Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway

International Immunopharmacology

Volumn 9, Issue 9, 2009, Pages 1032-1041

  Li, Xiao Qiang ^a   Cao, Wei ^a   Li, Tao ^b   Zeng, Ai Guo ^b   Hao, Li Li ^a   Zhang, Xiao Nan ^a   Mei, Qi Bing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Amlodipine; Cardiomyocyte; Inducible nitric oxide synthase (iNOS); Phosphatidylinositiol 3 kinase (PI3K); Tumor necrosis factor (TNF )

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMLODIPINE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG BLOOD LEVEL; DRUG MECHANISM; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; HEART DISEASE; HEART MUSCLE CELL; HEART PROTECTION; HEART RATE; HISTOLOGY; INFLAMMATION; MALE; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SEPSIS; THERAPY EFFECT; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMLODIPINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEART DISEASES; LIPOPOLYSACCHARIDES; MALE; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE II; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649398797     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.04.010     Document Type: Article

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