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Volumn 40, Issue 1, 2014, Pages 71-90

Review: The fate of cell grafts for the treatment of Huntington's disease: The post-mortem evidence

Author keywords

Cell transplantation; Excitotoxicity; Inflammation; Mutant huntingtin; Neurotrophic factors; Vasculature

Indexed keywords

AUTOPSY; AUTOSOMAL DOMINANT DISORDER; BRAIN ATROPHY; CELL FATE; CELL TRANSPLANTATION; GENETIC ENGINEERING; HUMAN; HUNTINGTON CHOREA; NONHUMAN; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; EXCITOTOXICITY; INFLAMMATION; NEUROTROPHIC FACTORS; VASCULARIZATION;

EID: 84892498964     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12104     Document Type: Review
Times cited : (9)

References (164)
  • 5
    • 0024822836 scopus 로고
    • Transplantation strategies in the treatment of Parkinson's disease: experimental basis and clinical trials
    • Lindvall O, Björklund A. Transplantation strategies in the treatment of Parkinson's disease: experimental basis and clinical trials. Acta Neurol Scand Suppl 1989; 126: 197-210
    • (1989) Acta Neurol Scand Suppl , vol.126 , pp. 197-210
    • Lindvall, O.1    Björklund, A.2
  • 7
    • 56349111924 scopus 로고    scopus 로고
    • Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study
    • Huang H, Chen L, Xi H, Wang H, Zhang J, Zhang F, Liu Y. Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study. Clin Transplant 2008; 22: 710-718
    • (2008) Clin Transplant , vol.22 , pp. 710-718
    • Huang, H.1    Chen, L.2    Xi, H.3    Wang, H.4    Zhang, J.5    Zhang, F.6    Liu, Y.7
  • 10
    • 77951975829 scopus 로고    scopus 로고
    • Stem cell transplantation in multiple sclerosis
    • Uccelli A, Mancardi G. Stem cell transplantation in multiple sclerosis. Curr Opin Neurol 2010; 23: 218-225
    • (2010) Curr Opin Neurol , vol.23 , pp. 218-225
    • Uccelli, A.1    Mancardi, G.2
  • 11
    • 84884942508 scopus 로고    scopus 로고
    • Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases
    • Rice CM, Kemp K, Wilkins A, Scolding NJ. Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases. Lancet 2013; 382: 1204-1213
    • (2013) Lancet , vol.382 , pp. 1204-1213
    • Rice, C.M.1    Kemp, K.2    Wilkins, A.3    Scolding, N.J.4
  • 13
    • 23844487540 scopus 로고    scopus 로고
    • Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study
    • Savitz SI, Dinsmore J, Wu J, Henderson GV, Stieg P, Caplan LR. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis 2005; 20: 101-107
    • (2005) Cerebrovasc Dis , vol.20 , pp. 101-107
    • Savitz, S.I.1    Dinsmore, J.2    Wu, J.3    Henderson, G.V.4    Stieg, P.5    Caplan, L.R.6
  • 15
    • 0035757820 scopus 로고    scopus 로고
    • Cell therapy to repair injured spinal cords: olfactory ensheathing glia transplantation
    • Ramón-Cueto A, Santos-Benito FF. Cell therapy to repair injured spinal cords: olfactory ensheathing glia transplantation. Restor Neurol Neurosci 2001; 19: 149-156
    • (2001) Restor Neurol Neurosci , vol.19 , pp. 149-156
    • Ramón-Cueto, A.1    Santos-Benito, F.F.2
  • 16
    • 0031887047 scopus 로고    scopus 로고
    • Safety of intrastriatal neurotransplantation for Huntington's disease patients
    • Kopyov OV, Jacques S, Lieberman A, Duma CM, Eagle KS. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp Neurol 1998; 149: 97-108
    • (1998) Exp Neurol , vol.149 , pp. 97-108
    • Kopyov, O.V.1    Jacques, S.2    Lieberman, A.3    Duma, C.M.4    Eagle, K.S.5
  • 24
    • 78650031174 scopus 로고    scopus 로고
    • Huntington's disease: from molecular pathogenesis to clinical treatment
    • Ross CA, Tabrizi SJ. Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 2011; 10: 83-98
    • (2011) Lancet Neurol , vol.10 , pp. 83-98
    • Ross, C.A.1    Tabrizi, S.J.2
  • 25
    • 84879800629 scopus 로고    scopus 로고
    • Axonopathy in Huntington's disease
    • Li J-Y, Conforti L. Axonopathy in Huntington's disease. Exp Neurol 2013; 246: 62-71
    • (2013) Exp Neurol , vol.246 , pp. 62-71
    • Li, J.-Y.1    Conforti, L.2
  • 26
    • 84883464853 scopus 로고    scopus 로고
    • Genetic manipulations of mutant huntingtin in mice: new insights into HD pathogenesis
    • Lee CYD, Cantle JP, Yang XW. Genetic manipulations of mutant huntingtin in mice: new insights into HD pathogenesis. FEBS J 2013; 280: 4382-4394
    • (2013) FEBS J , vol.280 , pp. 4382-4394
    • Lee, C.Y.D.1    Cantle, J.P.2    Yang, X.W.3
  • 27
    • 67449103113 scopus 로고    scopus 로고
    • Huntington disease and other choreas
    • vi
    • Cardoso F. Huntington disease and other choreas. Neurol Clin 2009; 27: 719-736, vi
    • (2009) Neurol Clin , vol.27 , pp. 719-736
    • Cardoso, F.1
  • 29
    • 84865770337 scopus 로고    scopus 로고
    • An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity
    • Cisbani G, Cicchetti F. An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity. Cell Death Dis 2012; 3: e382
    • (2012) Cell Death Dis , vol.3
    • Cisbani, G.1    Cicchetti, F.2
  • 30
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • Zuccato C, Valenza M, Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 2010; 90: 905-981
    • (2010) Physiol Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3
  • 31
    • 53049084348 scopus 로고    scopus 로고
    • The current clinical management of Huntington's disease
    • Phillips W, Shannon KM, Barker RA. The current clinical management of Huntington's disease. Mov Disord 2008; 23: 1491-1504
    • (2008) Mov Disord , vol.23 , pp. 1491-1504
    • Phillips, W.1    Shannon, K.M.2    Barker, R.A.3
  • 33
    • 0034589755 scopus 로고    scopus 로고
    • Clinical observations after neural transplantation in Parkinson's disease
    • Lindvall O, Hagell P. Clinical observations after neural transplantation in Parkinson's disease. Prog Brain Res 2000; 127: 299-320
    • (2000) Prog Brain Res , vol.127 , pp. 299-320
    • Lindvall, O.1    Hagell, P.2
  • 34
    • 0019448060 scopus 로고
    • Intracerebral grafting of dissociated CNS tissue suspensions: a new approach for neuronal transplantation to deep brain sites
    • Schmidt RH, Björklund A, Stenevi U. Intracerebral grafting of dissociated CNS tissue suspensions: a new approach for neuronal transplantation to deep brain sites. Brain Res 1981; 218: 347-356
    • (1981) Brain Res , vol.218 , pp. 347-356
    • Schmidt, R.H.1    Björklund, A.2    Stenevi, U.3
  • 35
    • 0022607703 scopus 로고
    • Anatomical predictors of behavioral recovery following fetal striatal transplants
    • Deckel AW, Moran TH, Coyle JT, Sanberg PR, Robinson RG. Anatomical predictors of behavioral recovery following fetal striatal transplants. Brain Res 1986; 365: 249-258
    • (1986) Brain Res , vol.365 , pp. 249-258
    • Deckel, A.W.1    Moran, T.H.2    Coyle, J.T.3    Sanberg, P.R.4    Robinson, R.G.5
  • 36
    • 0022551746 scopus 로고
    • Graft-induced behavioral recovery in an animal model of Huntington disease
    • Isacson O, Dunnett SB, Björklund A. Graft-induced behavioral recovery in an animal model of Huntington disease. Proc Natl Acad Sci USA 1986; 83: 2728-2732
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2728-2732
    • Isacson, O.1    Dunnett, S.B.2    Björklund, A.3
  • 37
    • 0021226160 scopus 로고
    • Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum
    • Isacson O, Brundin P, Kelly PA, Gage FH, Björklund A. Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature 1984; 311: 458-460
    • (1984) Nature , vol.311 , pp. 458-460
    • Isacson, O.1    Brundin, P.2    Kelly, P.A.3    Gage, F.H.4    Björklund, A.5
  • 38
    • 0022516247 scopus 로고
    • Locomotor hyperactivity: effects of multiple striatal transplants in an animal model of Huntington's disease
    • Sanberg PR, Henault MA, Deckel AW. Locomotor hyperactivity: effects of multiple striatal transplants in an animal model of Huntington's disease. Pharmacol Biochem Behav 1986; 25: 297-300
    • (1986) Pharmacol Biochem Behav , vol.25 , pp. 297-300
    • Sanberg, P.R.1    Henault, M.A.2    Deckel, A.W.3
  • 39
    • 0023698295 scopus 로고
    • Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum - I. Subcortical afferents
    • Wictorin K, Isacson O, Fischer W, Nothias F, Peschanski M, Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum - I. Subcortical afferents. Neuroscience 1988; 27: 547-562
    • (1988) Neuroscience , vol.27 , pp. 547-562
    • Wictorin, K.1    Isacson, O.2    Fischer, W.3    Nothias, F.4    Peschanski, M.5    Björklund, A.6
  • 40
    • 0024323286 scopus 로고
    • Host corticostriatal fibres establish synaptic connections with grafted striatal neurons in the ibotenic acid lesioned striatum
    • Wictorin K, Clarke DJ, Bolam JP, Björklund A. Host corticostriatal fibres establish synaptic connections with grafted striatal neurons in the ibotenic acid lesioned striatum. Eur J Neurosci 1989; 1: 189-195
    • (1989) Eur J Neurosci , vol.1 , pp. 189-195
    • Wictorin, K.1    Clarke, D.J.2    Bolam, J.P.3    Björklund, A.4
  • 51
    • 55249107197 scopus 로고    scopus 로고
    • Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease
    • Krystkowiak P, Gaura V, Labalette M, Rialland A, Remy P, Peschanski M, Bachoud-Lévi A-C. Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease. PLoS ONE 2007; 2: e166
    • (2007) PLoS ONE , vol.2
    • Krystkowiak, P.1    Gaura, V.2    Labalette, M.3    Rialland, A.4    Remy, P.5    Peschanski, M.6    Bachoud-Lévi, A.-C.7
  • 53
    • 0035793057 scopus 로고    scopus 로고
    • Novel therapies in the search for a cure for Huntington's disease
    • Beal MF, Hantraye P. Novel therapies in the search for a cure for Huntington's disease. Proc Natl Acad Sci USA 2001; 98: 3-4
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3-4
    • Beal, M.F.1    Hantraye, P.2
  • 54
    • 0024439946 scopus 로고
    • Intrastriatal grafts derived from fetal striatal primordia. I. Phenotypy and modular organization
    • Graybiel AM, Liu FC, Dunnett SB. Intrastriatal grafts derived from fetal striatal primordia. I. Phenotypy and modular organization. J Neurosci 1989; 9: 3250-3271
    • (1989) J Neurosci , vol.9 , pp. 3250-3271
    • Graybiel, A.M.1    Liu, F.C.2    Dunnett, S.B.3
  • 55
    • 0026594055 scopus 로고
    • Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease
    • Hantraye P, Riche D, Maziere M, Isacson O. Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease. Proc Natl Acad Sci USA 1992; 89: 4187-4191
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4187-4191
    • Hantraye, P.1    Riche, D.2    Maziere, M.3    Isacson, O.4
  • 58
    • 74549155949 scopus 로고    scopus 로고
    • Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease
    • Levine MS, Cepeda C, André VM. Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease. Neuron 2010; 65: 145-147
    • (2010) Neuron , vol.65 , pp. 145-147
    • Levine, M.S.1    Cepeda, C.2    André, V.M.3
  • 59
    • 0022548849 scopus 로고
    • Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease
    • Cross AJ, Slater P, Reynolds GP. Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease. Neurosci Lett 1986; 67: 198-202
    • (1986) Neurosci Lett , vol.67 , pp. 198-202
    • Cross, A.J.1    Slater, P.2    Reynolds, G.P.3
  • 61
    • 81255149512 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
    • Raymond LA, André VM, Cepeda C, Gladding CM, Milnerwood AJ, Levine MS. Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience 2011; 198: 252-273
    • (2011) Neuroscience , vol.198 , pp. 252-273
    • Raymond, L.A.1    André, V.M.2    Cepeda, C.3    Gladding, C.M.4    Milnerwood, A.J.5    Levine, M.S.6
  • 62
    • 77952135272 scopus 로고    scopus 로고
    • Dopamine and glutamate in Huntington's disease: a balancing act
    • André VM, Cepeda C, Levine MS. Dopamine and glutamate in Huntington's disease: a balancing act. CNS Neurosci Ther 2010; 16: 163-178
    • (2010) CNS Neurosci Ther , vol.16 , pp. 163-178
    • André, V.M.1    Cepeda, C.2    Levine, M.S.3
  • 63
    • 34547411294 scopus 로고    scopus 로고
    • Dopaminergic signaling and striatal neurodegeneration in Huntington's disease
    • Tang T-S, Chen X, Liu J, Bezprozvanny I. Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. J Neurosci 2007; 27: 7899-7910
    • (2007) J Neurosci , vol.27 , pp. 7899-7910
    • Tang, T.-S.1    Chen, X.2    Liu, J.3    Bezprozvanny, I.4
  • 67
    • 29144460321 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
    • Shin J-Y, Fang Z-H, Yu Z-X, Wang C-E, Li S-H, Li X-J. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 2005; 171: 1001-1012
    • (2005) J Cell Biol , vol.171 , pp. 1001-1012
    • Shin, J.-Y.1    Fang, Z.-H.2    Yu, Z.-X.3    Wang, C.-E.4    Li, S.-H.5    Li, X.-J.6
  • 68
    • 38349101590 scopus 로고    scopus 로고
    • Glutamate uptake is reduced in prefrontal cortex in Huntington's disease
    • Hassel B, Tessler S, Faull RLM, Emson PC. Glutamate uptake is reduced in prefrontal cortex in Huntington's disease. Neurochem Res 2008; 33: 232-237
    • (2008) Neurochem Res , vol.33 , pp. 232-237
    • Hassel, B.1    Tessler, S.2    Faull, R.L.M.3    Emson, P.C.4
  • 69
    • 78449287253 scopus 로고    scopus 로고
    • Dynamic changes in connexin expression following engraftment of neural stem cells to striatal tissue
    • Jäderstad J, Jäderstad LM, Herlenius E. Dynamic changes in connexin expression following engraftment of neural stem cells to striatal tissue. Exp Cell Res 2011; 317: 70-81
    • (2011) Exp Cell Res , vol.317 , pp. 70-81
    • Jäderstad, J.1    Jäderstad, L.M.2    Herlenius, E.3
  • 71
    • 84869498960 scopus 로고    scopus 로고
    • Connexin-based intercellular communication and astrocyte heterogeneity
    • Theis M, Giaume C. Connexin-based intercellular communication and astrocyte heterogeneity. Brain Res 2012; 1487: 88-98
    • (2012) Brain Res , vol.1487 , pp. 88-98
    • Theis, M.1    Giaume, C.2
  • 73
    • 33751237994 scopus 로고    scopus 로고
    • Mechanisms of disease: astrocytes in neurodegenerative disease
    • Maragakis NJ, Rothstein JD. Mechanisms of disease: astrocytes in neurodegenerative disease. Nat Clin Pract Neurol 2006; 2: 679-689
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 679-689
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 74
    • 0030951604 scopus 로고    scopus 로고
    • Regulation of intracellular sodium in cultured rat hippocampal neurones
    • Rose CR, Ransom BR. Regulation of intracellular sodium in cultured rat hippocampal neurones. J Physiol 1997; 499: 573-587
    • (1997) J Physiol , vol.499 , pp. 573-587
    • Rose, C.R.1    Ransom, B.R.2
  • 75
    • 33745003688 scopus 로고    scopus 로고
    • The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    • Wallraff A, Köhling R, Heinemann U, Theis M, Willecke K, Steinhäuser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci 2006; 26: 5438-5447
    • (2006) J Neurosci , vol.26 , pp. 5438-5447
    • Wallraff, A.1    Köhling, R.2    Heinemann, U.3    Theis, M.4    Willecke, K.5    Steinhäuser, C.6
  • 76
    • 35548969443 scopus 로고    scopus 로고
    • Glial regulation of the cerebral microvasculature
    • Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci 2007; 10: 1369-1376
    • (2007) Nat Neurosci , vol.10 , pp. 1369-1376
    • Iadecola, C.1    Nedergaard, M.2
  • 77
    • 33750447312 scopus 로고    scopus 로고
    • Glucose metabolism and proliferation in glia: role of astrocytic gap junctions
    • Tabernero A, Medina JM, Giaume C. Glucose metabolism and proliferation in glia: role of astrocytic gap junctions. J Neurochem 2006; 99: 1049-1061
    • (2006) J Neurochem , vol.99 , pp. 1049-1061
    • Tabernero, A.1    Medina, J.M.2    Giaume, C.3
  • 78
  • 79
    • 0023709178 scopus 로고
    • Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus
    • Date I, Kawamura K, Nakashima H. Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus. Exp Brain Res 1988; 73: 15-22
    • (1988) Exp Brain Res , vol.73 , pp. 15-22
    • Date, I.1    Kawamura, K.2    Nakashima, H.3
  • 81
    • 0030271484 scopus 로고    scopus 로고
    • Microglial cell responses to fetal ventral mesencephalic tissue grafting and to active and adoptive immunizations
    • Shinoda M, Hudson JL, Strömberg I, Hoffer BJ, Moorhead JW, Olson L. Microglial cell responses to fetal ventral mesencephalic tissue grafting and to active and adoptive immunizations. Exp Neurol 1996; 141: 173-180
    • (1996) Exp Neurol , vol.141 , pp. 173-180
    • Shinoda, M.1    Hudson, J.L.2    Strömberg, I.3    Hoffer, B.J.4    Moorhead, J.W.5    Olson, L.6
  • 82
    • 79952163901 scopus 로고    scopus 로고
    • Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications
    • Cicchetti F, Soulet D, Freeman TB. Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications. Brain 2011; 134: 641-652
    • (2011) Brain , vol.134 , pp. 641-652
    • Cicchetti, F.1    Soulet, D.2    Freeman, T.B.3
  • 83
  • 84
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard AR, Soulet D, Gowing G, Julien J-P, Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006; 49: 489-502
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 85
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 88
    • 0041906554 scopus 로고    scopus 로고
    • Strategies for the augmentation of grafted dopamine neuron survival
    • Sortwell CE. Strategies for the augmentation of grafted dopamine neuron survival. Front Biosci 2003; 8: s522-532
    • (2003) Front Biosci , vol.8
    • Sortwell, C.E.1
  • 89
    • 34548486673 scopus 로고    scopus 로고
    • Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
    • Terpstra BT, Collier TJ, Marchionini DM, Levine ND, Paumier KL, Sortwell CE. Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons. J Neurosci Methods 2007; 166: 13-19
    • (2007) J Neurosci Methods , vol.166 , pp. 13-19
    • Terpstra, B.T.1    Collier, T.J.2    Marchionini, D.M.3    Levine, N.D.4    Paumier, K.L.5    Sortwell, C.E.6
  • 90
    • 84892509315 scopus 로고    scopus 로고
    • Single cell suspension methodology favours survival and vascularization of fetal striatal grafts in the YAC128 mouse model of Huntington's disease
    • doi: 10.3727/096368913X668636 [Epub ahead of print]
    • Cisbani G, Saint-Pierre M, Cicchetti F. Single cell suspension methodology favours survival and vascularization of fetal striatal grafts in the YAC128 mouse model of Huntington's disease. Cell Transplant 2013. doi: 10.3727/096368913X668636 [Epub ahead of print]
    • (2013) Cell Transplant
    • Cisbani, G.1    Saint-Pierre, M.2    Cicchetti, F.3
  • 91
    • 0027236053 scopus 로고
    • Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons - II. Effects on nigral transplants in vivo
    • Mayer E, Fawcett JW, Dunnett SB. Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons - II. Effects on nigral transplants in vivo. Neuroscience 1993; 56: 389-398
    • (1993) Neuroscience , vol.56 , pp. 389-398
    • Mayer, E.1    Fawcett, J.W.2    Dunnett, S.B.3
  • 92
    • 0031905828 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells
    • Apostolides C, Sanford E, Hong M, Mendez I. Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience 1998; 83: 363-372
    • (1998) Neuroscience , vol.83 , pp. 363-372
    • Apostolides, C.1    Sanford, E.2    Hong, M.3    Mendez, I.4
  • 93
    • 0029804409 scopus 로고    scopus 로고
    • GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats
    • Wang Y, Tien LT, Lapchak PA, Hoffer BJ. GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats. Cell Tissue Res 1996; 286: 225-233
    • (1996) Cell Tissue Res , vol.286 , pp. 225-233
    • Wang, Y.1    Tien, L.T.2    Lapchak, P.A.3    Hoffer, B.J.4
  • 94
    • 0034099045 scopus 로고    scopus 로고
    • Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations
    • Mendez I, Dagher A, Hong M, Hebb A, Gaudet P, Law A, Weerasinghe S, King D, Desrosiers J, Darvesh S, Acorn T, Robertson H. Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations. J Neurosurg 2000; 92: 863-869
    • (2000) J Neurosurg , vol.92 , pp. 863-869
    • Mendez, I.1    Dagher, A.2    Hong, M.3    Hebb, A.4    Gaudet, P.5    Law, A.6    Weerasinghe, S.7    King, D.8    Desrosiers, J.9    Darvesh, S.10    Acorn, T.11    Robertson, H.12
  • 95
    • 0030940261 scopus 로고    scopus 로고
    • Influence of BDNF on the expression of the dopaminergic phenotype of tissue used for brain transplants
    • Zhou J, Bradford HF, Stern GM. Influence of BDNF on the expression of the dopaminergic phenotype of tissue used for brain transplants. Brain Res Dev Brain Res 1997; 100: 43-51
    • (1997) Brain Res Dev Brain Res , vol.100 , pp. 43-51
    • Zhou, J.1    Bradford, H.F.2    Stern, G.M.3
  • 96
    • 0029068334 scopus 로고
    • Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons
    • Du X, Iacovitti L. Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons. J Neurosci 1995; 15: 5420-5427
    • (1995) J Neurosci , vol.15 , pp. 5420-5427
    • Du, X.1    Iacovitti, L.2
  • 97
    • 0029011959 scopus 로고
    • Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons
    • Du X, Stull ND, Iacovitti L. Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons. Brain Res 1995; 680: 229-233
    • (1995) Brain Res , vol.680 , pp. 229-233
    • Du, X.1    Stull, N.D.2    Iacovitti, L.3
  • 98
    • 84874734906 scopus 로고    scopus 로고
    • Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons
    • Melo CV, Okumoto S, Gomes JR, Baptista MS, Bahr BA, Frommer WB, Duarte CB. Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience 2013; 237: 66-86
    • (2013) Neuroscience , vol.237 , pp. 66-86
    • Melo, C.V.1    Okumoto, S.2    Gomes, J.R.3    Baptista, M.S.4    Bahr, B.A.5    Frommer, W.B.6    Duarte, C.B.7
  • 100
    • 30344458778 scopus 로고    scopus 로고
    • Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge
    • Bemelmans A-P, Husson I, Jaquet M, Mallet J, Kosofsky BE, Gressens P. Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge. J Neurosci Res 2006; 83: 50-60
    • (2006) J Neurosci Res , vol.83 , pp. 50-60
    • Bemelmans, A.-P.1    Husson, I.2    Jaquet, M.3    Mallet, J.4    Kosofsky, B.E.5    Gressens, P.6
  • 101
    • 21544446985 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta
    • Baquet ZC, Bickford PC, Jones KR. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 2005; 25: 6251-6259
    • (2005) J Neurosci , vol.25 , pp. 6251-6259
    • Baquet, Z.C.1    Bickford, P.C.2    Jones, K.R.3
  • 103
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 2009; 5: 311-322
    • (2009) Nat Rev Neurol , vol.5 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2
  • 104
    • 34047130812 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Huntington's disease
    • Zuccato C, Cattaneo E. Role of brain-derived neurotrophic factor in Huntington's disease. Prog Neurobiol 2007; 81: 294-330
    • (2007) Prog Neurobiol , vol.81 , pp. 294-330
    • Zuccato, C.1    Cattaneo, E.2
  • 105
    • 29044439123 scopus 로고    scopus 로고
    • Differential localization of vesicular glutamate transporters 1 and 2 in the rat striatum
    • Raju DV, Smith Y. Differential localization of vesicular glutamate transporters 1 and 2 in the rat striatum. The Basal Ganglia VIII 2005; 56: 601-610
    • (2005) The Basal Ganglia VIII , vol.56 , pp. 601-610
    • Raju, D.V.1    Smith, Y.2
  • 107
    • 0034595722 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in Huntington disease
    • Ferrer I, Goutan E, Marín C, Rey MJ, Ribalta T. Brain-derived neurotrophic factor in Huntington disease. Brain Res 2000; 866: 257-261
    • (2000) Brain Res , vol.866 , pp. 257-261
    • Ferrer, I.1    Goutan, E.2    Marín, C.3    Rey, M.J.4    Ribalta, T.5
  • 108
  • 112
    • 0021278630 scopus 로고
    • An autoradiographic study of neuronal development, vascularization and glial cell migration from hippocampal transplants labelled in intermediate explant culture
    • Lindsay RM, Raisman G. An autoradiographic study of neuronal development, vascularization and glial cell migration from hippocampal transplants labelled in intermediate explant culture. Neuroscience 1984; 12: 513-530
    • (1984) Neuroscience , vol.12 , pp. 513-530
    • Lindsay, R.M.1    Raisman, G.2
  • 114
    • 0026148309 scopus 로고
    • Allografts of CNS tissue possess a blood-brain barrier. II. Angiogenesis in solid tissue and cell suspension grafts
    • Broadwell RD, Charlton HM, Ebert PS, Hickey WF, Shirazi Y, Villegas J, Wolf AL. Allografts of CNS tissue possess a blood-brain barrier. II. Angiogenesis in solid tissue and cell suspension grafts. Exp Neurol 1991; 112: 1-28
    • (1991) Exp Neurol , vol.112 , pp. 1-28
    • Broadwell, R.D.1    Charlton, H.M.2    Ebert, P.S.3    Hickey, W.F.4    Shirazi, Y.5    Villegas, J.6    Wolf, A.L.7
  • 115
    • 0028084486 scopus 로고
    • Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model
    • Nikkhah G, Cunningham MG, Jödicke A, Knappe U, Björklund A. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res 1994; 633: 133-143
    • (1994) Brain Res , vol.633 , pp. 133-143
    • Nikkhah, G.1    Cunningham, M.G.2    Jödicke, A.3    Knappe, U.4    Björklund, A.5
  • 116
    • 0021679497 scopus 로고
    • Fetal hypothalamic transplants: neuronal and neurovascular interrelationships
    • Scott DE. Fetal hypothalamic transplants: neuronal and neurovascular interrelationships. Neurosci Lett 1984; 51: 93-98
    • (1984) Neurosci Lett , vol.51 , pp. 93-98
    • Scott, D.E.1
  • 118
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008; 14: 504-506
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 120
    • 84861559058 scopus 로고    scopus 로고
    • Transmissible proteins: expanding the prion heresy
    • Soto C. Transmissible proteins: expanding the prion heresy. Cell 2012; 149: 968-977
    • (2012) Cell , vol.149 , pp. 968-977
    • Soto, C.1
  • 121
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010; 11: 301-307
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 122
    • 69149088365 scopus 로고    scopus 로고
    • Is Parkinson's disease a prion disorder?
    • Olanow CW, Prusiner SB. Is Parkinson's disease a prion disorder? Proc Natl Acad Sci USA 2009; 106: 12571-12572
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12571-12572
    • Olanow, C.W.1    Prusiner, S.B.2
  • 129
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM-Y. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012; 338: 949-953
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.-Y.7
  • 130
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    • Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM-Y. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 2012; 209: 975-986
    • (2012) J Exp Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O'Brien, P.4    Trojanowski, J.Q.5    Lee, V.-Y.6
  • 132
    • 77954385676 scopus 로고    scopus 로고
    • The propagation of prion-like protein inclusions in neurodegenerative diseases
    • Goedert M, Clavaguera F, Tolnay M. The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci 2010; 33: 317-325
    • (2010) Trends Neurosci , vol.33 , pp. 317-325
    • Goedert, M.1    Clavaguera, F.2    Tolnay, M.3
  • 133
    • 84866322000 scopus 로고    scopus 로고
    • Visualization of cell-to-cell transmission of mutant huntingtin oligomers
    • RRN1210
    • Herrera F, Tenreiro S, Miller-Fleming L, Outeiro TF. Visualization of cell-to-cell transmission of mutant huntingtin oligomers. PLoS Curr 2011; 3: RRN1210
    • (2011) PLoS Curr , vol.3
    • Herrera, F.1    Tenreiro, S.2    Miller-Fleming, L.3    Outeiro, T.F.4
  • 135
    • 59649095699 scopus 로고    scopus 로고
    • Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
    • Ren P-H, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, Kopito RR. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 2009; 11: 219-225
    • (2009) Nat Cell Biol , vol.11 , pp. 219-225
    • Ren, P.-H.1    Lauckner, J.E.2    Kachirskaia, I.3    Heuser, J.E.4    Melki, R.5    Kopito, R.R.6
  • 136
    • 77951238141 scopus 로고    scopus 로고
    • Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice
    • Bradford J, Shin J-Y, Roberts M, Wang C-E, Sheng G, Li S, Li X-J. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem 2010; 285: 10653-10661
    • (2010) J Biol Chem , vol.285 , pp. 10653-10661
    • Bradford, J.1    Shin, J.-Y.2    Roberts, M.3    Wang, C.-E.4    Sheng, G.5    Li, S.6    Li, X.-J.7
  • 137
    • 76049118058 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
    • Bradford J, Shin J-Y, Roberts M, Wang C-E, Li X-J, Li S. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci USA 2009; 106: 22480-22485
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22480-22485
    • Bradford, J.1    Shin, J.-Y.2    Roberts, M.3    Wang, C.-E.4    Li, X.-J.5    Li, S.6
  • 138
    • 84872353414 scopus 로고    scopus 로고
    • Neural tissue transplantation, repair, and rehabilitation
    • Dunnett SB. Neural tissue transplantation, repair, and rehabilitation. Handb Clin Neurol 2013; 110: 43-59
    • (2013) Handb Clin Neurol , vol.110 , pp. 43-59
    • Dunnett, S.B.1
  • 139
    • 78650956995 scopus 로고    scopus 로고
    • Technical factors that influence neural transplant safety in Huntington's disease
    • Freeman TB, Cicchetti F, Bachoud-Lévi AC, Dunnett SB. Technical factors that influence neural transplant safety in Huntington's disease. Exp Neurol 2011; 227: 1-9
    • (2011) Exp Neurol , vol.227 , pp. 1-9
    • Freeman, T.B.1    Cicchetti, F.2    Bachoud-Lévi, A.C.3    Dunnett, S.B.4
  • 140
    • 0032562172 scopus 로고    scopus 로고
    • Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence
    • Olsson M, Björklund A, Campbell K. Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence. Neuroscience 1998; 84: 867-876
    • (1998) Neuroscience , vol.84 , pp. 867-876
    • Olsson, M.1    Björklund, A.2    Campbell, K.3
  • 141
    • 0028585837 scopus 로고
    • The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence
    • Deacon TW, Pakzaban P, Isacson O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence. Brain Res 1994; 668: 211-219
    • (1994) Brain Res , vol.668 , pp. 211-219
    • Deacon, T.W.1    Pakzaban, P.2    Isacson, O.3
  • 142
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M, Nikkhah G, Bentlage C, Björklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 1995; 15: 3863-3875
    • (1995) J Neurosci , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Björklund, A.4
  • 143
    • 0034064954 scopus 로고    scopus 로고
    • Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease
    • Watts C, Brasted PJ, Dunnett SB. Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease. Exp Neurol 2000; 163: 85-97
    • (2000) Exp Neurol , vol.163 , pp. 85-97
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 144
    • 84892526947 scopus 로고    scopus 로고
    • TransEUro consortium. Available at:
    • TransEUro consortium. Available at: http://www.transeuro.org.uk/pages/objectives.html
  • 145
    • 84870533673 scopus 로고    scopus 로고
    • Important aspects of surgical methodology for transplantation in Parkinson's disease
    • P Brundin, CW Olanow, 7th edn. Berlin: Springer
    • Freeman TB, Brundin P. Important aspects of surgical methodology for transplantation in Parkinson's disease. Restorative Therapies in Parkinson's Disease. P Brundin, CW Olanow, 7th edn. Berlin: Springer, 2006
    • (2006) Restorative Therapies in Parkinson's Disease
    • Freeman, T.B.1    Brundin, P.2
  • 146
    • 0037121673 scopus 로고    scopus 로고
    • Characterisation of cell damage and death in embryonic mesencephalic tissue: a study on ultrastructure, vital stains and protease activity
    • Emgård M, Blomgren K, Brundin P. Characterisation of cell damage and death in embryonic mesencephalic tissue: a study on ultrastructure, vital stains and protease activity. Neuroscience 2002; 115: 1177-1187
    • (2002) Neuroscience , vol.115 , pp. 1177-1187
    • Emgård, M.1    Blomgren, K.2    Brundin, P.3
  • 147
    • 0033838272 scopus 로고    scopus 로고
    • The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces
    • Watts C, Brasted PJ, Dunnett SB. The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces. Cell Transplant 2000; 9: 395-407
    • (2000) Cell Transplant , vol.9 , pp. 395-407
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 149
    • 0023921432 scopus 로고
    • Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants
    • Krum JM, Rosenstein JM. Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants. J Comp Neurol 1988; 271: 331-345
    • (1988) J Comp Neurol , vol.271 , pp. 331-345
    • Krum, J.M.1    Rosenstein, J.M.2
  • 151
    • 0022483977 scopus 로고
    • Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system
    • Rosenstein JM, Brightman MW. Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system. J Comp Neurol 1986; 250: 339-351
    • (1986) J Comp Neurol , vol.250 , pp. 339-351
    • Rosenstein, J.M.1    Brightman, M.W.2
  • 152
    • 0022239947 scopus 로고
    • Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons
    • Brundin P, Nilsson OG, Gage FH, Björklund A. Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons. Exp Brain Res 1985; 60: 204-208
    • (1985) Exp Brain Res , vol.60 , pp. 204-208
    • Brundin, P.1    Nilsson, O.G.2    Gage, F.H.3    Björklund, A.4
  • 153
    • 0023946501 scopus 로고
    • Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release
    • Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Astedt B, Lindvall O, Björklund A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 1988; 70: 192-208
    • (1988) Exp Brain Res , vol.70 , pp. 192-208
    • Brundin, P.1    Strecker, R.E.2    Widner, H.3    Clarke, D.J.4    Nilsson, O.G.5    Astedt, B.6    Lindvall, O.7    Björklund, A.8
  • 154
    • 0024511225 scopus 로고
    • Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier
    • Brundin P, Widner H, Nilsson OG, Strecker RE, Björklund A. Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier. Exp Brain Res 1989; 75: 195-207
    • (1989) Exp Brain Res , vol.75 , pp. 195-207
    • Brundin, P.1    Widner, H.2    Nilsson, O.G.3    Strecker, R.E.4    Björklund, A.5
  • 156
    • 0031010545 scopus 로고    scopus 로고
    • Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants
    • Kordower JH, Styren S, Clarke M, DeKosky ST, Olanow CW, Freeman TB. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell Transplant 1997; 6: 213-219
    • (1997) Cell Transplant , vol.6 , pp. 213-219
    • Kordower, J.H.1    Styren, S.2    Clarke, M.3    DeKosky, S.T.4    Olanow, C.W.5    Freeman, T.B.6
  • 160
    • 18444373622 scopus 로고    scopus 로고
    • Immune problems in central nervous system cell therapy
    • Barker RA, Widner H. Immune problems in central nervous system cell therapy. NeuroRx 2004; 1: 472-481
    • (2004) NeuroRx , vol.1 , pp. 472-481
    • Barker, R.A.1    Widner, H.2
  • 161
    • 21944436225 scopus 로고    scopus 로고
    • Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
    • Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson O. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain 2005; 128: 1498-1510
    • (2005) Brain , vol.128 , pp. 1498-1510
    • Mendez, I.1    Sanchez-Pernaute, R.2    Cooper, O.3    Viñuela, A.4    Ferrari, D.5    Björklund, L.6    Dagher, A.7    Isacson, O.8
  • 163
    • 36549005041 scopus 로고    scopus 로고
    • Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease
    • Redmond DE, Vinuela A, Kordower JH, Isacson O. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease. Neurobiol Dis 2008; 29: 103-116
    • (2008) Neurobiol Dis , vol.29 , pp. 103-116
    • Redmond, D.E.1    Vinuela, A.2    Kordower, J.H.3    Isacson, O.4


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