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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 2, 2014, Pages 618-623

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position

(10) Hamada, Yoshio a,b Suzuki, Kenji b Nakanishi, Tomoya b Sarma, Diganta b Ohta, Hiroko b Yamaguchi, Ryoji b Yamasaki, Moe b Hidaka, Koushi b Ishiura, Shoichi c Kiso, Yoshiaki a,b,d

a KOBE GAKUIN UNIVERSITY (Japan)

b KYOTO PHARMACEUTICAL UNIVERSITY (Japan)

c UNIVERSITY OF TOKYO (Japan)

d NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY (Japan)

Author keywords

Secretase; Alzheimer's disease; BACE1; BACE1 inhibitor

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR; CHELIDONINE; DICARBOXYLIC ACID DERIVATIVE; HALOGEN; KMI 1303; PYRIDINE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; BETA SECRETASE 1; BETA SECRETASE 1 INHIBITOR; DIPICOLINIC ACID; HETEROCYCLIC COMPOUND; KMI 1040; KMI 1263; KMI 1331; KMI 789; KMI 827; KMI 848; KMI 870; KMI 871; KMI 876; KMI 886; KMI 887; KMI 898; KMI 899; KMI 900; KMI 902; KMI 903; KMI 911; KMI 922; KMI 923; KMI 926; KMI 943; KMI 991; MOLECULAR SCAFFOLD; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CELL CULTURE; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; ENZYME STABILITY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STUDY; TAUTOMERIZATION; WESTERN BLOTTING; CELL MEMBRANE PERMEABILITY; HYDROGENATION; HYDROPHOBICITY;

ALZHEIMER'S DISEASE; BACE1; BACE1 INHIBITOR; Β-SECRETASE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRANS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891838233 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.12.007 Document Type: Article

Times cited : (11)

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