Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: A controlled pilot study

Clinical Transplantation

Volumn 22, Issue 6, 2008, Pages 710-718

  Huang, Hongyun ^a   Chen, Lin ^a   Xi, Haitao ^a   Wang, Hongmei ^a   Zhang, Jian ^a   Zhang, Feng ^a   Liu, Yancheng ^a  

^a Beijing Hongtianji Neuroscience Academy   (China)

Author keywords

ALS Functional Rating Scale; Amyotrophic lateral sclerosis; Controlled clinical study; Motor neuron disease; Neurorestoratology; Olfactory ensheathing cell transplantation

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; AMYOTROPHIC LATERAL SCLEROSIS FUNCTIONAL RATING SCALE; ARTICLE; CELL TRANSPLANTATION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DETERIORATION; DISEASE COURSE; FEMALE; FETUS; FOLLOW UP; FRONTAL LOBE; HUMAN; HUMAN CELL; MALE; NERVE CELL CULTURE; NEUROLOGIC DISEASE; OLFACTORY ENSHEATHING CELL; OUTCOME ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; PYRAMIDAL TRACT; RATING SCALE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CELL TRANSPLANTATION; CELLS, CULTURED; FEMALE; FETAL TISSUE TRANSPLANTATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OLFACTORY BULB; PILOT PROJECTS; RECEPTOR, NERVE GROWTH FACTOR; YOUNG ADULT;

EID: 56349111924     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2008.00865.x     Document Type: Article

References (36)

1. Dib M. Amyotrophic lateral sclerosis: Progress and prospects for treatment. Drugs 2003: 63: 289.
2. Rowland LP, Shneider NA. Amyotrophic lateral sclerosis. N Engl J Med 2001: 344: 1688.
3. Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 1994: 330: 585.
4. Miller RG, Mitchell JD, Lyon M, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Amyotroph Lateral Scler Other Motor Neuron Disord 2003: 4: 191.
5. Morrison KE. Therapies in amyotrophic lateral sclerosis-beyond Riluzole. Curr Opin Pharmacol 2002: 2: 302.
6. Turner MR, Parton MJ, Leigh PN. Clinical trials in ALS: An overview. Semin Neurol 2001: 21: 167.
7. Victor M, Ropper AH (eds). Adams and Victor's Principles of Neurology, 7th edn. New York: McGraw-Hill Medical Publishing Division, 2001: 156.
8. Franklin RJ, Gilson JM, Franceschini IA, Barnett SC. Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS. Glia 1996: 17: 217.
9. Huang HY, Liu K, Huang W, Liu ZH, Young W. Olfactory ensheathing cells improves neural regeneration and functional recovery in spinal cord contusion injury. J Naval General Hospital PLA 2001: 14: 65.
10. Imaizumi T, Lankford KL, Burton WV, Fodor WL, Kocsis JD. Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nat Biotechnol 2000: 18: 949.
11. Kato T, Honmou O, Uede T, Hashi K, Kocsis JD. Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord. Glia 2000: 30: 209.
12. Li Y, Field PM, Raisman G. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 1997: 277: 2000.
13. Lu J, Feron F, Mackay-Sim A, Waite PM. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 2002: 125: 14.
14. Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000: 25: 425.
15. Huang HY, Wang HM, Xiu B et al. Preliminary report of clinical trial for olfactory ensheathing cell transplantation treating the spinal cord injury. J Naval General Hospital PLA 2002: 15: 18.
16. Huang HY, Chen L, Wang HM et al. Influence of patients age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord. Chin Med J (Engl) 2003: 116: 1488.
17. Huang HY, Wang HM, Gu Z et al. Preliminary report of olfactory ensheathing cell transplantation in the treatment of motor neurone disease or amyotrophic lateral sclerosis. Zhongguo Linchuang Kangfu 2004: 8: 2440.
18. World Medical Association Declaration of Helsinki. http://www.wma.net/e/ policy/pdf/17c.pdf. Accessed 2004, P5.
19. People's Republic of China, Ministry of Public Health, Science and Technology Bureau. Instruction for prepare and clinical application of the aborted human fetuses (91-006). In: Wu C ed. Intracranial Transplantation, 1st edn. Jinan: Shandong Science & Technology Press, 1993: 274.
20. Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000: 1: 293.
21. The ALS CNTF treatment study (ACTS) phase I-II Study Group. The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. Arch Neurol 1996: 53: 141.
22. Huang HY, Tan K, Chen L et al. MR spectroscopy evaluation and short-term outcome of olfactory ensheathing cell transplantation in amyotrophic lateral sclerosis patients. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2007: 21: 52.
23. Huang HY, Chen L, Wang HM et al. Olfactory ensheathing cell transplantation in the treatment of amyotrophic lateral sclerosis: recent result report of 88 cases. Zhongguo Linchuang Kangfu 2006: 10: 39.
24. Rosen DR, Siddique T, Patterson D et al. Mutations in Cu/Zn superoxide dismutasegene are associated with familial amyotrophic lateral sclerosis. Nature 1993: 362: 59.
25. Cudkowicz ME, Mc Kenna-Yasek D, Sapp PE et al. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann Neurol 1997: 41: 210.
26. Rocha JA, Reis C, Simoes F, Fonseca J, Mendes Ribeiro J. Diagnostic investigation and multidisciplinary management in motor neuron disease. J Neurol 2005: 252: 1435.
27. Traynor BJ, Bruijn L, Conwit R et al. Neuroprotective agents for clinical trials in ALS: A systematic assessment. Neurology 2006: 67: 20.
28. Ibrahim A, Li Y, Li D, Raisman G, El Masry WS. Olfactory ensheathing cells: Ripples of an incoming tide? Lancet Neurol 2006: 5: 453.
29. Ramon-Cueto A, Valverde F. Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties. Glia 1995: 14: 163.
30. Ramon-Cueto A, Avila J. Olfactory ensheathing glia: Properties and function. Brain Res Bull 1998: 46: 175.
31. Martin LJ, Liu Z. Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice. J Neuropathol Exp Neurol 2007: 66: 1002.
32. Cedarbaum JM, Stambler N. Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials. J Neurol Sci 1997: 152 (Suppl. 1): S1.
33. Kasarskis EJ, Dempsey-Hall L, Thompson MM, Luu LC, Mendiondo M, Kryscio R. Rating the severity of ALS by caregivers over the telephone using the ALSFRS-R. Amyotroph Lateral Scler Other Motor Neuron Disord 2005: 6: 50.
34. Miano B, Stoddard GJ, Davis S, Bromberg MB. Inter-evaluator reliability of the ALS functional rating scale. Amyotroph Lateral Scler Other Motor Neuron Disord 2004: 5: 235.
35. Barker RA, Widner H. Immune problems in central nervous system cell therapy. NeuroRx 2004: 1: 472.
36. Chen L, Huang HY, Xi HT et al. Effect of FK506 on neurological improvement in patients with amyotrophic lateral sclerosis following olfactory ensheathing cell transplantation. Zhongguo Linchuang Kangfu 2006: 10: 19.