Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 20, 2010, Pages 9093-9098

  Marjanovic, Jasmina ^a   Chalupska, Dominika ^a   Patenode, Caroline ^a   Coster, Adam ^a   Arnold, Evan ^a   Ye, Alice ^a   Anesi, George ^a   Lu, Ying ^a   Okun, Ilya ^b   Tkachenko, Sergey ^b   Haselkorn, Robert ^a   Gornicki, Piotr ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b CHEMDIV INC   (United States)

Author keywords

Fatty acid metabolism; Human health

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ACETYL COENZYME A CARBOXYLASE 2; ANTIOBESITY AGENT; CD 0170191; CD 0170213; ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; OBESITY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STRAIN DIFFERENCE; YEAST;

ACETYL-COA CARBOXYLASE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; FATTY ACIDS; GENE COMPONENTS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; OBESITY; ORGANISMS, GENETICALLY MODIFIED; YEASTS;

ANIMALIA; EUKARYOTA;

EID: 77952716488     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003721107     Document Type: Article

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