Role of NADPH oxidase and iNOS in vasoconstrictor responses of vessels from hypertensive and normotensive rats

British Journal of Pharmacology

Volumn 153, Issue 5, 2008, Pages 926-935

  Alvarez Y ^a   Briones, A M ^a   Hernanz, R ^b   Perez Giron J V ^b   Alonso, M J ^a,b   Salaices, M ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

Aorta; Hypertension; iNOS; NAD(P)H oxidase; Superoxide anion

Indexed keywords

APOCYNIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SEROTONIN; SUPEROXIDE;

ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASOCONSTRICTION;

EID: 40149097151     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707575     Document Type: Article

References (53)

1. Alonso MJ, Rodríguez‐Martínez MA, Martínez‐Orgado J, Marín J, Salaices M (1998). The L‐arginine inhibition of rat middle cerebral artery contractile responses is mediated by inducible nitric oxide synthase. J Auton Pharmacol 18: 105–113.
2. Álvarez Y, Briones AM, Balfagón G, Alonso MJ, Salaices M (2005). Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase‐2 in phenylephrine responses. J Hypertens 23: 767–777.
3. Álvarez Y, Pérez‐Girón JV, Hernanz R, Briones AM, García‐Redondo A, Beltrán A et al. (2007). Losartan reduces the increased participation of COX‐2 derived products in vascular responses of hypertensive rats. J Pharmacol Exp Ther 321: 381–388.
4. Ardanaz N, Pagano PJ (2006). Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction. Exp Biol Med (Maywood) 231: 237–251.
5. Bouloumie A, Bauersachs J, Linz W, Scholkens BA, Wiemer G, Fleming I et al. (1997). Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension 30: 934–941.
6. Briones AM, Alonso MJ, Hernanz R, Miguel M, Salaices M (2002a). Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats. J Cardiovasc Pharmacol 39: 378–388.
7. Briones AM, Alonso MJ, Hernanz R, Tovar S, Vila E, Salaices M (2002b). Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries. Life Sci 71: 1997–2014.
8. Briones AM, Alonso MJ, Marín J, Balfagón G, Salaices M (2000). Influence of hypertension on nitric oxide synthase expression and vascular effects of lipopolysaccharide in rat mesenteric arteries. Br J Pharmacol 131: 185–194.
9. Briones AM, Salaices M, Vila E (2005). Ageing alters the production of nitric oxide and prostanoids after IL‐1β exposure in mesenteric resistance arteries. Mech Ageing Dev 126: 710–721.
10. Cai H, Harrison DG (2000). Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840–844.
11. Chamseddine AH, Miller Jr FJ (2003). Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. Am J Physiol Heart Circ Physiol 285: H2284–H2289.
12. Chou TC, Yen MH, Li CY, Ding YA (1998). Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 31: 643–648.
13. Cruzado MC, Risler NR, Miatello RM, Yao G, Schiffrin EL, Touyz RM (2005). Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: effect of angiotensin II and role of insulin like growth factor‐1 receptor transactivation. Am J Hypertens 18: 81–87.
14. Feletou M, Vanhoutte PM (2006). Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 291: H985–H1002.
15. Ghosh M, Wang HD, McNeill JR (2004). Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA‐salt hypertensive rats. Br J Pharmacol 141: 562–573.
16. Girouard H, de Champlain J (2004). Inhibitory effect of melatonin on alpha1‐adrenergic‐induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. Am J Hypertens 17: 339–346.
17. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW (1994). Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141–1148.
18. Griendling KK, Sorescu D, Ushio‐Fukai M (2000). NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86: 494–501.
19. Hernanz R, Alonso MJ, Briones AM, Vila E, Simonsen U, Salaices M (2003). Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries. Br J Pharmacol 140: 671–680.
20. Hernanz R, Alonso MJ, Zibrandtsen H, Álvarez Y, Salaices M, Simonsen U (2004). Measurements of nitric oxide concentration and hyporeactivity in rat superior mesenteric artery exposed to endotoxin. Cardiovasc Res 62: 202–211.
21. Hong HJ, Loh SH, Yen MH (2000). Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase. Br J Pharmacol 131: 631–637.
22. Jiménez‐Altayó F, Briones AM, Giraldo J, Planas AM, Salaices M, Vila E (2006). Increased superoxide anion production by interleukin‐1β impairs nitric oxide‐mediated relaxation in resistance arteries. J Pharmacol Exp Ther 316: 42–52.
23. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA (1999). Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 33: 1353–1358.
24. Kimura Y, Hirooka Y, Sagara Y, Ito K, Kishi T, Shimokawa H et al. (2005). Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circ Res 96: 252–260.
25. Lassegue B, Griendling KK (2004). Reactive oxygen species in hypertension; an update. Am J Hypertens 17: 852–860.
26. Li H, Witte K, August M, Brausch I, Godtel‐Armbrust U, Habermeier A et al. (2006). Reversal of endothelial nitric oxide synthase uncoupling and up‐regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 47: 2536–2544.
27. Livak KJ, Schmittgen TD (2001). Analysis of relative gene expression data using real‐time quantitative PCR and the 2 −ΔΔCt method. Methods 25: 402–408.
28. Lodi F, Cogolludo A, Duarte J, Moreno L, Coviello A, Peral De Bruno M et al. (2006). Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats. Eur J Pharmacol 21: 97–103.
29. Marín J (1993). Mechanisms involved in the increased vascular resistance in hypertension. J Auton Pharmacol 13: 127–176.
30. Marín J, Rodríguez‐Martínez MA (1997). Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol Ther 75: 111–134.
31. Mattei P, Virdis A, Ghiadoni L, Taddei S, Salvetti A (1997). Endothelial function in hypertension. J Nephrol 10: 192–197.
32. McIntyre M, Bohr DF, Dominiczak AF (1999). Endothelial function in hypertension: the role of superoxide anion. Hypertension 34: 539–545.
33. Miyagawa K, Ohashi M, Yamashita S, Kojima M, Sato K, Ueda R et al. (2007). Increased oxidative stress impairs endothelial modulation of contractions in arteries from spontaneously hypertensive rats. J Hypertens 25: 415–421.
34. Mohazzab KM, Kaminski PM, Wolin MS (1994). NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol 266: H2568–H2572.
35. O'Brien AJ, Wilson AJ, Sibbald R, Singer M, Clapp LH (2001). Temporal variation in endotoxin‐induced vascular hyporeactivity in a rat mesenteric artery organ culture model. Br J Pharmacol 133: 351–360.
36. Paravicini TM, Touyz RM (2006). Redox signaling in hypertension. Cardiovasc Res 71: 247–258.
37. Püntmann VO, Hussain MB, Mayr M, Xu Q, Singer DR (2005). Role of oxidative stress in angiotensin‐II mediated contraction of human conduit arteries in patients with cardiovascular disease. Vasc Pharmacol 43: 277–282.
38. Rees DD, Cellek S, Palmer RM, Moncada S (1990). Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem Biophys Res Commun 173: 541–547.
39. Savoia C, Schiffrin EL (2006). Inflammation in hypertension. Curr Opin Nephrol Hypertens 15: 152–158.
40. Shen JZ, Zheng XF, Kwan CY (2000). Differential contractile actions of reactive oxygen species on rat aorta: selective activation of ATP receptor by H 2 O 2. Life Sci 14: PL291–PL296.
41. Souza HP, Laurindo FR, Ziegelstein RC, Berlowitz CO, Zweier JL (2001). Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control. Am J Physiol Heart Circ Physiol 280: H658–H667.
42. Srivastava P, Hegde LG, Patnaik GK, Dikshit M (1998). Role of endothelial‐derived reactive oxygen species and nitric oxide in norepinephrine‐induced rat aortic ring contractions. Pharmacol Res 38: 265–274.
43. Srivastava P, Rajanikanth M, Raghavan SA, Dikshit M (2002). Role of endogenous reactive oxygen derived species and cyclooxygenase mediators in 5‐hydroxytryptamine‐induced contractions in rat aorta: relationship to nitric oxide. Pharmacol Res 45: 375–382.
44. Sun Y, Carretero OA, Xu J, Rhaleb NE, Wang F, Lin C et al. (2005). Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate‐salt hypertension. Hypertension 46: 1355–1361.
45. Thakali K, Demel SL, Fink GD, Watts SW (2005). Endothelin‐1‐induced contraction in veins is independent of hydrogen peroxide. Am J Physiol Heart Circ Physiol 289: H1115–H1122.
46. Touyz RM (2004). Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance Hypertension 44: 248–252.
47. Vaziri ND, Ni Z (2005). Expression of NOX‐I, gp91phox, p47phox and P67phox in the aorta segments above and below coarctation. Biochim Biophys Acta 25: 321–327.
48. Vaziri ND, Ni Z, Oveisi F (1998). Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 31: 1248–1254.
49. Vaziri ND, Rodríguez‐Iturbe B (2006). Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2: 582–593.
50. Vo PA, Lad B, Tomlinson JA, Francis S, Ahluwalia A (2005). Autoregulatory role of endothelium‐derived nitric oxide (NO) on lipopolysaccharide‐induced vascular inducible NO synthase expression and function. J Biol Chem 280: 7236–7243.
51. Wu CC, Hong HJ, Chou TZ, Ding YA, Yen MH (1996). Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats. Biochem Biophys Res Commun 228: 459–466.
52. Zalba G, Beaumont FJ, San José G, Fortuño A, Fortuño MA, Díez J (2001). Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction Nephrol Dial Transplant 16: 2–5.
53. Zhang H, Du Y, Cohen RA, Chobanian A, Brecher P (1999). Adventitia as a source of inducible nitric oxide synthase in the rat aorta. Am J Hypertens 12: 467–475.