Constitutive upregulation of hypoxia-inducible factor-1α mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure

Oncogene

Volumn 22, Issue 42 REV. ISS. 4, 2003, Pages 6717-6724

  Koshikawa, Nobuko ^a   Iyozumi, Ayako ^a   Gassmann, Max ^b   Takenaga, Keizo ^a  

^a CHIBA CANCER CENTER   (Japan)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Angiogenesis; HIF 1 ; Hypoxia; Metastasis; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN; ARNT PROTEIN, MOUSE; AROMATIC HYDROCARBON RECEPTOR; DNA BINDING PROTEIN; ENDOTHELIAL CELL GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1BETA; LUCIFERASE; LYMPHOKINE; RECOMBINANT PROTEIN; RNA; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL; CONTROLLED STUDY; FEMALE; GENE ACTIVITY; HYPOXIA; LEWIS CARCINOMA; LUNG CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION; ANIMAL; ANOXIA; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL NUCLEUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NORTHERN BLOTTING; PATHOLOGY; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ANIMALIA;

ANIMALS; ANOXIA; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BLOTTING, NORTHERN; CELL NUCLEUS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENES, REPORTER; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; LUNG NEOPLASMS; LYMPHOKINES; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PLASMIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0242606270     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206765     Document Type: Article

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