett JL Finlay R Sposto 2002 Expression of p53 and prognosis in children with malignant gliomas N Engl J Med 346 420 427 11832530 10.1056/NEJMoa012224 1:CAS:528:DC%2BD38XhtVWqu78%3D (Pubitemid 34437697)
2. C.B.T.R.U.S.: CBTRUS (2008). Statistical report: primary brain tumors in the United States, 2000-2004. Published by the Central Brain Tumor Registry of the United States
3. RM Bachoo EA Maher KL Ligon NE Sharpless SS Chan MJ You Y Tang J DeFrances E Stover R Weissleder DH Rowitch DN Louis RA DePinho 2002 Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis Cancer Cell 1 269 277 12086863 10.1016/S1535-6108(02)00046-6 1:CAS:528:DC%2BD38XjsFGlt78%3D (Pubitemid 41039151)
4. MA Hack A Saghatelyan A de Chevigny A Pfeifer R Ashery-Padan PM Lledo M Gotz 2005 Neuronal fate determinants of adult olfactory bulb neurogenesis Nat Neurosci 8 865 872 15951811 1:CAS:528:DC%2BD2MXlvFWjs70%3D
5. B Menn JM Garcia-Verdugo C Yaschine O Gonzalez-Perez D Rowitch A Alvarez-Buylla 2006 Origin of oligodendrocytes in the subventricular zone of the adult brain J Neurosci 26 7907 7918 16870736 10.1523/JNEUROSCI.1299-06.2006 1:CAS:528:DC%2BD28XnvF2itr0%3D (Pubitemid 44315160)
6. EL Jackson JM Garcia-Verdugo S Gil-Perotin M Roy A Quinones-Hinojosa S VandenBerg A Alvarez-Buylla 2006 PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling Neuron 51 187 199 16846854 10.1016/j.neuron.2006.06.012 1:CAS:528:DC%2BD28XotVCjtb8%3D (Pubitemid 44063617)
7. Y Marie M Sanson K Mokhtari P Leuraud M Kujas JY Delattre J Poirier B Zalc K Hoang-Xuan 2001 OLIG2 as a specific marker of oligodendroglial tumour cells Lancet 358 298 300 11498220 10.1016/S0140-6736(01)05499-X 1:CAS:528:DC%2BD3MXlslCjsLk%3D (Pubitemid 32738972)
8. A Ohnishi H Sawa M Tsuda Y Sawamura T Itoh Y Iwasaki K Nagashima 2003 Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas J Neuropathol Exp Neurol 62 1052 1059 14575240 1:CAS:528:DC%2BD3sXos1Cqtrs%3D (Pubitemid 37229534)
9. KL Ligon E Huillard S Mehta S Kesari H Liu JA Alberta RM Bachoo M Kane DN Louis RA Depinho DJ Anderson CD Stiles DH Rowitch 2007 Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma Neuron 53 503 517 17296553 10.1016/j.neuron.2007.01.009 1:CAS:528:DC%2BD2sXis1altLk%3D (Pubitemid 46216748)
10. Y Cheng JC Pang HK Ng M Ding SF Zhang J Zheng DG Liu WS Poon 2000 Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas Histopathology 37 437 444 11119125 10.1046/j.1365-2559. 2000.01005.x 1:STN:280:DC%2BD3M%2FpsF2rtQ%3D%3D
11. BS Paugh C Qu C Jones Z Liu M Adamowicz-Brice J Zhang DA Bax B Coyle J Barrow D Hargrave J Lowe A Gajjar W Zhao A Broniscer DW Ellison RG Grundy SJ Baker 2010 Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease J Clin Oncol 28 3061 3068 20479398 10.1200/JCO.2009.26.7252
12. T Sung DC Miller RL Hayes M Alonso H Yee EW Newcomb 2000 Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas Brain Pathol 10 249 259 10764044 10.1111/j.1750-3639.2000.tb00258.x 1:CAS:528:DC%2BD3cXivVyhurs%3D (Pubitemid 30181093)
13. H Ohgaki 2005 Genetic pathways to glioblastomas Neuropathology 25 1 7 15822813 10.1111/j.1440-1789.2004.00600.x (Pubitemid 40477707)
14. H Ohgaki P Kleihues 2005 Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas J Neuropathol Exp Neurol 64 479 489 15977639 1:CAS:528:DC%2BD2MXlvVSgsbg%3D (Pubitemid 40781150)
15. H Ohgaki P Kleihues 2005 Epidemiology and etiology of gliomas Acta Neuropathol 109 93 108 15685439 10.1007/s00401-005-0991-y (Pubitemid 40287792)
16. H Ohgaki P Kleihues 2007 Genetic pathways to primary and secondary glioblastoma Am J Pathol 170 1445 1453 17456751 10.2353/ajpath.2007.070011 1:CAS:528:DC%2BD2sXlvFCns74%3D (Pubitemid 47339290)
17. I Lukashovav Zangen S Kneitz CM Monoranu S Rutkowski B Hinkes GH Vince B Huang W Roggendorf 2007 Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival Acta Neuropathol 113 325 337 17265049 10.1007/s00401-006-0190-5 (Pubitemid 46443567)
18. J Balss J Meyer W Mueller A Korshunov C Hartmann A von Deimling 2008 Analysis of the IDH1 codon 132 mutation in brain tumors Acta Neuropathol 116 597 602 18985363 10.1007/s00401-008-0455-2 1:CAS:528:DC%2BD1cXhtlyhsbfN
19. A Korshunov J Meyer D Capper A Christians M Remke H Witt S Pfister A von Deimling C Hartmann 2009 Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma Acta Neuropathol 118 401 405 19543740 10.1007/s00401-009-0550-z 1:CAS:528:DC%2BD1MXptVGjt7c%3D
20. AJ Sievert EM Jackson X Gai H Hakonarson AR Judkins AC Resnick LN Sutton PB Storm TH Shaikh JA Biegel 2009 Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene Brain Pathol 19 449 458 19016743 10.1111/j.1750-3639.2008.00225.x 1:CAS:528:DC%2BD1MXos1Ojt7w%3D
21. EE Bar A Lin T Tihan PC Burger CG Eberhart 2008 Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma J Neuropathol Exp Neurol 67 878 887 18716556 10.1097/NEN.0b013e3181845622 1:CAS:528:DC%2BD1cXhtFKisb3P
22. JD Schiffman JG Hodgson SR VandenBerg P Flaherty MY Polley M Yu PG Fisher DH Rowitch JM Ford MS Berger H Ji DH Gutmann CD James 2010 Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas Cancer Res 70 512 519 20068183 10.1158/0008-5472.CAN-09- 1851 1:CAS:528:DC%2BC3cXltlWrsg%3D%3D
23. KL Ligon JA Alberta AT Kho J Weiss MR Kwaan CL Nutt DN Louis CD Stiles DH Rowitch 2004 The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas J Neuropathol Exp Neurol 63 499 509 15198128 1:CAS:528:DC%2BD2cXlt1elsr8%3D (Pubitemid 38669670)
24. H Colman C Giannini L Huang J Gonzalez K Hess J Bruner G Fuller L Langford C Pelloski J Aaron P Burger K Aldape 2006 Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas Am J Surg Pathol 30 657 664 16699322 10.1097/01.pas.0000202048.28203.25 (Pubitemid 44265019)
25. RA Johnson KD Wright H Poppleton KM Mohankumar D Finkelstein SB Pounds V Rand SE Leary E White C Eden T Hogg P Northcott S Mack G Neale YD Wang B Coyle J Atkinson M DeWire TA Kranenburg Y Gillespie JC Allen T Merchant FA Boop RA Sanford A Gajjar DW Ellison MD Taylor RG Grundy RJ Gilbertson 2010 Cross-species genomics matches driver mutations and cell compartments to model ependymoma Nature 466 632 636 20639864 10.1038/nature09173 1:CAS:528:DC%2BC3cXovFCgu7k%3D
26. MK Sharma DB Mansur G Reifenberger A Perry JR Leonard KD Aldape MG Albin RJ Emnett S Loeser MA Watson R Nagarajan DH Gutmann 2007 Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin Cancer Res 67 890 900 17283119 10.1158/0008-5472.CAN-06-0973 1:CAS:528:DC%2BD2sXht1yntLg%3D
27. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80, 2004
28. BM Bolstad RA Irizarry M Astrand TP Speed 2003 A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 185 193 12538238 10.1093/bioinformatics/19. 2.185 1:CAS:528:DC%2BD3sXitlCnsL4%3D (Pubitemid 36181903)
29. RA Irizarry B Hobbs F Collin YD Beazer-Barclay KJ Antonellis U Scherf TP Speed 2003 Exploration, normalization, and summaries of high density oligonucleotide array probe level data Biostatistics 4 249 264 12925520 10.1093/biostatistics/4.2.249
30. RA Irizarry BM Bolstad F Collin LM Cope B Hobbs TP Speed 2003 Summaries of Affymetrix GeneChip probe level data Nucleic Acids Res 31 e15 12582260 10.1093/nar/gng015
31. C Li WH Wong 2001 Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection Proc Natl Acad Sci USA 98 31 36 11134512 10.1073/pnas.011404098 1:CAS:528:DC%2BD3MXkslKnuw%3D%3D (Pubitemid 32095858)
32. Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3
33. W Huang da BT Sherman RA Lempicki 2009 Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat Protoc 4 44 57 19131956 10.1038/nprot.2008.211
34. G Dennis Jr BT Sherman DA Hosack J Yang W Gao HC Lane RA Lempicki David 2003 Database for annotation, visualization, and integrated discovery Genome Biol 4 P3 12734009 10.1186/gb-2003-4-5-p3
35. M Preusser H Budka K Rossler JA Hainfellner 2007 OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms Histopathology 50 365 370 17257132 10.1111/j.1365-2559.2007.02614.x 1:STN:280:DC%2BD2s%2FlsVWruw%3D%3D (Pubitemid 46169421)
36. K Ishizawa T Komori S Shimada T Hirose 2008 Olig2 and CD99 are useful negative markers for the diagnosis of brain tumors Clin Neuropathol 27 118 128 18552083 1:STN:280:DC%2BD1czosFKjtg%3D%3D (Pubitemid 351678187)
37. C Godfraind 2009 Classification and controversies in pathology of ependymomas Childs Nerv Syst 25 1185 1193 19212775 10.1007/s00381-008-0804-4
38. J Yang M Adamian T Li 2006 Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells Mol Biol Cell 17 1033 1040 16339073 10.1091/mbc.E05-10-0943 1:CAS:528:DC%2BD28XhtlWqs7o%3D (Pubitemid 43191133)
39. J Yang T Li 2006 Focus on molecules: rootletin Exp Eye Res 83 1 2 16318850 10.1016/j.exer.2005.10.013 1:CAS:528:DC%2BD28XltF2rsr4%3D (Pubitemid 43783232)
40. J Yang X Liu G Yue M Adamian O Bulgakov T Li 2002 Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet J Cell Biol 159 431 440 12427867 10.1083/jcb.200207153 1:CAS:528:DC%2BD38XoslKmtrY%3D (Pubitemid 35332830)
41. K Tabu Y Ohba T Suzuki Y Makino T Kimura A Ohnishi M Sakai T Watanabe S Tanaka H Sawa 2007 Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA Mol Cancer Res 5 1099 1109 17951409 10.1158/1541-7786.MCR-07-0096 1:CAS:528:DC%2BD2sXhtFygsLjF (Pubitemid 350070764)
42. H Takei ST Yogeswaren KK Wong V Mehta M Chintagumpala RC Dauser CC Lau AM Adesina 2008 Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival J Neurooncol 86 183 190 17690840 10.1007/s11060-007-9455-7 (Pubitemid 350263416)
43. MK Sharma BA Zehnbauer MA Watson DH Gutmann 2005 RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma Neurology 65 1335 1336 16247081 10.1212/01.wnl.0000180409.78098.d7 (Pubitemid 41508250)
44. SI Bannykh CC Stolt J Kim A Perry M Wegner 2006 Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas J Neurooncol 76 115 127 16205963 10.1007/s11060-005-5533-x 1:CAS:528: DC%2BD28Xis1Sgsrc%3D (Pubitemid 43135844)
45. C Colin N Baeza C Bartoli F Fina N Eudes I Nanni PM Martin L Ouafik D Figarella-Branger 2006 Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization Oncogene 25 2818 2826 16314830 10.1038/sj.onc.1209305 1:CAS:528:DC%2BD28XktVGrs7w%3D
46. DH Gutmann NM Hedrick J Li R Nagarajan A Perry MA Watson 2002 Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas Cancer Res 62 2085 2091 11929829 1:CAS:528: DC%2BD38XivVylu74%3D (Pubitemid 34408456)
47. KK Wong YM Chang YT Tsang L Perlaky J Su A Adesina DL Armstrong M Bhattacharjee R Dauser SM Blaney M Chintagumpala CC Lau 2005 Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups Cancer Res 65 76 84 15665281 1:CAS:528: DC%2BD2MXhvFagsw%3D%3D (Pubitemid 40070797)
48. A Buffo MR Vosko D Erturk GF Hamann M Jucker D Rowitch M Gotz 2005 Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair Proc Natl Acad Sci USA 102 18183 18188 16330768 10.1073/pnas.0506535102 1:CAS:528:DC%2BD2MXhtlersrvP (Pubitemid 41798522)
49. Y Chen DK Miles T Hoang J Shi E Hurlock SG Kernie QR Lu 2008 The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury J Neurosci 28 10983 10989 18945906 10.1523/JNEUROSCI.3545-08.2008 1:CAS:528:DC%2BD1cXhtlWnsL3O
50. JE Goldman E Corbin 1988 Isolation of a major protein component of Rosenthal fibers Am J Pathol 130 569 578 3348359 1:CAS:528:DyaL1cXitValu7w%3D (Pubitemid 18091385)
51. RA Quinlan M Brenner JE Goldman A Messing 2007 GFAP and its role in Alexander disease Exp Cell Res 313 2077 2087 17498694 10.1016/j.yexcr.2007.04. 004 1:CAS:528:DC%2BD2sXmtFOitrc%3D (Pubitemid 46842983)
52. JP Kilday R Rahman S Dyer L Ridley J Lowe B Coyle R Grundy 2009 Pediatric ependymoma: biological perspectives Mol Cancer Res 7 765 786 19531565 10.1158/1541-7786.MCR-08-0584 1:CAS:528:DC%2BD1MXns1Sktr0%3D
53. Barton VN, Donson AM, Kleinschmidt-Demasters BK, Birks DK, Handler MH, Foreman NK (2009) Unique molecular characteristics of pediatric myxopapillary ependymoma. Brain Pathol 20:560-570
54. D Tamiolakis N Papadopoulos I Venizelos M Lambropoulou S Nikolaidou S Bolioti A Kiziridou J Manavis G Alexiadis C Simopoulos 2006 Loss of chromosome 1 in myxopapillary ependymoma suggests a region out of chromosome 22 as critical for tumour biology: a FISH analysis of four cases on touch imprint smears Cytopathology 17 199 204 16879268 10.1111/j.1365-2303.2006.00287.x 1:STN:280:DC%2BD28vls1Cksw%3D%3D (Pubitemid 44124659)
55. HJ Gilhuis J van der Laak P Wesseling RH Boerman G Beute JL Teepen JA Grotenhuis AC Kappelle 2004 Inverse correlation between genetic aberrations and malignancy grade in ependymal tumors: a paradox? J Neurooncol 66 111 116 15015776 10.1023/B:NEON.0000013493.31107.20 1:STN:280:DC%2BD2c7isVGltg%3D%3D (Pubitemid 38258365)