A yeast-based assay identifies drugs active against human mitochondrial disorders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages 11989-11994

  Couplan, Elodie ^a   Aiyar, Raeka S ^b   Kucharczyk, Roza ^c,d   Kabala, Anna ^c,d   Ezkurdia, Nahia ^c   Gagneur, Julien ^b   St Onge, Robert P ^e   Salin, Bénédicte ^c   Soubigou, Flavie ^a   Le Cann, Marie ^a   Steinmetz, Lars M ^b   Di Rago, Jean Paul ^c   Blondel, Marc ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c Institut de Biochimie et Genetique Cellulaires   (France)

^d INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Budding yeast; Drug screening; NARP cybrid; Transcription profiling

Indexed keywords

CHLORHEXIDINE; OLEIC ACID; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MITOCHONDRIAL GENOME; MITOCHONDRIAL MEMBRANE; NARP SYNDROME; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; YEAST CELL;

CELL LINE; CHLORHEXIDINE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; HUMANS; MITOCHONDRIAL MYOPATHIES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLEIC ACID; RETINITIS PIGMENTOSA; SACCHAROMYCETALES;

ANIMALIA; SACCHAROMYCETALES;

EID: 79961042033     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101478108     Document Type: Article

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