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Volumn 15, Issue 2, 2014, Pages 164-174

Inducible nitric oxide synthase as a possible target in hypertension

Author keywords

Endothelial dysfunction; Hypertension; Inducible nitric oxide synthase; Inducible nitric oxide synthase inhibition; Nitric oxide

Indexed keywords

AMINOGUANIDINE; AMLODIPINE; ARGINASE; ARGININE; CARVEDILOL; COPTIS CHINENSIS EXTRACT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIMASARTAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACIDIPINE; N [3 (AMINOMETHYL) BENZYL] ACETAMIDINE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NEBIVOLOL; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEROXYNITRITE; PROANTHOCYANIDIN; PYRROLIDINE DITHIOCARBAMATE; QUERCETIN; QUINAPRIL; RAMIPRIL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG; VALSARTAN;

EID: 84892950455     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113146660227     Document Type: Review
Times cited : (63)

References (157)
  • 1
    • 0038460302 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560-72.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 2
    • 34250350040 scopus 로고    scopus 로고
    • 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    • Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105-87.
    • (2007) J Hypertens , vol.25 , pp. 1105-1187
    • Mancia, G.1    De Backer, G.2    Dominiczak, A.3
  • 3
    • 0029021148 scopus 로고
    • Hypertension in mice lacking the gene for endothelial nitric oxide synthase
    • Huang PL, Huang Z, Mashimo H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377: 239-42.
    • (1995) Nature , vol.377 , pp. 239-242
    • Huang, P.L.1    Huang, Z.2    Mashimo, H.3
  • 4
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-12.
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 5
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593-615.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 6
    • 0030694038 scopus 로고    scopus 로고
    • Biosynthesis and action of nitric oxide in mammalian cells
    • Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1997; 22: 477-81.
    • (1997) Trends Biochem Sci , vol.22 , pp. 477-481
    • Mayer, B.1    Hemmens, B.2
  • 7
    • 0037315499 scopus 로고    scopus 로고
    • Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats
    • Rodriguez-Iturbe B, Zhan CD, Quiroz Y, Sindhu RK, Vaziri ND. Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension 2003; 41: 341-6.
    • (2003) Hypertension , vol.41 , pp. 341-346
    • Rodriguez-Iturbe, B.1    Zhan, C.D.2    Quiroz, Y.3    Sindhu, R.K.4    Vaziri, N.D.5
  • 8
    • 41349098142 scopus 로고    scopus 로고
    • Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension
    • Watson T, Goon PK, Lip GY. Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension. Antioxidants & redox signaling 2008; 10: 1079-88.
    • (2008) Antioxidants & redox signaling , vol.10 , pp. 1079-1088
    • Watson, T.1    Goon, P.K.2    Lip, G.Y.3
  • 9
    • 63349099519 scopus 로고    scopus 로고
    • Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension
    • Castro MM, Rizzi E, Rodrigues GJ, et al. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med 2009; 46: 1298-307.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1298-1307
    • Castro, M.M.1    Rizzi, E.2    Rodrigues, G.J.3
  • 10
    • 84859099989 scopus 로고    scopus 로고
    • Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability
    • Castro MM, Rizzi E, Ceron CS, et al. Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability. Nitric Oxide 2012; 26: 162-8.
    • (2012) Nitric Oxide , vol.26 , pp. 162-168
    • Castro, M.M.1    Rizzi, E.2    Ceron, C.S.3
  • 11
    • 0031886546 scopus 로고    scopus 로고
    • Alterations of nitric oxide synthase expression with aging and hypertension in rats
    • Chou TC, Yen MH, Li CY, Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 1998; 31: 643-8.
    • (1998) Hypertension , vol.31 , pp. 643-648
    • Chou, T.C.1    Yen, M.H.2    Li, C.Y.3    Ding, Y.A.4
  • 13
    • 0033567070 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and vascular injury
    • Kibbe M, Billiar T, Tzeng E. Inducible nitric oxide synthase and vascular injury. Cardiovasc Res 1999; 43: 650-7.
    • (1999) Cardiovasc Res , vol.43 , pp. 650-657
    • Kibbe, M.1    Billiar, T.2    Tzeng, E.3
  • 14
    • 0027482241 scopus 로고
    • Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte
    • Charles IG, Palmer RM, Hickery MS, et al. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 1993; 90: 11419-23.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11419-11423
    • Charles, I.G.1    Palmer, R.M.2    Hickery, M.S.3
  • 15
    • 30544432090 scopus 로고    scopus 로고
    • Srcmediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase
    • Hausel P, Latado H, Courjault-Gautier F, Felley-Bosco E. Srcmediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase. Oncogene 2006; 25: 198-206.
    • (2006) Oncogene , vol.25 , pp. 198-206
    • Hausel, P.1    Latado, H.2    Courjault-Gautier, F.3    Felley-Bosco, E.4
  • 16
    • 0033976342 scopus 로고    scopus 로고
    • Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
    • Jung F, Palmer LA, Zhou N, Johns RA. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res 2000; 86: 319-25.
    • (2000) Circ Res , vol.86 , pp. 319-325
    • Jung, F.1    Palmer, L.A.2    Zhou, N.3    Johns, R.A.4
  • 17
    • 0034673363 scopus 로고    scopus 로고
    • Effect of hypoxia on nitric oxide production and its synthase gene expression in rat smooth muscle cells
    • Hong Y, Suzuki S, Yatoh S, et al. Effect of hypoxia on nitric oxide production and its synthase gene expression in rat smooth muscle cells. Biochem Biophys Res Commun 2000; 268: 329-32.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 329-332
    • Hong, Y.1    Suzuki, S.2    Yatoh, S.3
  • 18
    • 4544317836 scopus 로고    scopus 로고
    • Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath
    • Lane C, Knight D, Burgess S, et al. Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 2004; 59: 757-60.
    • (2004) Thorax , vol.59 , pp. 757-760
    • Lane, C.1    Knight, D.2    Burgess, S.3
  • 19
    • 0036006788 scopus 로고    scopus 로고
    • Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells
    • Zulueta JJ, Sawhney R, Kayyali U, et al. Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 2002; 26: 22-30.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 22-30
    • Zulueta, J.J.1    Sawhney, R.2    Kayyali, U.3
  • 20
    • 0345547431 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • Kleinert H, Schwarz PM, Forstermann U. Regulation of the expression of inducible nitric oxide synthase. Biol Chem 2003; 384: 1343-64.
    • (2003) Biol Chem , vol.384 , pp. 1343-1364
    • Kleinert, H.1    Schwarz, P.M.2    Forstermann, U.3
  • 21
  • 22
    • 0034665081 scopus 로고    scopus 로고
    • Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
    • Delgado M, Ganea D. Inhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. J Immunol 2000; 165: 3051-7.
    • (2000) J Immunol , vol.165 , pp. 3051-3057
    • Delgado, M.1    Ganea, D.2
  • 23
    • 0031022516 scopus 로고    scopus 로고
    • An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide
    • Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ. An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 1997; 272: 1226-30.
    • (1997) J Biol Chem , vol.272 , pp. 1226-1230
    • Gao, J.1    Morrison, D.C.2    Parmely, T.J.3    Russell, S.W.4    Murphy, W.J.5
  • 24
    • 0031416497 scopus 로고    scopus 로고
    • Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B
    • De Vera ME, Taylor BS, Wang Q, Shapiro RA, Billiar TR, Geller DA. Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B. Am J Physiol 1997; 273: G1290-6.
    • (1997) Am J Physiol , vol.273 , pp. 1290-1296
    • De Vera, M.E.1    Taylor, B.S.2    Wang, Q.3    Shapiro, R.A.4    Billiar, T.R.5    Geller, D.A.6
  • 25
    • 0033780038 scopus 로고    scopus 로고
    • Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase
    • Hong HJ, Loh SH, Yen MH. Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase. Br J Pharmacol 2000; 131: 631-7.
    • (2000) Br J Pharmacol , vol.131 , pp. 631-637
    • Hong, H.J.1    Loh, S.H.2    Yen, M.H.3
  • 26
    • 84866501095 scopus 로고    scopus 로고
    • Malvidin-3-glucoside protects endothelial cells up-regulating endothelial NO synthase and inhibiting peroxynitrite-induced NF-kB activation
    • Paixao J, Dinis TC, Almeida LM. Malvidin-3-glucoside protects endothelial cells up-regulating endothelial NO synthase and inhibiting peroxynitrite-induced NF-kB activation. Chem Biol Interact 2012; 199: 192-200.
    • (2012) Chem Biol Interact , vol.199 , pp. 192-200
    • Paixao, J.1    Dinis, T.C.2    Almeida, L.M.3
  • 27
    • 84863284965 scopus 로고    scopus 로고
    • Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-kappaB signaling pathway in RAW 264. 7 cells
    • Yoon EK, Kim HK, Cui S, Kim YH, Lee SH. Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-kappaB signaling pathway in RAW 264. 7 cells. Int J Mol Med 2012; 29: 711-7.
    • (2012) Int J Mol Med , vol.29 , pp. 711-717
    • Yoon, E.K.1    Kim, H.K.2    Cui, S.3    Kim, Y.H.4    Lee, S.H.5
  • 28
    • 0028305712 scopus 로고
    • Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression
    • Mukaida N, Morita M, Ishikawa Y, et al. Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 1994; 269: 13289-95.
    • (1994) J Biol Chem , vol.269 , pp. 13289-13295
    • Mukaida, N.1    Morita, M.2    Ishikawa, Y.3
  • 29
    • 0031854198 scopus 로고    scopus 로고
    • Inhibition of NFkappa B/Rel nuclear translocation by dexamethasone: Mechanism for the inhibition of iNOS gene expression
    • Jeon YJ, Han SH, Lee YW, Yea SS, Yang KH. Inhibition of NFkappa B/Rel nuclear translocation by dexamethasone: mechanism for the inhibition of iNOS gene expression. Biochem Mol Biol Int 1998; 45: 435-41.
    • (1998) Biochem Mol Biol Int , vol.45 , pp. 435-441
    • Jeon, Y.J.1    Han, S.H.2    Lee, Y.W.3    Yea, S.S.4    Yang, K.H.5
  • 30
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
    • Yu Z, Zhang W, Kone BC. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 2002; 367: 97-105.
    • (2002) Biochem J , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 31
    • 0031888836 scopus 로고    scopus 로고
    • Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells
    • Saura M, Zaragoza C, Diaz-Cazorla M, et al. Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells. Kidney Int 1998; 53: 38-49.
    • (1998) Kidney Int , vol.53 , pp. 38-49
    • Saura, M.1    Zaragoza, C.2    Diaz-Cazorla, M.3
  • 32
    • 0034714259 scopus 로고    scopus 로고
    • Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR
    • Rodriguez-Pascual F, Hausding M, Ihrig-Biedert I, et al. Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J Biol Chem 2000; 275: 26040-9.
    • (2000) J Biol Chem , vol.275 , pp. 26040-26049
    • Rodriguez-Pascual, F.1    Hausding, M.2    Ihrig-Biedert, I.3
  • 34
    • 18044371822 scopus 로고    scopus 로고
    • AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
    • Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107: 451-64.
    • (2001) Cell , vol.107 , pp. 451-464
    • Chen, C.Y.1    Gherzi, R.2    Ong, S.E.3
  • 35
    • 21744442278 scopus 로고    scopus 로고
    • Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene
    • Fechir M, Linker K, Pautz A, et al. Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. Mol Pharmacol 2005; 67: 2148-61.
    • (2005) Mol Pharmacol , vol.67 , pp. 2148-2161
    • Fechir, M.1    Linker, K.2    Pautz, A.3
  • 36
    • 24144499990 scopus 로고    scopus 로고
    • Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR
    • Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, Kleinert H. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res 2005; 33: 4813-27.
    • (2005) Nucleic Acids Res , vol.33 , pp. 4813-4827
    • Linker, K.1    Pautz, A.2    Fechir, M.3    Hubrich, T.4    Greeve, J.5    Kleinert, H.6
  • 37
    • 0033986606 scopus 로고    scopus 로고
    • Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: Role of cationic amino acid transporters
    • Closs EI, Scheld JS, Sharafi M, Forstermann U. Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol 2000; 57: 68-74.
    • (2000) Mol Pharmacol , vol.57 , pp. 68-74
    • Closs, E.I.1    Scheld, J.S.2    Sharafi, M.3    Forstermann, U.4
  • 38
    • 34249818191 scopus 로고    scopus 로고
    • Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling
    • Mori M. Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J Nutr 2007; 137: 1616S-20S.
    • (2007) J Nutr , vol.137 , pp. 1616-1620
    • Mori, M.1
  • 39
    • 0034618752 scopus 로고    scopus 로고
    • Regulation of nitric oxide production by arginine metabolic enzymes
    • Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes. Biochem Biophys Res Commun 2000; 275: 715-9.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 715-719
    • Mori, M.1    Gotoh, T.2
  • 40
    • 0028810841 scopus 로고
    • Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control
    • Forstermann U, Gath I, Schwarz P, Closs EI, Kleinert H. Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control. Biochem Pharmacol 1995; 50: 1321-32.
    • (1995) Biochem Pharmacol , vol.50 , pp. 1321-1332
    • Forstermann, U.1    Gath, I.2    Schwarz, P.3    Closs, E.I.4    Kleinert, H.5
  • 41
    • 0029618106 scopus 로고
    • Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer
    • Tzeng E, Billiar TR, Robbins PD, Loftus M, Stuehr DJ. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proc Natl Acad Sci USA. 1995; 92: 11771-5.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11771-11775
    • Tzeng, E.1    Billiar, T.R.2    Robbins, P.D.3    Loftus, M.4    Stuehr, D.J.5
  • 42
    • 0028037534 scopus 로고
    • Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells
    • Muhl H, Pfeilschifter J. Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. Kidney Int 1994; 46: 1302-6.
    • (1994) Kidney Int , vol.46 , pp. 1302-1306
    • Muhl, H.1    Pfeilschifter, J.2
  • 43
    • 33747014907 scopus 로고    scopus 로고
    • Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma
    • Wang SS, Davis S, Cerhan JR, et al. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis 2006; 27: 1828-34.
    • (2006) Carcinogenesis , vol.27 , pp. 1828-1834
    • Wang, S.S.1    Davis, S.2    Cerhan, J.R.3
  • 44
    • 84863990529 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase haplotype associated with migraine and aura
    • de OSMT, Goncalves FM, Martins-Oliveira A, et al. Inducible nitric oxide synthase haplotype associated with migraine and aura. Mol Cell Biochem 2012; 364: 303-8.
    • (2012) Mol Cell Biochem , vol.364 , pp. 303-308
    • de, O.S.M.T.1    Goncalves, F.M.2    Martins-Oliveira, A.3
  • 45
    • 84865246970 scopus 로고    scopus 로고
    • Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy
    • Amaral LM, Palei AC, Sandrim VC, et al. Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy. J Hum Hypertens 2012; 26: 547-52.
    • (2012) J Hum Hypertens , vol.26 , pp. 547-552
    • Amaral, L.M.1    Palei, A.C.2    Sandrim, V.C.3
  • 46
    • 84872495694 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy
    • Oliveira-Paula GH, Lacchini R, Coeli-Lacchini FB, Junior HM, Tanus-Santos JE. Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy. Gene 2013; 515: 391-5.
    • (2013) Gene , vol.515 , pp. 391-395
    • Oliveira-Paula, G.H.1    Lacchini, R.2    Coeli-Lacchini, F.B.3    Junior, H.M.4    Tanus-Santos, J.E.5
  • 47
    • 0029091366 scopus 로고
    • Nitric oxide and its role in the cardiovascular system
    • Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 1995; 38: 87-104.
    • (1995) Prog Cardiovasc Dis , vol.38 , pp. 87-104
    • Loscalzo, J.1    Welch, G.2
  • 49
    • 77958153150 scopus 로고    scopus 로고
    • Hemodynamic effects of inducible nitric oxide synthase inhibition combined with sildenafil during acute pulmonary embolism
    • Dias-Junior CA, Neto-Neves EM, Montenegro MF, Tanus-Santos JE. Hemodynamic effects of inducible nitric oxide synthase inhibition combined with sildenafil during acute pulmonary embolism. Nitric Oxide 2010; 23: 284-8.
    • (2010) Nitric Oxide , vol.23 , pp. 284-288
    • Dias-Junior, C.A.1    Neto-Neves, E.M.2    Montenegro, M.F.3    Tanus-Santos, J.E.4
  • 50
    • 0035000099 scopus 로고    scopus 로고
    • Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure
    • Stathopulos PB, Lu X, Shen J, Scott JA, et al. Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure. Am J Physiol Heart Circ Physiol 2001; 280: H859-67.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280 , pp. 859-867
    • Stathopulos, P.B.1    Lu, X.2    Shen, J.3    Scott, J.A.4
  • 51
    • 9044252721 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase in human heart failure
    • Haywood GA, Tsao PS, von der Leyen HE, et al. Expression of inducible nitric oxide synthase in human heart failure. Circulation 1996; 93: 1087-94.
    • (1996) Circulation , vol.93 , pp. 1087-1094
    • Haywood, G.A.1    Tsao, P.S.2    von der Leyen, H.E.3
  • 52
    • 4444283872 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase is increased in patients with heart failure due to ischemic disease
    • Ferreiro CR, Chagas AC, Carvalho MH, et al. Expression of inducible nitric oxide synthase is increased in patients with heart failure due to ischemic disease. Braz J Med Biol Res 2004; 37: 1313-20.
    • (2004) Braz J Med Biol Res , vol.37 , pp. 1313-1320
    • Ferreiro, C.R.1    Chagas, A.C.2    Carvalho, M.H.3
  • 54
    • 34247160943 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure
    • Zhang P, Xu X, Hu X, van Deel ED, Zhu G, Chen Y. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res. 2007; 100: 1089-98.
    • (2007) Circ Res , vol.100 , pp. 1089-1098
    • Zhang, P.1    Xu, X.2    Hu, X.3    van Deel, E.D.4    Zhu, G.5    Chen, Y.6
  • 55
    • 28144445062 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction
    • Liu YH, Carretero OA, Cingolani OH, et al. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol 2005; 289: H2616-23.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , pp. 2616-2623
    • Liu, Y.H.1    Carretero, O.A.2    Cingolani, O.H.3
  • 56
    • 0035822692 scopus 로고    scopus 로고
    • Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice
    • Feng Q, Lu X, Jones DL, Shen J, Arnold JM. Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice. Circulation 2001; 104: 700-4.
    • (2001) Circulation , vol.104 , pp. 700-704
    • Feng, Q.1    Lu, X.2    Jones, D.L.3    Shen, J.4    Arnold, J.M.5
  • 57
    • 77954735297 scopus 로고    scopus 로고
    • Increased expression and co-localization of ACE, angiotensin II AT(1) receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries
    • Ohishi M, Dusting GJ, Fennessy PA, Mendelsohn FA, Li XC, Zhuo JL. Increased expression and co-localization of ACE, angiotensin II AT(1) receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries. Int J Physiol Pathophysiol Pharmacol 2010; 2: 111-24.
    • (2010) Int J Physiol Pathophysiol Pharmacol , vol.2 , pp. 111-124
    • Ohishi, M.1    Dusting, G.J.2    Fennessy, P.A.3    Mendelsohn, F.A.4    Li, X.C.5    Zhuo, J.L.6
  • 58
    • 0034665303 scopus 로고    scopus 로고
    • Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice
    • Detmers PA, Hernandez M, Mudgett J, et al. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice. J Immunol 2000; 165: 3430-5.
    • (2000) J Immunol , vol.165 , pp. 3430-3435
    • Detmers, P.A.1    Hernandez, M.2    Mudgett, J.3
  • 59
    • 0035954312 scopus 로고    scopus 로고
    • Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice
    • Kuhlencordt PJ, Chen J, Han F, Astern J, Huang PL. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 2001; 103: 3099-104.
    • (2001) Circulation , vol.103 , pp. 3099-3104
    • Kuhlencordt, P.J.1    Chen, J.2    Han, F.3    Astern, J.4    Huang, P.L.5
  • 60
    • 0034730108 scopus 로고    scopus 로고
    • Effect of chronic treatment with the inducible nitric oxide synthase inhibitor Niminoethyl-L-lysine or with L-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits
    • Behr-Roussel D, Rupin A, Simonet S, et al. Effect of chronic treatment with the inducible nitric oxide synthase inhibitor Niminoethyl-L-lysine or with L-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits. Circulation 2000; 102: 1033-8.
    • (2000) Circulation , vol.102 , pp. 1033-1038
    • Behr-Roussel, D.1    Rupin, A.2    Simonet, S.3
  • 61
    • 33745503461 scopus 로고    scopus 로고
    • Selective iNOS inhibitor, ONO1714 successfully retards the development of highcholesterol diet induced atherosclerosis by novel mechanism
    • Hayashi T, Matsui-Hirai H, Fukatsu A, et al. Selective iNOS inhibitor, ONO1714 successfully retards the development of highcholesterol diet induced atherosclerosis by novel mechanism. Atherosclerosis 2006; 187: 316-24.
    • (2006) Atherosclerosis , vol.187 , pp. 316-324
    • Hayashi, T.1    Matsui-Hirai, H.2    Fukatsu, A.3
  • 62
    • 0026667091 scopus 로고
    • Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage
    • Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest 1992; 90: 278-81.
    • (1992) J Clin Invest , vol.90 , pp. 278-281
    • Baylis, C.1    Mitruka, B.2    Deng, A.3
  • 64
    • 0030802281 scopus 로고    scopus 로고
    • The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by N(omega)-nitro-L-arginine methyl ester
    • Sander M, Hansen J, Victor RG. The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by N(omega)-nitro-L-arginine methyl ester. Hypertension 1997; 30: 64-70.
    • (1997) Hypertension , vol.30 , pp. 64-70
    • Sander, M.1    Hansen, J.2    Victor, R.G.3
  • 65
    • 0027399299 scopus 로고
    • Effect of hypertension induced by nitric oxide synthase inhibition on structure and function of resistance arteries in the rat
    • Deng LY, Thibault G, Schiffrin EL. Effect of hypertension induced by nitric oxide synthase inhibition on structure and function of resistance arteries in the rat. Clin Exp Hypertens 1993; 15: 527-37.
    • (1993) Clin Exp Hypertens , vol.15 , pp. 527-537
    • Deng, L.Y.1    Thibault, G.2    Schiffrin, E.L.3
  • 66
    • 1842506278 scopus 로고    scopus 로고
    • Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCAsalt hypertensive rats
    • Ghosh M, Wang HD, McNeill JR. Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCAsalt hypertensive rats. Br J Pharmacol 2004; 141: 562-73.
    • (2004) Br J Pharmacol , vol.141 , pp. 562-573
    • Ghosh, M.1    Wang, H.D.2    McNeill, J.R.3
  • 67
    • 0038352012 scopus 로고    scopus 로고
    • Diminished expression of constitutive nitric oxide synthases in the kidney of spontaneously hypertensive rat
    • Kumar U, Shin Y, Wersinger C, Patel Y, Sidhu A. Diminished expression of constitutive nitric oxide synthases in the kidney of spontaneously hypertensive rat. Clin Exp Hypertens 2003; 25: 271-82.
    • (2003) Clin Exp Hypertens , vol.25 , pp. 271-282
    • Kumar, U.1    Shin, Y.2    Wersinger, C.3    Patel, Y.4    Sidhu, A.5
  • 68
    • 0033646389 scopus 로고    scopus 로고
    • Chronic nitric oxide inhibition aggravates hypertension in erythropoietintreated renal failure rats
    • Moreau C, Lariviere R, Kingma I, Grose JH, Lebel M. Chronic nitric oxide inhibition aggravates hypertension in erythropoietintreated renal failure rats. Clin Exp Hypertens 2000; 22: 663-74.
    • (2000) Clin Exp Hypertens , vol.22 , pp. 663-674
    • Moreau, C.1    Lariviere, R.2    Kingma, I.3    Grose, J.H.4    Lebel, M.5
  • 70
    • 25844513144 scopus 로고    scopus 로고
    • Oxidative stress and nitric oxide deficiency in the kidney: A critical link to hypertension?
    • Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regul Integr Comp Physiol 2005; 289: R913-35.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289 , pp. 913-935
    • Wilcox, C.S.1
  • 71
    • 0037059589 scopus 로고    scopus 로고
    • Reduced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in vascular smooth muscle cells of stroke-prone spontaneously hypertensive rats
    • Hirafuji M, Tsunoda M, Machida T, et al. Reduced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in vascular smooth muscle cells of stroke-prone spontaneously hypertensive rats. Life Sci 2002; 70: 917-26.
    • (2002) Life Sci , vol.70 , pp. 917-926
    • Hirafuji, M.1    Tsunoda, M.2    Machida, T.3
  • 72
    • 40149097151 scopus 로고    scopus 로고
    • Role of NADPH oxidase and iNOS in vasoconstrictor responses of vessels from hypertensive and normotensive rats
    • Alvarez Y, Briones AM, Hernanz R, Perez-Giron JV, Alonso MJ, Salaices M. Role of NADPH oxidase and iNOS in vasoconstrictor responses of vessels from hypertensive and normotensive rats. Br J Pharmacol 2008; 153: 926-35.
    • (2008) Br J Pharmacol , vol.153 , pp. 926-935
    • Alvarez, Y.1    Briones, A.M.2    Hernanz, R.3    Perez-Giron, J.V.4    Alonso, M.J.5    Salaices, M.6
  • 73
    • 80051956734 scopus 로고    scopus 로고
    • Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension
    • Cau SB, Guimaraes DA, Rizzi E, et al. Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension. Br J Pharmacol 2011; 164: 372-81.
    • (2011) Br J Pharmacol , vol.164 , pp. 372-381
    • Cau, S.B.1    Guimaraes, D.A.2    Rizzi, E.3
  • 74
    • 77953808269 scopus 로고    scopus 로고
    • Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model
    • de Oliveira-Sales EB, Nishi EE, Boim MA, Dolnikoff MS, Bergamaschi CT, Campos RR. Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model. Am J Hypertens 2010; 23: 708-15.
    • (2010) Am J Hypertens , vol.23 , pp. 708-715
    • de Oliveira-Sales, E.B.1    Nishi, E.E.2    Boim, M.A.3    Dolnikoff, M.S.4    Bergamaschi, C.T.5    Campos, R.R.6
  • 75
    • 0035726142 scopus 로고    scopus 로고
    • Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats
    • Hong HJ, Hsiao G, Cheng TH, Yen MH. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 2001; 38: 1044-8.
    • (2001) Hypertension , vol.38 , pp. 1044-1048
    • Hong, H.J.1    Hsiao, G.2    Cheng, T.H.3    Yen, M.H.4
  • 76
    • 0041828198 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase, left ventricular function and remodeling in Dahl salt-sensitive hypertensive rats
    • Horinaka S, Kobayashi N, Mori Y, Yagi H, Onoda M, Matsuoka H. Expression of inducible nitric oxide synthase, left ventricular function and remodeling in Dahl salt-sensitive hypertensive rats. Int J Cardiol 2003; 91: 25-35.
    • (2003) Int J Cardiol , vol.91 , pp. 25-35
    • Horinaka, S.1    Kobayashi, N.2    Mori, Y.3    Yagi, H.4    Onoda, M.5    Matsuoka, H.6
  • 77
    • 67649966605 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats
    • Kimura Y, Hirooka Y, Kishi T, Ito K, Sagara Y, Sunagawa K. Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats. Clin Exp Hypertens 2009; 31: 281-6.
    • (2009) Clin Exp Hypertens , vol.31 , pp. 281-286
    • Kimura, Y.1    Hirooka, Y.2    Kishi, T.3    Ito, K.4    Sagara, Y.5    Sunagawa, K.6
  • 78
    • 13444279868 scopus 로고    scopus 로고
    • Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress
    • Kimura Y, Hirooka Y, Sagara Y, et al. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circ Res 2005; 96: 252-60.
    • (2005) Circ Res , vol.96 , pp. 252-260
    • Kimura, Y.1    Hirooka, Y.2    Sagara, Y.3
  • 79
    • 14644445184 scopus 로고    scopus 로고
    • Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat
    • Kumar U, Chen J, Sapoznikhov V, Canteros G, White BH, Sidhu A. Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat. Clin Exp Hypertens 2005; 27: 17-31.
    • (2005) Clin Exp Hypertens , vol.27 , pp. 17-31
    • Kumar, U.1    Chen, J.2    Sapoznikhov, V.3    Canteros, G.4    White, B.H.5    Sidhu, A.6
  • 80
    • 0034889199 scopus 로고    scopus 로고
    • Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats
    • Ma XL, Gao F, Nelson AH, et al. Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats. J Pharmacol Exp Ther 2001; 298: 879-85.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 879-885
    • Ma, X.L.1    Gao, F.2    Nelson, A.H.3
  • 82
    • 0242608651 scopus 로고    scopus 로고
    • Ramipril improves nitric oxide availability in hypertensive rats with failing hearts after myocardial infarction
    • Linz W, Itter G, Dobrucki LW, Malinski T, Wiemer G. Ramipril improves nitric oxide availability in hypertensive rats with failing hearts after myocardial infarction. J Renin Angiotensin Aldosterone Syst 2003; 4: 180-5.
    • (2003) J Renin Angiotensin Aldosterone Syst , vol.4 , pp. 180-185
    • Linz, W.1    Itter, G.2    Dobrucki, L.W.3    Malinski, T.4    Wiemer, G.5
  • 83
    • 33646844625 scopus 로고    scopus 로고
    • Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats
    • Suzuki A, Yamamoto N, Jokura H, et al. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens 2006; 24: 1065-73.
    • (2006) J Hypertens , vol.24 , pp. 1065-1073
    • Suzuki, A.1    Yamamoto, N.2    Jokura, H.3
  • 84
    • 78650894319 scopus 로고    scopus 로고
    • Crosstalk of reactive oxygen species and NFkappaB signaling
    • Morgan MJ, Liu ZG. Crosstalk of reactive oxygen species and NFkappaB signaling. Cell Res 2011; 21: 103-15.
    • (2011) Cell Res , vol.21 , pp. 103-115
    • Morgan, M.J.1    Liu, Z.G.2
  • 85
    • 21644464007 scopus 로고    scopus 로고
    • Oxidative-nitrosative stress in hypertension
    • Escobales N, Crespo MJ. Oxidative-nitrosative stress in hypertension. Curr Vasc Pharmacol 2005; 3: 231-46.
    • (2005) Curr Vasc Pharmacol , vol.3 , pp. 231-246
    • Escobales, N.1    Crespo, M.J.2
  • 86
    • 33644631485 scopus 로고    scopus 로고
    • Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol
    • Pacher P, Nivorozhkin A, Szabo C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 2006; 58: 87-114.
    • (2006) Pharmacol Rev , vol.58 , pp. 87-114
    • Pacher, P.1    Nivorozhkin, A.2    Szabo, C.3
  • 87
  • 88
    • 22444433668 scopus 로고    scopus 로고
    • Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH
    • Wolin MS, Ahmad M, Gupte SA. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am J Physiol Lung Cell Mol Physiol 2005; 289: L159-73.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289 , pp. 159-173
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 89
    • 17744377431 scopus 로고    scopus 로고
    • The sources of oxidative stress in the vessel wall
    • Wolin MS, Ahmad M, Gupte SA. The sources of oxidative stress in the vessel wall. Kidney Int 2005; 67: 1659-61.
    • (2005) Kidney Int , vol.67 , pp. 1659-1661
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 90
    • 18044388568 scopus 로고    scopus 로고
    • Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SODdeficient mice
    • Yan C, Huang A, Wu Z, et al. Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SODdeficient mice. Am J Physiol Heart Circ Physiol 2005; 288: H2225-31.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , pp. 2225-2231
    • Yan, C.1    Huang, A.2    Wu, Z.3
  • 91
    • 3142616781 scopus 로고    scopus 로고
    • Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII
    • Cai H, McNally JS, Weber M, Harrison DG. Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. J Mol Cell Cardiol 2004; 37: 121-5.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 121-125
    • Cai, H.1    McNally, J.S.2    Weber, M.3    Harrison, D.G.4
  • 92
    • 84862278910 scopus 로고    scopus 로고
    • Aldosterone, oxidative stress, and NFkappaB activation in hypertension-related cardiovascular and renal diseases
    • Queisser N, Schupp N. Aldosterone, oxidative stress, and NFkappaB activation in hypertension-related cardiovascular and renal diseases. Free Radic Biol Med 2012; 53: 314-27.
    • (2012) Free Radic Biol Med , vol.53 , pp. 314-327
    • Queisser, N.1    Schupp, N.2
  • 93
    • 2542455472 scopus 로고    scopus 로고
    • iNOS-mediated nitric oxide production and its regulation
    • Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci 2004; 75: 639-53.
    • (2004) Life Sci , vol.75 , pp. 639-653
    • Aktan, F.1
  • 94
    • 67649649657 scopus 로고    scopus 로고
    • Functional single nucleotide polymorphism-1026C/A of inducible nitric oxide synthase gene with increased YY1-binding affinity is associated with hypertension in a Chinese Han population
    • Fu L, Zhao Y, Lu J, et al. Functional single nucleotide polymorphism-1026C/A of inducible nitric oxide synthase gene with increased YY1-binding affinity is associated with hypertension in a Chinese Han population. J Hypertens 2009; 27(5): 991-1000.
    • (2009) J Hypertens , vol.27 , Issue.5 , pp. 991-1000
    • Fu, L.1    Zhao, Y.2    Lu, J.3
  • 95
    • 77953539737 scopus 로고    scopus 로고
    • Identification of Yin Yang 1-interacting partners at-1026C/A in the human iNOS promoter
    • Li W, Liu H, Fu L, Li D, Zhao Y. Identification of Yin Yang 1-interacting partners at-1026C/A in the human iNOS promoter. Arch Biochem Biophys 2010; 498: 119-26.
    • (2010) Arch Biochem Biophys , vol.498 , pp. 119-126
    • Li, W.1    Liu, H.2    Fu, L.3    Li, D.4    Zhao, Y.5
  • 96
    • 0032456059 scopus 로고    scopus 로고
    • Analytical methods for 3-nitrotyrosine as a marker of exposure to reactive nitrogen species: A review
    • Herce-Pagliai C, Kotecha S, Shuker DE. Analytical methods for 3-nitrotyrosine as a marker of exposure to reactive nitrogen species: a review. Nitric Oxide 1998; 2: 324-36.
    • (1998) Nitric Oxide , vol.2 , pp. 324-336
    • Herce-Pagliai, C.1    Kotecha, S.2    Shuker, D.E.3
  • 97
    • 0344643456 scopus 로고    scopus 로고
    • Peroxynitrite-induced cytotoxicity: Mechanism and opportunities for intervention
    • Virag L, Szabo E, Gergely P, Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 2003; 140-141: 113-24.
    • (2003) Toxicol Lett , vol.140-141 , pp. 113-124
    • Virag, L.1    Szabo, E.2    Gergely, P.3    Szabo, C.4
  • 98
    • 0036628344 scopus 로고    scopus 로고
    • Superoxide, superoxide dismutase and ischemic injury
    • Salvemini D, Cuzzocrea S. Superoxide, superoxide dismutase and ischemic injury. Curr Opin Investig Drugs 2002; 3: 886-95.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 886-895
    • Salvemini, D.1    Cuzzocrea, S.2
  • 99
    • 19544392527 scopus 로고    scopus 로고
    • Nitrosative stress and pharmacological modulation of heart failure
    • Pacher P, Schulz R, Liaudet L, Szabo C. Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci 2005; 26: 302-10.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 302-310
    • Pacher, P.1    Schulz, R.2    Liaudet, L.3    Szabo, C.4
  • 101
    • 0031786851 scopus 로고    scopus 로고
    • Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension
    • Cardillo C, Panza JA. Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension. Vasc Med 1998; 3: 138-44.
    • (1998) Vasc Med , vol.3 , pp. 138-144
    • Cardillo, C.1    Panza, J.A.2
  • 102
    • 84856103582 scopus 로고    scopus 로고
    • Vascular remodeling in hypertension: Mechanisms and treatment
    • Schiffrin EL. Vascular remodeling in hypertension: mechanisms and treatment. Hypertension 2012; 59: 367-74.
    • (2012) Hypertension , vol.59 , pp. 367-374
    • Schiffrin, E.L.1
  • 103
    • 0036812534 scopus 로고    scopus 로고
    • Peroxynitrite in myocardial ischemia-reperfusion injury
    • Lalu MM, Wang W, Schulz R. Peroxynitrite in myocardial ischemia-reperfusion injury. Heart Fail Rev 2002; 7: 359-69.
    • (2002) Heart Fail Rev , vol.7 , pp. 359-369
    • Lalu, M.M.1    Wang, W.2    Schulz, R.3
  • 104
    • 0035800858 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinases by peroxynitriteinduced protein S-glutathiolation via disulfide S-oxide formation
    • Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H. Activation of matrix metalloproteinases by peroxynitriteinduced protein S-glutathiolation via disulfide S-oxide formation. J Biol Chem 2001; 276: 29596-602.
    • (2001) J Biol Chem , vol.276 , pp. 29596-29602
    • Okamoto, T.1    Akaike, T.2    Sawa, T.3    Miyamoto, Y.4    van der Vliet, A.5    Maeda, H.6
  • 105
    • 84857656374 scopus 로고    scopus 로고
    • Circulating matrix metalloproteinases and their inhibitors in hypertension
    • Fontana V, Silva PS, Gerlach RF, Tanus-Santos JE. Circulating matrix metalloproteinases and their inhibitors in hypertension. Clin Chim Acta 2012; 413: 656-62.
    • (2012) Clin Chim Acta , vol.413 , pp. 656-662
    • Fontana, V.1    Silva, P.S.2    Gerlach, R.F.3    Tanus-Santos, J.E.4
  • 106
    • 70350117109 scopus 로고    scopus 로고
    • Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
    • Kim JH, Bugaj LJ, Oh YJ, et al. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol 2009; 107: 1249-57.
    • (2009) J Appl Physiol , vol.107 , pp. 1249-1257
    • Kim, J.H.1    Bugaj, L.J.2    Oh, Y.J.3
  • 107
    • 24944547366 scopus 로고    scopus 로고
    • Crystal structure of human arginase I at 1. 29-A resolution and exploration of inhibition in the immune response
    • Di Costanzo L, Sabio G, Mora A, et al. Crystal structure of human arginase I at 1. 29-A resolution and exploration of inhibition in the immune response. Proc Natl Acad Sci USA 2005; 102: 13058-63.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13058-13063
    • Di Costanzo, L.1    Sabio, G.2    Mora, A.3
  • 108
    • 0028902552 scopus 로고
    • Nitric oxide synthases: Properties and catalytic mechanism
    • Griffith OW, Stuehr DJ. Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol 1995; 57: 707-36.
    • (1995) Annu Rev Physiol , vol.57 , pp. 707-736
    • Griffith, O.W.1    Stuehr, D.J.2
  • 109
    • 80051552037 scopus 로고    scopus 로고
    • Snitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
    • Dunn J, Gutbrod S, Webb A, Pak A, Jandu SK, Bhunia A, et al. Snitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase. Mol Cell Biochem. 2011; 355: 83-9.
    • (2011) Mol Cell Biochem , vol.355 , pp. 83-89
    • Dunn, J.1    Gutbrod, S.2    Webb, A.3    Pak, A.4    Jandu, S.K.5    Bhunia, A.6
  • 110
    • 34848861137 scopus 로고    scopus 로고
    • Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction
    • Santhanam L, Lim HK, Miriel V, et al. Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Circ Res 2007; 101: 692-702.
    • (2007) Circ Res , vol.101 , pp. 692-702
    • Santhanam, L.1    Lim, H.K.2    Miriel, V.3
  • 111
    • 77954812507 scopus 로고    scopus 로고
    • Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension
    • Bagnost T, Ma L, da Silva RF, et al. Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. Cardiovasc Res 2010; 87: 569-77.
    • (2010) Cardiovasc Res , vol.87 , pp. 569-577
    • Bagnost, T.1    Ma, L.2    da Silva, R.F.3
  • 112
    • 18344378606 scopus 로고    scopus 로고
    • Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats
    • Demougeot C, Prigent-Tessier A, Marie C, Berthelot A. Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. J Hypertens 2005; 23: 971-8.
    • (2005) J Hypertens , vol.23 , pp. 971-978
    • Demougeot, C.1    Prigent-Tessier, A.2    Marie, C.3    Berthelot, A.4
  • 113
    • 9644282852 scopus 로고    scopus 로고
    • Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles
    • Zhang C, Hein TW, Wang W, et al. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension 2004; 44: 935-43.
    • (2004) Hypertension , vol.44 , pp. 935-943
    • Zhang, C.1    Hein, T.W.2    Wang, W.3
  • 114
    • 31944449184 scopus 로고    scopus 로고
    • Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension
    • Sun Y, Carretero OA, Xu J, et al. Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension. Hypertension 2005; 46: 1355-61.
    • (2005) Hypertension , vol.46 , pp. 1355-1361
    • Sun, Y.1    Carretero, O.A.2    Xu, J.3
  • 115
    • 58149401216 scopus 로고    scopus 로고
    • Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension
    • Sun Y, Carretero OA, Xu J, Rhaleb NE, Yang JJ, Pagano PJ, et al. Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension. Hypertension 2009; 53: 49-56.
    • (2009) Hypertension , vol.53 , pp. 49-56
    • Sun, Y.1    Carretero, O.A.2    Xu, J.3    Rhaleb, N.E.4    Yang, J.J.5    Pagano, P.J.6
  • 116
    • 77954525347 scopus 로고    scopus 로고
    • Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension
    • Dias FA, Urboniene D, Yuzhakova MA, et al. Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension. Front Biosci (Elite Ed) 2010; 2: 312-24.
    • (2010) Front Biosci (Elite Ed) , vol.2 , pp. 312-324
    • Dias, F.A.1    Urboniene, D.2    Yuzhakova, M.A.3
  • 118
    • 0027161713 scopus 로고
    • Role of endothelium-derived nitric oxide in the abnormal endotheliumdependent vascular relaxation of patients with essential hypertension
    • Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endotheliumdependent vascular relaxation of patients with essential hypertension. Circulation 1993; 87: 1468-74.
    • (1993) Circulation , vol.87 , pp. 1468-1474
    • Panza, J.A.1    Casino, P.R.2    Kilcoyne, C.M.3    Quyyumi, A.A.4
  • 119
    • 0032499667 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension
    • Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998; 97: 2222-9.
    • (1998) Circulation , vol.97 , pp. 2222-2229
    • Taddei, S.1    Virdis, A.2    Ghiadoni, L.3    Magagna, A.4    Salvetti, A.5
  • 122
    • 0024428094 scopus 로고
    • Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
    • Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; 2: 997-1000.
    • (1989) Lancet , vol.2 , pp. 997-1000
    • Vallance, P.1    Collier, J.2    Moncada, S.3
  • 123
    • 85027923032 scopus 로고    scopus 로고
    • Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans
    • Smith CJ, Santhanam L, Bruning RS, Stanhewicz A, Berkowitz DE, Holowatz LA. Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension 2011; 58: 935-42.
    • (2011) Hypertension , vol.58 , pp. 935-942
    • Smith, C.J.1    Santhanam, L.2    Bruning, R.S.3    Stanhewicz, A.4    Berkowitz, D.E.5    Holowatz, L.A.6
  • 124
    • 1642414294 scopus 로고    scopus 로고
    • Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine
    • Escames G, Khaldy H, Leon J, Gonzalez L, Acuna-Castroviejo D. Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine. J Hypertens 2004; 22: 629-35.
    • (2004) J Hypertens , vol.22 , pp. 629-635
    • Escames, G.1    Khaldy, H.2    Leon, J.3    Gonzalez, L.4    Acuna-Castroviejo, D.5
  • 125
    • 0032916426 scopus 로고    scopus 로고
    • Different frequencies of inducible nitric oxide synthase genotypes in older hypertensives
    • Glenn CL, Wang WY, Morris BJ. Different frequencies of inducible nitric oxide synthase genotypes in older hypertensives. Hypertension 1999; 33: 927-32.
    • (1999) Hypertension , vol.33 , pp. 927-932
    • Glenn, C.L.1    Wang, W.Y.2    Morris, B.J.3
  • 126
    • 3042750272 scopus 로고    scopus 로고
    • Candidate genes, association studies and haplotype analysis in the search for the genetic basis of hypertension
    • Yagil Y, Yagil C. Candidate genes, association studies and haplotype analysis in the search for the genetic basis of hypertension. J Hypertens 2004; 22: 1255-8.
    • (2004) J Hypertens , vol.22 , pp. 1255-1258
    • Yagil, Y.1    Yagil, C.2
  • 127
    • 33646169337 scopus 로고    scopus 로고
    • Selective inhibitors of inducible nitric oxide synthase: Potential agents for the treatment of inflammatory diseases?
    • Tinker AC, Wallace AV. Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? Curr Top Med Chem 2006; 6: 77-92.
    • (2006) Curr Top Med Chem , vol.6 , pp. 77-92
    • Tinker, A.C.1    Wallace, A.V.2
  • 128
    • 78649945686 scopus 로고    scopus 로고
    • Polyphenol-containing azuki bean (Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats
    • Mukai Y, Sato S. Polyphenol-containing azuki bean (Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats. J Nutr Biochem 2011; 22: 16-21.
    • (2011) J Nutr Biochem , vol.22 , pp. 16-21
    • Mukai, Y.1    Sato, S.2
  • 129
    • 84873342210 scopus 로고    scopus 로고
    • Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats
    • Sharma B, Singh N. Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats. Pharmacol Biochem Behav 2013; 103: 821-30.
    • (2013) Pharmacol Biochem Behav , vol.103 , pp. 821-830
    • Sharma, B.1    Singh, N.2
  • 130
    • 35248815939 scopus 로고    scopus 로고
    • Aminoguanidine produces beneficial haemodynamic effects in a canine model of acute pulmonary thromboembolism
    • Dias-Junior CA, Sertorio JT, Tanus-Santos JE. Aminoguanidine produces beneficial haemodynamic effects in a canine model of acute pulmonary thromboembolism. Acta Physiol (Oxf) 2007; 191: 189-96.
    • (2007) Acta Physiol (Oxf) , vol.191 , pp. 189-196
    • Dias-Junior, C.A.1    Sertorio, J.T.2    Tanus-Santos, J.E.3
  • 131
    • 11144328891 scopus 로고    scopus 로고
    • The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats
    • Cheng PY, Chen JJ, Yen MH. The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. Am J Hypertens 2004; 17: 1127-34.
    • (2004) Am J Hypertens , vol.17 , pp. 1127-1134
    • Cheng, P.Y.1    Chen, J.J.2    Yen, M.H.3
  • 132
    • 84871960610 scopus 로고    scopus 로고
    • Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: The role of nitric oxide
    • Huang CF, Hsu CN, Chien SJ, Lin YJ, Huang LT, Tain YL. Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide. Eur J Pharmacol 2013; 699: 233-40.
    • (2013) Eur J Pharmacol , vol.699 , pp. 233-240
    • Huang, C.F.1    Hsu, C.N.2    Chien, S.J.3    Lin, Y.J.4    Huang, L.T.5    Tain, Y.L.6
  • 133
    • 84866548746 scopus 로고    scopus 로고
    • Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats
    • Mukohda M, Okada M, Hara Y, Yamawaki H. Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats. J Pharmacol Sci 2012; 120: 26-35.
    • (2012) J Pharmacol Sci , vol.120 , pp. 26-35
    • Mukohda, M.1    Okada, M.2    Hara, Y.3    Yamawaki, H.4
  • 134
    • 33749326981 scopus 로고    scopus 로고
    • Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats
    • Chan V, Hoey A, Brown L. Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats. Br J Pharmacol 2006; 148: 902-8.
    • (2006) Br J Pharmacol , vol.148 , pp. 902-908
    • Chan, V.1    Hoey, A.2    Brown, L.3
  • 135
    • 34248645698 scopus 로고    scopus 로고
    • Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: Role of methylglyoxal
    • Wang X, Chang T, Jiang B, Desai K, Wu L. Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal. Am J Hypertens 2007; 20: 629-36.
    • (2007) Am J Hypertens , vol.20 , pp. 629-636
    • Wang, X.1    Chang, T.2    Jiang, B.3    Desai, K.4    Wu, L.5
  • 136
    • 18544407925 scopus 로고    scopus 로고
    • Vasoactive systems in L-NAME hypertension: The role of inducible nitric oxide synthase
    • Pechanova O, Dobesova Z, Cejka J, Kunes J, Zicha J. Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase. J Hypertens 2004; 22: 167-73.
    • (2004) J Hypertens , vol.22 , pp. 167-173
    • Pechanova, O.1    Dobesova, Z.2    Cejka, J.3    Kunes, J.4    Zicha, J.5
  • 138
  • 139
    • 0028828569 scopus 로고
    • Aminoguanidine-provoked leukocyte adherence to rat mesenteric venules: Role of constitutive nitric oxide synthase inhibition
    • Lopez-Belmonte J, Whittle BJ. Aminoguanidine-provoked leukocyte adherence to rat mesenteric venules: role of constitutive nitric oxide synthase inhibition. Br J Pharmacol 1995; 116: 2710-4.
    • (1995) Br J Pharmacol , vol.116 , pp. 2710-2714
    • Lopez-Belmonte, J.1    Whittle, B.J.2
  • 140
    • 0026766944 scopus 로고
    • Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine
    • Ohrui T, Yamauchi K, Sekizawa K, Ohkawara Y, Maeyama K, Sasaki M, et al. Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine. J Pharmacol Exp Ther 1992; 261: 1268-72.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 1268-1272
    • Ohrui, T.1    Yamauchi, K.2    Sekizawa, K.3    Ohkawara, Y.4    Maeyama, K.5    Sasaki, M.6
  • 141
    • 0032831472 scopus 로고    scopus 로고
    • Salt-induced hypertension in Dahl salt-resistant and saltsensitive rats with NOS II inhibition
    • Rudd MA, Trolliet M, Hope S, Scribner AW, Daumerie G, Toolan G, et al. Salt-induced hypertension in Dahl salt-resistant and saltsensitive rats with NOS II inhibition. Am J Physiol 1999; 277: H732-9.
    • (1999) Am J Physiol , vol.277 , pp. 732-739
    • Rudd, M.A.1    Trolliet, M.2    Hope, S.3    Scribner, A.W.4    Daumerie, G.5    Toolan, G.6
  • 145
    • 80054977120 scopus 로고    scopus 로고
    • XJP-1, a novel ACEI, with anti-inflammatory properties in HUVECs
    • Fu R, Chen Z, Wang Q, Guo Q, Xu J, Wu X. XJP-1, a novel ACEI, with anti-inflammatory properties in HUVECs. Atherosclerosis 2011; 219: 40-8.
    • (2011) Atherosclerosis , vol.219 , pp. 40-48
    • Fu, R.1    Chen, Z.2    Wang, Q.3    Guo, Q.4    Xu, J.5    Wu, X.6
  • 146
    • 68649104444 scopus 로고    scopus 로고
    • Palmatine from Coptidis rhizoma reduces ischemia-reperfusionmediated acute myocardial injury in the rat
    • Kim YM, Ha YM, Jin YC, Shi LY, Lee YS, Kim HJ, et al. Palmatine from Coptidis rhizoma reduces ischemia-reperfusionmediated acute myocardial injury in the rat. Food Chem Toxicol 2009; 47: 2097-102.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2097-2102
    • Kim, Y.M.1    Ha, Y.M.2    Jin, Y.C.3    Shi, L.Y.4    Lee, Y.S.5    Kim, H.J.6
  • 147
    • 61349085601 scopus 로고    scopus 로고
    • Total synthesis and antihypertensive activity of (+/-)7, 8-dihydroxy-3-methylisochromanone-4
    • Liu J, Ren H, Xu J, Bai R, Yan Q, Huang W, et al. Total synthesis and antihypertensive activity of (+/-)7, 8-dihydroxy-3-methylisochromanone-4. Bioorg Med Chem Lett 2009; 19: 1822-4.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 1822-1824
    • Liu, J.1    Ren, H.2    Xu, J.3    Bai, R.4    Yan, Q.5    Huang, W.6
  • 148
    • 0032758164 scopus 로고    scopus 로고
    • The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats
    • Liu JC, Chan P, Chen YJ, Tomlinson B, Hong SH, Cheng JT. The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats. Pharmacology 1999; 59: 283-9.
    • (1999) Pharmacology , vol.59 , pp. 283-289
    • Liu, J.C.1    Chan, P.2    Chen, Y.J.3    Tomlinson, B.4    Hong, S.H.5    Cheng, J.T.6
  • 151
    • 67649398797 scopus 로고    scopus 로고
    • Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway
    • Li XQ, Cao W, Li T, et al. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol 2009; 9: 1032-41.
    • (2009) Int Immunopharmacol , vol.9 , pp. 1032-1041
    • Li, X.Q.1    Cao, W.2    Li, T.3
  • 152
    • 3042783090 scopus 로고    scopus 로고
    • Cardiac angiotensin II participates in coronary microvessel inflammation of unstable angina and strengthens the immunomediated component
    • Neri Serneri GG, Boddi M, Modesti PA, et al. Cardiac angiotensin II participates in coronary microvessel inflammation of unstable angina and strengthens the immunomediated component. Circ Res 2004; 94: 1630-7.
    • (2004) Circ Res , vol.94 , pp. 1630-1637
    • Neri Serneri, G.G.1    Boddi, M.2    Modesti, P.A.3
  • 154
    • 84875495558 scopus 로고    scopus 로고
    • Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation
    • Ryu S, Shin JS, Cho YW, et al. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation. Biol Pharm Bull 2013; 36: 467-74.
    • (2013) Biol Pharm Bull , vol.36 , pp. 467-474
    • Ryu, S.1    Shin, J.S.2    Cho, Y.W.3
  • 155
    • 34147183822 scopus 로고    scopus 로고
    • In vitro effect of carvedilol on professional phagocytes
    • Pecivova J, Macickova T, Lojek A, et al. In vitro effect of carvedilol on professional phagocytes. Pharmacology 2007; 79: 86-92.
    • (2007) Pharmacology , vol.79 , pp. 86-92
    • Pecivova, J.1    Macickova, T.2    Lojek, A.3
  • 156
    • 84858072791 scopus 로고    scopus 로고
    • Nebivolol regulates eNOS and iNOS expressions and alleviates oxidative stress in cerebral ischemia/reperfusion injury in rats
    • Heeba GH, El-Hanafy AA. Nebivolol regulates eNOS and iNOS expressions and alleviates oxidative stress in cerebral ischemia/reperfusion injury in rats. Life Sci 2012; 90: 388-95.
    • (2012) Life Sci , vol.90 , pp. 388-395
    • Heeba, G.H.1    El-Hanafy, A.A.2
  • 157
    • 84863990529 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase haplotype associated with migraine and aura
    • de OSMT, Goncalves FM, Martins-Oliveira A, et al. Inducible nitric oxide synthase haplotype associated with migraine and aura. Mol Cell Biochem 2012; 364: 303-8.
    • (2012) Mol Cell Biochem , vol.364 , pp. 303-308
    • de, O.S.M.T.1    Goncalves, F.M.2    Martins-Oliveira, A.3


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