-
1
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
DOI 10.1038/34432
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998;391:184-7. (Pubitemid 28092478)
-
(1998)
Nature
, vol.391
, Issue.6663
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Hoglund, P.10
Jarvinen, H.11
Kristo, P.12
Pelin, K.13
Ridanpaa, M.14
Salovaara, R.15
Toro, T.16
Bodmer, W.17
Olschwang, S.18
Olsen, A.S.19
Stratton, M.R.20
De La Chapelle, A.21
Aaltonen, L.A.22
more..
-
2
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002;62:3659-62. (Pubitemid 34728843)
-
(2002)
Cancer Research
, vol.62
, Issue.13
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
3
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-75.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
Cibulskis, K.6
-
4
-
-
64549113040
-
Somatic LKB1 mutations promote cervical cancer progression
-
Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, et al. Somatic LKB1 mutations promote cervical cancer progression. PLoS One 2009;4:e5137.
-
(2009)
PLoS One
, vol.4
-
-
Wingo, S.N.1
Gallardo, T.D.2
Akbay, E.A.3
Liang, M.C.4
Contreras, C.M.5
Boren, T.6
-
5
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
DOI 10.1073/pnas.1533136100
-
Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 2003;100:8839-43. (Pubitemid 36899185)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.15
, pp. 8839-8843
-
-
Hong, S.-P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
6
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003;2:28.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Mäkelä, T.P.6
-
7
-
-
10744230065
-
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade
-
DOI 10.1016/j.cub.2003.10.031
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003;13:2004-8. (Pubitemid 37425212)
-
(2003)
Current Biology
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.D.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
8
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
DOI 10.1073/pnas.0308061100
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004;101:3329-35. (Pubitemid 38338195)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
9
-
-
34347220473
-
Defining the Role of mTOR in Cancer
-
DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22. (Pubitemid 47001784)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
10
-
-
79955398591
-
Otto Warburg′s contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV. Otto Warburg′s contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011;11:325-37.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
11
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
DOI 10.1093/emboj/cdg292
-
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, et al. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 2003;22:3062-72. (Pubitemid 36758626)
-
(2003)
EMBO Journal
, vol.22
, Issue.12
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
Alessi, D.R.7
Clevers, H.C.8
-
12
-
-
72949115493
-
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
-
Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 2009;326:1707-11.
-
(2009)
Science
, vol.326
, pp. 1707-1711
-
-
Zeqiraj, E.1
Filippi, B.M.2
Deak, M.3
Alessi, D.R.4
Van Aalten, D.M.5
-
13
-
-
0141753981
-
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
-
DOI 10.1093/emboj/cdg490
-
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, et al. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 2003;22:5102-14. (Pubitemid 37222030)
-
(2003)
EMBO Journal
, vol.22
, Issue.19
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutkowski, M.6
Prescott, A.R.7
Clevers, H.C.8
Alessi, D.R.9
-
14
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
DOI 10.1038/sj.emboj.7600110
-
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004;23:833-43. (Pubitemid 38418750)
-
(2004)
EMBO Journal
, vol.23
, Issue.4
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
15
-
-
14244251499
-
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate
-
DOI 10.1016/j.febslet.2005.01.042
-
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, et al. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett 2005;579:1417-23. (Pubitemid 40289190)
-
(2005)
FEBS Letters
, vol.579
, Issue.6
, pp. 1417-1423
-
-
Jaleel, M.1
McBride, A.2
Lizcano, J.M.3
Deak, M.4
Toth, R.5
Morrice, N.A.6
Alessi, D.R.7
-
17
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, et al. Structure of mammalian AMPK and its regulation by ADP. Nature 2011;472:230-3.
-
(2011)
Nature
, vol.472
, pp. 230-233
-
-
Xiao, B.1
Sanders, M.J.2
Underwood, E.3
Heath, R.4
Mayer, F.V.5
Carmena, D.6
-
18
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, et al. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011;332:1433-5.
-
(2011)
Science
, vol.332
, pp. 1433-1435
-
-
Oakhill, J.S.1
Steel, R.2
Chen, Z.P.3
Scott, J.W.4
Ling, N.5
Tam, S.6
-
19
-
-
23044437445
-
2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
-
DOI 10.1016/j.cmet.2005.06.005, PII S1550413105001701
-
Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, et al. Ca2dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2005;2:21-33. (Pubitemid 43239822)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.-P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
20
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
-
DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
-
Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005;2:9-19. (Pubitemid 43239821)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
21
-
-
23844471263
-
2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
DOI 10.1074/jbc.M503824200
-
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 2005;280:29060-6. (Pubitemid 41161355)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.32
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
22
-
-
0023642627
-
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
-
Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 1987;223:217-22.
-
(1987)
FEBS Lett
, vol.223
, pp. 217-222
-
-
Carling, D.1
Zammit, V.A.2
Hardie, D.G.3
-
23
-
-
0027428833
-
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion
-
DOI 10.1073/pnas.90.20.9261
-
Sato R, Goldstein JL, Brown MS. Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proc Natl Acad Sci USA 1993;90:9261-5. (Pubitemid 23315763)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.20
, pp. 9261-9265
-
-
Sato, R.1
Goldstein, J.L.2
Brown, M.S.3
-
24
-
-
1342310736
-
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
-
DOI 10.1038/ncb1080
-
Almeida A, Moncada S, Bolaños JP. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol 2004;6:45-51. (Pubitemid 38425729)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.1
, pp. 45-51
-
-
Almeida, A.1
Moncada, S.2
Bolanos, J.P.3
-
25
-
-
0034687210
-
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
-
Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, et al. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 2000;10:1247-55.
-
(2000)
Curr Biol
, vol.10
, pp. 1247-1255
-
-
Marsin, A.S.1
Bertrand, L.2
Rider, M.H.3
Deprez, J.4
Beauloye, C.5
Vincent, M.F.6
-
26
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13:1016-23.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
27
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012;13:251-62.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
28
-
-
84859778293
-
Sabatini DM mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
-
29
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex1
-
Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex1. Mol Cell 2010;39:171-83.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
-
30
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84. (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
31
-
-
27744569843
-
MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
DOI 10.1016/j.cell.2005.10.024, PII S0092867405011578
-
Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005;123:569-80. (Pubitemid 41608461)
-
(2005)
Cell
, vol.123
, Issue.4
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenis, J.4
-
32
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
DOI 10.1101/gad.1199104
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004;18:1533-8. (Pubitemid 38868905)
-
(2004)
Genes and Development
, vol.18
, Issue.13
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.-L.5
-
33
-
-
0345167800
-
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
-
DOI 10.1016/S0092-8674(03)00929-2
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90. (Pubitemid 37506046)
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
34
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
DOI 10.1016/j.ccr.2004.06.007, PII S1535610804001771
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004;6:91-9. (Pubitemid 38903165)
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
35
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30:214-26. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
36
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
DOI 10.1042/BJ20080281
-
Huang J, Manning BD. The TSC1-TSC2 complex: A molecular switchboard controlling cell growth. Biochem J 2008;412:179-90. (Pubitemid 351758225)
-
(2008)
Biochemical Journal
, vol.412
, Issue.2
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
37
-
-
37149042642
-
A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
-
DOI 10.1038/sj.onc.1210594, PII 1210594
-
Sanchez-Cespedes M. A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 2007;26:7825-32. (Pubitemid 350261789)
-
(2007)
Oncogene
, vol.26
, Issue.57
, pp. 7825-7832
-
-
Sanchez-Cespedes, M.1
-
38
-
-
34748845413
-
Prevalence and specificity of LKB1 genetic alterations in lung cancers
-
Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y, et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007;26:5911-8.
-
(2007)
Oncogene
, vol.26
, pp. 5911-5918
-
-
Matsumoto, S.1
Iwakawa, R.2
Takahashi, K.3
Kohno, T.4
Nakanishi, Y.5
Matsuno, Y.6
-
39
-
-
84872005418
-
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and-independent pathways
-
Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and-independent pathways. J Cell Biol 2012;199:1117-30.
-
(2012)
J Cell Biol
, vol.199
, pp. 1117-1130
-
-
Lo, B.1
Strasser, G.2
Sagolla, M.3
Austin, C.D.4
Junttila, M.5
Mellman, I.6
-
40
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
DOI 10.1038/nature01045
-
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 2002;419:162-7. (Pubitemid 35025443)
-
(2002)
Nature
, vol.419
, Issue.6903
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
Loda, M.7
Carrasco, D.R.8
DePinho, R.A.9
-
41
-
-
84893119554
-
MTOR-dependent regulation of polyposis and HIF-1 mediated glucose metabolism in an LKB1 mouse model of peutz-jeghers syndrome
-
[in press]
-
Shackelford DB, Vasquez DS, Corbiel J, Wu S, Leblanc M, Wu CL, et al. mTOR-dependent regulation of polyposis and HIF-1 mediated glucose metabolism in an LKB1 mouse model of peutz-jeghers syndrome. Proc Natl Acad Sci USA 2009.[in press].
-
(2009)
Proc Natl Acad Sci USA
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbiel, J.3
Wu, S.4
Leblanc, M.5
Wu, C.L.6
-
42
-
-
80054726323
-
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
-
MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol 2011;187:4187-98.
-
(2011)
J Immunol
, vol.187
, pp. 4187-4198
-
-
MacIver, N.J.1
Blagih, J.2
Saucillo, D.C.3
Tonelli, L.4
Griss, T.5
Rathmell, J.C.6
-
43
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010;468:653-8.
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
44
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010;468:701-4.
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
Hu, J.2
Jiang, S.3
Liu, Y.4
Sahin, E.5
Zhuang, L.6
-
45
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010;468:659-63.
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
-
46
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab 2013;17:113-24.
-
(2013)
Cell Metab
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
-
47
-
-
33745823168
-
2+ in T lymphocytes
-
DOI 10.1084/jem.20052469
-
Tamás P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG, et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2 T lymphocytes. J Exp Med 2006;203:1665-70. (Pubitemid 44036271)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1665-1670
-
-
Tamas, P.1
Hawley, S.A.2
Clarke, R.G.3
Mustard, K.J.4
Green, K.5
Hardie, D.G.6
Cantrell, D.A.7
-
48
-
-
84873584845
-
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
-
Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 2013;23:143-58.
-
(2013)
Cancer Cell
, vol.23
, pp. 143-158
-
-
Shackelford, D.B.1
Abt, E.2
Gerken, L.3
Vasquez, D.S.4
Seki, A.5
Leblanc, M.6
-
49
-
-
84862777541
-
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
-
Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature 2012;483:613-7.
-
(2012)
Nature
, vol.483
, pp. 613-617
-
-
Chen, Z.1
Cheng, K.2
Walton, Z.3
Wang, Y.4
Ebi, H.5
Shimamura, T.6
-
50
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011;331:456-61.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
-
51
-
-
84859167179
-
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
-
Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, et al. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 2012;483:608-12.
-
(2012)
Nature
, vol.483
, pp. 608-612
-
-
Liu, L.1
Ulbrich, J.2
Müller, J.3
Wüstefeld, T.4
Aeberhard, L.5
Kress, T.R.6
-
52
-
-
39749102904
-
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
-
DOI 10.1158/1078-0432.CCR-07-4007
-
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, et al. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 2008;14:1167-71. (Pubitemid 351302565)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.4
, pp. 1167-1171
-
-
Wei, C.1
Amos, C.I.2
Zhang, N.3
Wang, X.4
Rashid, A.5
Walker, C.L.6
Behringer, R.R.7
Frazier, M.L.8
-
53
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008;358:140-51.
-
(2008)
N Engl J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, L.R.3
Elwing, J.M.4
Chuck, G.5
Leonard, J.M.6
-
54
-
-
79955510505
-
Efficacy and safety of sirolimus in lymphangioleiomyomatosis
-
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med 2011;364:1595-606.
-
(2011)
N Engl J Med
, vol.364
, pp. 1595-1606
-
-
McCormack, F.X.1
Inoue, Y.2
Moss, J.3
Singer, L.G.4
Strange, C.5
Nakata, K.6
-
55
-
-
79251614530
-
Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder
-
Shorning BY, Griffiths D, Clarke AR. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One 2011;6:e16209.
-
(2011)
PLoS One
, vol.6
-
-
Shorning, B.Y.1
Griffiths, D.2
Clarke, A.R.3
-
56
-
-
84866147755
-
Stromal liver kinase B1 STK11 signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex1
-
Tanwar PS, Kaneko-Tarui T, Zhang L, Tanaka Y, Crum CP, Teixeira JM. Stromal liver kinase B1 STK11 signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex1. PLoS Genet 2012;8:e1002906.
-
(2012)
PLoS Genet
, vol.8
-
-
Tanwar, P.S.1
Kaneko-Tarui, T.2
Zhang, L.3
Tanaka, Y.4
Crum, C.P.5
Teixeira, J.M.6
-
57
-
-
77949469320
-
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
-
Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, et al. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech 2010;3:181-93.
-
(2010)
Dis Model Mech
, vol.3
, pp. 181-193
-
-
Contreras, C.M.1
Akbay, E.A.2
Gallardo, T.D.3
Haynie, J.M.4
Sharma, S.5
Tagao, O.6
-
58
-
-
77949655175
-
TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
-
Liang MC, Ma J, Chen L, Kozlowski P, Qin W, Li D, et al. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Oncogene 2010;29:1588-97.
-
(2010)
Oncogene
, vol.29
, pp. 1588-1597
-
-
Liang, M.C.1
Ma, J.2
Chen, L.3
Kozlowski, P.4
Qin, W.5
Li, D.6
-
59
-
-
79953298958
-
Next-generation mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy
-
Wander SA, Hennessy BT, Slingerland JM. Next-generation mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy. J Clin Invest 2011;121:1231-41.
-
(2011)
J Clin Invest
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
60
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 2009;7:e38.
-
(2009)
PLoS Biol
, vol.7
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
-
61
-
-
54249162351
-
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, et al. Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol 2008;4:691-9.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 691-699
-
-
Apsel, B.1
Blair, J.A.2
Gonzalez, B.3
Nazif, T.M.4
Feldman, M.E.5
Aizenstein, B.6
-
62
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008;7:1851-63.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
Furet, P.4
Schnell, C.5
Fritsch, C.6
-
63
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008;14:1351-6.
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
-
64
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012;485:55-61.
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
Ingolia, N.T.4
Janes, M.R.5
Sher, A.6
-
65
-
-
33847072201
-
AMP-activated protein kinase as a drug target
-
Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007;47:185-210.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 185-210
-
-
Hardie, D.G.1
-
66
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
DOI 10.1136/bmj.38415.708634.F7
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005;330:1304-5. (Pubitemid 40813563)
-
(2005)
British Medical Journal
, vol.330
, Issue.7503
, pp. 1304-1305
-
-
Evans, J.M.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
67
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006;29:254-8. (Pubitemid 44106500)
-
(2006)
Diabetes Care
, vol.29
, Issue.2
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
68
-
-
77956401999
-
Metformin and other biguanides in oncology: Advancing the research agenda
-
Pollak M. Metformin and other biguanides in oncology: Advancing the research agenda. Cancer Prev Res (Phila) 2010;3:1060-5.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
69
-
-
0035082644
-
Prevention of pancreatic cancer induction in hamsters by metformin
-
Schneider MB, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding XZ, et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 2001;120:1263-70. (Pubitemid 32246678)
-
(2001)
Gastroenterology
, vol.120
, Issue.5
, pp. 1263-1270
-
-
Schneider, M.B.1
Matsuzaki, H.2
Haorah, J.3
Ulrich, A.4
Standop, J.5
Ding, X.-Z.6
Adrian, T.E.7
Pour, P.M.8
-
70
-
-
24644475793
-
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
-
DOI 10.1016/j.exger.2005.07.007, PII S0531556505001531
-
Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, et al. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 2005;40:685-93. (Pubitemid 41265819)
-
(2005)
Experimental Gerontology
, vol.40
, Issue.8-9
, pp. 685-693
-
-
Anisimov, V.N.1
Berstein, L.M.2
Egormin, P.A.3
Piskunova, T.S.4
Popovich, I.G.5
Zabezhinski, M.A.6
Kovalenko, I.G.7
Poroshina, T.E.8
Semenchenko, A.V.9
Provinciali, M.10
Re, F.11
Franceschi, C.12
-
71
-
-
33748118458
-
Neither LKB1 Nor AMPK Are the Direct Targets of Metformin
-
DOI 10.1053/j.gastro.2006.07.032, PII S0016508506016751
-
Hardie DG. Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology 2006;131:973; author reply 974-5. (Pubitemid 44307086)
-
(2006)
Gastroenterology
, vol.131
, Issue.3
, pp. 973
-
-
Hardie, D.G.1
-
72
-
-
84857975015
-
Metformin: Multi-faceted protection against cancer
-
Del Barco S, Vazquez-Martin A, Cufí S, Oliveras-Ferraros C, Bosch-Barrera J, Joven J, et al. Metformin: Multi-faceted protection against cancer. Oncotarget 2011;2:896-917.
-
(2011)
Oncotarget
, vol.2
, pp. 896-917
-
-
Del Barco, S.1
Vazquez-Martin, A.2
Cufí, S.3
Oliveras-Ferraros, C.4
Bosch-Barrera, J.5
Joven, J.6
-
73
-
-
77955287742
-
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
-
Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 2010;11:390-401.
-
(2010)
Cell Metab
, vol.11
, pp. 390-401
-
-
Kalender, A.1
Selvaraj, A.2
Kim, S.Y.3
Gulati, P.4
Brûlé, S.5
Viollet, B.6
-
74
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression. Nat Rev Cancer 2009;9:563-75.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
75
-
-
84861222690
-
The ancient drug salicylate directly activates AMP-activated protein kinase
-
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 2012;336:918-22.
-
(2012)
Science
, vol.336
, pp. 918-922
-
-
Hawley, S.A.1
Fullerton, M.D.2
Ross, F.A.3
Schertzer, J.D.4
Chevtzoff, C.5
Walker, K.J.6
-
76
-
-
84867817838
-
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
-
Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012;367:1596-606.
-
(2012)
N Engl J Med
, vol.367
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
Morikawa, T.4
Kuchiba, A.5
Yamauchi, M.6
-
77
-
-
84861648941
-
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
-
Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, et al. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 2012;142:1504-15.e3.
-
(2012)
Gastroenterology
, vol.142
-
-
Din, F.V.1
Valanciute, A.2
Houde, V.P.3
Zibrova, D.4
Green, K.A.5
Sakamoto, K.6
-
78
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
DOI 10.1016/j.cmet.2006.05.005, PII S1550413106001604
-
Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 2006;3:403-16. (Pubitemid 43811782)
-
(2006)
Cell Metabolism
, vol.3
, Issue.6
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
Kifle, L.4
Cao, N.5
Perham, M.6
Dickinson, R.7
Adler, A.8
Gagne, G.9
Iyengar, R.10
Zhao, G.11
Marsh, K.12
Kym, P.13
Jung, P.14
Camp, H.S.15
Frevert, E.16
-
79
-
-
56049112796
-
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
-
Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol 2008;15:1220-30.
-
(2008)
Chem Biol
, vol.15
, pp. 1220-1230
-
-
Scott, J.W.1
Van Denderen, B.J.2
Jorgensen, S.B.3
Honeyman, J.E.4
Steinberg, G.R.5
Oakhill, J.S.6
-
80
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
DOI 10.1042/BJ20080557
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 2008;412:211-21. (Pubitemid 351758227)
-
(2008)
Biochemical Journal
, vol.412
, Issue.2
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, M.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
McBurnie, W.7
Fleming, S.8
Alessi, D.R.9
-
81
-
-
84858287883
-
Phenformin as prophylaxis and therapy in breast cancer xenografts
-
Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, et al. Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer 2012;106:1117-22.
-
(2012)
Br J Cancer
, vol.106
, pp. 1117-1122
-
-
Appleyard, M.V.1
Murray, K.E.2
Coates, P.J.3
Wullschleger, S.4
Bray, S.E.5
Kernohan, N.M.6
-
82
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
DOI 10.1042/0264-6021:3480607
-
Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex1 of the mitochondrial respiratory chain. Biochem J 2000;348 Pt 3:607-14. (Pubitemid 30410251)
-
(2000)
Biochemical Journal
, vol.348
, Issue.3
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
83
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012;485:661-5.
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
85
-
-
77953238558
-
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors
-
Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell 2010;17:547-59.
-
(2010)
Cancer Cell
, vol.17
, pp. 547-559
-
-
Carretero, J.1
Shimamura, T.2
Rikova, K.3
Jackson, A.L.4
Wilkerson, M.D.5
Borgman, C.L.6
-
86
-
-
84862119127
-
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma
-
Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, et al. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell 2012;21:751-64.
-
(2012)
Cancer Cell
, vol.21
, pp. 751-764
-
-
Liu, W.1
Monahan, K.B.2
Pfefferle, A.D.3
Shimamura, T.4
Sorrentino, J.5
Chan, K.T.6
-
87
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
88
-
-
79961215490
-
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
-
Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med 2011;3:94ra70.
-
(2011)
Sci Transl Med
, vol.3
-
-
Chan, D.A.1
Sutphin, P.D.2
Nguyen, P.3
Turcotte, S.4
Lai, E.W.5
Banh, A.6
-
89
-
-
67549102923
-
Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis
-
Gandhi L, McNamara KL, Li D, Borgman CL, McDermott U, Brandstetter KA, et al. Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis. Cancer Prev Res (Phila) 2009;2:330-7.
-
(2009)
Cancer Prev Res (Phila)
, vol.2
, pp. 330-337
-
-
Gandhi, L.1
McNamara, K.L.2
Li, D.3
Borgman, C.L.4
McDermott, U.5
Brandstetter, K.A.6
-
90
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
-
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 2002;62:2261-6. (Pubitemid 34411702)
-
(2002)
Cancer Research
, vol.62
, Issue.8
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.-O.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
91
-
-
0037173013
-
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
-
DOI 10.1073/pnas.122254599
-
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, et al. Role of Lkb1, the causative gene of Peutz-Jegher′s syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 2002;99:8903-8. (Pubitemid 34693656)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.13
, pp. 8903-8908
-
-
Jishage, K.-I.1
Nezu, J.-I.2
Kawase, Y.3
Iwata, T.4
Watanabe, M.5
Miyoshi, A.6
Ose, A.7
Habu, K.8
Kake, T.9
Kamada, N.10
Ueda, O.11
Kinoshita, M.12
Jenne, D.E.13
Shimane, M.14
Suzuki, H.15
-
92
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, et al. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 2002;99:12327-32.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
-
93
-
-
41349114071
-
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
-
DOI 10.1038/ng.98, PII NG98
-
Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet 2008;40:455-9. (Pubitemid 351450888)
-
(2008)
Nature Genetics
, vol.40
, Issue.4
, pp. 455-459
-
-
Katajisto, P.1
Vaahtomeri, K.2
Ekman, N.3
Ventela, E.4
Ristimaki, A.5
Bardeesy, N.6
Feil, R.7
DePinho, R.A.8
Makela, T.P.9
-
94
-
-
0037102428
-
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
-
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 2002;62:4549-53.
-
(2002)
Cancer Res
, vol.62
, pp. 4549-4553
-
-
Nakau, M.1
Miyoshi, H.2
Seldin, M.F.3
Imamura, M.4
Oshima, M.5
Taketo, M.M.6
-
95
-
-
29244474612
-
Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
-
DOI 10.1158/0008-5472.CAN-05-0716
-
Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, et al. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 2005;65:11297-303. (Pubitemid 41821686)
-
(2005)
Cancer Research
, vol.65
, Issue.24
, pp. 11297-11303
-
-
Wei, C.1
Amos, C.I.2
Stephens, L.C.3
Campos, I.4
Deng, J.M.5
Behringer, R.R.6
Rashid, A.7
Frazier, M.L.8
-
96
-
-
33645022897
-
Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1p53-/-compound mutant mice
-
Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1p53-/-compound mutant mice. Oncogene 2006;25:1816-20.
-
(2006)
Oncogene
, vol.25
, pp. 1816-1820
-
-
Takeda, H.1
Miyoshi, H.2
Kojima, Y.3
Oshima, M.4
Taketo, M.M.5
-
97
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
DOI 10.1038/nature06030, PII NATURE06030
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007;448:807-10. (Pubitemid 47266337)
-
(2007)
Nature
, vol.448
, Issue.7155
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
Liang, M.-C.11
Cai, D.12
Naumov, G.N.13
Bao, L.14
Contreras, C.M.15
Li, D.16
Chen, L.17
Krishnamurthy, J.18
Koivunen, J.19
Chirieac, L.R.20
Padera, R.F.21
Bronson, R.T.22
Lindeman, N.I.23
Christiani, D.C.24
Lin, X.25
Shapiro, G.I.26
Janne, P.A.27
Johnson, B.E.28
Meyerson, M.29
Kwiatkowski, D.J.30
Castrillon, D.H.31
Bardeesy, N.32
Sharpless, N.E.33
Wong, K.-K.34
more..
-
98
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Hammerman et al., Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012;489:519-25.
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
Hammerman1
-
99
-
-
38849193504
-
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
-
DOI 10.1158/0008-5472.CAN-07-5014
-
Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, et al. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res 2008;68:759-66. (Pubitemid 351206752)
-
(2008)
Cancer Research
, vol.68
, Issue.3
, pp. 759-766
-
-
Contreras, C.M.1
Gurumurthy, S.2
Haynie, J.M.3
Shirley, L.J.4
Akbay, E.A.5
Wingo, S.N.6
Schorge, J.O.7
Broaddus, R.R.8
Wong, K.-K.9
Bardeesy, N.10
Castrillon, D.H.11
-
100
-
-
70350436136
-
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
-
McCarthy A, Lord CJ, Savage K, Grigoriadis A, Smith DP, Weigelt B, et al. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol 2009;219:306-16.
-
(2009)
J Pathol
, vol.219
, pp. 306-316
-
-
McCarthy, A.1
Lord, C.J.2
Savage, K.3
Grigoriadis, A.4
Smith, D.P.5
Weigelt, B.6
-
101
-
-
84857132136
-
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
-
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, et al. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci USA 2012;109:E388-97.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Partanen, J.I.1
Tervonen, T.A.2
Myllynen, M.3
Lind, E.4
Imai, M.5
Katajisto, P.6
-
102
-
-
42049113832
-
Lkb1 deficiency causes prostate neoplasia in the mouse
-
DOI 10.1158/0008-5472.CAN-07-5169
-
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 2008;68:2223-32. (Pubitemid 351521795)
-
(2008)
Cancer Research
, vol.68
, Issue.7
, pp. 2223-2232
-
-
Pearson, H.B.1
McCarthy, A.2
Collins, C.M.P.3
Ashworth, A.4
Clarke, A.R.5
-
103
-
-
39749194712
-
Pancreatic Lkb1 deletion leads to acinar polarity defects and cystic neoplasms
-
DOI 10.1128/MCB.01621-07
-
Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, et al. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 2008;28:2414-25. (Pubitemid 351429985)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.7
, pp. 2414-2425
-
-
Hezel, A.F.1
Gurumurthy, S.2
Granot, Z.3
Swisa, A.4
Chu, G.C.5
Bailey, G.6
Dor, Y.7
Bardeesy, N.8
DePinho, R.A.9
-
104
-
-
39149083762
-
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
-
DOI 10.1158/0008-5472.CAN-07-3225
-
Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res 2008;68:55-63. (Pubitemid 351380105)
-
(2008)
Cancer Research
, vol.68
, Issue.1
, pp. 55-63
-
-
Gurumurthy, S.1
Hezel, A.F.2
Berger, J.H.3
Bosenberg, M.W.4
Bardeesy, N.5
-
105
-
-
33646703327
-
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma
-
DOI 10.1038/sj.onc.1209325, PII 1209325
-
Qiu W, Schönleben F, Thaker HM, Goggins M, Su GH. A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma. Oncogene 2006;25:2937-42. (Pubitemid 43739244)
-
(2006)
Oncogene
, vol.25
, Issue.20
, pp. 2937-2942
-
-
Qiu, W.1
Schonleben, F.2
Thaker, H.M.3
Goggins, M.4
Su, G.H.5
-
106
-
-
77955488036
-
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
-
597.e1-6
-
Morton JP, Jamieson NB, Karim SA, Athineos D, Ridgway RA, Nixon C, et al. LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology 2010;139:586-97, 597.e1-6.
-
(2010)
Gastroenterology
, vol.139
, pp. 586-597
-
-
Morton, J.P.1
Jamieson, N.B.2
Karim, S.A.3
Athineos, D.4
Ridgway, R.A.5
Nixon, C.6
|