Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge

Journal of Neuroscience Research

Volumn 83, Issue 1, 2006, Pages 50-60

  Bemelmans, Alexis Pierre ^a,b   Husson, Isabelle ^c,d,e   Jaquet, Muriel ^b   Mallet, Jacques ^a   Kosofsky, Barry E ^c,d,f   Gressens, Pierre ^c,d,e  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b HÔPITAL OPHTALMIQUE JULES GONIN   (Switzerland)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL ROBERT DEBRÉ   (France)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

BDNF; Cerebral palsy; Excitotoxicity; Gene transfer; Lentivirus; Neuroprotection; NMDA; Periventricular leukomalacia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN CYST; BRAIN DAMAGE; CEREBRAL PALSY; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; GENE TRANSFER; HIGH RISK INFANT; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PERIVENTRICULAR WHITE MATTER CYST; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRAL GENE DELIVERY SYSTEM; WHITE MATTER;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HIV-1; HUMANS; INJECTIONS, INTRAVENTRICULAR; LENTIVIRUS; MALE; MICE; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; RECOMBINANT PROTEINS;

EID: 30344458778     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20704     Document Type: Article

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