메뉴 건너뛰기




Volumn 273, Issue 6 36-6, 1997, Pages

Dexamethasone suppresses iNOS gene expression by upregulating I-κBα and inhibiting NF-κB

Author keywords

Gene regulation; Glucocorticoids; Inducible nitric oxide synthase; Interferon ; Interleukin 1 ; Nuclear factor B; Tumor necrosis

Indexed keywords

CYTOKINE; DEXAMETHASONE; DNA; GAMMA INTERFERON; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LUCIFERASE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0031416497     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.6.g1290     Document Type: Article
Times cited : (113)

References (14)
  • 1
    • 0028102802 scopus 로고
    • Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells
    • Asano, K., C. B. Chee, B. Gaston, C. M. Lilly, C. Gerard, J. M. Drazen, and J. S. Stamler. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91: 10089-10093, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10089-10093
    • Asano, K.1    Chee, C.B.2    Gaston, B.3    Lilly, C.M.4    Gerard, C.5    Drazen, J.M.6    Stamler, J.S.7
  • 2
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
    • Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270: 286-290, 1995.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 3
    • 0029778179 scopus 로고    scopus 로고
    • Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of I-κBα synthesis
    • Brostjan, C., J. Anrather, V. Csizmadia, D. Stroka, M. Soares, F. H. Bach, and H. Winkler. Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of I-κBα synthesis. J. Biol. Chem. 271: 19612-19616, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19612-19616
    • Brostjan, C.1    Anrather, J.2    Csizmadia, V.3    Stroka, D.4    Soares, M.5    Bach, F.H.6    Winkler, H.7
  • 5
    • 0028867527 scopus 로고
    • Hepatic inducible nitric oxide synthase: Regulation and function
    • De Vera, M. E., D. A. Geller, and T. R. Billiar. Hepatic inducible nitric oxide synthase: regulation and function. Biochem. Soc. Trans. 23: 1008-1013, 1995.
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 1008-1013
    • De Vera, M.E.1    Geller, D.A.2    Billiar, T.R.3
  • 6
    • 16044374495 scopus 로고    scopus 로고
    • Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes
    • De Vera, M. E., Y. M. Kim, H. R. Wong, T. R. Billiar, and D. A. Geller. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24: 1238-1245, 1996.
    • (1996) Hepatology , vol.24 , pp. 1238-1245
    • De Vera, M.E.1    Kim, Y.M.2    Wong, H.R.3    Billiar, T.R.4    Geller, D.A.5
  • 8
    • 0028972555 scopus 로고
    • A central role for interleukin-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase: IL-1β induces hepatic nitric oxide synthesis
    • Geller, D. A., M. E. de Vera, D. A. Russell, R. A. Shapiro, A. K. Nussler, R. L. Simmons, and T. R. Billiar. A central role for interleukin-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase: IL-1β induces hepatic nitric oxide synthesis. J. Immunol. 155: 4890-4898, 1995.
    • (1995) J. Immunol. , vol.155 , pp. 4890-4898
    • Geller, D.A.1    De Vera, M.E.2    Russell, D.A.3    Shapiro, R.A.4    Nussler, A.K.5    Simmons, R.L.6    Billiar, T.R.7
  • 11
    • 0029912242 scopus 로고    scopus 로고
    • Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB
    • Griscavage, J. M., S. Wilk, and L. J. Ignarro. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93: 3308-3312, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3308-3312
    • Griscavage, J.M.1    Wilk, S.2    Ignarro, L.J.3
  • 13
    • 0025015647 scopus 로고
    • Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
    • Jonat, C., H. J. Rahmsdorf, K.-K. Park, A. Cato, S. Gebel, H. Ponta, and P. Herrlich. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189-1204, 1990.
    • (1990) Cell , vol.62 , pp. 1189-1204
    • Jonat, C.1    Rahmsdorf, H.J.2    Park, K.-K.3    Cato, A.4    Gebel, S.5    Ponta, H.6    Herrlich, P.7
  • 14
    • 0031031148 scopus 로고    scopus 로고
    • Nitric oxide protects cultured rat hepatocytes from TNF-α-induced apoptosis by inducing heat shock protein 70 expression
    • Kim, Y. M., M. E. de Vera, S. C. Watkins, and T. R. Billiar. Nitric oxide protects cultured rat hepatocytes from TNF-α-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272: 1402-1411, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1402-1411
    • Kim, Y.M.1    De Vera, M.E.2    Watkins, S.C.3    Billiar, T.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.