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Volumn 90, Issue 1060, 2014, Pages 113-117

The role of amyloid β in the pathogenesis of Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BAPINEUZUMAB; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SOLANEZUMAB;

EID: 84892867546     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/postgradmedj-2013-201515rep     Document Type: Review
Times cited : (16)

References (81)
  • 1
    • 41149125591 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic prospects in dementia
    • Cacabelos R. Pharmacogenomics and therapeutic prospects in dementia. Eur Arch Psychiatry Clin Neurosci 2008;258:28-47.
    • (2008) Eur Arch Psychiatry Clin Neurosci , vol.258 , pp. 28-47
    • Cacabelos, R.1
  • 3
    • 84892900334 scopus 로고    scopus 로고
    • Dementia 2012: A National Challenge. Alzheimer's Society 2012, accessed Feb
    • Dementia 2012: A National Challenge. Alzheimer's Society 2012. http://www. alzheimers.org.uk/dementia2012 (accessed Feb 2013).
    • (2013)
  • 4
    • 84858694031 scopus 로고    scopus 로고
    • Mild cognitive impairment associated with underlying Alzheimer's disease versus Lewy body disease
    • Boeve BF. Mild cognitive impairment associated with underlying Alzheimer's disease versus Lewy body disease. Parkinsonism Relat Disord 2012;18:S41-4.
    • (2012) Parkinsonism Relat Disord , vol.18
    • Boeve, B.F.1
  • 5
    • 84865835722 scopus 로고    scopus 로고
    • Differences between early and late-onset Alzheimer's disease in neuropsychological tests
    • Sá F, Pinto P, Cunha C, et al. Differences between early and late-onset Alzheimer's disease in neuropsychological tests. Front Neurol 2012;3:81.
    • (2012) Front Neurol , vol.3 , pp. 81
    • Sá, F.1    Pinto, P.2    Cunha, C.3
  • 6
    • 77956629252 scopus 로고    scopus 로고
    • EFNS guidelines for the diagnosis and management of Alzheimer's disease
    • Hort J, O'Brien JT, Gainotti G, et al. EFNS guidelines for the diagnosis and management of Alzheimer's disease. Eur J Neurol 2010;17:1236-48.
    • (2010) Eur J Neurol , vol.17 , pp. 1236-1248
    • Hort, J.1    O'Brien, J.T.2    Gainotti, G.3
  • 8
    • 0031593592 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease: A critical update
    • Jellinger KA, Bancher C. Neuropathology of Alzheimer's disease: a critical update. J Neural Transm Suppl 1998;54:77-95.
    • (1998) J Neural Transm Suppl , vol.54 , pp. 77-95
    • Jellinger, K.A.1    Bancher, C.2
  • 9
    • 79959294944 scopus 로고    scopus 로고
    • Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide
    • Mohamed A, Cortez L, de Chaves EP. Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide. Curr Protein Pept Sci 2011;12:235-57.
    • (2011) Curr Protein Pept Sci , vol.12 , pp. 235-257
    • Mohamed, A.1    Cortez, L.2    De Chaves, E.P.3
  • 10
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007;8:101-12.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 11
    • 0035997231 scopus 로고    scopus 로고
    • Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
    • Evin G, Weidemann A. Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides. Peptides 2002;23:1285-97.
    • (2002) Peptides , vol.23 , pp. 1285-1297
    • Evin, G.1    Weidemann, A.2
  • 13
    • 77957257176 scopus 로고    scopus 로고
    • Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
    • Sandberg A, Luheshi LM, Söllvander S, et al. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proc Natl Acad Sci U S A 2010;107:15595-600.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15595-15600
    • Sandberg, A.1    Luheshi, L.M.2    Söllvander, S.3
  • 14
    • 79960999902 scopus 로고    scopus 로고
    • Diagnostics for amyloid fibril formation: Where to begin?
    • Hatters DM, Griffin MD. Diagnostics for amyloid fibril formation: where to begin? Methods Mol Biol 2011;752:121-36.
    • (2011) Methods Mol Biol , vol.752 , pp. 121-136
    • Hatters, D.M.1    Griffin, M.D.2
  • 15
    • 9044229145 scopus 로고    scopus 로고
    • On the nucleation and growth of amyloid beta-protein fibrils: Detection of nuclei and quantitation of rate constants
    • Lomakin A, Chung DS, Benedek GB, et al. On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A 1996;93:1125-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1125-1129
    • Lomakin, A.1    Chung, D.S.2    Benedek, G.B.3
  • 16
    • 0033863798 scopus 로고    scopus 로고
    • Review: Modulating factors in amyloid-beta fibril formation
    • McLaurin J, Yang D, Yip CM, et al. Review: modulating factors in amyloid-beta fibril formation. J Struct Biol 2000;130:259-70.
    • (2000) J Struct Biol , vol.130 , pp. 259-270
    • McLaurin, J.1    Yang, D.2    Yip, C.M.3
  • 17
    • 0035860781 scopus 로고    scopus 로고
    • Amyloid beta-protein oligomerization: Prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins
    • Bitan G, Lomakin A, Teplow DB. Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem 2001;276:35176-84.
    • (2001) J Biol Chem , vol.276 , pp. 35176-35184
    • Bitan, G.1    Lomakin, A.2    Teplow, D.B.3
  • 18
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992;256:184-5.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 19
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Aβ oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012;15:349-57.
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 20
    • 0041816383 scopus 로고    scopus 로고
    • Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization
    • Bitan G, Vollers SS, Teplow DB. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem 2003;278:34882-9.
    • (2003) J Biol Chem , vol.278 , pp. 34882-34889
    • Bitan, G.1    Vollers, S.S.2    Teplow, D.B.3
  • 21
    • 16644379264 scopus 로고    scopus 로고
    • Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
    • Cleary JP. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 2005;8:79-84.
    • (2005) Nat Neurosci , vol.8 , pp. 79-84
    • Cleary, J.P.1
  • 22
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 1998;95:6448-53.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3
  • 23
    • 2942544246 scopus 로고    scopus 로고
    • Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers
    • Wang Z, Chang L, Klein WL, et al. Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers. J Med Chem 2004;47:3329-33.
    • (2004) J Med Chem , vol.47 , pp. 3329-3333
    • Wang, Z.1    Chang, L.2    Klein, W.L.3
  • 24
    • 33750365052 scopus 로고    scopus 로고
    • Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
    • Lashuel HA, Lansbury PT Jr. Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Q Rev Biophys 2006;39:167-201.
    • (2006) Q Rev Biophys , vol.39 , pp. 167-201
    • Lashuel, H.A.1    Lansbury Jr., P.T.2
  • 25
    • 0037975676 scopus 로고    scopus 로고
    • Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
    • Hoshi M, Sato M, Matsumoto S, et al. Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta. Proc Natl Acad Sci USA 2003;100:6370-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6370-6375
    • Hoshi, M.1    Sato, M.2    Matsumoto, S.3
  • 26
    • 0001611370 scopus 로고
    • Electron microscopic observation on a fibrous component in amyloid of diverse origins
    • Cohen AS, Calkins E. Electron microscopic observation on a fibrous component in amyloid of diverse origins. Nature 1959;183:1202-3.
    • (1959) Nature , vol.183 , pp. 1202-1203
    • Cohen, A.S.1    Calkins, E.2
  • 27
    • 0014578835 scopus 로고
    • Characterization of the amyloid fibril as a cross-beta protein
    • Bonar L, Cohen AS, Skinner MM. Characterization of the amyloid fibril as a cross-beta protein. Proc Soc Exp Biol Med 1969;131:1373-5.
    • (1969) Proc Soc Exp Biol Med , vol.131 , pp. 1373-1375
    • Bonar, L.1    Cohen, A.S.2    Skinner, M.M.3
  • 28
    • 0037457928 scopus 로고    scopus 로고
    • Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions
    • Gordon DJ, Meredith SC. Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions. Biochemistry 2003;42:475-85.
    • (2003) Biochemistry , vol.42 , pp. 475-485
    • Gordon, D.J.1    Meredith, S.C.2
  • 29
    • 78651158156 scopus 로고
    • Ultrastructural studies in Alzheimer's presenile dementia
    • Terry RD, Gonatas NK, Weiss M. Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 1964;44:269-97.
    • (1964) Am J Pathol , vol.44 , pp. 269-297
    • Terry, R.D.1    Gonatas, N.K.2    Weiss, M.3
  • 30
    • 0027447286 scopus 로고
    • Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
    • Pike CJ, Burdick D, Walencewicz AJ, et al. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993;13:1676-87.
    • (1993) J Neurosci , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3
  • 31
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 1990;250:279-82.
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 32
    • 0028172886 scopus 로고
    • Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
    • Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A 1994;91:12243-7.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12243-12247
    • Lorenzo, A.1    Yankner, B.A.2
  • 33
    • 75149180052 scopus 로고    scopus 로고
    • Competing discrete interfacial effects are critical for amyloidogenesis
    • Jean L, Lee CF, Lee C, et al. Competing discrete interfacial effects are critical for amyloidogenesis. FASEB J 2010;24:309-17.
    • (2010) FASEB J , vol.24 , pp. 309-317
    • Jean, L.1    Lee, C.F.2    Lee, C.3
  • 34
    • 71049123175 scopus 로고    scopus 로고
    • Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding
    • Zhou Z, Fan JB, Zhu HL, et al. Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding. J Biol Chem 2009;284:30148-58.
    • (2009) J Biol Chem , vol.284 , pp. 30148-30158
    • Zhou, Z.1    Fan, J.B.2    Zhu, H.L.3
  • 35
    • 0002080057 scopus 로고    scopus 로고
    • The neuropathology of Alzheimer disease and the structural basis of its cognitive alterations
    • 2nd edn. Philadelphia: Lippincott Williams & Wilkins, Terry RD, Katzman R, Bick KL
    • Terry RD, Masliah E, Hansen LA. The neuropathology of Alzheimer disease and the structural basis of its cognitive alterations. In: Terry RD, Katzman R, Bick KL Alzheimer disease. 2nd edn. Philadelphia: Lippincott Williams & Wilkins, 1999:187-206.
    • (1999) Alzheimer Disease , pp. 187-206
    • Terry, R.D.1    Masliah, E.2    Hansen, L.A.3
  • 36
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • Mucke L, Masliah E, Yu GQ, et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000;20:4050-8.
    • (2000) J Neurosci , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3
  • 37
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, et al. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001;21:372-81.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3
  • 38
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesné S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006;440:352-7.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesné, S.1    Koh, M.T.2    Kotilinek, L.3
  • 39
    • 34548258322 scopus 로고    scopus 로고
    • Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
    • Cheng IH, Scearce-Levie K, Legleiter J, et al. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 2007;282:23818-28.
    • (2007) J Biol Chem , vol.282 , pp. 23818-23828
    • Cheng, I.H.1    Scearce-Levie, K.2    Legleiter, J.3
  • 40
    • 0029031348 scopus 로고
    • Apoptotic cell death induced by beta-amyloid 1-42 is cell type dependent
    • Gschwind M, Huber G. Apoptotic cell death induced by beta-amyloid 1-42 is cell type dependent. J Neurochem 1995;65:292-300.
    • (1995) J Neurochem , vol.65 , pp. 292-300
    • Gschwind, M.1    Huber, G.2
  • 41
    • 0028952749 scopus 로고
    • Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture
    • Podlisny MB, Ostaszewski BL, Squazzo SL, et al. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 1995;270:9564-70.
    • (1995) J Biol Chem , vol.270 , pp. 9564-9570
    • Podlisny, M.B.1    Ostaszewski, B.L.2    Squazzo, S.L.3
  • 42
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    • Oddo S, Caccamo A, Tran L, et al. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem 2006;281:1599-604.
    • (2006) J Biol Chem , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3
  • 43
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
    • Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 2009;110:1129-34.
    • (2009) J Neurochem , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 45
    • 12344276497 scopus 로고    scopus 로고
    • Organotypic brain slice cultures: An efficient and reliable method for neurotoxicological screening and mechanistic studies
    • Noraberg J. Organotypic brain slice cultures: an efficient and reliable method for neurotoxicological screening and mechanistic studies. Altern Lab Anim 2004;32:329-37.
    • (2004) Altern Lab Anim , vol.32 , pp. 329-337
    • Noraberg, J.1
  • 46
    • 0037271080 scopus 로고    scopus 로고
    • Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein
    • Kim HJ, Chae SC, Lee DK, et al. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. FASEB J 2003;17:118-20.
    • (2003) FASEB J , vol.17 , pp. 118-120
    • Kim, H.J.1    Chae, S.C.2    Lee, D.K.3
  • 47
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008;14:837-42.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3
  • 48
    • 78650010366 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers
    • Decker H, Jürgensen S, Adrover MF, et al. N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers. J Neurochem 2010;115:1520-9.
    • (2010) J Neurochem , vol.115 , pp. 1520-1529
    • Decker, H.1    Jürgensen, S.2    Adrover, M.F.3
  • 49
    • 84859882643 scopus 로고    scopus 로고
    • Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): Responder analyses of nine clinical trials with patients with moderate to severe AD
    • Hellweg R, Wirth Y, Janetzky W, et al. Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD. Int J Geriatr Psychiatry 2012;27:651-6.
    • (2012) Int J Geriatr Psychiatry , vol.27 , pp. 651-656
    • Hellweg, R.1    Wirth, Y.2    Janetzky, W.3
  • 50
    • 84860509122 scopus 로고    scopus 로고
    • Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial
    • Fox C, Crugel M, Maidment I, et al. Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial. PLoS ONE 2012;7:e35185.
    • (2012) PLoS ONE , vol.7
    • Fox, C.1    Crugel, M.2    Maidment, I.3
  • 51
    • 67650492537 scopus 로고    scopus 로고
    • Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
    • Lossi L, Alasia S, Salio C, et al. Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS. Prog Neurobiol 2009;88:221-45.
    • (2009) Prog Neurobiol , vol.88 , pp. 221-245
    • Lossi, L.1    Alasia, S.2    Salio, C.3
  • 52
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 2003;100:10417-22.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3
  • 53
    • 0033179979 scopus 로고    scopus 로고
    • Age-dependent degradation of amyloid precursor protein in the post-mortem mouse brain cortex
    • Asaithambi A, Mukherjee S, Thakur MK. Age-dependent degradation of amyloid precursor protein in the post-mortem mouse brain cortex. Mol Biol Rep 1999;26:179-84.
    • (1999) Mol Biol Rep , vol.26 , pp. 179-184
    • Asaithambi, A.1    Mukherjee, S.2    Thakur, M.K.3
  • 54
    • 0029098802 scopus 로고
    • Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau
    • Panda D, Goode BL, Feinstein SS, et al. Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau. Biochemistry 1995;34:11117-27.
    • (1995) Biochemistry , vol.34 , pp. 11117-11127
    • Panda, D.1    Goode, B.L.2    Feinstein, S.S.3
  • 55
    • 79955044494 scopus 로고    scopus 로고
    • Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration
    • Jin M, Shepardson N, Yang T, et al. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A 2011;108:5819-24.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5819-5824
    • Jin, M.1    Shepardson, N.2    Yang, T.3
  • 56
    • 79551510136 scopus 로고    scopus 로고
    • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation
    • Shipton OA, Leitz JR, Dworzak J, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci 2011;31:1688-92.
    • (2011) J Neurosci , vol.31 , pp. 1688-1692
    • Shipton, O.A.1    Leitz, J.R.2    Dworzak, J.3
  • 57
    • 80051665699 scopus 로고    scopus 로고
    • Cognitive effects of cell-derived and synthetically derived Aβ oligomers
    • Reed MN, Hofmeister JJ, Jungbauer L, et al. Cognitive effects of cell-derived and synthetically derived Aβ oligomers. Neurobiol Aging 2011;32:1784-94.
    • (2011) Neurobiol Aging , vol.32 , pp. 1784-1794
    • Reed, M.N.1    Hofmeister, J.J.2    Jungbauer, L.3
  • 58
    • 79953133327 scopus 로고    scopus 로고
    • Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species
    • Jan A, Adolfsson O, Allaman I, et al. Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. J Biol Chem 2011;286:8585-96.
    • (2011) J Biol Chem , vol.286 , pp. 8585-8596
    • Jan, A.1    Adolfsson, O.2    Allaman, I.3
  • 59
    • 0033527637 scopus 로고    scopus 로고
    • Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells
    • Chung H, Brazil MI, Soe TT, et al. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem 1999;274:32301-8.
    • (1999) J Biol Chem , vol.274 , pp. 32301-32308
    • Chung, H.1    Brazil, M.I.2    Soe, T.T.3
  • 60
    • 0037387147 scopus 로고    scopus 로고
    • A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
    • Bamberger ME, Harris ME, McDonald DR, et al. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 2003;23:2665-74.
    • (2003) J Neurosci , vol.23 , pp. 2665-2674
    • Bamberger, M.E.1    Harris, M.E.2    McDonald, D.R.3
  • 61
    • 34247264399 scopus 로고    scopus 로고
    • Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils
    • Majumdar A, Cruz D, Asamoah N, et al. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell 2007;18:1490-6.
    • (2007) Mol Biol Cell , vol.18 , pp. 1490-1496
    • Majumdar, A.1    Cruz, D.2    Asamoah, N.3
  • 62
    • 79955970157 scopus 로고    scopus 로고
    • Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of CIC-7 to lysosomes
    • Majumdar A, Capetillo-Zarate E, Cruz D, et al. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of CIC-7 to lysosomes. Mol Biol Cell 2011;22:1664-76.
    • (2011) Mol Biol Cell , vol.22 , pp. 1664-1676
    • Majumdar, A.1    Capetillo-Zarate, E.2    Cruz, D.3
  • 63
    • 55949096479 scopus 로고    scopus 로고
    • Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin
    • Sakono M, Zako T, Ueda H, et al. Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin. FEBS J 2003;275:5982-93.
    • (2003) FEBS J , vol.275 , pp. 5982-5993
    • Sakono, M.1    Zako, T.2    Ueda, H.3
  • 64
    • 33644953299 scopus 로고    scopus 로고
    • Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme
    • Chinopoulos C, Adam-Vizi V. Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 2006;273:433-50.
    • (2006) FEBS J , vol.273 , pp. 433-450
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 65
    • 0035110055 scopus 로고    scopus 로고
    • Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease
    • Ditaranto K, Tekirian TL, Yang AJ. Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease. Neurobiol Dis 2001;8:19-31.
    • (2001) Neurobiol Dis , vol.8 , pp. 19-31
    • Ditaranto, K.1    Tekirian, T.L.2    Yang, A.J.3
  • 66
    • 79959676154 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: Implications for Alzheimer's disease
    • Pan XD, Zhu YG, Lin N, et al. Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease. Mol Neurodegener 2011;6:45.
    • (2011) Mol Neurodegener , vol.6 , pp. 45
    • Pan, X.D.1    Zhu, Y.G.2    Lin, N.3
  • 67
    • 34248560960 scopus 로고    scopus 로고
    • Amyloid-beta in Alzheimer disease: The null versus the alternate hypotheses
    • Lee HG, Zhu X, Castellani RJ, et al. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther 2007;321:823-9.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 823-829
    • Lee, H.G.1    Zhu, X.2    Castellani, R.J.3
  • 68
    • 0036829434 scopus 로고    scopus 로고
    • Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain
    • Smith MA, Casadesus G, Joseph JA, et al. Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 2002;33:1194-9.
    • (2002) Free Radic Biol Med , vol.33 , pp. 1194-1199
    • Smith, M.A.1    Casadesus, G.2    Joseph, J.A.3
  • 69
    • 0034733705 scopus 로고    scopus 로고
    • Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc
    • Cuajungco MP, Goldstein LE, Nunomura A, et al. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J Biol Chem 2000;275:19439-42.
    • (2000) J Biol Chem , vol.275 , pp. 19439-19442
    • Cuajungco, M.P.1    Goldstein, L.E.2    Nunomura, A.3
  • 70
    • 0042387935 scopus 로고    scopus 로고
    • Human Abeta1-42 reduces iron-induced toxicity in rat cerebral cortex
    • Bishop GM, Robinson SR. Human Abeta1-42 reduces iron-induced toxicity in rat cerebral cortex. J Neurosci Res 2003;73:316-23.
    • (2003) J Neurosci Res , vol.73 , pp. 316-323
    • Bishop, G.M.1    Robinson, S.R.2
  • 71
    • 0035661661 scopus 로고    scopus 로고
    • Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins
    • Kontush A. Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins. Cell Mol Neurobiol 2001;21:299-315.
    • (2001) Cell Mol Neurobiol , vol.21 , pp. 299-315
    • Kontush, A.1
  • 72
    • 77957785420 scopus 로고    scopus 로고
    • Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
    • Kuperstein I, Broerson K, Benilova I, et al. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J 2010;29:3408-20.
    • (2010) EMBO J , vol.29 , pp. 3408-3420
    • Kuperstein, I.1    Broerson, K.2    Benilova, I.3
  • 73
  • 74
    • 82355191922 scopus 로고    scopus 로고
    • CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease
    • Sierks MR, Chatterjee G, McGraw C, et al. CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol (Camb) 2011;3:1188-96.
    • (2011) Integr Biol (Camb) , vol.3 , pp. 1188-1196
    • Sierks, M.R.1    Chatterjee, G.2    McGraw, C.3
  • 75
    • 79960883095 scopus 로고    scopus 로고
    • Neuroimaging in Alzheimer's disease: Current role in clinical practice and potential future applications
    • Ferreira LK, Busatto GF. Neuroimaging in Alzheimer's disease: current role in clinical practice and potential future applications. Clinics (Sao Paulo) 2011;66:19-24.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 19-24
    • Ferreira, L.K.1    Busatto, G.F.2
  • 76
    • 58749111447 scopus 로고    scopus 로고
    • Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer
    • Verdurand M, Bort G, Tadino V, et al. Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer. Nucl Med Commun 2008;29:920-6.
    • (2008) Nucl Med Commun , vol.29 , pp. 920-926
    • Verdurand, M.1    Bort, G.2    Tadino, V.3
  • 77
    • 36749078121 scopus 로고    scopus 로고
    • Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    • Kayed R, Head E, Sarsoza F, et al. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener 2007;2:18.
    • (2007) Mol Neurodegener , vol.2 , pp. 18
    • Kayed, R.1    Head, E.2    Sarsoza, F.3
  • 78
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S, Koller M, Black RS, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005;64:1553-62.
    • (2005) Neurology , vol.64 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3
  • 79
    • 84871660406 scopus 로고    scopus 로고
    • Pathogenesis and disease-modifying therapy in Alzheimer's disease: The flat line of progress
    • Castellani RJ, Perry G. Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress. Arch Med Res 2012;43:694-8.
    • (2012) Arch Med Res , vol.43 , pp. 694-698
    • Castellani, R.J.1    Perry, G.2
  • 80
  • 81
    • 80055034288 scopus 로고    scopus 로고
    • Alzheimer's prevention initiative: A plan to accelerate the evaluation of presymptomatic treatments
    • Reiman EM, Langbaum JB, Fleisher AS, et al. Alzheimer's prevention initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alzheimers Dis 2011;3:321-9.
    • (2011) J Alzheimers Dis , vol.3 , pp. 321-329
    • Reiman, E.M.1    Langbaum, J.B.2    Fleisher, A.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.