Review: Modulating factors in amyloid-β fibril formation

Journal of Structural Biology

Volumn 130, Issue 2-3, 2000, Pages 259-270

  McLaurin, J ^a,c   Yang, D S ^a   Yip, C M ^b,c,d   Fraser, P E ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Amyloid; Amyloid peptides; Atomic force microscopy; Electron microscopy; structure; circular dichroism spectroscopy

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; AMYLOID BETA PROTEIN; APOLIPOPROTEIN; COMPLEMENT COMPONENT C1Q; GANGLIOSIDE; LAMININ; PHOSPHOLIPID;

ALZHEIMER DISEASE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ELECTRON MICROSCOPY; HUMAN; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; REVIEW; SENILE PLAQUE;

EID: 0033863798     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2000.4289     Document Type: Review

References (106)

1. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes
2. Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis
3. Amyloid β-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes
4. Familial Mediterranean fever - Diagnosis and treatment
5. Morphological development of Aβ(1-40) amyloid fibrils
6. Endogenous proteins controlling amyloid β-peptide polymerization
7. Ferrous iron release from transferrin by human neutrophil-derived superoxide an ion: Effect of pH and iron saturation
8. Selective aggregation of endogenous β-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc
9. pH-dependent binding of synthetic β-amyloid peptides to glycosaminoglycans
10. Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide
11. Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide
12. Rapid induction of Alzheimer Aβ amyloid formation by zinc
13. Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E
14. Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer's disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability
15. The sulfate moieties of glycosaminoglycans are critical for the enhancement of β-amyloid protein fibril formation
16. The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes
17. Aggregation and metal-binding of mutant forms of the amyloid A beta peptide of Alzheimer's disease
18. Alzheimer's Aβ(1-42) is generated in the endoplasmic reticulum/intermediate compartment on NT2N cells
19. Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease
20. Alpha2-macroglobulin attenuates β-amyloid peptide 140 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons
21. β1-antichymotrypsin regulates Alzheimer β-amyloid peptide fibril formation
22. Cleavage of amyloid β peptide during constitutive processing of its precursor
23. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
24. Modified-peptide inhibitors of amyloid β-peptide polymerization
25. pH-dependent structural transitions of Alzheimer amyloid peptides
26. Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: Implications for amyloid fibrilproteoglycan interactions
27. β1-antichymotrypsin binding to Alzheimer Aβ peptides is sequence specific and induces fibril disaggregation in vitro
28. Conformation and fibrillogenesis of Alzheimer Aβ peptides with selected substitution of charged residues
29. A strategy for designing inhibitors of β-amyloid toxicity
30. Proteoglycan-mediated inhibition of Aβ proteolysis. A potential cause of senile plaque accumulation
31. Congo red inhibits proteoglycan and serum amyloid P binding to amyloid β fibrils
32. Amyloid β-peptide is produced by cultured cells during normal metabolism
33. Molecular determinants of amyloid deposition in Alzheimer's disease: Conformational studies of synthetic β-protein fragments
34. Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-β protein
35. Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
36. Fibrillogenesis of Alzheimer Aβ peptides studied by fluorescence energy transfer
37. Zinc-induced Alzheimer's Abetal-40 aggregation is mediated by conformational factors
38. α2-macroglobulin associates with β-amyloid peptide and prevents fibril formation
39. Acetylcholinesterase accelerates assembly of amyloid-β peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
40. Structure of β-crystallite assemblies formed by Alzheimer β-amyloid protein analogues: Analysis by X-ray diffraction
41. A specific structural interaction of Alzheimer's peptide Aβ1-42 with α-1-antichymotrypsin
42. Alzheimer's peptide Aβ1-42 binds to two β-sheets of α1-antichymotrypsin and transforms it from inhibitor to substrate
43. The carboxy terminus of the beta amyloid protein is critical for seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
44. Seeding one dimensional crystallization of amyloid: A pathogenic mechanism in Alzheimer's disease and Scrapie?
45. 2+ sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons
46. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro
47. In situ atomic force micrscopy study of Alzheimer's β-amyloid peptide on different substrates: New insights into mechanism of β-sheet formation
48. Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein
49. Role of endoplasmic rericulum, endosomal-lysosomal compartments, and microtubules in amyloid precursor protein metabolism of human neurons
50. The effect of pH upon human transferrin: Selective labelling of the two iron-binding sites
51. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
52. 2+-sensitive channel in reconstituted lipid vesicles
53. Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the Aβ peptide of Alzheimer's disease
54. Colchicine prevents kidney transplant amyloidosis in familial Mediterranean fever
55. Colchicine treatment of AA amyloidosis of familial Mediterranean fever: An analysis of factors affecting outcome
56. On the nucleation and growth of amyloid β-protein fibrils: Detection of nuclei and quantitation of rate constants
57. Copper, iron and zinc in Alzheimer's disease senile plaques
58. Is the binding of β-amyloid protein to antichymotrypsin in Alzheimers plaques mediated by a b-strand insertion?
59. Amyloid-associated proteins alpha(1)-anticymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
60. Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes
61. Apolipoprotein J and Alzheimer's amyloid β solubility
62. Interactions of amyloid β-peptide (1-40) with ganglioside-containing membranes
63. Membrane disruption by Alzheimer β-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity
64. Characterization of the interactions of Alzheimer beta amyloid peptides with phospholipid membranes
65. Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides
66. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-β fibril growth and arrest
67. Interactions of Alzheimer amyloid-β peptides with glycosaminoglycans: Effects on fibril nucleation and growth
68. Inositol stereoisomers stabilize an oligomeric aggregate of Alzhiemer amyloid-β peptide and inhibit Aβ-induced toxicity
69. Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide
70. Laminin inhibits Aβ42 fibril formation in vitro
71. Neurotoxicity of acetylcholinesterase amyloid β-peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes
72. Evidence for a membrane defect in Alzheimer disease brain
73. 1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress
74. Uptake of 67Cu by ceruloplasmin in vitro
75. Recognition sequence design for peptidyl modulators of β-amyloid aggregation and toxicity
76. The Alzheimer amyloid components a-1-anti-chymotrypsin and b-protein form a stable complex in vitro
77. Morphology and toxicity of Aβ (1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
78. Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro
79. Amyloidosis
80. The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
81. Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease
82. Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease
83. Identification in immunolocalization of a new class of proteoglycan (keratan sulfate) to the neuritic plaques of Alzheimer's disease
84. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type
85. The α-helical to β-strand transition in the amino-terminal fragment of the amyloid β-peptide modulates amyloid formation
86. Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure
87. Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation
88. Apolipoprotein E and Alzheimer disease
89. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)
90. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis
91. Alzheimer β-amyloid peptide 25-35: Electrostatic interactions with phospholipid membranes
92. Self-association of β-amyloid peptide (1-40) in solution and binding to lipid membranes
93. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
94. Controlling amyloid β-peptide fibril formation with protease-stable ligands
95. Heparin-binding properties of the amyloidogenic peptides Aβ and amylin
96. Charge-based binding of complement component C1q to the Alzheimer amyloid β-peptide
97. Relative efficacies of amyloid β peptide (Aβ) binding proteins in Aβ aggregation
98. The complex of microglial cells and amyloid star in three-dimensional reconstruction
99. Intracellular generation and accumulation of amyloid β-pepitde terminating at amino acid 42
100. Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation
101. Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain
102. GM1 ganglioside-bound amyloid β-protein (Aβ): A possible form of preamyloid in Alzheimer's disease
103. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1-42 pathogenesis
104. The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Aβ40 and Aβ42 secretion
105. Manipulating the amyloid-β aggregation pathway with chemical chaperones
106. Direct observation of amyloid-β peptide insertion and assembly within membrane bilayers: Implications for the pathogenesis of Alzheimer's disease