Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism

Atherosclerosis

Volumn 187, Issue 2, 2006, Pages 316-324

  Hayashi, Toshio ^a   Matsui Hirai, Hisako ^a   Fukatsu, Akiko ^a   Sumi, Daigo ^a   Kano Hayashi, Hatsuyo ^a   Rani P, Juliet Arockia ^a   Iguchi, Akihisa ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Atherosclerosis; Inducible nitric oxide synthase; Nitric oxide

Indexed keywords

7 CHLORO 3 IMINO 5 METHYL 2 AZABICYCLO[4.1.0]HEPTANE; ACETYLCHOLINE; AMINOGUANIDINE; ARGININE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIATHEROSCLEROTIC ACTIVITY; ARTERY DILATATION; ARTICLE; ATHEROGENIC DIET; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; HEART PROTECTION; HYPERCHOLESTEROLEMIA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; UPREGULATION;

AMIDINES; ANIMALS; AORTA, THORACIC; ARGININE; ATHEROSCLEROSIS; BLOTTING, WESTERN; CHOLESTEROL, DIETARY; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 2-RING; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RABBITS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; UP-REGULATION; VASODILATION;

EID: 33745503461     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.10.023     Document Type: Article

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