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Volumn 122, Issue 22, 2009, Pages 4070-4080

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

Author keywords

ATR; DNA damage; DNA replication; Replication stress; RPA

Indexed keywords

ATR PROTEIN; REPLICATION FACTOR A; SINGLE STRANDED DNA;

EID: 70849110242     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.053702     Document Type: Article
Times cited : (139)

References (49)
  • 1
    • 0027203525 scopus 로고    scopus 로고
    • Allalunis-Turner, M. J., Barron, G. M., Day, R. S., 3rd, Dobler, K. D. and Mirzayans, R. (1993). Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. Radiat. Res. 134, 349-354.
    • Allalunis-Turner, M. J., Barron, G. M., Day, R. S., 3rd, Dobler, K. D. and Mirzayans, R. (1993). Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. Radiat. Res. 134, 349-354.
  • 2
    • 59449109775 scopus 로고    scopus 로고
    • Mitotic crisis: The unmasking of a novel role for RPA
    • Anantha, R. W. and Borowiec, J. A. (2009). Mitotic crisis: the unmasking of a novel role for RPA. Cell Cycle 8, 357-361.
    • (2009) Cell Cycle , vol.8 , pp. 357-361
    • Anantha, R.W.1    Borowiec, J.A.2
  • 3
    • 37249080597 scopus 로고    scopus 로고
    • Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair
    • Anantha, R. W., Vassin, V. M. and Borowiec, J. A. (2007). Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J. Biol. Chem. 282, 35910-35923.
    • (2007) J. Biol. Chem , vol.282 , pp. 35910-35923
    • Anantha, R.W.1    Vassin, V.M.2    Borowiec, J.A.3
  • 4
    • 51349140504 scopus 로고    scopus 로고
    • RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
    • Anantha, R. W., Sokolova, E. and Borowiec, J. A. (2008). RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc. Natl. Acad. Sci. USA 105, 12903-12908.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 12903-12908
    • Anantha, R.W.1    Sokolova, E.2    Borowiec, J.A.3
  • 5
    • 34249947870 scopus 로고    scopus 로고
    • The DNA damage response during an unperturbed S-phase
    • Ben-Yehoyada, M., Gautier, J. and Dupre, A. (2007). The DNA damage response during an unperturbed S-phase. DNA Repair (Amst) 6, 914-922.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 914-922
    • Ben-Yehoyada, M.1    Gautier, J.2    Dupre, A.3
  • 6
    • 3442896884 scopus 로고    scopus 로고
    • Replication protein A phosphorylation and the cellular response to DNA damage
    • Binz, S. K., Sheehan, A. M. and Wold, M. S. (2004). Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst) 3, 1015-1024.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1015-1024
    • Binz, S.K.1    Sheehan, A.M.2    Wold, M.S.3
  • 7
    • 2342618116 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
    • Block, W. D., Yu, Y. and Lees-Miller, S. P. (2004). Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucl. Acids Res. 32, 997-1005.
    • (2004) Nucl. Acids Res , vol.32 , pp. 997-1005
    • Block, W.D.1    Yu, Y.2    Lees-Miller, S.P.3
  • 8
    • 0028607553 scopus 로고
    • The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication
    • Brush, G. S., Anderson, C. W. and Kelly, T. J. (1994). The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc. Natl. Acad. Sci. USA 91, 12520-12524.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12520-12524
    • Brush, G.S.1    Anderson, C.W.2    Kelly, T.J.3
  • 9
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun, T. S., Pacek, M., Yee, M. C., Walter, J. C. and Cimprich, K. A. (2005). Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 10
    • 0141864666 scopus 로고    scopus 로고
    • Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
    • Davalos, A. R. and Campisi, J. (2003). Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J. Cell Biol. 162, 1197-1209.
    • (2003) J. Cell Biol , vol.162 , pp. 1197-1209
    • Davalos, A.R.1    Campisi, J.2
  • 11
    • 0034141739 scopus 로고    scopus 로고
    • Stability and nuclear distribution of mammalian replication protein A heterotrimeric complex
    • Dimitrova, D. S. and Gilbert, D. M. (2000). Stability and nuclear distribution of mammalian replication protein A heterotrimeric complex. Exp. Cell Res. 254, 321-327.
    • (2000) Exp. Cell Res , vol.254 , pp. 321-327
    • Dimitrova, D.S.1    Gilbert, D.M.2
  • 12
    • 0026539144 scopus 로고
    • cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication
    • Dutta, A. and Stillman, B. (1992). cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11, 2189-2199.
    • (1992) EMBO J , vol.11 , pp. 2189-2199
    • Dutta, A.1    Stillman, B.2
  • 13
    • 0027517871 scopus 로고
    • Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle
    • Fang, F. and Newport, J. W. (1993). Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle. J. Cell Sci. 106, 983-994.
    • (1993) J. Cell Sci , vol.106 , pp. 983-994
    • Fang, F.1    Newport, J.W.2
  • 14
    • 0029835157 scopus 로고    scopus 로고
    • Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin- dependent kinases. Cyclin-substrate interactions dictate the efficiency of phosphorylation
    • Gibbs, E., Pan, Z. Q., Niu, H. and Hurwitz, J. (1996). Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin- dependent kinases. Cyclin-substrate interactions dictate the efficiency of phosphorylation. J. Biol. Chem. 271, 22847-22854.
    • (1996) J. Biol. Chem , vol.271 , pp. 22847-22854
    • Gibbs, E.1    Pan, Z.Q.2    Niu, H.3    Hurwitz, J.4
  • 15
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo, Z., Kumagai, A., Wang, S. X. and Dunphy, W. G. (2000). Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 14, 2745-2756.
    • (2000) Genes Dev , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 16
    • 0029740726 scopus 로고    scopus 로고
    • Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication
    • Henricksen, L. A., Carter, T., Dutta, A. and Wold, M. S. (1996). Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication. Nucl. Acids Res. 24, 3107-3112.
    • (1996) Nucl. Acids Res , vol.24 , pp. 3107-3112
    • Henricksen, L.A.1    Carter, T.2    Dutta, A.3    Wold, M.S.4
  • 18
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K. and Sugimoto, K. (2001). Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294, 867-870.
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 19
    • 0033954476 scopus 로고    scopus 로고
    • Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation
    • Liu, J. S., Kuo, S. R., McHugh, M. M., Beerman, T. A. and Melendy, T. (2000). Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation. J. Biol. Chem. 275, 1391-1397.
    • (2000) J. Biol. Chem , vol.275 , pp. 1391-1397
    • Liu, J.S.1    Kuo, S.R.2    McHugh, M.M.3    Beerman, T.A.4    Melendy, T.5
  • 20
    • 33751187885 scopus 로고    scopus 로고
    • DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation
    • Liu, J. S., Kuo, S. R. and Melendy, T. (2006). DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation. J. Cell Biochem. 99, 1452-1462.
    • (2006) J. Cell Biochem , vol.99 , pp. 1452-1462
    • Liu, J.S.1    Kuo, S.R.2    Melendy, T.3
  • 22
    • 38349078295 scopus 로고    scopus 로고
    • NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse
    • Manthey, K. C., Opiyo, S., Glanzer, J. G., Dimitrova, D., Elliott, J. and Oakley, G. G. (2007). NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J. Cell Sci. 120, 4221-4229.
    • (2007) J. Cell Sci , vol.120 , pp. 4221-4229
    • Manthey, K.C.1    Opiyo, S.2    Glanzer, J.G.3    Dimitrova, D.4    Elliott, J.5    Oakley, G.G.6
  • 23
    • 34249947699 scopus 로고    scopus 로고
    • Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166.
    • Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166.
  • 24
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo, J. A., Cohen, J. and Toczyski, D. P. (2001). Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15, 2809-2821.
    • (2001) Genes Dev , vol.15 , pp. 2809-2821
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 25
    • 0030858642 scopus 로고    scopus 로고
    • Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint
    • Morgan, S. E. and Kastan, M. B. (1997). Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. Cancer Res. 57, 3386-3389.
    • (1997) Cancer Res , vol.57 , pp. 3386-3389
    • Morgan, S.E.1    Kastan, M.B.2
  • 26
    • 31444452984 scopus 로고    scopus 로고
    • ATRIP associates with replication protein A-coated ssDNA through multiple interactions
    • Namiki, Y. and Zou, L. (2006). ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc. Natl. Acad. Sci. USA 103, 580-585.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 580-585
    • Namiki, Y.1    Zou, L.2
  • 27
    • 0030924695 scopus 로고    scopus 로고
    • Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro
    • Niu, H., Erdjument-Bromage, H., Pan, Z. Q., Lee, S. H., Tempst, P. and Hurwitz, J. (1997). Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J. Biol. Chem. 272, 12634-12641.
    • (1997) J. Biol. Chem , vol.272 , pp. 12634-12641
    • Niu, H.1    Erdjument-Bromage, H.2    Pan, Z.Q.3    Lee, S.H.4    Tempst, P.5    Hurwitz, J.6
  • 28
    • 0242417571 scopus 로고    scopus 로고
    • RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions
    • Oakley, G. G., Patrick, S. M., Yao, J., Carty, M. P., Turchi, J. J. and Dixon, K. (2003). RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry 42, 3255-3264.
    • (2003) Biochemistry , vol.42 , pp. 3255-3264
    • Oakley, G.G.1    Patrick, S.M.2    Yao, J.3    Carty, M.P.4    Turchi, J.J.5    Dixon, K.6
  • 29
    • 33845991538 scopus 로고    scopus 로고
    • RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint
    • Olson, E., Nievera, C. J., Klimovich, V., Fanning, E. and Wu, X. (2006). RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint. J. Biol. Chem. 281, 39517-39533.
    • (2006) J. Biol. Chem , vol.281 , pp. 39517-39533
    • Olson, E.1    Nievera, C.J.2    Klimovich, V.3    Fanning, E.4    Wu, X.5
  • 30
    • 45449110194 scopus 로고    scopus 로고
    • Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases
    • Ouyang, K. J., Woo, L. L. and Ellis, N. A. (2008). Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases. Mech. Ageing Dev. 129, 425-440.
    • (2008) Mech. Ageing Dev , vol.129 , pp. 425-440
    • Ouyang, K.J.1    Woo, L.L.2    Ellis, N.A.3
  • 31
    • 0028016304 scopus 로고
    • Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase
    • Pan, Z. Q., Amin, A. A., Gibbs, E., Niu, H. and Hurwitz, J. (1994). Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91, 8343-8347.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8343-8347
    • Pan, Z.Q.1    Amin, A.A.2    Gibbs, E.3    Niu, H.4    Hurwitz, J.5
  • 32
    • 0029074504 scopus 로고
    • Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair
    • Pan, Z.-Q., Park, C. H., Amin, A. A., Hurwitz, J. and Sancar, A. (1995). Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair. Proc. Natl. Acad. Sci. USA 92, 4636-4640.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4636-4640
    • Pan, Z.-Q.1    Park, C.H.2    Amin, A.A.3    Hurwitz, J.4    Sancar, A.5
  • 33
    • 34249937178 scopus 로고    scopus 로고
    • The ATR pathway: Fine-tuning the fork
    • Paulsen, R. D. and Cimprich, K. A. (2007). The ATR pathway: fine-tuning the fork. DNA Repair (Amst) 6, 953-966.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 953-966
    • Paulsen, R.D.1    Cimprich, K.A.2
  • 34
    • 0033514993 scopus 로고    scopus 로고
    • Nuclear foci of mammalian recombination proteins are located at single- stranded DNA regions formed after DNA damage
    • Raderschall, E., Golub, E. I. and Haaf, T. (1999). Nuclear foci of mammalian recombination proteins are located at single- stranded DNA regions formed after DNA damage. Proc. Natl. Acad. Sci. USA 96, 1921-1926.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1921-1926
    • Raderschall, E.1    Golub, E.I.2    Haaf, T.3
  • 35
    • 50649100744 scopus 로고    scopus 로고
    • Mechanism of Eukaryotic Homologous Recombination
    • San Filippo, J., Sung, P. and Klein, H. (2008). Mechanism of Eukaryotic Homologous Recombination. Annu. Rev. Biochem. 77, 229-257.
    • (2008) Annu. Rev. Biochem , vol.77 , pp. 229-257
    • San Filippo, J.1    Sung, P.2    Klein, H.3
  • 36
    • 34547902426 scopus 로고    scopus 로고
    • The intra-S-phase checkpoint affects both DNA replication initiation and elongation: Single-cell and -DNA fiber analyses
    • Seiler, J. A., Conti, C., Syed, A., Aladjem, M. I. and Pommier, Y. (2007). The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. Mol. Cell. Biol. 27, 5806-5818.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 5806-5818
    • Seiler, J.A.1    Conti, C.2    Syed, A.3    Aladjem, M.I.4    Pommier, Y.5
  • 37
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo, J. M., Lopes, M. and Foiani, M. (2002). Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297, 599-602.
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 38
    • 0035797444 scopus 로고    scopus 로고
    • Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    • Tercero, J. A. and Diffley, J. F. (2001). Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412, 553-557.
    • (2001) Nature , vol.412 , pp. 553-557
    • Tercero, J.A.1    Diffley, J.F.2
  • 40
    • 34147201111 scopus 로고    scopus 로고
    • The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement
    • Unsal-Kacmaz, K., Chastain, P. D., Qu, P. P., Minoo, P., Cordeiro-Stone, M., Sancar, A. and Kaufmann, W. K. (2007). The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell. Biol. 27, 3131-3142.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 3131-3142
    • Unsal-Kacmaz, K.1    Chastain, P.D.2    Qu, P.P.3    Minoo, P.4    Cordeiro-Stone, M.5    Sancar, A.6    Kaufmann, W.K.7
  • 41
    • 1342325347 scopus 로고    scopus 로고
    • Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
    • Vassin, V. M., Wold, M. S. and Borowiec, J. A. (2004). Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol. Cell. Biol. 24, 1930-1943.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 1930-1943
    • Vassin, V.M.1    Wold, M.S.2    Borowiec, J.A.3
  • 42
    • 0035577796 scopus 로고    scopus 로고
    • Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase
    • Wang, H., Guan, J., Perrault, A. R., Wang, Y. and Iliakis, G. (2001). Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. Cancer Res. 61, 8554-8563.
    • (2001) Cancer Res , vol.61 , pp. 8554-8563
    • Wang, H.1    Guan, J.2    Perrault, A.R.3    Wang, Y.4    Iliakis, G.5
  • 43
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward, I. M. and Chen, J. (2001). Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276, 47759-47762.
    • (2001) J. Biol. Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 44
    • 0026778383 scopus 로고
    • Mechanism of action of hydroxyurea
    • Yarbro, J. W. (1992). Mechanism of action of hydroxyurea. Semin. Oncol. 19, 1-10.
    • (1992) Semin. Oncol , vol.19 , pp. 1-10
    • Yarbro, J.W.1
  • 45
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden, R. I., Pardo-Reoyo, S., Sgagias, M., Cowan, K. H. and Brody, L. C. (2002). BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30, 285-289.
    • (2002) Nat. Genet , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 46
    • 0030810633 scopus 로고    scopus 로고
    • Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells
    • Zernik-Kobak, M., Vasunia, K., Connelly, M., Anderson, C. W. and Dixon, K. (1997). Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem. 272, 23896-23904.
    • (1997) J. Biol. Chem , vol.272 , pp. 23896-23904
    • Zernik-Kobak, M.1    Vasunia, K.2    Connelly, M.3    Anderson, C.W.4    Dixon, K.5
  • 47
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H. and Piwnica-Worms, H. (2001). ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129-4139.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 48
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L. and Elledge, S. J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 49
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou, L., Cortez, D. and Elledge, S. J. (2002). Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16, 198-208.
    • (2002) Genes Dev , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3


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