Functional expression of parasite drug targets and their human orthologs in yeast

PLoS Neglected Tropical Diseases

Volumn 5, Issue 10, 2011, Pages

  Bilsland, Elizabeth ^a   Pir, Pinar ^a   Gutteridge, Alex ^a   Johns, Alexander ^a   King, Ross D ^b   Oliver, Stephen G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; PHOSPHOGLYCERATE KINASE; PROTEIN N MYRISTOYLTRANSFERASE; PYRIMETHAMINE; ANTIPROTOZOAL AGENT; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG RESISTANCE; DRUG SCREENING; DRUG SENSITIVITY; DRUG TARGETING; FUNCTIONAL GENOMICS; GENE DELETION; GENE OVEREXPRESSION; NONHUMAN; OPEN READING FRAME; ORTHOLOGY; PHENOTYPE; PLASMODIUM; PROMOTER REGION; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SCHISTOSOMA; SITE DIRECTED MUTAGENESIS; TRYPANOSOMA; YEAST; BIOSYNTHESIS; DRUG EFFECT; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; TRANSGENIC ORGANISM;

ANTIPROTOZOAL AGENTS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ORGANISMS, GENETICALLY MODIFIED; PROTOZOAN PROTEINS; PYRIMETHAMINE; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 80055078977     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001320     Document Type: Article

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