Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Chen, Xia ^a   Lepier, Alexandra ^b,c   Berninger, Benedikt ^b,c   Tolkovsky, Aviva M ^a   Herbert, Joe ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ANKYRIN G; BETA III TUBULIN; BETA TUBULIN; CELL MARKER; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NEUROGENIN 2; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN C FOS; PROX1 PROTEIN; RETROVIRUS VECTOR; TBR1 PROTEIN; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLUTAMIC ACID; NERVE PROTEIN; NGN2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; GENE; GLUTAMATERGIC NERVE CELL; GRAFT SURVIVAL; GRANULE CELL; HIPPOCAMPAL CA3 REGION; IN VITRO STUDY; IN VIVO STUDY; INNERVATION; MALE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NERVE PROJECTION; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NEUROGENIN 2 GENE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; REPORTER GENE; SUBVENTRICULAR ZONE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; GENETIC TRANSDUCTION; GENETICS; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; STEM CELL;

RATTUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; DENTATE GYRUS; GLUTAMIC ACID; MALE; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONS; RATS; STEM CELLS; TRANSDUCTION, GENETIC;

EID: 84863176803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031547     Document Type: Article

References (36)

1. Ormerod BK, Palmer TD, Caldwell MA, (2008) Neurodegeneration and cell replacement. Philosophical Transactions of the Royal Society B-Biological Sciences 363: 153-170.
2. Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJ, et al. (1995) Survival and Differentiation of Adult Neuronal Progenitor Cells Transplanted to the Adult Brain. Proceedings of the National Academy of Sciences of the United States of America 92: 11879-11883.
3. Shetty AK, Rao MS, Hattiangady B, (2008) Behavior of Hippocampal Stem/Progenitor Cells Following Grafting into the Injured Aged Hippocampus. Journal of Neuroscience Research 86: 3062-3074.
4. Raedt R, Van Dycke A, Waeytens A, Wyckhuys T, Vonck K, et al. (2009) Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus. Epilepsy Res 87: 148-159.
5. Chen X, Tolkovsky AM, Herbert J, (2011) Cell Origin and Culture History Determine Successful Integration of Neural Precursor Transplants into the Dentate Gyrus of the Adult Rat. Plos One 6.
6. Sinclair SR, Fawcett JW, Dunnett SB, (1999) Dopamine cells in nigral grafts differentiate prior to implantation. European Journal of Neuroscience 11: 4341-4348.
7. Yi SH, Jo AY, Park CH, Koh HC, Park RH, et al. (2008) Mash1 and Neurogenin 2 Enhance Survival and Differentiation of Neural Precursor Cells After Transplantation to Rat Brains via Distinct Modes of Action. Molecular Therapy 16: 1873-1882.
8. Bertrand N, Castro DS, Guillemot F, (2002) Proneural genes and the specification of neural cell types. Nature Reviews Neuroscience 3: 517-530.
9. Fode C, Ma QF, Casarosa S, Ang SL, Anderson DJ, et al. (2000) A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes & Development 14: 67-80.
10. Brill MS, Ninkovic J, Winpenny E, Hodge RD, Ozen I, et al. (2009) Adult generation of glutamatergic olfactory bulb interneurons. Nature Neuroscience 12: 1524-U1569.
11. Berninger B, Guillemot F, Gotz M, (2007) Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells. European Journal of Neuroscience 25: 2581-2590.
12. Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, et al. (2010) Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons. Plos Biology 8.
13. Galichet C, Guillemot F, Parras CM, (2008) Neurogenin 2 has an essential role in development of the dentate gyrus. Development 135: 2031-2041.
14. Ming GL, Song HJ, (2005) Adult neurogenesis in the mammalian central nervous system. Annual Review of Neuroscience 28: 223-250.
15. Merkle FT, Mirzadeh Z, Alvarez-Buylla A, (2007) Mosaic organization of neural stem cells in the adult brain. Science 317: 381-384.
16. Temple S, (2001) The development of neural stem cells. Nature 414: 112-117.
17. Milosevic A, Noctor SC, Martinez-Cerdeno V, Kriegstein AR, Goldman JE, (2008) Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation. Molecular and Cellular Neuroscience 39: 324-334.
18. Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, et al. (1998) The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20: 483-494.
19. Dragunow M, Faull R, (1989) The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods 29: 261-265.
20. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, et al. (2001) Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A 98: 11024-11031.
21. Liu JX, Pinnock SB, Herbert J, (2011) Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat. PLoS One 6: e17562.
22. Pinnock SB, Blake AM, Platt NJ, Herbert J, (2011) The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine. PLoS One 5: e13652.
23. Nieto M, Schuurmans C, Britz O, Guillemot F, (2001) Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29: 401-413.
24. Yan RT, Ma WX, Wang SZ, (2001) neurogenin2 elicits the genesis of retinal neurons from cultures of nonneural cells. Proceedings of the National Academy of Sciences of the United States of America 98: 15014-15019.
25. Britz O, Mattar P, Nguyen L, Langevin LM, Zimmer C, et al. (2006) A role for proneural genes in the maturation of cortical progenitor cells. Cerebral Cortex 16: I138-I151.
26. Winpenny E, Lebel-Potter M, Fernandez ME, Brill MS, Gotz M, et al. (2011) Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells. Neural Dev 6: 12.
27. Karalay OKO, Doberauer K, Vadodaria KC, Knobloch M, Berti L, et al. (2011) Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences of the United States of America 108: 5807-5812.
28. Sekiguchi M, Hayashi F, Tsuchida K, Inokuchi K, (2009) Neuron type-selective effects of activin on development of the hippocampus. Neuroscience Letters 452: 232-237.
29. Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, et al. (2010) Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis. Plos Biology 8.
30. Galeeva A, Treuter E, Tomarev S, Pelto-Huikko M, (2007) A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Neuroscience 146: 604-616.
31. Heinrich C, Nitta N, Flubacher A, Muller M, Fahrner A, et al. (2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. Journal of Neuroscience 26: 4701-4713.
32. Aungst JL, Heyward PM, Puche AC, Karnup SV, Hayar A, et al. (2003) Centre-surround inhibition among olfactory bulb glomeruli. Nature 426: 623-629.
33. Winpenny E, Raineteau O, (2011) You are what you express: glutamatergic neurogenesis in the adult SVZ. Cell Cycle 9: 2259-2260.
34. Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A, (1999) Adult-derived neural precursors transplanted into multiple regions in the adult brain. Annals of Neurology 46: 867-877.
35. Suhonen JO, Peterson DA, Ray J, Gage FH, (1996) Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383: 624-627.
36. Heinrich C, Gascon S, Masserdotti G, Lepier A, Sanchez R, et al. (2011) Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nature Protocols 6: 214-228.