메뉴 건너뛰기




Volumn 41, Issue 1, 2014, Pages 76-83

Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features

Author keywords

cutaneous squamous cell carcinoma; hypoxia inducible factor 1 ; prolyl hydroxylases 2; vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; UNCLASSIFIED DRUG; VASCULOTROPIN; EGLN1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84892832222     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/1346-8138.12314     Document Type: Article
Times cited : (19)

References (37)
  • 1
    • 33644781737 scopus 로고    scopus 로고
    • Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness
    • Jokilehto T, Rantanen K, Luukkaa M, et al,. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin Cancer Res 2006; 12: 1080-1087.
    • (2006) Clin Cancer Res , vol.12 , pp. 1080-1087
    • Jokilehto, T.1    Rantanen, K.2    Luukkaa, M.3
  • 2
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR,. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 3
    • 75149165633 scopus 로고    scopus 로고
    • Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
    • Henze AT, Riedel J, Diem T, et al,. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 2010; 70: 357-366.
    • (2010) Cancer Res , vol.70 , pp. 357-366
    • Henze, A.T.1    Riedel, J.2    Diem, T.3
  • 4
    • 27744489232 scopus 로고    scopus 로고
    • The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
    • Boddy JL, Fox SB, Han C, et al,. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res 2005; 11: 7658-7663.
    • (2005) Clin Cancer Res , vol.11 , pp. 7658-7663
    • Boddy, J.L.1    Fox, S.B.2    Han, C.3
  • 5
    • 4644259153 scopus 로고    scopus 로고
    • Cellular oxygen sensing need in CNS function: Physiological and pathological implications
    • Acker T, Acker H,. Cellular oxygen sensing need in CNS function: physiological and pathological implications. J Exp Biol 2004; 207: 3171-3188.
    • (2004) J Exp Biol , vol.207 , pp. 3171-3188
    • Acker, T.1    Acker, H.2
  • 6
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, et al,. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-421.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 7
    • 0032403263 scopus 로고    scopus 로고
    • Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer
    • Zhong H, Agani F, Baccala AA, et al,. Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer. Cancer Res 1998; 58: 5280-5284.
    • (1998) Cancer Res , vol.58 , pp. 5280-5284
    • Zhong, H.1    Agani, F.2    Baccala, A.A.3
  • 8
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al,. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 9
    • 70350452792 scopus 로고    scopus 로고
    • Targeting the hypoxia-inducible factor (HIF) pathway in cancer
    • Poon E, Harris AL, Ashcroft M,. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev Mol Med 2009; 11: e26.
    • (2009) Expert Rev Mol Med , vol.11
    • Poon, E.1    Harris, A.L.2    Ashcroft, M.3
  • 10
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-A key regulatory factor in tumour growth
    • Harris AL,. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 11
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM,. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 12
    • 31444440290 scopus 로고    scopus 로고
    • Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
    • Shen J, Samul R, Silva RL, et al,. Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 2006; 13: 225-234.
    • (2006) Gene Ther , vol.13 , pp. 225-234
    • Shen, J.1    Samul, R.2    Silva, R.L.3
  • 13
    • 33644621321 scopus 로고    scopus 로고
    • Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF)
    • Murata M, Takanami T, Shimizu S, et al,. Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF). Curr Eye Res 2006; 31: 171-180.
    • (2006) Curr Eye Res , vol.31 , pp. 171-180
    • Murata, M.1    Takanami, T.2    Shimizu, S.3
  • 14
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • Gordan JD, Simon MC,. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007; 17: 71-77.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 15
    • 11144239579 scopus 로고    scopus 로고
    • 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma
    • Ricker JL, Chen Z, Yang XP, et al,. 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res 2004; 10: 8665-8673.
    • (2004) Clin Cancer Res , vol.10 , pp. 8665-8673
    • Ricker, J.L.1    Chen, Z.2    Yang, X.P.3
  • 16
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • Appelhoff RJ, Tian YM, Raval RR, et al,. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 2004; 279: 38458-38465.
    • (2004) J Biol Chem , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1    Tian, Y.M.2    Raval, R.R.3
  • 17
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    • Berra E, Benizri E, Ginouves A, et al,. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003; 22: 4082-4090.
    • (2003) EMBO J , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3
  • 18
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al,. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 19
    • 84867514301 scopus 로고    scopus 로고
    • Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
    • Meijer TW, Kaanders JH, Span PN, et al,. Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res 2012; 18: 5585-5594.
    • (2012) Clin Cancer Res , vol.18 , pp. 5585-5594
    • Meijer, T.W.1    Kaanders, J.H.2    Span, P.N.3
  • 20
    • 79959660044 scopus 로고    scopus 로고
    • Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas
    • Chaux A, Albadine R, Toubaji A, et al,. Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas. Am J Surg Pathol 2011; 35: 1014-1020.
    • (2011) Am J Surg Pathol , vol.35 , pp. 1014-1020
    • Chaux, A.1    Albadine, R.2    Toubaji, A.3
  • 21
    • 67349266221 scopus 로고    scopus 로고
    • Scoring of p16(INK4a) immunohistochemistry based on independent nuclear staining alone can sufficiently distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study
    • Han CP, Kok LF, Wang PH, et al,. Scoring of p16(INK4a) immunohistochemistry based on independent nuclear staining alone can sufficiently distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. Mod Pathol 2009; 22: 797-806.
    • (2009) Mod Pathol , vol.22 , pp. 797-806
    • Han, C.P.1    Kok, L.F.2    Wang, P.H.3
  • 22
    • 84861668879 scopus 로고    scopus 로고
    • Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients
    • Eckert AW, Kappler M, Schubert J, et al,. Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients. Oral Maxillofac Surg 2012; 16: 189-196.
    • (2012) Oral Maxillofac Surg , vol.16 , pp. 189-196
    • Eckert, A.W.1    Kappler, M.2    Schubert, J.3
  • 23
    • 79959688925 scopus 로고    scopus 로고
    • Coexpression of hypoxia-inducible factor-1alpha and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients
    • Eckert AW, Lautner MH, Schutze A, et al,. Coexpression of hypoxia-inducible factor-1alpha and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology 2011; 58: 1136-1147.
    • (2011) Histopathology , vol.58 , pp. 1136-1147
    • Eckert, A.W.1    Lautner, M.H.2    Schutze, A.3
  • 24
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL,. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 25
    • 26244431767 scopus 로고    scopus 로고
    • Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach
    • Tao J, Tu YT, Huang CZ, et al,. Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach. Br J Dermatol 2005; 153: 715-724.
    • (2005) Br J Dermatol , vol.153 , pp. 715-724
    • Tao, J.1    Tu, Y.T.2    Huang, C.Z.3
  • 26
    • 0242606270 scopus 로고    scopus 로고
    • Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure
    • Koshikawa N, Iyozumi A, Gassmann M, et al,. Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure. Oncogene 2003; 22: 6717-6724.
    • (2003) Oncogene , vol.22 , pp. 6717-6724
    • Koshikawa, N.1    Iyozumi, A.2    Gassmann, M.3
  • 27
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: Using two hands to flip the angiogenic switch
    • Semenza GL,. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 2000; 19: 59-65.
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 28
    • 77954175077 scopus 로고    scopus 로고
    • PHD2 in tumour angiogenesis
    • Chan DA, Giaccia AJ,. PHD2 in tumour angiogenesis. Br J Cancer 2010; 103: 1-5.
    • (2010) Br J Cancer , vol.103 , pp. 1-5
    • Chan, D.A.1    Giaccia, A.J.2
  • 29
    • 28844470450 scopus 로고    scopus 로고
    • Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues
    • Soilleux EJ, Turley H, Tian YM, et al,. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology 2005; 47: 602-610.
    • (2005) Histopathology , vol.47 , pp. 602-610
    • Soilleux, E.J.1    Turley, H.2    Tian, Y.M.3
  • 30
    • 17944375360 scopus 로고    scopus 로고
    • C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, et al,. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107: 43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 31
    • 33747691662 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    • McMahon S, Charbonneau M, Grandmont S, et al,. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem 2006; 281: 24171-24181.
    • (2006) J Biol Chem , vol.281 , pp. 24171-24181
    • McMahon, S.1    Charbonneau, M.2    Grandmont, S.3
  • 32
    • 34047255064 scopus 로고    scopus 로고
    • Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
    • Hewitson KS, Lienard BM, McDonough MA, et al,. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem 2007; 282: 3293-3301.
    • (2007) J Biol Chem , vol.282 , pp. 3293-3301
    • Hewitson, K.S.1    Lienard, B.M.2    McDonough, M.A.3
  • 33
    • 34248199954 scopus 로고    scopus 로고
    • The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
    • Barth S, Nesper J, Hasgall PA, et al,. The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol 2007; 27: 3758-3768.
    • (2007) Mol Cell Biol , vol.27 , pp. 3758-3768
    • Barth, S.1    Nesper, J.2    Hasgall, P.A.3
  • 34
    • 84874629159 scopus 로고    scopus 로고
    • Hypoxia-regulated microRNAs in human cancer
    • Shen G, Li X, Jia YF, et al,. Hypoxia-regulated microRNAs in human cancer. Acta Pharmacol Sin 2013; 34: 336-341.
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 336-341
    • Shen, G.1    Li, X.2    Jia, Y.F.3
  • 35
    • 84879556042 scopus 로고    scopus 로고
    • Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics
    • Nguyen MP, Lee S, Lee YM,. Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics. Arch Pharm Res 2013; 36: 252-263.
    • (2013) Arch Pharm Res , vol.36 , pp. 252-263
    • Nguyen, M.P.1    Lee, S.2    Lee, Y.M.3
  • 36
    • 65649138377 scopus 로고    scopus 로고
    • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
    • Chan DA, Kawahara TL, Sutphin PD, et al,. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009; 15: 527-538.
    • (2009) Cancer Cell , vol.15 , pp. 527-538
    • Chan, D.A.1    Kawahara, T.L.2    Sutphin, P.D.3
  • 37
    • 51049097730 scopus 로고    scopus 로고
    • The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential
    • Lee KA, Lynd JD, O'Reilly S, et al,. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 2008; 6: 829-842.
    • (2008) Mol Cancer Res , vol.6 , pp. 829-842
    • Lee, K.A.1    Lynd, J.D.2    O'Reilly, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.