New classes of PDE7 inhibitors identified by a fission yeast-based HTS

Journal of Biomolecular Screening

Volumn 15, Issue 4, 2010, Pages 359-367

  Alaamery, Manala ^a,b   Wyman, Arlene R ^a   Ivey, F Douglas ^a   Allain, Christina ^a   Demirbas, Didem ^a   Wang, Lili ^a   Ceyhan, Ozge ^a   Hoffman, Charles S ^a  

^a BOSTON COLLEGE   (United States)

^b LABORATORY FOR MOLECULAR MEDICINE   (United States)

Author keywords

CAMP; High throughput; Inhibitors; PDE7; Phosphodiesterase; Schizosaccharomyces pombe

Indexed keywords

2 METHYL 5 NITROBENZENESULFONIC ACID DIMETHYLAMIDE; 3 AMINO 4 (2 FURYL)THIENO[2,3 B]THIOPHENE 2,5 DICARBONITRILE; ANDROSTERONE ACETATE; ANDROSTERONE DERIVATIVE; BC 11; BC 30; BC 39; CANRENONE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE VII; PHOSPHODIESTERASE VII INHIBITOR; PHOSPHODIESTERASE VIIA; PHOSPHODIESTERASE VIIB; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; FUNGAL STRAIN; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOSACCHAROMYCES POMBE;

ANTI-INFLAMMATORY AGENTS; CATALYTIC DOMAIN; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 7; ENZYME ASSAYS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; OROTIC ACID; PHOSPHODIESTERASE INHIBITORS; SCHIZOSACCHAROMYCES; TUMOR NECROSIS FACTOR-ALPHA;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 77952391406     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110362100     Document Type: Article

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