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Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1649-1653

BACE1 inhibitors: Optimization by replacing the P1′ residue with non-acidic moiety

(11) Hamada, Yoshio a Abdel Rahman, Hamdy a Yamani, Abdellah a Nguyen, Jeffrey Tri a Stochaj, Monika a Hidaka, Koushi a Kimura, Tooru a Hayashi, Yoshio a Saito, Kazuki b Ishiura, Shoichi c Kiso, Yoshiaki a

a Center for Frontier Research in Medicinal Science (Japan)

b KYOTO PHARMACEUTICAL UNIVERSITY (Japan)

c UNIVERSITY OF TOKYO (Japan)

Author keywords

Alzheimer's disease; BACE1; BACE1 inhibitor; Secretase

Indexed keywords

BETA SECRETASE INHIBITOR; KMI 260; KMI 420; KMI 429; KMI 477; KMI 491; KMI 517; KMI 541; KMI 684; KMI 694; KMI 701; KMI 735; KMI 749; KMI 752; KMI 758; KMI 761; KMI 773; KMI 806; KMI 811; KMI 817; KMI 818; KMI 819; KMI 845; KMI 880; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CELL ASSAY; CELL CULTURE; CHEMICAL MODIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR SIZE; SUBSTITUTION REACTION;

EID: 39849104028 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2008.01.058 Document Type: Article

Times cited : (36)

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