Neural tissue transplantation, repair, and rehabilitation

Handbook of Clinical Neurology

Volumn 110, Issue , 2013, Pages 43-59

  Dunnett, Stephen B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84872353414     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-52901-5.00004-6     Document Type: Chapter

References (209)

1. Aebischer P., Tresco P.A., Sagen J., et al. Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats. Brain Res 1991, 560:43-49.
2. Aebischer P., Pochon N.A., Heyd B., et al. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Hum Gene Ther 1996, 7:851-860.
3. Aebischer P., Schluep M., Déglon N., et al. Intrathecal delivery of CNTF using encapsulated genetically-modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 1996, 2:696-699.
4. Ahlskog J.E. Cerebral transplantation for Parkinson's disease: current progress and future prospects. Mayo Clin Proc 1993, 68:578-591.
5. Andersson E., Tryggvason U., Deng Q.L., et al. Identification of intrinsic determinants of midbrain dopamine neurons. Cell 2006, 124:393-405.
6. Aubry L., Bugi A., Lefort N., et al. Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats. Proc Natl Acad Sci U S A 2008, 105:16707-16712.
7. Bachoud-Lévi A.C., Déglon N., Nguyen J.P., et al. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum Gene Ther 2000, 11:1723-1729.
8. Bachoud-Lévi A.C., Rémy P., Nguyen J.P., et al. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 2000, 356:1975-1979.
9. Bachoud-Lévi A.C., Gaura V., Brugières P., et al. Persistent benefit of foetal neural transplants in patients with Huntington's disease six years after surgery. Lancet Neurol 2006, 5:303-309.
10. Backlund E.O., Granberg P.O., Hamberger B., et al. Transplantation of adrenal medullary tissue to striatum in parkinsonism: first clinical trials. J Neurosurg 1985, 62:169-173.
11. Balse E., Lazarus C., Kelche C., et al. Intrahippocampal grafts containing cholinergic and serotonergic fetal neurons ameliorate spatial reference but not working memory in rats with fimbria-fornix/cingular bundle lesions. Brain Res Bull 1999, 49:263-272.
12. Bang O.Y., Lee J.S., Lee P.H., et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005, 57:874-882.
13. Barker R.A., Dunnett S.B. Neural Repair, Transplantation and Rehabilitation 1999, The Psychology Press, Hove, UK.
14. Björklund A., Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral transplants. Brain Res 1979, 177:555-560.
15. Björklund A., Stenevi U. In vivo evidence for a hippocampal adrenergic neuronotrophic factor specifically released on septal deafferentation. Brain Res 1981, 229:403-428.
16. Björklund A., Stenevi U., Svendgaard N.-A. Growth of transplanted monoaminergic neurones into the adult hippocampus along the perforant path. Nature 1976, 262:787-790.
17. Björklund A., Dunnett S.B., Stenevi U., et al. Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res 1980, 199:307-333.
18. Björklund A., Schmidt R.H., Stenevi U. Functional reinnervation of the neostriatum in the adult rat by use of intraparenchymal grafting of dissociated cell suspensions from the substantia nigra. Cell Tiss Res 1980, 212:39-45.
19. Björklund L., Sánchez-Pernaute R., Chung S., et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 2002, 99:2344-2349.
20. Boer G.J. Restorative therapies for Parkinson's disease: ethical issues. Restorative Therapies for Parkinson's Disease 2006, 12-49. Springer, New York. P. Brundin, C.W. Olanow (Eds.).
21. Boer G.J., Widner H. Clinical neurotransplantation: core assessment protocol rather than sham surgery as control. Brain Res Bull 2002, 58:547-553.
22. Boer G.J., Gash D.M., Dick L., et al. Vasopressin neuron survival in neonatal Brattleboro rats; critical factors in graft development and innervation of the host brain. Neuroscience 1985, 15:1087-1109.
23. Bohn M.C., Cupit L., Marciano F., et al. Adrenal grafts enhance recovery of striatal dopaminergic fibers. Science 1987, 237:913-916.
24. Brasted P., Humby T., Dunnett S.B., et al. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. J Neurosci 1997, 17:8919-8926.
25. Brasted P.J., Watts C., Robbins T.W., et al. Associative plasticity in striatal transplants. Proc Natl Acad Sci U S A 1999, 96:10524-10529.
26. Brasted P.J., Watts C., Torres E.M., et al. Behavioural recovery following striatal transplantation: effects of postoperative training and P zone volume. Exp Brain Res 1999, 128:535-538.
27. Brasted P.J., Robbins T.W., Dunnett S.B. Behavioral recovery after transplantation into a rat model of Huntington's disease requires both anatomical connectivity and extensive postoperative training. Behav Neurosci 2000, 114:431-436.
28. Bregman B.S., McAtee M., Dal H.N., et al. Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol 1997, 148:475-494.
29. Brown V.J., Dunnett S.B. Comparison of adrenal and fetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions. Exp Brain Res 1989, 78:214-218.
30. Brundin P., Widner H., Nilsson O.G., et al. Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier. Exp Brain Res 1989, 75:195-207.
31. Brundin P., Karlsson J., Emgård M., et al. Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplant 2000, 9:179-195.
32. Brundin P., Pogarell O., Hagell P., et al. Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain 2000, 123:1380-1390.
33. Carli M., Evenden J.L., Robbins T.W. Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention. Nature 1985, 313:679-682.
34. Cheng H., Cao Y.H., Olson L. Spinal cord repair in adult paraplegic rats: partial restoration of hind-limb function. Science 1996, 273:510-513.
35. Clarke D.J., Dunnett S.B. Synaptic relationships between cortical and dopaminergic inputs and intrinsic GABAergic systems within intrastriatal striatal grafts. J Chem Neuroanat 1993, 6:147-158.
36. Cooper B.R., Cott J.M., Breese G.R. Effects of catecholamine-depleting drugs and amphetamine on self-stimulation of brain following various 6-hydroxydopamine treatments. Psychopharmacologia 1974, 37:235-248.
37. David S., Aguayo A.J. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 1981, 214:931-933.
38. Dobkin B.H. Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke 2007, 38:832-839.
39. Dobkin B.H. Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation. Dev Neurobiol 2007, 67:1133-1147.
40. Döbrössy M.D., Dunnett S.B. The influence of environment and experience on neural grafts. Nat Rev Neurosci 2001, 2:871-879.
41. Döbrössy M.D., Dunnett S.B. Motor training affects recovery of function after striatal lesions and grafts. Exp Neurol 2003, 184:184-194.
42. Döbrössy M.D., Dunnett S.B. Environmental enrichment affects striatal graft morphology and functional recovery. Eur J Neurosci 2004, 19:159-168.
43. Döbrössy M.D., Dunnett S.B. Optimising plasticity: environmental and training associated factors in transplant-mediated brain repair. Rev Neurosci 2005, 16:1-21.
44. Döbrössy M.D., Dunnett S.B. Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise. Eur J Neurosci 2006, 24:3223-3233.
45. Döbrössy M.D., Dunnett S.B. The effects of lateralised training on spontaneous forelimb preference, lesion deficits and graft mediated functional recovery after unilateral striatal lesions in rats. Exp Neurol 2006, 199:373-383.
46. Döbrössy M.D., Dunnett S.B. Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington's disease. Cell Transplant 2008, 17:1125-1134.
47. Döbrössy M.D., Le Moal M., Monatron M.F., et al. Influence of the environment on the efficacy of intrastriatal dopaminergic grafts. Exp Neurol 2000, 165:172-183.
48. Dowd E., Dunnett S.B. Deficits in a lateralised associative learning task in dopamine-depleted rats, with selective recovery by dopamine-rich transplants. Eur J Neurosci 2004, 20:1953-1959.
49. Dowd E., Dunnett S.B. Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility. Behav Brain Res 2005, 165:181-186.
50. Dowd E., Dunnett S.B. Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions using a lateralised nose-poking task in rats. Behav Brain Res 2005, 159:153-161.
51. Dowd E., Dunnett S.B. Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions. Biochem Soc Trans 2007, 35:428-432.
52. Dowd E., Monville C., Torres E.M., et al. Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. Eur J Neurosci 2005, 22:2587-2595.
53. Dunnett S.B. Neural transplantation in animal models of dementia. Eur J Neurosci 1990, 2:567-587.
54. Dunnett S.B. The role and repair of forebrain cholinergic systems in short-term memory. Studies using the delayed matching-to-position task in rats. Advances in Neurology 1993, Vol. 59:53-65. Raven Press, New York.
55. Dunnett S.B. Striatal reconstruction by striatal grafts. J Neural Transm 1999, 115-129.
56. Dunnett S.B. Cell replacement therapy: mechanisms of functional recovery. Encyclopedia of Neuroscience 2009, 643-647. Elsevier, Amsterdam. L.R. Squire (Ed.).
57. Dunnett S.B. Neural transplantation. History of Neurology 2009, Vol. 95:887-914. Elsevier, Amsterdam, (3rd Series). S. Finger (Ed.).
58. Dunnett S.B., Björklund A. Neural Transplantation: A Practical Approach 1992, IRL Press, Oxford.
59. Dunnett S.B., Björklund A. Staging and dissection of rat embryos. Neural Transplantation: A Practical Approach 1992, 1-19. IRL Press, Oxford. S.B. Dunnett, A. Björklund (Eds.).
60. Dunnett S.B., Björklund A. Transplantation of dopamine neurons: extent and mechanisms of functional recovery in rodent models of Parkinson's disease 2010, 454-477. Dopamine Handbook. Oxford University Press, New York. L.L. Iversen, S.D. Iversen, S.B. Dunnett, A. Björklund (Eds.).
61. Dunnett S.B., Mayer E. Neural grafts, growth factors and trophic mechanisms of recovery. Neurodegeneration 1992, 183-217. Academic Press, New York. A.J. Hunter, M. Clarke (Eds.).
62. Dunnett S.B., Rosser A.E. Cell therapy in Huntington's disease. NeuroRx 2004, 1:394-405.
63. Dunnett S.B., White A. Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat. Exp Neurol 2006, 199:479-489.
64. Dunnett S.B., Björklund A., Stenevi U., et al. Behavioral recovery following transplantation of substantia nigra in rats subjected to 6-OHDA lesions of the nigrostriatal pathway. 1. Unilateral lesions. Brain Res 1981, 215:147-161.
65. Dunnett S.B., Gage F.H., Björklund A., et al. Hippocampal deafferentation: transplant-derived reinnervation and functional recovery. Scand J Psychol 1982, 104-111.
66. Dunnett S.B., Toniolo G., Fine A., et al. Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis. 2. Sensorimotor and learning impairments. Neuroscience 1985, 16:787-797.
67. Dunnett S.B., Whishaw I.Q., Bunch S.T., et al. Acetylcholine-rich neuronal grafts in the forebrain of rats: effects of environmental enrichment, neonatal noradrenaline depletion, host transplantation site and regional source of embryonic donor cells on graft size and acetylcholinesterase- positive fiber outgrowth. Brain Res 1986, 378:357-373.
68. Dunnett S.B., Whishaw I.Q., Rogers D.C., et al. Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Res 1987, 415:63-78.
69. Dunnett S.B., Badman F., Rogers D.C., et al. Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. Exp Neurol 1988, 102:57-64.
70. Dunnett S.B., Hernandez T.D., Summerfield A., et al. Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Exp Brain Res 1988, 71:411-424.
71. Dunnett S.B., Boulton A.A., Baker G.B. Neuromethods 36: Neural Transplantation Methods 2000, Humana Press, Totowa, NJ.
72. Dunnett S.B., Nathwani F., Björklund A. The integration and function of striatal grafts. Prog Brain Res 2000, 127:345-380.
73. Dunnett S.B., Björklund A., Lindvall O. Cell therapy in Parkinson's disease: stop or go?. Nat Rev Neurosci 2001, 2:365-369.
74. Emerich D.F., Salzberg H.C. Update on immunoisolation cell therapy for CNS diseases. Cell Transplant 2001, 10:3-24.
75. Emerich D.F., Lindner M.D., Winn S.R., et al. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci 1996, 16:5168-5181.
76. Emerich D.F., Bruhn S.L., Chu Y., et al. Cellular delivery of CNTF but not NT-4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease. Cell Transplant 1998, 7:213-225.
77. Eriksdotter-Nilsson M., Skirboll S., Ebendal T., et al. NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye. Exp Brain Res 1989, 74:89-98.
78. Falci S., Holtz A., Åkesson E., et al. Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt. J Neurotrauma 1997, 14:875-884.
79. Fawcett J.W., Rosser A.E., Dunnett S.B. Brain Damage, Brain Repair 2001, Oxford University Press, Oxford.
80. Fine A., Dunnett S.B., Björklund A., et al. Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. Proc Natl Acad Sci U S A 1985, 82:5227-5230.
81. Flerkó B., Szentágothai J. Oestrogen sensitive nervous structures in the hypothalamus. Acta Endocrinol 1957, 26:121-127.
82. Folkerth R.D., Durso R. Survival and proliferation of non-neural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts. Neurology 1996, 46:1219-1225.
83. Frackowiak R., Tallis R., Boniface S., et al. Report. Restoring Neurological Function: Putting the Neurosciences to Work in Neurorehabilitation 2004, Academy of Medical Sciences, London.
84. Fray P.J., Dunnett S.B., Iversen S.D., et al. Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self stimulation. Science 1983, 219:416-419.
85. Freed C.R., Breeze R.E., Fahn S. Placebo surgery in trials of therapy for Parkinson's disease. N Engl J Med 2000, 342:353-354.
86. Freed C.R., Greene P.E., Breeze R.E., et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001, 344:710-719.
87. Freed C.R., Leehey M.A., Zawada M., et al. Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?. J Neurol 2003, 250:S44-S46.
88. Freed W.J. Neural Transplantation: An Introduction 2000, MIT Press, Cambridge, MA, USA.
89. Freed W.J., Morihisa J.M., Spoor E., et al. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 1981, 292:351-352.
90. Freeman T.B., Widner H. Cell Transplantation for Neurological Disorders 1998, Humana, Totowa, NJ.
91. Freeman T.B., Sanberg P.R., Nauert G.M., et al. The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts. Cell Transplant 1995, 4:141-154.
92. Freeman T.B., Watts R.L., Hauser R.A., et al. A prospective, randomized, double-blind, surgical placebo-controlled trial of intrastriatal transplantation of fetal porcine ventral mesencephalic tissue (Neurocell-PD) in subjects with Parkinson's disease. Exp Neurol 2002, 175:426.
93. Gaffan D. Memory, action and the corpus striatum: current developments in the memory-habit distinction. Semin Neurosci 1996, 8:33-38.
94. Gage F.H. Cell therapy. Nature 1998, 392:S18-S24.
95. Gage F.H., Björklund A. Trophic and growth-regulating mechanisms in the central nervous system monitored by intracerebral neural transplants. Ciba Found Symp 1987, 126:143-159.
96. Gage F.H., Björklund A., Stenevi U., et al. Intrahippocampal septal grafts ameliorate learning impairments in aged rats. Science 1984, 225:533-536.
97. Gash D.M., Sladek J.R., Sladek C.D. Functional development of grafted vasopressin neurons. Science 1980, 210:1367-1369.
98. Georgievska B., Carlsson T., Lacar B., et al. Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor. Eur J Neurosci 2004, 20:3121-3130.
99. Goetz C.G., Stebbins G.T., Klawans H.L., et al. United Parkinson Foundation neurotransplantation registry multicenter United States and Canadian data base, presurgical and 12 month follow-up. Prog Brain Res 1990, 82:611-617.
100. Grabowski M., Sorensen J.C., Mattsson B., et al. Influence of an enriched environment and cortical grafting on functional outcome in brain infarcts of adult rats. Exp Neurol 1995, 133:96-102.
101. Halasz B., Pupp L., Uhlarik S., et al. Growth of hypophysectomised rats bearing pituitary transplants in the hypothalamus. Acta Physiol Acad Sci Hung 1963, 23:287-292.
102. Halberstadt C.R., Emerich D.F. Cellular Transplantation: from Laboratory to Clinic. Academic Press San Diego 2007.
103. Hall R.D., Bloom F.E., Olds J. Neuronal and neurochemical substrates of reinforcement. Neurosci Res Prog Bull 1977, 15:133-314.
104. Hargraves R.W., Freed W.J. Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra. Life Sci 1987, 40:959-966.
105. Hauser R.A., Freeman T.B., Snow B.J., et al. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 1999, 56:179-187.
106. Hauser R.A., Furtado S., Cimino C.R., et al. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology 2002, 58:687-695.
107. Hicks A.U., Hewlett K., Windle V., et al. Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke. Neuroscience 2007, 146:31-40.
108. Huang H., Chen L., Xi H., et al. Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients (in Chinese). Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2009, 23:14-20.
109. Isacson O. Cell replacement therapy for Huntington's disease. Encyclopedia of Neuroscience 2009, 1-4. Elsevier, Amsterdam. L.R. Squire (Ed.).
110. Isacson O., Dunnett S.B., Björklund A. Graft-induced behavioral recovery in an animal model of Huntington disease. Proc Natl Acad Sci U S A 1986, 83:2728-2732.
111. Johansson B.B., Grabowski M. Functional recovery after brain infarction: plasticity and neural transplantation. Brain Pathol 1994, 4:85-95.
112. Johansson M., Friedemann M., Hoffer B., et al. Effects of glial cell line-derived neurotrophic factor on developing and mature ventral mesencephalic grafts in oculo. Exp Neurol 1995, 134:25-34.
113. Keene C.D., Sonnen J.A., Swanson P.D., et al. Neural transplantation in Huntington disease: long-term grafts in two patients. Neurology 2007, 68:2093-2098.
114. Kelche C., Dalrymple-Alford J.C., Will B. Housing conditions modulate the effects of intracerebral grafts in rats with brain lesions. Behav Brain Res 1988, 28:287-295.
115. Kelche C., Roeser C., Jeltsch H., et al. The effects of intrahippocampal grafts, training, and postoperative housing on behavioral recovery after septohippocampal damage in the rat. Neurobiol Learn Mem 1995, 63:155-166.
116. Kelly C.M., Precious S.V., Scherf C., et al. Neonatal desensitization allows long-term survival of neuronal xenotransplants without immunosuppression. Nat Methods 2009, 6:271-273.
117. Kempermann G., Kuhn H.G., Gage F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997, 386:493-495.
118. Kim D.S., Kim J.Y., Kang M., et al. Derivation of functional dopamine neurons from embryonic stem cells. Cell Transplant 2007, 16:117-123.
119. Kim J.H., Auerbach J.M., Rodriguez-Gomez J.A., et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002, 418:50-56.
120. Kirik D., Björklund A. Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results. Brain 2005, 128:1478-1479.
121. Knigge K.M. Gonadotrophic action of neonatal pituitary glands implanted in the rat brain. Am J Physiol 1962, 202:387-391.
122. Ko J.Y., Park C.H., Koh H.C., et al. Human embryonic stem cell-derived neural precursors as a continuous, stable, and on-demand source for human dopamine neurons. J Neurochem 2007, 103:1417-1429.
123. Kondziolka D., Wechsler L., Goldstein S., et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000, 55:565-569.
124. Kordower J.H., Winn S.R., Liu Y.-T., et al. The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci U S A 1994, 91:10898-10902.
125. Kordower J.H., Freeman T.B., Chen E.Y., et al. Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease. Mov Disord 1998, 13:383-393.
126. Kordower J.H., Chu Y.P., Hauser R.A., et al. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008, 14:504-506.
127. Korecka J.A., Verhaagen J., Hol E.M. Cell-replacement and gene-therapy strategies for Parkinson's and Alzheimer's disease. Regen Med 2007, 2:425-446.
128. Krieger D.T., Perlow M.J., Gibson M.J., et al. Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Nature 1982, 298:468-471.
129. Li J.Y., Englund E., Holton J.L., et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008, 14:501-503.
130. Lindner M.D., Winn S.R., Baetge E.E., et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp Neurol 1995, 132:62-76.
131. Lindvall O., Hagell P. Clinical observations after neural transplantation in Parkinson's disease. Prog Brain Res 2000, 127:299-320.
132. Lindvall O., Wahlberg L.U. Encapsulated cell biodelivery of GDNF: a novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?. Exp Neurol 2008, 209:82-88.
133. Lindvall O., Brundin P., Widner H., et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 1990, 247:574-577.
134. Low W.C., Lewis P.R., Bunch S.T., et al. Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions. Nature 1982, 300:260-262.
135. Lund R.D., Bannerjee R. Immunological considerations in neural transplantation. Neural Transplantation: A Practical Approach 1992, 161-176. IRL Press, Oxford. S.B. Dunnett, A. Björklund (Eds.).
136. Madrazo I., Drucker-Colín R., Díaz V., et al. Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N Engl J Med 1987, 316:831-834.
137. Mamelak A.N., Eggerding F.A., Oh D.S., et al. Fatal cyst formation after fetal mesencephalic allograft transplant for Parkinson's disease. J Neurosurg 1998, 89:592-598.
138. Martinez-Serrano A., Björklund A. Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging. Proc Natl Acad Sci U S A 1998, 95:1858-1863.
139. Mason H.A., Rakowiecki S.M., Raftopoulou M., et al. Notch signaling coordinates the patterning of striatal compartments. Development 2005, 132:4247-4258.
140. Mattsson B., Sorensen J.C., Zimmer J., et al. Neural grafting to experimental neocortical infarcts improves behavioral outcome and reduces thalamic atrophy in rats housed in enriched but not in standard environments. Stroke 1997, 28:1225-1231.
141. Mayer E., Brown V.J., Dunnett S.B., et al. Striatal graft-associated recovery of a lesion-induced performance deficit in the rat requires learning to use the transplant. Eur J Neurosci 1992, 4:119-126.
142. Mazzocchi-Jones D., Döbrössy M.D., Dunnett S.B. Striatal grafts and synaptic plasticity. Adv Behav Biol 2005, 56:313-320.
143. McBride J.L., Behrstock S.P., Chen E.Y., et al. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. J Comp Neurol 2004, 475:211-219.
144. Mendez I., Dagher A., Hong M., et al. Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease: report of two cases and technical considerations. J Neurosurg 2000, 92:863-869.
145. Mendez I., Dagher A., Hong M., et al. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study - report of three cases. J Neurosurg 2002, 96:589-596.
146. Mendez I., Vinuela A., Astradsson A., et al. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med 2008, 14:507-509.
147. Meyers R. The modification of alternating tremors, rigidity and festination by surgery of basal ganglia. Association for Research in Nervous and Mental Diseases Proceedings 1942, 21:602-665.
148. Meyers R. Surgical experiments in therapy of certain "extrapyramidal" diseases: current evaluation. Acta Psychiat Neurol 1951, 1-42.
149. Mishkin M., Malamut B., Bachevalier J. Memories and habits: two neural systems. Neurobiology of Learning and Memory 1984, 65-77. Guilford Press, New York. G. Lynch, J.L. McGaugh, N.M. Weinberger (Eds.).
150. Mittleman G., Brown V.J., Robbins T.W. Intentional neglect following unilateral ibotenic acid lesions of the striatum. Neurosci Res Comm 1988, 2:1-8.
151. Montoya C.P., Astell S., Dunnett S.B. Effects of nigral and striatal grafts on skilled forelimb use in the rat. Prog Brain Res 1990, 82:459-466.
152. Morizane A., Li J.Y., Brundin P. From bench to bed: the potential of stem cells for the treatment of Parkinson's disease. Cell Tissue Res 2008, 331:323-336.
153. Murry C.E., Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008, 132:661-680.
154. Nilsson O.G., Shapiro M.L., Gage F.H., et al. Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. Exp Brain Res 1987, 67:195-215.
155. Nilsson O.G., Brundin P., Björklund A. Amelioration of spatial memory impairment by intrahippocampal grafts of mixed septal and raphe tissue in rats with combined cholinergic and serotonergic denervation of the forebrain. Brain Res 1990, 515:193-206.
156. Olanow C.W., Kordower J.H., Freeman T.B. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 1996, 19:102-109.
157. Olson L., Seiger Å. Brain tissue transplanted to the anterior chamber of the eye. 1. Fluorescence histochemistry of immature catecholamine and 5-hydroxytryptamine neurons innervating the iris. Z Zellforsch Mikrosk Anat 1972, 195:175-194.
158. Olson L., Seiger Å., Strömberg I. Intraocular transplantation in rodents: a detailed account of the procedure and examples of its use in neurobiology with special reference to brain tissue grafting. Adv 1983, 4:407-442.
159. Olson L., Ayer-LeLievre C., Ebendal T., et al. Grafts, growth factors and grafts that make growth factors. Prog Brain Res 1990, 82:55-66.
160. Packard M.G., Knowlton B.J. Learning and memory functions of the basal ganglia. Annu Rev Neurosci 2002, 25:563-593.
161. Pakzaban P., Isacson O. Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers. Neuroscience 1994, 62:989-1001.
162. Pallage V., Toniolo G., Will B., et al. Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions. Brain Res 1986, 386:197-208.
163. Pappas G.D., Lazorthes Y., Bès J.C., et al. Relief of intractable cancer pain by human chromaffin cell transplants: experience at two medical centers. Neurol Res 1997, 19:71-77.
164. Pearse D.D., Sanchez A.R., Pereira F.C., et al. Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: survival, migration, axon association, and functional recovery. Glia 2007, 55:976-1000.
165. Pedersen E.B., Zimmer J., Finsen B. Triple immunosuppression protects murine intracerebral, hippocampal xenografts in adult rat hosts: effects on cellular infiltration, major histocompatibility complex antigen induction and blood-brain barrier leakage. Neuroscience 1997, 78:685-701.
166. Perlmann T., Wallén-Mackenzie A. Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells. Cell Tiss Res 2004, 318:45-52.
167. Perlow M.J., Freed W.J., Hoffer B.J., et al. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 1979, 204:643-647.
168. Petersén Å., Emgård M., Brundin P. Impact of a preceding striatal excitotoxic lesion and treatment with ciliary neurotrophic factor on striatal graft survival. Brain Res Bull 1999, 50:275-281.
169. Piccini P., Pavese N., Hagell P., et al. Factors affecting the clinical outcome after neural transplantation in Parkinson's disease. Brain 2005, 128:2977-2986.
170. Polgar S., Ng J. A critical analysis of evidence for using sham surgery in Parkinson's disease: implications for public health. Aust N Z J Public Health 2007, 31:270-274.
171. Polgar S., Borlongan C.V., Koutouzis T.K., et al. Implications of neurological rehabilitation for advancing intracerebral transplantation. Brain Res Bull 1997, 44:229-232.
172. Polgar S., Morris M.E., Reilly S., et al. Reconstructive neurosurgery for Parkinson's disease: a systematic review and preliminary meta-analysis. Brain Res Bull 2003, 60:1-24.
173. Poltorak M., Freed W.J. Immunological reactions induced by intracerebral transplantation - evidence that host microglia but not astroglia are the antigen-presenting cells. Exp Neurol 1989, 103:222-233.
174. Quinn N.P. The clinical application of cell grafting techniques in patients with Parkinson's disease. Prog Brain Res 1990, 82:619-625.
175. Rabinovich S.S., Seledtsov V.I., Poveschenko O.V., et al. Transplantation treatment of spinal cord injury patients. Biomed Pharmacother 2003, 57:428-433.
176. Rahimi O., Juliano S.L. Transplants of NGF-secreting fibroblasts restore stimulus-evoked activity in barrel cortex of basal-forebrain-lesioned rats. J Neurophysiol 2001, 86:2081-2096.
177. 18F]fluorodopa uptake in five grafted Parkinsonian patients. Ann Neurol 1995, 38:580-588.
178. Reuter I., Tai Y.F., Pavese N., et al. Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease. J Neurol Neurosurg Psychiatry 2008, 79:948-951.
179. Riess P., Molcanyi M., Bentz K., et al. Embryonic stem cell transplantation after experimental traumatic brain injury dramatically improves neurological outcome, but may cause tumors. J Neurotrauma 2007, 24:216-225.
180. Rosenblad C., Martinez-Serrano A., Björklund A. Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience 1996, 75:979-985.
181. Rosser A.E., Barker R.A., Guillard J., et al. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no 36485475). J Neurol Neurosurg Psychiatry 2002, 73:678-685.
182. Roy N.S., Cleren C., Singh S.K., et al. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 2006, 12:1259-1268.
183. Saporta S., Willing A.E., Zigova T., et al. Comparison of calcium-binding proteins expressed in cultured hNT neurons and hNT neurons transplanted into the rat striatum. Exp Neurol 2001, 167:252-259.
184. Schenk F., Contant B., Werffeli P. Intrahippocampal cholinergic grafts in aged rats compensate impairments in a radial maze and in a place learning task. Exp Brain Res 1990, 82:641-650.
185. Schultz W. Predictive reward signal of dopamine neurons. J Neurophysiol 1998, 80:1-27.
186. Schultz W., Dayan P., Montague P.R. A neural substrate of prediction and reward. Science 1997, 275:1593-1599.
187. Shankle W.R., Hara J., Bjornsen L., et al. Omentum transposition surgery for patients with Alzheimer's disease: a case series. Neurol Res 2008, 30:313-325.
188. Shihabuddin L.S., Palmer T.D., Gage F.H. The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease. Mol Med Today 1999, 5:474-480.
189. Shoham S., Emson P. Effects of combined ventral forebrain grafts to neocortex and amygdala on behavior of rats with damage to the nucleus basalis magnocellularis. Brain Res Bull 1997, 43:381-392.
190. Silverman A.J., Zimmerman E.A., Gibson M.J., et al. Implantation of normal fetal preoptic area into hypogonadal mutant mice: temporal relationships of the growth of gonadotrophin-releasing hormone neurons and the development of the pituitary/testicular axis. Neuroscience 1985, 16:69-84.
191. Sinclair S.R., Svendsen C.N., Torres E.M., et al. GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts. Neuroreport 1996, 7:2547-2552.
192. Springer J.E., Collier T.J., Sladek J.R., et al. Transplantation of male mouse submaxillary gland increases survival of axotomised basal forebrain neurons. J Neurosci Res 1988, 19:291-296.
193. Stenevi U., Björklund A., Svendgaard N.-A. Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival. Brain Res 1976, 114:1-20.
194. Strömberg I., Almqvist P., Bygdeman M., et al. Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies. J Neurosci 1989, 9:614-624.
195. Svendsen C.N., Caldwell M.A., Shen J., et al. Long term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol 1997, 148:135-146.
196. Tan S.A., Aebischer P. The problems of delivering neuroactive molecules to the CNS. Ciba Found Symp 1996, 196:211-236.
197. Tan S.A., Déglon N., Zurn A.D., et al. Rescue of motoneurons from axotomy-induced cell-death by polymer encapsulated cells genetically-engineered to release CNTF. Cell Transplant 1996, 5:577-587.
198. Tarricone B.J., Simon J.R., Low W.C. Intrahippocampal transplants of septal cholinergic neurons: choline acetyltransferase activity, muscarinic receptor binding, and spatial memory function. Brain Res 1993, 632:41-47.
199. Thompson L., Barraud P., Andersson E., et al. Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J Neurosci 2005, 25:6467-6477.
200. Tuszynski M.H. Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol 2002, 1:51-57.
201. Van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999, 2:266-270.
202. Wictorin K. Anatomy and connectivity of intrastriatal striatal transplants. Prog Neurobiol 1992, 38:611-639.
203. Widner H., Tetrud J., Rehncrona S., et al. Fifteen months' follow-up on bilateral embryonic mesencephalic grafts in two cases of severe MPTP-induced parkinsonism. Adv Neurol 1993, 60:729-733.
204. Wilby M., Sinclair S.R., Muir E.M., et al. A GDNF-secreting clone of the Schwann cell line SCTM41 enhances survival and fibre outgrowth from embryonic nigral neurones grafted to the striatum and the lesioned substantia nigra. J Neurosci 1999, 19:2301-2312.
205. Winkler C., Kirik D., Björklund A., et al. Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement. Prog Brain Res 2000, 127:233-265.
206. Winkler J., Suhr S.T., Gage F.H., et al. Essential role of neocortical acetylcholine in spatial memory. Nature 1995, 375:484-487.
207. Wirth E.D., Reier P.J., Fessler R.G., et al. Feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001, 18:911-929.
208. Zeng J.S., Mattsson B., Schulz M.K., et al. Expression of zinc-positive cells and terminals in fetal neocortical homografts to adult rat depends on lesion type and rearing conditions. Exp Neurol 2000, 164:176-183.
209. Zurn A.D., Widmer H.R., Aebischer P. Sustained delivery of GDNF: towards a treatment for Parkinson's disease. Brain Res Rev 2001, 36:222-229.