The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target

Molecular and Biochemical Parasitology

Volumn 168, Issue 1, 2009, Pages 16-23

  Mina, John G ^a   Pan, Ssu Ying ^a   Wansadhipathi, Nilu K ^a   Bruce, Catherine R ^a   Shams Eldin, Hosam ^b   Schwarz, Ralph T ^b,c   Steel, Patrick G ^a   Denny, Paul W ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

Author keywords

Drug target; Sphingolipid synthase; Trypanosoma; Trypanosomiasis

Indexed keywords

ANTIFUNGAL AGENT; AUREOBASIDIN A; CERAMIDE DERIVATIVE; FUNGAL PROTEIN; INOSITOL PHOSPHORYLCERAMIDE; ISOPROTEIN; PROTOZOAL PROTEIN; SPHINGOLIPID SYNTHASE; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GROWTH REGULATION; GROWTH STIMULATION; IN VITRO STUDY; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA INTERFERENCE; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS; YEAST;

ANIMALS; ANTIFUNGAL AGENTS; CELL SURVIVAL; HEXOSYLTRANSFERASES; PROTOZOAN PROTEINS; SPHINGOLIPIDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; FUNGI; HEXAPODA; KINETOPLASTIDA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 68749094985     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.06.002     Document Type: Article

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