Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling

Science Signaling

Volumn 4, Issue 190, 2011, Pages

  Schoenborn, Jamie R ^a,c   Tan, Ying Xim ^a   Zhang, Chao ^a   Shokat, Kevan M ^a,b   Weiss, Arthur ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD45 ANTIGEN; PROTEIN DOWNSTREAM OF KINASE 1; PROTEIN KINASE LCK; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CSK TYROSINE PROTEIN KINASE; CSK TYROSINE-PROTEIN KINASE; DNA BINDING PROTEIN; DOK1 PROTEIN, HUMAN; DOK1 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOPROTEIN; PROTEIN TYROSINE KINASE; PTPRC PROTEIN, HUMAN; PTPRC PROTEIN, MOUSE; RNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHOSPHORYLATION;

ANIMALS; ANTIGENS, CD45; DNA-BINDING PROTEINS; HUMANS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 80052946904     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001893     Document Type: Article

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46. Acknowledgments: We thank the members of the Weiss laboratory for thoughtful input throughout this project. We are grateful to the staff of the University of California, San Francisco (UCSF) Sandler-Moore MS core facility, especially E. Johansen, H. E. Witkowska, and S. C. Hall, for their help in this study. Funding: This work was supported by Howard Hughes Medical Institute (A.W. and K.M.S.), NIH grant PO1 AI091580, NIH F32 training grant (J.R.S.), and the Singapore Agency for Science, Technology and Research (Y.X.T.). MS analyses were performed by the UCSF Sandler- Moore Mass Spectrometry Core Facility, which acknowledges support from the Sandler Family Foundation, the Gordon and Betty Moore Foundation, and NIH/National Cancer Institute Cancer Center Support Grant P30 CA082103. Author contributions: J.R.S. designed, performed, and analyzed the experiments and prepared the manuscript; Y.X.T. designed, performed, and analyzed the Dok-1 experiments and helped to prepare the manuscript; C.Z. and K.M.S. assisted in the technical design of the analog-sensitive Csk allele and generated the PP1 analog library; and A.W. was responsible for the overall supervision of the project and experimental design and helped to prepare the manuscript. Competing interests: The authors declare that they have no competing interests.