A fission yeast-based platform for phosphodiesterase inhibitor HTSs and analyses of phosphodiesterase activity

Handbook of Experimental Pharmacology

Volumn 204, Issue , 2011, Pages 135-149

  Demirbas, Didem ^a   Ceyhan, Ozge ^a   Wyman, Arlene R ^a   Hoffman, Charles S ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

cAMP; Cell based assay; cGMP; High throughput; Inhibitors; Phosphodiesterase; PKA; Schizosaccharomyces pombe

Indexed keywords

ADENYLATE CYCLASE; BC 35; BC 54; BC 69; BC 76; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; G PROTEIN COUPLED RECEPTOR; PHOSPHODIESTERASE 1B; PHOSPHODIESTERASE 4B2; PHOSPHODIESTERASE 7A1; PHOSPHODIESTERASE 8A; PHOSPHODIESTERASE 9A; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PHOSPHODIESTERASE VII; PROTEIN FBP 1; ROLIPRAM; SPLEEN EXONUCLEASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; PHOSPHODIESTERASE;

ARTICLE; CATALYSIS; DNA LIBRARY; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; EXPRESSION VECTOR; FUNGAL STRAIN; HIGH THROUGHPUT SCREENING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; METABOLISM; METHODOLOGY; PHYSIOLOGY; REVIEW; SCHIZOSACCHAROMYCES;

CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; SCHIZOSACCHAROMYCES;

EID: 79960924241     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-17969-3_5     Document Type: Article

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