The utility of yeast as a tool for cell-based, target-directed high-throughput screening

Parasitology

Volumn 141, Issue 1, 2014, Pages 8-16

  Norcliffe, J L ^a   Alvarez Ruiz, E ^b   Martin Plaza, J J ^b   Steel, P G ^a   Denny, P W ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b GLAXOSMITHKLINE   (Spain)

Author keywords

HTS; NTDs; Yeast

Indexed keywords

ANTIPARASITIC AGENT; NEW DRUG; PROTOZOAL PROTEIN;

ARTICLE; HETEROLOGOUS EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; YEAST; YEAST CELL; BIOASSAY; COMMUNICABLE DISEASES; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; ECONOMICS; GENE EXPRESSION; GENETIC ENGINEERING; GENETICS; METABOLISM; NEGLECTED DISEASES; SACCHAROMYCES CEREVISIAE; TROPICAL MEDICINE; UTILIZATION;

BIOLOGICAL ASSAY; COMMUNICABLE DISEASES; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; GENE EXPRESSION; GENETIC ENGINEERING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NEGLECTED DISEASES; PROTOZOAN PROTEINS; SACCHAROMYCES CEREVISIAE; TROPICAL MEDICINE;

EID: 84891887955     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013000425     Document Type: Article

References (48)

1. Alaamery, M. A., Wyman, A. R., Ivey, F. D., Allain, C., Demirbas, D., Wang, L., Ceyhan, O. and Hoffman, C. S. (2010). New classes of PDE7 inhibitors identified by a fission yeast-based HTS. Journal of Biomolecular Screening 15, 359-367
2. Allarakhia, M. and Ajuwon, L. (2012). Understanding and creating value from open source drug discovery for neglected tropical diseases. Expert Opinion on Drug Discovery 7, 643-657
3. An,W. F. and Tolliday, N. (2010). Cell-based assays for high-Throughput screening. Molecular Biotechnology 45, 180-186
4. Bach, S., Talarek, N., Andrieu, T., Vierfond, J. M., Mettey, Y., Galons, H., Dormont, D., Meijer, L., Cullin, C. and Blondel, M. (2003). Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nature Biotechnology 21, 1075-1081
5. Bach, S., Tribouillard, D., Talarek, N., Desban, N., Gug, F., Galons, H. and Blondel, M. (2006). A yeast-based assay to isolate drugs active against mammalian prions. Methods 39, 72-77
6. Barberis, A., Gunde, T., Berset, C., Audetat, S. and Luthi, U. (2005). Yeast as a screening tool. Drug Discovery Today 2, 187-192
7. Bender, A. T. and Beavo, J. A. (2006). Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacology Reviews 58, 488-520
8. Benko, Z., Elder, R. T., Liang, D. and Zhao, R. Y. (2010). Fission yeast as a HTS platform for molecular probes of HIV-1 Vpr-induced cell death. International Journal of High Throughput Screening 1, 151-162
9. Bilsland, E., Pir, P., Gutteridge, A., Johns, A., King, R. D. and Oliver, S. G. (2011). Functional expression of parasite drug targets and their human orthologs in yeast. PLoS Neglected Tropical Diseases 5, e1320
10. Bilsland, E., Sparks, A., Williams, K., Moss, H. J., de Clare, M., Pir, P., Rowland, J., Aubrey, W., Pateman, R., Young, M., Carrington, M., King, R. D. and Oliver, S. G. (2013). Yeast-based automated highthroughput screens to identify new anti-parasitic leads. Open Biology 3, 120158
11. Castrillo, J. I. and Oliver, S. G. (2011). Yeast systems biology: The challenge of eukaryotic complexity. Methods in Molecular Biology 759, 3-28
12. Ceyhan, O., Birsoy, K. and Hoffman, C. S. (2012). Identification of biologically active PDE11-selective inhibitors using a yeast-based high-Throughput screen. Chemical Biology 19, 155-163
13. Conti, M. and Beavo, J. (2007). Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annual Review of Biochemistry 76, 481-511
14. Cottier, V., Barberis, A. and Luthi, U. (2006). Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-Throughput format. Antimicrobial Agents and Chemotherapy 50, 565-571
15. Couplan, E., Aiyar, R. S., Kucharczyk, R., Kabala, A., Ezkurdia, N., Gagneur, J., St Onge, R. P., Salin, B., Soubigou, F., Le Cann, M., Steinmetz, L. M., di Rago, J. P. and Blondel, M. (2011). A yeast-based assay identifies drugs active against human mitochondrial disorders. Proceedings of the National Academy of Sciences, USA 108, 11989-11994
16. Demirbas, D., Ceyhan, O., Wyman, A. R. and Hoffman, C. S. (2011). A fission yeast-based platform for phosphodiesterase inhibitor HTSs and analyses of phosphodiesterase activity. In Handbook of Experimental Pharmacology (ed. Hoffmann, F. B.), pp. 135-149. Springer-Verlag, Germany
17. Denny, P.W., Shams-Eldin, H., Price, H. P., Smith, D. F. and Schwarz, R. T. (2006). The protozoan inositol phosphorylceramide synthase: A novel drug target which defines a new class of sphingolipid synthase. Journal of Biological Chemistry 281, 28200-28209
18. Fernandez-Acero, T., Rodriguez-Escudero, I., Vicente, F., Monteiro, M. C., Tormo, J. R., Cantizani, J., Molina, M. and Cid, V. J. (2012). A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors. Journal of Biomolecular Screening 17, 1018-1029
19. Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M., Brenk, R., Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A., Smith, D. F. and Wyatt, P. G. (2010). N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 464, 728-732
20. Friedmann, Y., Shriki, A., Bennett, E. R., Golos, S., Diskin, R., Marbach, I., Bengal, E. and Engelberg, D. (2006). JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Molecular Pharmacology 70, 1395-1405
21. Grozinger, C. M., Chao, E. D., Blackwell, H. E., Moazed, D. and Schreiber, S. L. (2001). Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. Journal of Biological Chemistry 276, 38837-38843
22. Heby, O., Persson, L. and Rentala, M. (2007). Targeting the polyamine biosynthetic enzymes: A promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. Amino Acids 33, 359-366
23. Hughes, T. R. (2002). Yeast and drug discovery. Functional and Integrative Genomics 2, 199-211
24. Ivey, F. D., Wang, L., Demirbas, D., Allain, C. and Hoffman, C. S. (2008). Development of a fission yeast-based high-Throughput screen to identify chemical regulators of cAMP phosphodiesterases. Journal of Biomolecular Screening 13, 62-71
25. Khozoie, C., Pleass, R. J. and Avery, S. V. (2009). The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes tryptophan starvation. Journal of Biological Chemistry 284, 17968-17974
26. Klein, R. D., Favreau, M. A., Alexander-Bowman, S. J., Nulf, S. C., Vanover, L., Winterrowd, C. A., Yarlett, N., Martinez, M., Keithly, J. S., Zantello, M. R., Thomas, E. M. and Geary, T. G. (1997). Haemonchus contortus: Cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors. Experimental Parasitology 87, 171-184
27. Kurtz, S., Luo, G., Hahnenberger, K. M., Brooks, C., Gecha, O., Ingalls, K., Numata, K. and Krystal, M. (1995). Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: Identification of a novel inhibitor of influenza virus. Antimicrobial Agents and Chemotherapy 39, 2204-2209
28. Li,W., Mo,W., Shen, D., Sun, L., Wang, J., Lu, S., Gitschier, J. M. and Zhou, B. (2005). Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genetics 1, e36
29. Limenitakis, J. and Soldati-Favre, D. (2011). Functional genetics in Apicomplexa: Potentials and limits. FEBS Letters 585, 1579-1588
30. Lipinski, C. A., Lombardo, F., Dominy, B.W. and Feeney, P. J. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews 46, 3-26
31. Marjanovic, J., Chalupska, D., Patenode, C., Coster, A., Arnold, E., Ye, A., Anesi, G., Lu, Y., Okun, I., Tkachenko, S., Haselkorn, R. and Gornicki, P. (2010). Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity. Proceedings of the National Academy of Sciences, USA 107, 9093-9098
32. McCue, P. P. and Phang, J. M. (2008). Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemicalgenetic profiling in yeast. Journal of Agriculture and Food Chemistry 56, 11011-11017
33. Middendorp, O., Ortler, C., Neumann, U., Paganetti, P., Luthi, U. and Barberis, A. (2004). Yeast growth selection system for the identification of cell-Active inhibitors of beta-secretase. Biochimica et Biophysica Acta 1674, 29-39
34. Mina, J. G., Mosely, J. A., Ali, H. Z., Denny, P.W. and Steel, P. G. (2011). Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): Insights into the ceramide binding domain. Organic and Biomolecular Chemistry 9, 1823-1830
35. Mina, J. G., Mosely, J. A., Ali, H. Z., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. and Denny, P.W. (2010). A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase. International Journal of Biochemistry and Cell Biology 42, 1553-1561
36. Mina, J. G., Pan, S. Y., Wansadhipathi, N. K., Bruce, C. R., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. and Denny, P.W. (2009). The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Molecular and Biochemical Parasitology 168, 16-23
37. Muller, S. and Knapp, S. (2010). Targeting kinases for the treatment of inflammatory diseases. Expert Opinion on Drug Discovery 5, 867-881
38. Munder, T. and Hinnen, A. (1999). Yeast cells as tools for target-oriented screening. Applied Microbiology and Biotechnology 52, 311-320
39. Nagiec, M. M., Nagiec, E. E., Baltisberger, J. A., Wells, G. B., Lester, R. L. and Dickson, R. C. (1997). Sphingolipid synthesis as a target for antifungal drugs. Journal of Biological Chemistry 272, 9809-9817
40. Seebeck, T., Sterk, G. J. and Ke, H. (2011). Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: Exploiting the benefit of enzymes that are highly conserved between host and parasite. Future Medicinal Chemistry 3, 1289-1306
41. Sibley, C. H., Brophy, V. H., Cheesman, S., Hamilton, K. L., Hankins, E. G., Wooden, J.M. and Kilbey, B. (1997). Yeast as a model system to study drugs effective against apicomplexan proteins. Methods 13, 190-207
42. Simon, J. A. and Bedalov, A. (2004). Yeast as a model system for anticancer drug discovery. Nature Reviews Cancer 4, 481-492
43. Siqueira-Neto, J. L., Moon, S., Jang, J., Yang, G., Lee, C., Moon,H. K., Chatelain, E., Genovesio, A., Cechetto, J., and Freitas-Junior, L. H. (2012). An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. PLoS Neglected Tropical Diseases 6, e1671
44. World Heath Organization (2012a). http://www.who.int/neglected- diseases/diseases/en/.
45. World Heath Organization (2012b). www.who.int/neglected-diseases/ London-Declaration-NTDs.pdf
46. Wu, G. (2010). Recent progress in phosphoinositide 3-kinases: Oncogenic properties and prognostic and therapeutic implications. Current Protein and Peptide Science 11, 425-435
47. Young, K., Lin, S., Sun, L., Lee, E., Modi, M., Hellings, S., Husbands, M., Ozenberger, B., and Franco, R. (1998). Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. Nature Biotechnology 16, 946-950
48. Zaks-Makhina, E., Kim, Y., Aizenman, E., and Levitan, E. S. (2004). Novel neuroprotective K+ channel inhibitor identified by high-Throughput screening in yeast. Molecular Pharmacology 65, 214-219