Modulation of human lymphocyte proliferative response with aging

Experimental Gerontology

Volumn 37, Issue 2-3, 2002, Pages 369-387

  Douziech, Nadine ^a   Seres, Ildikò ^b   Larbi, Anis ^a   Szikszay, Edit ^b   Roy, Pierre Michel ^a   Arcand, Marcel ^a   Dupuis, Gilles ^c   Fulop Jr , Tamàs ^a  

^a UNIVERSITY INSTITUTE OF GERIATRICS OF SHERBROOKE   (Canada)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Aging; Cyclodextrin; Membrane rafts; Mitogen activated protein kinase; Proliferation; Signal transduction; T lymphocytes; TcR CD3 complex; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIBODY; ASCORBIC ACID; CALCIMYCIN; CALCIUM; CD3 ANTIGEN; CHOLERA TOXIN; CHOLESTEROL; CYCLODEXTRIN; IMMUNOMODULATING AGENT; ISOPRENALINE; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PERTUSSIS TOXIN; PHYTOHEMAGGLUTININ; PROTEIN KINASE C; RECOMBINANT INTERLEUKIN 2; SYNAPTOPHYSIN;

AGE; AGED; AGING; ARTICLE; CALCIUM METABOLISM; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GROUPS BY AGE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; MITOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIOXIDANTS; ASCORBIC ACID; CELL DIVISION; CELL MEMBRANE; CHOLESTEROL; HUMANS; INTERLEUKIN-2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOHEMAGGLUTININS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VITAMIN E;

EID: 0037012033     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00204-2     Document Type: Article

References (103)

1. Chronic PMA treatment of Jurkat T lymphocytes results in decreased protein tyrosine phosphorylation and inhibition of CD3 - But not Ti-dependent antibody-triggered Ca2 + signaling
2. Costimulatory signals modulate the antiproliferative effects of agents that elevate cAMP in T cells
3. Induction of cAMP dependent protein kinase (PKA) activity in T cells after stimulation of the prostaglandin E2 or the β-adrenergic receptors relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation
4. Long-term dietary antioxidant supplementation reduces production of selected inflammatory mediators by murine macrophages
5. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals
6. A signaling pathway to translational control
7. Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: Role of lymphocyte phenotype and cytokine production
8. Aging and T-cell-mediated immunity
9. Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin
10. The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4 + T cells
11. Recent developments in lymphocyte activation: Linking kinases to downstream signaling events
12. Impaired phorbol ester and calcium ionophore induced proliferation of T cells from old humans
13. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase a
14. Plasma membrane cholesterol regulates human lymphocyte cytotoxic function
15. The mitogen-activated protein kinase signal transduction pathway
16. Differential effect of aging on cholesterol modulation of carbachol-stimulated low-Km GTPase in striatal synaptosomes
17. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent energy
18. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects
19. Thy-1-mediated activation of rat mast cells: The role of Thy-1 membrane microdomains
20. Inhibiton of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production
21. Costimulatory mechanisms in the elderly
22. Morphologic and functional alteration of mucosal T cells by cholera toxin and its B subunit
23. Differential effect of cholera toxin on CD45RA + and CD45RO- T cells: Specific inhibition of cytokin production but not proliferation of human naive T cells
24. Signal transduction changes in granulocytes and lymphocytes with ageing
25. Alteration of transmembrane signalling with aging. Identification of G proteins in lymphocytes and granulocytes
26. Age-related impairment of p56lck and ZAP70 activities in human T lymphocytes activated through the TcR/CD3 complex
27. Determination of PKC isozymes in human T lymphocytes after CD3 stimulation with aging
28. Determination of IL-2 receptor number of ConA stimulated human lymphocytes with aging
29. Cyclodextrin modulation of T lymphocyte signal transduction with aging
30. Ascorbic acid is an outstanding anti-oxidant in human blood plasma
31. Immune response to influenza vaccine in healthy elderly: Lack of association with plasma β-carotene, retinol, α-tocopherol, or zinc
32. Ras regulation and function in lymphocytes
33. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice
34. Effects of cholera toxin on macrophage production of co-stimulatory cytokines
35. Aging-related deficiency in intracellular calcium response to anti-CD3 or concanavalin A in murine T-cell subsets
36. Antioxidants, cytokines, and influenza infection in aged mice and elderly humans
37. Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes
38. Aging: A theory based on free radical and radiation chemistry
39. Influence of age on the proliferation and peripheralization of thymic T. cells
40. Role of interleukin (IL)-2 receptor β-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein kinase c-Jun N-terminal kinase) activation - IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation
41. Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor
42. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane
43. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
44. The role of lipid rafts in T cell antigen receptor (TCR) signalling
45. GP160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4(+) T lymphocytes
46. Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification
47. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes
48. Signal transduction by the TCR for antigen
49. Differential activation of mitogen activated protein kinases by nitric oxide-related species
50. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women
51. The role of metabolism in the antioxidant function of vitamin E
52. Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging
53. Thiol antioxidant, N-acetylcysteine, activates extracellular signal-regulated kinase signaling pathway in articular chondrocytes
54. Admission criteria for immunogerontological studies in man: The SENIEUR protocol
55. Increased cAMP and cAMP-dependent protein kinase activity mediate anti-CD2 induced suppression of anti-CD3-driven interleukin-2 production and CD25 expression
56. Age influence on the immune system
57. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
58. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
59. Immunodeficiency of aging: Restoration effects of phorbol ester combined with calcium ionophore
60. Aging and immune function
61. Effect of aging on T lymphocyte activation
62. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
63. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation
64. Intracellular adapter molecules
65. Analaysis of the T-cell activation signaling pathway mediated by tyrosin kinases, protein kinase C and Ras protein, which is modulated by intracellular cyclic AMP
66. Oxygen and the control of gene expression
67. Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats
68. Reactive oxygen species and anti-oxidants in signal transduction and gene expression
69. Differential effects of N-acetyl-l-cysteine on IL-2-vs IL-12-driven proliferation of a T cell clone: Implications for distinct signalling pathways
70. Altered T cell signalling in ageing
71. Signal transduction in T lymphocytes
72. Drug solubilizers to aid pharmacologists: Amorphous cyclodextrin derivatives
73. The role of SLP-76 and LAT in lymphocyte development
74. Antigen receptor tail clue
75. Pertussis toxin potentiates T(H)1 and T(H)2 responses to co-injected antigen - Adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28
76. p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4(+)CD45RO(+) T cells and Th2 effector cells
77. Anti-oxidant and redox regulation of gene transcription
78. Dietary Vitamin E and T cell-mediated function in the elderly: Effectiveness and mechanism of action
79. Alteration of lymphocyte membrane phospholipids and intracellular free calcium concentrations in hyperlipidemic subjects
80. Functional rafts in cell membranes
81. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review)
82. Antioxidant defense: Vitmins E and C and carotenoids
83. New insights into membrane dynamics from the analysis of cell surface interactions by physical methods
84. Partial restoration of ConA induced proliferation, IL-2 receptor expression and IL-2 synthesis in aged murine lymphocytes with PMA and ionomycin
85. Impairment of signal transduction in T cells from old mice
86. Vitamin E: Enhances the immune functions of young but not old mice under restraint stress
87. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
88. Cell surface markers, Inositol phosphate levels and membrane potential of lymphocytes from young and old human patients
89. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes
90. mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
91. Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging
92. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
93. In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice
94. Membrane compartmentation is required for efficient T cell activation
95. Cluster formation by protein kinase Cθ during murine T cell activation: Effect of age
96. LAT the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
97. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
98. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells
99. The role of membrane-associated adaptors in T cell receptor signalling
100. P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice
101. Age-depndent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescent recovery after photobleaching in tissue smears