Identification of human intracellular targets of the medicinal herb St. John's wort by chemical-genetic profiling in yeast

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 22, 2008, Pages 11011-11017

  McCue, Patrick P ^a,b,c   Phang, James M ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Alternative medicine; Botanical; Depression; Dietary supplement; Hypericum perforatum; Microarray; St. John's wort; Wound healing; Yeast

Indexed keywords

FUNGAL DNA; PLANT EXTRACT;

ARTICLE; BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM; CHEMISTRY; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; GENE DELETION; GENETICS; HUMAN; HYPERICUM; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

CENTRAL NERVOUS SYSTEM; DNA, FUNGAL; GENE DELETION; HUMANS; HYPERICUM; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLANT EXTRACTS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

HYPERICUM PERFORATUM; SACCHAROMYCES CEREVISIAE;

EID: 57849146808     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf801593a     Document Type: Article

References (25)

1. Charrois, T. L.; Sadler, C.; Vohra, S. Complementary, holistic, and integrative medicine: St. John's wort. Pediatr. Rev. 2007, 28, 69-72.
2. Linde, K.; Berner, M.; Egger, M.; Mulrow, C. St. John's wort for depression: meta-analysis of randomised controlled trials. Br. J. Psychiatry 2005, 186, 99-107.
3. Schempp, C. M.; Kirkin, V.; Simon-Haarhaus, B.; Kersten, A.; Kiss, J.; Termeer, C. C.; Gilb, B.; Kaufmann, T.; Borner, C.; Sleeman, J. P.; Simon, J. C. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene 2002, 21, 1242-1250.
4. Jayasuriya, H.; McChesney, J. D.; Swanson, S. M.; Pezzuto, J. M. Antimicrobial and cytotoxic activity of rottlerin-type compounds from Hypericum drummondii. J. Nat. Prod. 1989, 52, 325-331.
5. Ferraz, A.; Faria, D. H.; Benneti, M. N.; da Rocha, A. B.; Schwartsmann, G.; Henriques, A.; von Poser, G. L. Screening for antiproliferative activity of six southern Brazilian species of Hypericum. Phytomedicine 2005, 12, 112-115.
6. Patocka, J. The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. J. Appl. Biomed. 2003, 1, 61-70.
7. Ioannides, C. Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 2002, 32, 451-478.
8. Shoemaker, D. D.; Lashkari, D. A.; Morris, D.; Mittmann, M.; Davis, R. W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat. Genet. 1996, 14, 450-456.
9. Winzeler, E. A.; Shoemaker, D. D.; Astromoff, A.; Liang, H.; Anderson, K.; Andre, B.; Bangham, R.; Benito, R.; Boeke, J. D.; Bussey, H.; Chu, A. M.; Connelly, C.; Davis, K.; Dietrich, F.; Dow, S. W.; El Bakkoury, M.; Foury, F.; Friend, S. H.; Gentalen, E.; Giaever, G.; Hegemann, J. H.; Jones, T.; Laub, M.; Liao, H.; Liebundguth, N.; Lockhart, D. J.; Lucau-Danila, A.; Lussier, M.; M'Rabet, N.; Menard, P.; Mittmann, M.; Pai, C.; Rebischung, C.; Revueita, J. L.; Riles, L.; Roberts, C. J.; Ross-MacDonald, P.; Scherens, B.; Snyder, M.; Sookhai-Mahadeo, S.; Storms, R. K.; Veronneau, S.; Voet, M.; Volckaert, G.; Ward, T. R.; Wysocki, R.; Yen, G. S.; Yu, K.; Zimmermann, K.; Philippsen, P.; Johnston, M.; Davis, R. W. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999, 285, 901-906.
10. Giaever, G.; Flaherty, P.; Kumm, J.; Proctor, M.; Nislow, C.; Jaramillo, D. F.; Chu, A. M.; Jordan, M. I.; Arkin, A. P.; Davis, R. W. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 793-798.
11. Birrell, G. W.; Giaever, G.; Chu, A. M.; Davis, R. W.; Brown, J. M. A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 12608-12613.
12. Doostzadeh, J.; Davis, R. W.; Giaever, G. N.; Nislow, C.; Langston, J. W. Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease. Toxicol. Sci. 2007, 95, 182-187.
13. McCue, P.; Zheng, Z.; Pinkham, J. L.; Shetty, K. A model for enhanced pea seedling vigour following low pH and salicylic acid treatments. Process Biochem. 2000, 35, 603-613.
14. McCue, P.; Kwon, Y. I.; Shetty, K. Anti-diabetic and antihypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac. J. Clin. Nutr. 2005, 14, 145-152.
15. Ang, C. Y.; Cui, Y.; Chang, H. C.; Luo, W.; Heinze, T. M.; Lin, L. J.; Mattia, A. Determination of St. John's wort components in dietary supplements and functional foods by liquid chromatography. J. AOAC Int. 2002, 85, 1360-1369.
16. Yuan, D. S.; Pan, X.; Ooi, S. L.; Peyser, B. D.; Spencer, F. A.; Irizarry, R. A.; Boeke, J. D. Improved microarray methods for profiling the Yeast Knockout strain collection. Nucleic Acids Res. 2005, 33, e103.
17. Peyser, B. D.; Irizarry, R. A.; Tiffany, C. W.; Chen, O.; Yuan, D. S.; Boeke, J. D.; Spencer, F. A. Improved statistical analysis of budding yeast TAG microarrays revealed by defined spike-in pools. Nucleic Acids Res. 2005, 33, e140.
18. Clarimón, J.; Bertranpetit, J.; Boada, M.; Tàrraga, L.; Comas, D. HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. J. Geriatr. Psychiatry Neurol. 2003, 16, 146-150.
19. Wu, Y. R.; Wang, C. K.; Chen, C. M.; Hsu, Y.; Lin, S. J.; Lin, Y. Y.; Fung, H. C.; Chang, K. H.; Lee-Chen, G. J. Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease. Hum. Genet. 2004, 114, 236-241.
20. Fung, H. C.; Chen, C. M.; Wu, Y. R.; Hsu, W. C.; Ro, L. S.; Lin, J. C.; Chang, K. H.; Wang, H. K.; Lin, S. J.; Chan, H.; Lin, Y. Y.; Wei, S. L.; Hsu, Y.; Hwang, J. C.; Tung, L. C.; Lee-Chen, G. J. Heat shock protein 70 and tumor necrosis factor α in Taiwanese patients with dementia. Dement. Geriatr. Cogn. Disord. 2005, 20, 1-7.
21. Pae, C. U.; Kim, T. S.; Kwon, O. J.; Artioli, P.; Serretti, A.; Lee, C. U.; Lee, S. J.; Lee, C.; Paik, I. H.; Kim, J. J. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. Neurosci. Res. 2005, 53, 8-13.
22. Pae, C. U.; Mandelli, L.; Serretti, A.; Patkar, A. A.; Kim, J. J.; Lee, C. U.; Lee, S. J.; Lee, C.; De Ronchi, D.; Paik, I. H. Heat-shock protein-70 genes and response to antidepressants in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31, 1006-1011.
23. Goehler, H.; Lalowski, M.; Stelzl, U.; Waelter, S.; Stroedicke, M.; Worm, U.; Droege, A.; Lindenberg, K. S.; Knoblich, M.; Haenig, G; Herbst, M.; Suopanki, J.; Scherzinger, E.; Abraham, C.; Bauer, B.; Hasenbank, R.; Fritzsche, A.; Ludewig, A. H.; Büssow, K.; Coleman, S. H.; Gutekunst, C. A.; Landwehrmeyer, B. G.; Lehrach, H.; Wanker, E. E. A protein interaction network links GTTl, an enhancer of huntingtin aggregation, to Huntington's disease. Mol. Cell 2004, 15, 853-865.
24. Karadimas, C. L.; Vu, T. H.; Holve, S. A.; Chronopoulou, P.; Quinzii, C.; Johnsen, S. D.; Kurth, J.; Eggers, E.; Palenzuela, L.; Tanji, K.; Boitilla, E.; De Vivo, D. C.; DiMauro, S.; Hirano, M. Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. Am. J. Hum. Genet. 2006, 79, 544-548.
25. Outeiro, T. F.; Kontopoulos, E.; Altmann, S. M.; Kufareva, I.; Strathearn, K. E.; Amore, A. M.; Volk, C. B.; Maxwell, M. M.; Rochet, J. C.; McLean, P. J.; Young, A. B.; Abagyan, R.; Feany, M. B.; Hyman, B. T.; Kazantsev, A. G. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007, 317, 516-519.