BACE1 inhibitor peptides: Can an infinitely small k cat value turn the substrate of an enzyme into its inhibitor?

ACS Medicinal Chemistry Letters

Volumn 3, Issue 3, 2012, Pages 193-197

  Hamada, Yoshio ^a,b   Ishiura, Shoichi ^c   Kiso, Yoshiaki ^a,b,d  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

secretase; Alzheimer's disease; BACE1; BACE1 inhibitor; inhibitor peptide; substrate

Indexed keywords

AMYLOID BETA PROTEIN; ARGININE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; KMI 1006; KMI 1027; KMI 1303; KMI 1504; KMI 1632; KMI 1633; KMI 1634; KMI 1635; KMI 1638; KMI 1639; KMI 1705; KMI 1706; KMI 1707; KMI 1708; KMI 1709; KMI 1710; KMI 1791; KMI 1792; KMI 1793; KMI 1794; KMI 1795; KMI 1855; KMI 1857; KMI 1858; KMI 429; KMI 446; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL ASSAY; CHEMICAL INTERACTION; COMPUTER MODEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION;

EID: 84858256185     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2002373     Document Type: Article

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